HUP0303055A2 - Zaleplon polimorf módosulatai és eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Zaleplon polimorf módosulatai és eljárás előállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0303055A2 HUP0303055A2 HU0303055A HUP0303055A HUP0303055A2 HU P0303055 A2 HUP0303055 A2 HU P0303055A2 HU 0303055 A HU0303055 A HU 0303055A HU P0303055 A HUP0303055 A HU P0303055A HU P0303055 A2 HUP0303055 A2 HU P0303055A2
- Authority
- HU
- Hungary
- Prior art keywords
- zaleplon
- polymorphs
- preparation
- methods
- pharmaceutical compositions
- Prior art date
Links
- HUNXMJYCHXQEGX-UHFFFAOYSA-N zaleplon Chemical compound CCN(C(C)=O)C1=CC=CC(C=2N3N=CC(=C3N=CC=2)C#N)=C1 HUNXMJYCHXQEGX-UHFFFAOYSA-N 0.000 title abstract 5
- 229960004010 zaleplon Drugs 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000012986 modification Methods 0.000 abstract 3
- 230000004048 modification Effects 0.000 abstract 3
- 206010021118 Hypotonia Diseases 0.000 abstract 1
- 230000000049 anti-anxiety effect Effects 0.000 abstract 1
- 230000003556 anti-epileptic effect Effects 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000036640 muscle relaxation Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000004799 sedative–hypnotic effect Effects 0.000 abstract 1
- 210000002027 skeletal muscle Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
A találmány zaleplon (N-[3-(3-cianopirazolo[1,5a]-pirimidin-7-il)fenil]-N-etilacetamid) új, kristályos polimorf módosulataira, ezekelőállítási eljárására, valamint ezen polimorf módosulatokattartalmazó gyógyszerkészítményekre vonatkozik. A zaleplon új,kristályos polimorf módosulatai azak a zaleplon I, II és II formák,szorongásellenes, epilepsziaellenes hatásúak, alkalmasak nyugtató-hipnotikus hatás kifejlesztésére, valamint vázizomlazításra. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22278500P | 2000-08-03 | 2000-08-03 | |
PCT/US2001/024510 WO2002012244A2 (en) | 2000-08-03 | 2001-08-02 | Polymorphs of zaleplon and methods for the preparation thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0303055A2 true HUP0303055A2 (hu) | 2004-01-28 |
HUP0303055A3 HUP0303055A3 (en) | 2004-11-29 |
Family
ID=22833666
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0303055A HUP0303055A3 (en) | 2000-08-03 | 2001-08-02 | Polymorphs of zaleplon and methods for the preparation thereof and pharmaceutical compositions containing them |
Country Status (18)
Country | Link |
---|---|
US (2) | US20020072527A1 (hu) |
EP (1) | EP1305315A2 (hu) |
JP (1) | JP2004505979A (hu) |
KR (2) | KR20070086867A (hu) |
CN (2) | CN1847244A (hu) |
AR (1) | AR036324A1 (hu) |
AU (2) | AU2001283119B2 (hu) |
BR (1) | BR0113244A (hu) |
CA (1) | CA2417875C (hu) |
HU (1) | HUP0303055A3 (hu) |
IL (1) | IL154088A0 (hu) |
MX (1) | MXPA03001048A (hu) |
NO (1) | NO20030523L (hu) |
NZ (1) | NZ527455A (hu) |
PL (1) | PL365678A1 (hu) |
SG (1) | SG125971A1 (hu) |
WO (1) | WO2002012244A2 (hu) |
ZA (1) | ZA200300779B (hu) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TR200402588T3 (tr) * | 2001-06-12 | 2004-11-22 | Biogal Gyogyszergyar Rt | N-[3-(3-siyanopirazolo[1,5-A]pirimidin-7-il)fenil]-N- etilasetamidin(zaleplon) üretim işlemi |
US20050032818A1 (en) * | 2001-06-12 | 2005-02-10 | Entire Interest | N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylacetamide and crystalline forms of zaleplon |
JP2005523874A (ja) * | 2001-08-01 | 2005-08-11 | テバ ジョジセルジャール レースベニュタールシャシャーグ | N−〔3−(3−シアノピラゾロ〔1,5−a〕ピリミジン−7−イル)フェニル〕−N−エチルアセタミド(ザレプロン)の精製方法、及び当該方法により得られうるザレプロンの結晶型 |
ZA200406577B (en) * | 2002-02-15 | 2006-06-28 | Teva Gyogyzeryan Reszvenytarsa | Powder composition comprising zaleplon of defined particle size distribution and pharmaceutical products made therefrom |
AU2002343201A1 (en) * | 2002-10-16 | 2004-05-04 | Sanmar Speciality Chemicals Limited | Synthesis of zaleplon |
DE112004001615T5 (de) * | 2003-09-04 | 2006-06-14 | Cipla Ltd. | Zaleplon-Synthese |
US20070098788A1 (en) * | 2005-10-28 | 2007-05-03 | Gore Subhash P | Non-benzodiazepine hypnotic compositions |
EP1956021A1 (en) * | 2006-10-11 | 2008-08-13 | Ferrer Internacional, S.A. | Process for the manufacture of a crystalline pyrazolo[1,5-a]pyrimidine compound |
US20100196286A1 (en) * | 2008-12-01 | 2010-08-05 | Armer Thomas A | Inhalation delivery methods and devices |
WO2010074753A1 (en) * | 2008-12-23 | 2010-07-01 | Map Pharmaceuticals, Inc. | Inhalation devices and related methods for administration of sedative hypnotic compounds |
CN102816163A (zh) * | 2012-08-20 | 2012-12-12 | 四川禾邦阳光制药股份有限公司 | 扎来普隆的新晶型及制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4626538A (en) * | 1983-06-23 | 1986-12-02 | American Cyanamid Company | [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines |
KR0167261B1 (ko) * | 1995-10-19 | 1999-04-15 | 문정환 | 전원공급 제어회로 |
US5714607A (en) * | 1995-12-01 | 1998-02-03 | American Cyanamid Company | Process improvement in the synthesis of N- 3-(3-cyano-pyrazolo 1,5-a!pyrimidin-7-yl)phenyl!-N-ethylacetamide |
AR029780A1 (es) * | 2000-12-13 | 2003-07-16 | Gador Sa | Procedimiento mejorado para la obtencion de n-[3(3-ciano-pirazolo[1,5-a]pirimidin-7-il)fenil]-n-etil-acetamida |
JP2005523874A (ja) * | 2001-08-01 | 2005-08-11 | テバ ジョジセルジャール レースベニュタールシャシャーグ | N−〔3−(3−シアノピラゾロ〔1,5−a〕ピリミジン−7−イル)フェニル〕−N−エチルアセタミド(ザレプロン)の精製方法、及び当該方法により得られうるザレプロンの結晶型 |
-
2001
- 2001-08-02 EP EP01961891A patent/EP1305315A2/en not_active Withdrawn
- 2001-08-02 US US09/921,017 patent/US20020072527A1/en not_active Abandoned
- 2001-08-02 AU AU2001283119A patent/AU2001283119B2/en not_active Ceased
- 2001-08-02 WO PCT/US2001/024510 patent/WO2002012244A2/en active IP Right Grant
- 2001-08-02 IL IL15408801A patent/IL154088A0/xx unknown
- 2001-08-02 CA CA002417875A patent/CA2417875C/en not_active Expired - Fee Related
- 2001-08-02 KR KR1020077015099A patent/KR20070086867A/ko not_active Application Discontinuation
- 2001-08-02 PL PL01365678A patent/PL365678A1/xx not_active Application Discontinuation
- 2001-08-02 BR BR0113244-0A patent/BR0113244A/pt not_active IP Right Cessation
- 2001-08-02 SG SG200500627A patent/SG125971A1/en unknown
- 2001-08-02 MX MXPA03001048A patent/MXPA03001048A/es not_active Application Discontinuation
- 2001-08-02 CN CNA2006100802084A patent/CN1847244A/zh active Pending
- 2001-08-02 JP JP2002518219A patent/JP2004505979A/ja active Pending
- 2001-08-02 AU AU8311901A patent/AU8311901A/xx active Pending
- 2001-08-02 CN CNA018148565A patent/CN1610682A/zh active Pending
- 2001-08-02 KR KR10-2003-7001399A patent/KR20030036659A/ko active Search and Examination
- 2001-08-02 NZ NZ527455A patent/NZ527455A/en unknown
- 2001-08-02 HU HU0303055A patent/HUP0303055A3/hu unknown
- 2001-08-03 AR ARP010103740A patent/AR036324A1/es unknown
-
2003
- 2003-01-29 ZA ZA200300779A patent/ZA200300779B/en unknown
- 2003-02-03 NO NO20030523A patent/NO20030523L/no not_active Application Discontinuation
-
2004
- 2004-08-23 US US10/924,436 patent/US20050176735A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2004505979A (ja) | 2004-02-26 |
KR20070086867A (ko) | 2007-08-27 |
CA2417875A1 (en) | 2002-02-14 |
CN1847244A (zh) | 2006-10-18 |
KR20030036659A (ko) | 2003-05-09 |
US20020072527A1 (en) | 2002-06-13 |
US20050176735A1 (en) | 2005-08-11 |
AR036324A1 (es) | 2004-09-01 |
AU8311901A (en) | 2002-02-18 |
IL154088A0 (en) | 2003-07-31 |
HUP0303055A3 (en) | 2004-11-29 |
MXPA03001048A (es) | 2004-02-26 |
BR0113244A (pt) | 2003-07-08 |
WO2002012244A3 (en) | 2002-06-13 |
CN1610682A (zh) | 2005-04-27 |
NO20030523D0 (no) | 2003-02-03 |
SG125971A1 (en) | 2006-10-30 |
AU2001283119B2 (en) | 2007-11-15 |
NO20030523L (no) | 2003-03-11 |
NZ527455A (en) | 2005-07-29 |
PL365678A1 (en) | 2005-01-10 |
CA2417875C (en) | 2008-12-09 |
EP1305315A2 (en) | 2003-05-02 |
ZA200300779B (en) | 2003-08-22 |
WO2002012244A2 (en) | 2002-02-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
GB9A | Succession in title |
Owner name: MEDA AB, SE Free format text: FORMER OWNER(S): WYETH, US |
|
FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |