HUP0300996A2 - 4,5-Dihidro-tiazol-2-ilamin származékok, eljárás előállításukra és alkalmazásuk NO szintáz inhibitorokként és ezeket tartalmazó gyógyszerkészítmények - Google Patents
4,5-Dihidro-tiazol-2-ilamin származékok, eljárás előállításukra és alkalmazásuk NO szintáz inhibitorokként és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0300996A2 HUP0300996A2 HU0300996A HUP0300996A HUP0300996A2 HU P0300996 A2 HUP0300996 A2 HU P0300996A2 HU 0300996 A HU0300996 A HU 0300996A HU P0300996 A HUP0300996 A HU P0300996A HU P0300996 A2 HUP0300996 A2 HU P0300996A2
- Authority
- HU
- Hungary
- Prior art keywords
- dihydro
- alk
- general formula
- phenyl group
- thiazo
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- REGFWZVTTFGQOJ-UHFFFAOYSA-N 4,5-dihydro-1,3-thiazol-2-amine Chemical class NC1=NCCS1 REGFWZVTTFGQOJ-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000008299 Nitric Oxide Synthase Human genes 0.000 abstract 1
- 108010021487 Nitric Oxide Synthase Proteins 0.000 abstract 1
- 102100029438 Nitric oxide synthase, inducible Human genes 0.000 abstract 1
- 101710089543 Nitric oxide synthase, inducible Proteins 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/18—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
Abstract
A találmány hatóanyagként (I) általános képletű 4,5-dihidro-1,3-tiazol-2-ilamin-származékokat vagy ezek gyógyászatilag elfogadhatósóit tartalmazó gyógyászati készítményekre, az új (I) általánosképletű származékokra, azok előállítási eljárására, valamint avegyületeket tartalmazó gyógyászati készítményekre vonatkozik. Az (I)általános képletben R jelentése -alk-S-alk-Ar általános képletűcsoport, fenilcsoport vagy 1-6 szénatomos egyenes vagy elágazó láncúalkoxicsoporttal vagy halogénatommal szubsztituált fenilcsoport; Arjelentése fenilcsoport és alk jelentése 1-6 szénatomos egyenes vagyelágazó láncú alkiléncsoport. A vegyületek hasznosak olyan betegségekmegelőzésére vagy kezelésére, amelyekben az indukciós NO-szintáz enzim(NOS-2) által indukált rendellenes nitrogén-monoxid (NO) termelésszerepet játszik. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0007396A FR2810036B1 (fr) | 2000-06-09 | 2000-06-09 | Derives de 4,5-dihydro-1,3-thiazol-2-ylamine, leur preparation et les compositions phamarceutiques les contenant |
PCT/FR2001/001759 WO2001093867A1 (fr) | 2000-06-09 | 2001-06-07 | Derives de 4,5-dihydro-thiazol-2-ylamine et leur utilisation comme inhibiteurs de no synthase |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0300996A2 true HUP0300996A2 (hu) | 2003-08-28 |
HUP0300996A3 HUP0300996A3 (en) | 2006-02-28 |
Family
ID=8851133
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0300996A HUP0300996A3 (en) | 2000-06-09 | 2001-06-07 | 4,5-dihydro-thiazo-2-ylamine derivatives and their use as no-synthase inhibitors and pharmaceutical compositions containing them |
Country Status (27)
Country | Link |
---|---|
EP (1) | EP1299103B1 (hu) |
JP (1) | JP4171297B2 (hu) |
KR (1) | KR20030017990A (hu) |
CN (1) | CN1441673A (hu) |
AP (1) | AP2002002707A0 (hu) |
AT (1) | ATE305298T1 (hu) |
AU (2) | AU2001266123B2 (hu) |
BR (1) | BR0111543A (hu) |
CA (1) | CA2411572C (hu) |
DE (1) | DE60113686T2 (hu) |
DK (1) | DK1299103T3 (hu) |
DZ (1) | DZ3366A1 (hu) |
EA (1) | EA200300009A1 (hu) |
EC (1) | ECSP024374A (hu) |
ES (1) | ES2246327T3 (hu) |
FR (1) | FR2810036B1 (hu) |
HR (1) | HRP20020971A2 (hu) |
HU (1) | HUP0300996A3 (hu) |
IL (1) | IL153327A0 (hu) |
MA (1) | MA25815A1 (hu) |
MX (1) | MXPA02012072A (hu) |
NO (1) | NO20025885L (hu) |
NZ (1) | NZ522967A (hu) |
OA (1) | OA12285A (hu) |
PL (1) | PL360282A1 (hu) |
WO (1) | WO2001093867A1 (hu) |
ZA (1) | ZA200209770B (hu) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8088935B2 (en) | 2003-12-23 | 2012-01-03 | Ironwood Pharmaceuticals, Inc. | Compounds and methods for the treatment of asthma |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08503940A (ja) * | 1992-11-27 | 1996-04-30 | ザ ウエルカム ファウンデーション リミテッド | 酵素阻害薬 |
ATE177078T1 (de) * | 1993-10-21 | 1999-03-15 | Searle & Co | Amidino-derivate als no-synthetase inhibitoren |
AU4149696A (en) * | 1994-11-15 | 1996-06-06 | Merck & Co., Inc. | Substituted heterocycles as inhibitors of nitric oxide synthase |
-
2000
- 2000-06-09 FR FR0007396A patent/FR2810036B1/fr not_active Expired - Fee Related
-
2001
- 2001-06-07 CN CN01812587A patent/CN1441673A/zh active Pending
- 2001-06-07 BR BR0111543-0A patent/BR0111543A/pt not_active Application Discontinuation
- 2001-06-07 AU AU2001266123A patent/AU2001266123B2/en not_active Ceased
- 2001-06-07 DK DK01943579T patent/DK1299103T3/da active
- 2001-06-07 EP EP01943579A patent/EP1299103B1/fr not_active Expired - Lifetime
- 2001-06-07 WO PCT/FR2001/001759 patent/WO2001093867A1/fr active IP Right Grant
- 2001-06-07 HU HU0300996A patent/HUP0300996A3/hu unknown
- 2001-06-07 IL IL15332701A patent/IL153327A0/xx unknown
- 2001-06-07 AP APAP/P/2002/002707A patent/AP2002002707A0/en unknown
- 2001-06-07 AU AU6612301A patent/AU6612301A/xx active Pending
- 2001-06-07 CA CA002411572A patent/CA2411572C/fr not_active Expired - Fee Related
- 2001-06-07 OA OA1200200371A patent/OA12285A/fr unknown
- 2001-06-07 DE DE60113686T patent/DE60113686T2/de not_active Expired - Lifetime
- 2001-06-07 EA EA200300009A patent/EA200300009A1/ru unknown
- 2001-06-07 KR KR1020027016786A patent/KR20030017990A/ko not_active Application Discontinuation
- 2001-06-07 ES ES01943579T patent/ES2246327T3/es not_active Expired - Lifetime
- 2001-06-07 AT AT01943579T patent/ATE305298T1/de not_active IP Right Cessation
- 2001-06-07 PL PL36028201A patent/PL360282A1/xx unknown
- 2001-06-07 JP JP2002501440A patent/JP4171297B2/ja not_active Expired - Fee Related
- 2001-06-07 MX MXPA02012072A patent/MXPA02012072A/es active IP Right Grant
- 2001-06-07 NZ NZ522967A patent/NZ522967A/en unknown
- 2001-06-07 DZ DZ013366A patent/DZ3366A1/xx active
-
2002
- 2002-12-02 ZA ZA200209770A patent/ZA200209770B/en unknown
- 2002-12-06 HR HR20020971A patent/HRP20020971A2/xx not_active Application Discontinuation
- 2002-12-06 NO NO20025885A patent/NO20025885L/no not_active Application Discontinuation
- 2002-12-09 MA MA26940A patent/MA25815A1/fr unknown
- 2002-12-09 EC EC2002004374A patent/ECSP024374A/es unknown
Also Published As
Publication number | Publication date |
---|---|
BR0111543A (pt) | 2003-07-01 |
HRP20020971A2 (en) | 2005-02-28 |
AP2002002707A0 (en) | 2002-12-31 |
WO2001093867A1 (fr) | 2001-12-13 |
OA12285A (en) | 2006-05-12 |
HUP0300996A3 (en) | 2006-02-28 |
EA200300009A1 (ru) | 2003-04-24 |
JP4171297B2 (ja) | 2008-10-22 |
JP2003535135A (ja) | 2003-11-25 |
DK1299103T3 (da) | 2006-01-23 |
NZ522967A (en) | 2005-07-29 |
DE60113686T2 (de) | 2006-07-13 |
ZA200209770B (en) | 2004-03-02 |
EP1299103A1 (fr) | 2003-04-09 |
IL153327A0 (en) | 2003-07-06 |
ES2246327T3 (es) | 2006-02-16 |
ECSP024374A (es) | 2003-02-06 |
PL360282A1 (en) | 2004-09-06 |
AU2001266123B2 (en) | 2007-01-25 |
ATE305298T1 (de) | 2005-10-15 |
AU6612301A (en) | 2001-12-17 |
NO20025885L (no) | 2003-01-29 |
EP1299103B1 (fr) | 2005-09-28 |
CA2411572A1 (fr) | 2001-12-13 |
KR20030017990A (ko) | 2003-03-04 |
DE60113686D1 (de) | 2006-02-09 |
CA2411572C (fr) | 2009-11-10 |
DZ3366A1 (fr) | 2001-12-13 |
MA25815A1 (fr) | 2003-07-01 |
CN1441673A (zh) | 2003-09-10 |
MXPA02012072A (es) | 2004-08-19 |
FR2810036B1 (fr) | 2004-04-23 |
NO20025885D0 (no) | 2002-12-06 |
FR2810036A1 (fr) | 2001-12-14 |
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