HUP0204157A2 - Új 1,3-dihidro-2H-indol-2-on-származékok, eljárás a vegyületek előállítására és a vegyületeket tartalmazó gyógyászati készítmények - Google Patents
Új 1,3-dihidro-2H-indol-2-on-származékok, eljárás a vegyületek előállítására és a vegyületeket tartalmazó gyógyászati készítményekInfo
- Publication number
- HUP0204157A2 HUP0204157A2 HU0204157A HUP0204157A HUP0204157A2 HU P0204157 A2 HUP0204157 A2 HU P0204157A2 HU 0204157 A HU0204157 A HU 0204157A HU P0204157 A HUP0204157 A HU P0204157A HU P0204157 A2 HUP0204157 A2 HU P0204157A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- compounds
- alkoxy group
- indol
- halogen atom
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004566 azetidin-1-yl group Chemical group N1(CCC1)* 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- QNLOWBMKUIXCOW-UHFFFAOYSA-N indol-2-one Chemical group C1=CC=CC2=NC(=O)C=C21 QNLOWBMKUIXCOW-UHFFFAOYSA-N 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- -1 methylenedioxy group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P11/06—Antiasthmatics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
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- A61P25/22—Anxiolytics
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- A61P25/00—Drugs for disorders of the nervous system
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
Abstract
A találmány (I) általános képletű vegyületekre, a képletben - R1jelentése halogénatom; alkilcsoport; alkoxicsoport;trifluormetilcsoport; vagy trifluormetoxicsoport; - R2 jelentésehidrogénatom; halogénatom; alkilcsoport; alkoxicsoport; vagytrifluormetilcsoport; - vagy R2 az indol-2-on gyűrű 6-os helyzetébenkapcsolódik, és R1 és R2 együtt két vegyértékű trimetiléncsoportotalkot; - R3 jelentése halogénatom; hidroxilcsoport; alkilcsoport;alkoxicsoport; vagy trifluormetoxicsoport; - R4 jelentésehidrogénatom; halogénatom; alkilcsoport; vagy alkoxicsoport; - vagy R4a fenilcsoport 3-as helyzetében kapcsolódik, és R3 és R4 együttmetiléndioxicsoportot alkot; - R5 jelentése etilaminocsoport;dimetilaminocsoport; azetidin-1-ilcsoport; vagy alkoxicsoport; - R6jelentése alkoxicsoport; - R7 jelentése alkoxicsoport; a vegyületekelőállítására alkalmas eljárásra és közbenső termékekre, valamint avegyületeket tartalmazó gyógyászati készítményekre vonatkozik. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0000958A FR2804115B1 (fr) | 2000-01-25 | 2000-01-25 | Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant |
PCT/FR2001/000228 WO2001055134A2 (fr) | 2000-01-25 | 2001-01-24 | Derives de 1,3-dihydro-2h-indol-2-one et leur utilisation en tant que ligands pour les recepteurs v1b ou v1b et v1a de l'arginine-vasopressine |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0204157A2 true HUP0204157A2 (hu) | 2003-04-28 |
HUP0204157A3 HUP0204157A3 (en) | 2005-04-28 |
HU225157B1 HU225157B1 (en) | 2006-07-28 |
Family
ID=8846308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0204157A HU225157B1 (en) | 2000-01-25 | 2001-01-24 | 1,3-dihydro-2h-indol-2-one derivatives, process for preparation of the compounds and pharmaceutical compositions containing the same |
Country Status (13)
Country | Link |
---|---|
US (1) | US6624164B2 (hu) |
EP (1) | EP1254134B1 (hu) |
JP (1) | JP4861591B2 (hu) |
AT (1) | ATE245644T1 (hu) |
AU (1) | AU2001235596A1 (hu) |
DE (1) | DE60100506T2 (hu) |
DK (1) | DK1254134T3 (hu) |
ES (1) | ES2203596T3 (hu) |
FR (1) | FR2804115B1 (hu) |
HU (1) | HU225157B1 (hu) |
PT (1) | PT1254134E (hu) |
TR (1) | TR200301723T4 (hu) |
WO (1) | WO2001055134A2 (hu) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2805536B1 (fr) * | 2000-02-25 | 2002-08-23 | Sanofi Synthelabo | Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant |
JP4618127B2 (ja) * | 2003-08-28 | 2011-01-26 | 大正製薬株式会社 | 1,3−ジヒドロ−2h−インドール−2−オン誘導体 |
US8580842B2 (en) | 2003-09-30 | 2013-11-12 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
US20050070718A1 (en) | 2003-09-30 | 2005-03-31 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
US7517899B2 (en) | 2004-03-30 | 2009-04-14 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
US7414052B2 (en) | 2004-03-30 | 2008-08-19 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
WO2006070742A1 (ja) * | 2004-12-27 | 2006-07-06 | Kyoto University | 麻薬性鎮痛剤の耐性形成抑制剤 |
WO2006080574A1 (ja) * | 2005-01-28 | 2006-08-03 | Taisho Pharmaceutical Co., Ltd. | 1,3-ジヒドロ-2h-インドール-2-オン化合物、及び芳香族複素環が縮合したピロリジン-2-オン化合物 |
DE102005014904A1 (de) * | 2005-03-26 | 2007-02-01 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
CA2602194A1 (en) | 2005-03-24 | 2006-09-28 | Abbott Gmbh & Co. Kg | Substituted oxindol derivatives, drugs containing said derivatives and the use thereof |
DE102005014936A1 (de) | 2005-03-24 | 2006-12-14 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
WO2007063123A1 (de) | 2005-12-02 | 2007-06-07 | Abbott Gmbh & Co. Kg | Substituierte oxindol-derivate, diese enthaltende arzneimittel und deren verwendung |
JP5437070B2 (ja) * | 2006-08-26 | 2014-03-12 | アボット ゲーエムベーハー ウント カンパニー カーゲー | 置換ベンゾイミダゾロン誘導体、それを含む薬剤およびそれの使用 |
DE102006040915A1 (de) * | 2006-08-26 | 2008-03-20 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
US8486979B2 (en) | 2006-12-12 | 2013-07-16 | Abbvie Inc. | 1,2,4 oxadiazole compounds and methods of use thereof |
US20080167286A1 (en) * | 2006-12-12 | 2008-07-10 | Abbott Laboratories | Pharmaceutical compositions and their methods of use |
UY30846A1 (es) | 2006-12-30 | 2008-07-31 | Abbott Gmbh & Amp | Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos |
WO2010009775A1 (de) | 2007-12-07 | 2010-01-28 | Abbott Gmbh & Co. Kg | Carbamat-substituierte oxindol-derivate und ihre verwendung zur behandlung von vasopressin-abhängigen erkrankungen |
MX2010006202A (es) | 2007-12-07 | 2011-03-04 | Abbott Gmbh & Co Kg | Derivados de oxindol substituidos por amidometil y el uso de los mismos para el tratamiento de enfermedades dependientes de la vasopresina. |
BRPI0820668A2 (pt) * | 2007-12-07 | 2017-08-22 | Abbott Gmbh & Co Kg | Derivados de oxindol substituídos por 5-halogênio e seu uso para tratar doenças dependentes de vasopressina |
CA2707671C (en) | 2007-12-07 | 2016-02-02 | Abbott Gmbh & Co. Kg | 5,6-disubstituted oxindole-derivatives and use thereof for treating vasopressine-dependent diseases |
RU2487872C2 (ru) * | 2007-12-27 | 2013-07-20 | Эбботт Гмбх Унд Ко.Кг | Замещенные производные оксиндола и их применение для лечения заболеваний, зависимых от вазопрессина |
FR2927625B1 (fr) * | 2008-02-19 | 2010-03-12 | Sanofi Aventis | Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique |
FR2930249B1 (fr) | 2008-04-21 | 2010-05-14 | Sanofi Aventis | Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique. |
WO2010138600A2 (en) | 2009-05-29 | 2010-12-02 | Abbott Laboratories | Pharmaceutical compositions for the treatment of pain |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5940149B2 (ja) * | 1977-11-09 | 1984-09-28 | 大塚製薬株式会社 | オキシインド−ル誘導体 |
JPS55129284A (en) * | 1979-03-27 | 1980-10-06 | Shionogi & Co Ltd | 3-(1-imipazolyl)indolin-2-one |
US4760083A (en) * | 1986-04-10 | 1988-07-26 | E. I. Dupont De Nemours & Company | 3,3-disubstituted indolines |
US5338755A (en) * | 1990-07-31 | 1994-08-16 | Elf Sanofi | N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present |
FR2714378B1 (fr) | 1993-12-24 | 1996-03-15 | Sanofi Sa | Dérivés de l'indol-2-one substitués en 3 par un groupe azoté, leur préparation, les compositions pharmaceutiques en contenant. |
FR2757157B1 (fr) | 1996-12-13 | 1999-12-31 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant |
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2000
- 2000-01-25 FR FR0000958A patent/FR2804115B1/fr not_active Expired - Fee Related
-
2001
- 2001-01-24 EP EP01907687A patent/EP1254134B1/fr not_active Expired - Lifetime
- 2001-01-24 AT AT01907687T patent/ATE245644T1/de active
- 2001-01-24 HU HU0204157A patent/HU225157B1/hu not_active IP Right Cessation
- 2001-01-24 PT PT01907687T patent/PT1254134E/pt unknown
- 2001-01-24 TR TR2003/01723T patent/TR200301723T4/xx unknown
- 2001-01-24 US US10/182,638 patent/US6624164B2/en not_active Expired - Fee Related
- 2001-01-24 DK DK01907687T patent/DK1254134T3/da active
- 2001-01-24 AU AU2001235596A patent/AU2001235596A1/en not_active Abandoned
- 2001-01-24 JP JP2001560993A patent/JP4861591B2/ja not_active Expired - Fee Related
- 2001-01-24 DE DE60100506T patent/DE60100506T2/de not_active Expired - Lifetime
- 2001-01-24 WO PCT/FR2001/000228 patent/WO2001055134A2/fr active IP Right Grant
- 2001-01-24 ES ES01907687T patent/ES2203596T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO2001055134A2 (fr) | 2001-08-02 |
US20030139413A1 (en) | 2003-07-24 |
PT1254134E (pt) | 2003-11-28 |
EP1254134A2 (fr) | 2002-11-06 |
HU225157B1 (en) | 2006-07-28 |
ATE245644T1 (de) | 2003-08-15 |
EP1254134B1 (fr) | 2003-07-23 |
DK1254134T3 (da) | 2003-11-03 |
FR2804115B1 (fr) | 2002-03-08 |
JP2003523354A (ja) | 2003-08-05 |
FR2804115A1 (fr) | 2001-07-27 |
TR200301723T4 (tr) | 2004-02-23 |
US6624164B2 (en) | 2003-09-23 |
JP4861591B2 (ja) | 2012-01-25 |
DE60100506T2 (de) | 2004-05-13 |
DE60100506D1 (de) | 2003-08-28 |
WO2001055134A3 (fr) | 2002-03-14 |
HUP0204157A3 (en) | 2005-04-28 |
ES2203596T3 (es) | 2004-04-16 |
AU2001235596A1 (en) | 2001-08-07 |
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