HUP0300160A2 - Eljárás (+)-cisz-szertralin előállítására - Google Patents

Eljárás (+)-cisz-szertralin előállítására

Info

Publication number
HUP0300160A2
HUP0300160A2 HU0300160A HUP0300160A HUP0300160A2 HU P0300160 A2 HUP0300160 A2 HU P0300160A2 HU 0300160 A HU0300160 A HU 0300160A HU P0300160 A HUP0300160 A HU P0300160A HU P0300160 A2 HUP0300160 A2 HU P0300160A2
Authority
HU
Hungary
Prior art keywords
sertraline
cis
preparing
disertraline
sertralone
Prior art date
Application number
HU0300160A
Other languages
English (en)
Inventor
Neomi Gershon
Mariuara Mendelovich
Tammy Nidam
Gideon Pilarsky
Original Assignee
Teva Pharmaceutical Industries Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd. filed Critical Teva Pharmaceutical Industries Ltd.
Publication of HUP0300160A2 publication Critical patent/HUP0300160A2/hu
Publication of HUP0300160A3 publication Critical patent/HUP0300160A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/52—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of imines or imino-ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/86—Separation
    • C07C209/88—Separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A találmány szerinti (+)-disz-szertralin-hidroklorid előállítására éstisztítására szolgáló eljárásváltozatokkal szertralon Schiff bázisból(szertralin-l-iminből) nagyobb, mint 3:1, nagyobb vagy egyenlő, mint8:1, vagy 8,1 és 12,1 közötti cisz/transz arányú szertralin állíthatóelő. Ó
HU0300160A 2000-03-14 2001-03-14 Process for preparing (+)-cis-sertraline HUP0300160A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18935500P 2000-03-14 2000-03-14
PCT/US2001/008090 WO2001068566A1 (en) 2000-03-14 2001-03-14 Novel process for preparing (+)-cis-sertraline

Publications (2)

Publication Number Publication Date
HUP0300160A2 true HUP0300160A2 (hu) 2003-06-28
HUP0300160A3 HUP0300160A3 (en) 2005-07-28

Family

ID=22696967

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0300160A HUP0300160A3 (en) 2000-03-14 2001-03-14 Process for preparing (+)-cis-sertraline

Country Status (15)

Country Link
US (2) US6552227B2 (hu)
EP (1) EP1268369A4 (hu)
JP (1) JP2003527359A (hu)
KR (3) KR20070002101A (hu)
CN (1) CN1232481C (hu)
AU (2) AU4363401A (hu)
CA (1) CA2402656A1 (hu)
CZ (1) CZ20023269A3 (hu)
HR (1) HRP20020773A2 (hu)
HU (1) HUP0300160A3 (hu)
IL (1) IL151691A0 (hu)
PL (1) PL357262A1 (hu)
SK (1) SK14212002A3 (hu)
WO (1) WO2001068566A1 (hu)
ZA (1) ZA200207225B (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0300160A3 (en) * 2000-03-14 2005-07-28 Teva Pharma Process for preparing (+)-cis-sertraline
US6723878B2 (en) 2001-06-15 2004-04-20 Orion Corporation Fermion Method for preparing sertraline
CA2448499A1 (en) * 2001-06-15 2002-12-27 Orion Corporation Fermion A novel process for the preparation of (is-cis) -4-(3, 4-dichlorophenyl) -1, 2, 3, 4 - tetrahydro-n-methyl-1-naphthalenamine
AU2003251290A1 (en) * 2002-04-29 2003-11-17 Teva Pharmaceutical Industries Ltd. Process for preparation of polymorphic form ii of sertraline hydrochloride, pharmaceutical formulations and methods of administration thereof
ES2242555T1 (es) * 2003-04-14 2005-11-16 Teva Pharmaceutical Industries Limited Hidrogenacion de intermediarios de imina de sertralina con catalizadores.
WO2005023752A2 (en) * 2003-09-05 2005-03-17 Teva Pharmaceutical Industries Ltd. A recycling process for preparing sertraline
US7818444B2 (en) 2004-04-30 2010-10-19 Move Networks, Inc. Apparatus, system, and method for multi-bitrate content streaming
US8868772B2 (en) * 2004-04-30 2014-10-21 Echostar Technologies L.L.C. Apparatus, system, and method for adaptive-rate shifting of streaming content
WO2005121074A2 (en) * 2004-06-09 2005-12-22 Ranbaxy Laboratories Limited Processes for the preparation of sertraline hydrochloride
US7345201B2 (en) * 2005-02-23 2008-03-18 Teva Pharmaceutical Industries, Ltd. Processes for preparing sertraline
GB0507090D0 (en) * 2005-04-07 2005-05-11 Sandoz Ag Process for preparing polymorphic form ll of sertraline hydrochloride
WO2007119247A2 (en) * 2006-04-17 2007-10-25 Unichem Laboratories Limited Improved manufacturing procedure for the preparation of polymorphic form ii of cis-(1s)-n-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthleneamine hydrochloride (sertraline hydrochloride)
KR101340270B1 (ko) 2011-11-10 2013-12-10 보령제약 주식회사 (+)-시스-서트랄린의 선택적인 제조방법
CN103524354A (zh) * 2013-10-23 2014-01-22 山东鲁药制药有限公司 一种盐酸舍曲林的制备方法
CN111763150B (zh) * 2019-12-27 2024-03-08 上虞京新药业有限公司 一种手性盐酸舍曲林的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4536518A (en) * 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
GB9114947D0 (en) * 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline
US5248699A (en) * 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
HU222341B1 (hu) * 1996-12-18 2003-06-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás sertralin előállítására és az eljárásban alkalmazott intermedier
IN191358B (hu) * 1998-01-16 2003-11-29 Pfizer Prod Inc
AR018164A1 (es) * 1998-03-18 2001-10-31 Ciba Sc Holding Ag Proceso para la preparacion de cis-ciclohexilidenaminas
HU226424B1 (en) * 1998-05-05 2008-12-29 Egis Gyogyszergyar Nyrt Process for producing enantiomer mixture for preparation of sertraline
JP2000026378A (ja) * 1998-07-03 2000-01-25 Sumika Fine Chemicals Co Ltd 塩酸セルトラリンの製法
AU1031500A (en) 1998-11-03 2000-05-22 Dandy A/S Sucrose fatty acid esters for use as increased release of active ingredients
US6500987B1 (en) 1998-11-27 2002-12-31 Teva Pharmaceutical Industries Ltd. Sertraline hydrochloride polymorphs
US6593496B1 (en) 1999-06-09 2003-07-15 Pfizer Inc Process for preparing sertraline from chiral tetralone
US6495721B1 (en) 1999-08-09 2002-12-17 Teva Pharmaceutical Industries Ltd. Sertraline hydrochloride Form II and methods for the preparation thereof
IN185109B (hu) 1999-09-01 2000-11-18 Torrent Pharmaceuticals Ltd
PT1248605E (pt) 1999-12-21 2007-03-30 Teva Pharma Novos polimorfos de cloridrato de sertralina, processos para a sua preparação, composições que os contêm e métodos para a sua utilização
HUP0300160A3 (en) * 2000-03-14 2005-07-28 Teva Pharma Process for preparing (+)-cis-sertraline

Also Published As

Publication number Publication date
EP1268369A4 (en) 2005-09-21
AU4363401A (en) 2001-09-24
CN1232481C (zh) 2005-12-21
SK14212002A3 (sk) 2003-07-01
KR20070002102A (ko) 2007-01-04
AU2001243634B2 (en) 2006-05-25
CN1429188A (zh) 2003-07-09
PL357262A1 (en) 2004-07-26
KR20020089394A (ko) 2002-11-29
EP1268369A1 (en) 2003-01-02
KR100704590B1 (ko) 2007-04-10
IL151691A0 (en) 2003-04-10
HUP0300160A3 (en) 2005-07-28
HRP20020773A2 (en) 2005-02-28
ZA200207225B (en) 2003-09-09
JP2003527359A (ja) 2003-09-16
US20030166970A1 (en) 2003-09-04
CZ20023269A3 (cs) 2003-09-17
US6809221B2 (en) 2004-10-26
WO2001068566A1 (en) 2001-09-20
US20020019570A1 (en) 2002-02-14
CA2402656A1 (en) 2001-09-20
US6552227B2 (en) 2003-04-22
KR20070002101A (ko) 2007-01-04

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees