HUP0302449A2 - 8-Klór-2,3-benzodiazepin-származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra - Google Patents

8-Klór-2,3-benzodiazepin-származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra

Info

Publication number
HUP0302449A2
HUP0302449A2 HU0302449A HUP0302449A HUP0302449A2 HU P0302449 A2 HUP0302449 A2 HU P0302449A2 HU 0302449 A HU0302449 A HU 0302449A HU P0302449 A HUP0302449 A HU P0302449A HU P0302449 A2 HUP0302449 A2 HU P0302449A2
Authority
HU
Hungary
Prior art keywords
compounds
chloro
benzodiazepine derivatives
general formula
producing
Prior art date
Application number
HU0302449A
Other languages
English (en)
Inventor
István Ling
József Barkóczy
Gyula Simig
Gábor Szénási
Gábor Gigler
Szabolcs Kertész
Gyula Szűcs
Géza Szabó
Miklós Végh
László Gábor Hársing
Original Assignee
EGIS Gyógyszergyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EGIS Gyógyszergyár Rt. filed Critical EGIS Gyógyszergyár Rt.
Priority to HU0302449A priority Critical patent/HUP0302449A3/hu
Publication of HU0302449D0 publication Critical patent/HU0302449D0/hu
Priority to CZ20060131A priority patent/CZ2006131A3/cs
Priority to KR1020067002464A priority patent/KR20060120578A/ko
Priority to EP04769081A priority patent/EP1660462B1/en
Priority to CNB2004800254093A priority patent/CN100551915C/zh
Priority to AU2004261491A priority patent/AU2004261491B2/en
Priority to PL379245A priority patent/PL379245A1/pl
Priority to SI200431033T priority patent/SI1660462T1/sl
Priority to PT04769081T priority patent/PT1660462E/pt
Priority to CA002534458A priority patent/CA2534458A1/en
Priority to DE602004017878T priority patent/DE602004017878D1/de
Priority to UAA200602304A priority patent/UA84159C2/ru
Priority to PL04769081T priority patent/PL1660462T3/pl
Priority to PCT/HU2004/000082 priority patent/WO2005012265A1/en
Priority to ZA200601698A priority patent/ZA200601698B/en
Priority to SK5021-2006A priority patent/SK50212006A3/sk
Priority to DK04769081T priority patent/DK1660462T3/da
Priority to US10/567,598 priority patent/US7960375B2/en
Priority to ES04769081T priority patent/ES2317038T3/es
Priority to JP2006522422A priority patent/JP4752011B2/ja
Priority to EA200600373A priority patent/EA009373B1/ru
Priority to AT04769081T priority patent/ATE414695T1/de
Publication of HUP0302449A2 publication Critical patent/HUP0302449A2/hu
Publication of HUP0302449A3 publication Critical patent/HUP0302449A3/hu
Priority to IL173476A priority patent/IL173476A/en
Priority to BG109462A priority patent/BG109462A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Az (I) általános képletű 8-klór-2,3-benzodiazepin-származékok (melyképletben R jelentése kis szénatomszámú alkilcsoport vagy -NH-R1általános képletű csoport, ahol Rl jelentése kis szénatomszámú alkil-vagy kis szénatomszámú cikloalkilcsoport) és gyógyászatilag alkalmassóik AMPA/kainát receptor gátló vegyületek adagolásával kezelhetőközponti idegrendszeri rendellenességek kezelésére alkalmazhatók. Atalálmány az (I) általános képletű vegyületekre és sóikra,előállításukra, az e vegyületeket tartalmazó gyógyászatikészítményekre és e vegyületek gyógyászati készítmény előállításáratörténő felhasználására valamint a (II) és (VIII) általános képletű (Y kilépő csoport) intermedierekre vonatkozik. Ó
HU0302449A 2003-08-04 2003-08-04 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them HUP0302449A3 (en)

Priority Applications (24)

Application Number Priority Date Filing Date Title
HU0302449A HUP0302449A3 (en) 2003-08-04 2003-08-04 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them
AT04769081T ATE414695T1 (de) 2003-08-04 2004-07-29 8-chlor-2,3-benzodiazepinderivate
PL04769081T PL1660462T3 (pl) 2003-08-04 2004-07-29 Pochodne 8-chloro-2,3-benzodiazepiny
ZA200601698A ZA200601698B (en) 2003-08-04 2004-07-29 8-chloro-2,3-benzodiazephine derivatives
EP04769081A EP1660462B1 (en) 2003-08-04 2004-07-29 8-chloro-2,3-benzodiazepine derivatives
CNB2004800254093A CN100551915C (zh) 2003-08-04 2004-07-29 8-氯-2,3-苯二氮䓬衍生物
AU2004261491A AU2004261491B2 (en) 2003-08-04 2004-07-29 8-chloro-2,3-benzodiazepine derivatives
PL379245A PL379245A1 (pl) 2003-08-04 2004-07-29 Pochodne 8-chloro-2,3-benzodiazepiny
SI200431033T SI1660462T1 (sl) 2003-08-04 2004-07-29 8-kloro-2,3-benzodiazepinski derivati
PT04769081T PT1660462E (pt) 2003-08-04 2004-07-29 Derivados de 8-cloro-2,3-benzodiazepina
CA002534458A CA2534458A1 (en) 2003-08-04 2004-07-29 8-chloro-2,3-benzodiazepine derivatives
DE602004017878T DE602004017878D1 (de) 2003-08-04 2004-07-29 8-chlor-2,3-benzodiazepinderivate
UAA200602304A UA84159C2 (en) 2003-08-04 2004-07-29 8-chloro-2,3-benzodiazepine derivatives
CZ20060131A CZ2006131A3 (cs) 2003-08-04 2004-07-29 8-chlor-2,3-benzodiazepinové deriváty
PCT/HU2004/000082 WO2005012265A1 (en) 2003-08-04 2004-07-29 8-chloro-2,3-benzodiazepine derivatives
KR1020067002464A KR20060120578A (ko) 2003-08-04 2004-07-29 8-클로로-2,3-벤조디아제핀 유도체
SK5021-2006A SK50212006A3 (sk) 2003-08-04 2004-07-29 8-Chlór-2,3-benzodiazepínové deriváty
DK04769081T DK1660462T3 (da) 2003-08-04 2004-07-29 8-chlor-2,3-benzodiazepinderivater
US10/567,598 US7960375B2 (en) 2003-08-04 2004-07-29 8-chloro-2,3-benzodiazepine derivatives
ES04769081T ES2317038T3 (es) 2003-08-04 2004-07-29 Derivados de 8-cloro-2,3-benzodiacepinas.
JP2006522422A JP4752011B2 (ja) 2003-08-04 2004-07-29 ８−クロロ−２，３−ベンゾジアゼピン誘導体
EA200600373A EA009373B1 (ru) 2003-08-04 2004-07-29 Производные 8-хлор-2,3-бензодиазепина
IL173476A IL173476A (en) 2003-08-04 2006-01-31 History of 8-chloro-2, 3-benzodiazepines
BG109462A BG109462A (en) 2003-08-04 2006-03-02 8-CHLORO-2,3-BENZODIAZEPINE DERIVATIVES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0302449A HUP0302449A3 (en) 2003-08-04 2003-08-04 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them

Publications (3)

Publication Number Publication Date
HU0302449D0 HU0302449D0 (en) 2003-10-28
HUP0302449A2 true HUP0302449A2 (hu) 2005-04-28
HUP0302449A3 HUP0302449A3 (en) 2005-06-28

Family

ID=89981556

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0302449A HUP0302449A3 (en) 2003-08-04 2003-08-04 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them

Country Status (23)

Country Link
US (1) US7960375B2 (hu)
EP (1) EP1660462B1 (hu)
JP (1) JP4752011B2 (hu)
KR (1) KR20060120578A (hu)
CN (1) CN100551915C (hu)
AT (1) ATE414695T1 (hu)
AU (1) AU2004261491B2 (hu)
BG (1) BG109462A (hu)
CA (1) CA2534458A1 (hu)
CZ (1) CZ2006131A3 (hu)
DE (1) DE602004017878D1 (hu)
DK (1) DK1660462T3 (hu)
EA (1) EA009373B1 (hu)
ES (1) ES2317038T3 (hu)
HU (1) HUP0302449A3 (hu)
IL (1) IL173476A (hu)
PL (2) PL379245A1 (hu)
PT (1) PT1660462E (hu)
SI (1) SI1660462T1 (hu)
SK (1) SK50212006A3 (hu)
UA (1) UA84159C2 (hu)
WO (1) WO2005012265A1 (hu)
ZA (1) ZA200601698B (hu)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives
HU191702B (en) 1984-06-27 1987-03-30 Gyogyszerkutato Intezet New process for preparing 1-aryl-5 h-2,3-benzodiazepines
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU195788B (en) * 1986-05-21 1988-07-28 Gyogyszerkutato Intezet Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them
HU206719B (en) 1990-12-21 1992-12-28 Gyogyszerkutato Intezet Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them
DE19604920A1 (de) * 1996-02-01 1997-08-07 Schering Ag Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
HU9600871D0 (en) * 1996-04-04 1996-05-28 Gyogyszerkutato Intezet New 2,3-benzodiazepine derivatives
HU225100B1 (hu) * 2000-12-21 2006-06-28 Egyt Gyogyszervegyeszeti Gyar 2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk

Also Published As

Publication number Publication date
ZA200601698B (en) 2007-05-30
HU0302449D0 (en) 2003-10-28
ES2317038T3 (es) 2009-04-16
PL379245A1 (pl) 2006-08-07
CN100551915C (zh) 2009-10-21
EA200600373A1 (ru) 2006-08-25
KR20060120578A (ko) 2006-11-27
ATE414695T1 (de) 2008-12-15
HUP0302449A3 (en) 2005-06-28
PL1660462T3 (pl) 2009-07-31
IL173476A0 (en) 2006-06-11
AU2004261491A1 (en) 2005-02-10
CA2534458A1 (en) 2005-02-10
US7960375B2 (en) 2011-06-14
WO2005012265A1 (en) 2005-02-10
UA84159C2 (en) 2008-09-25
JP2007501216A (ja) 2007-01-25
EP1660462B1 (en) 2008-11-19
IL173476A (en) 2013-01-31
PT1660462E (pt) 2009-02-20
DK1660462T3 (da) 2009-03-16
CN1871223A (zh) 2006-11-29
US20080153814A1 (en) 2008-06-26
JP4752011B2 (ja) 2011-08-17
CZ2006131A3 (cs) 2006-12-13
SI1660462T1 (sl) 2009-04-30
EA009373B1 (ru) 2007-12-28
DE602004017878D1 (de) 2009-01-02
EP1660462A1 (en) 2006-05-31
SK50212006A3 (sk) 2006-08-03
AU2004261491B2 (en) 2009-12-17
BG109462A (en) 2006-11-30

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Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDOE RESZV, HU

Free format text: FORMER OWNER(S): EGIS GYOGYSZERGYAR RT., HU

FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished