HUP0202545A2 - Inhalációs adagolásra alkalmas mikrorészecskék - Google Patents

Inhalációs adagolásra alkalmas mikrorészecskék

Info

Publication number
HUP0202545A2
HUP0202545A2 HU0202545A HUP0202545A HUP0202545A2 HU P0202545 A2 HUP0202545 A2 HU P0202545A2 HU 0202545 A HU0202545 A HU 0202545A HU P0202545 A HUP0202545 A HU P0202545A HU P0202545 A2 HUP0202545 A2 HU P0202545A2
Authority
HU
Hungary
Prior art keywords
microparticles
coating
active ingredient
active
coating material
Prior art date
Application number
HU0202545A
Other languages
English (en)
Inventor
Jean-Pierre Benoit
Claire Dulieu
Dominique Le Meurlay
Joël Richard
Original Assignee
Mainelab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mainelab filed Critical Mainelab
Publication of HUP0202545A2 publication Critical patent/HUP0202545A2/hu
Publication of HUP0202545A3 publication Critical patent/HUP0202545A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/22—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of calcitonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

A találmány olyan inhalációs, biokompatibilis mikrorészecskékrevonatkozik, amelyek legalább egy hatóanyagot és legalább egy, ahatóanyagot bevonó bevonatréteget tartalmaznak, amely bevonat amikrorészecske külső rétegét jelenti és legalább egy bevonóanyagottartalmaz, amelyek jellemzője, hogy a mikrorészecskék átlagos átmérője1-30 mm, látszólagos sűrűsége 0,2-0,8 g/cm3, és a bevonóanyag és ahatóanyag érintkeztetését és a szuperkritikus folyadék zártgyártótartályba keverés mellett történő bevitelét mint elengedhetetlenlépéseket tartalmazó eljárással állítható elő. Ezek a mikrorészecskéknem aggregálódnak az adagolás során, és kívánt esetben biztosítják ahatóanyag késleltetett felszabadulását. A találmány szerintimikrorészecskék biológiai hozzáférhetősége nagyobb mint 60%, mivel atüdő alveoláris régióját nagyobb mennyiségben érik el. Ó
HU0202545A 1999-08-11 2000-08-09 Microparticles for pulmonary administration HUP0202545A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9910411A FR2797398B1 (fr) 1999-08-11 1999-08-11 Microparticules pour administration pulmonaire
PCT/FR2000/002282 WO2001012160A1 (fr) 1999-08-11 2000-08-09 Microparticules pour administration pulmonaire

Publications (2)

Publication Number Publication Date
HUP0202545A2 true HUP0202545A2 (hu) 2004-03-01
HUP0202545A3 HUP0202545A3 (en) 2004-05-28

Family

ID=9549086

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202545A HUP0202545A3 (en) 1999-08-11 2000-08-09 Microparticles for pulmonary administration

Country Status (13)

Country Link
EP (1) EP1204409A1 (hu)
JP (1) JP2003506479A (hu)
KR (1) KR20020038719A (hu)
CN (1) CN1220484C (hu)
AU (1) AU784168B2 (hu)
CA (1) CA2380883A1 (hu)
FR (1) FR2797398B1 (hu)
HU (1) HUP0202545A3 (hu)
IL (1) IL148063A0 (hu)
MX (1) MXPA02001520A (hu)
NO (1) NO20020555L (hu)
WO (1) WO2001012160A1 (hu)
ZA (1) ZA200201109B (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2809309B1 (fr) * 2000-05-23 2004-06-11 Mainelab Microspheres a liberation prolongee pour administration injectable
AU2003213402A1 (en) * 2002-03-18 2003-09-29 Yamanouchi Pharmaceutical Co., Ltd. Powdery medicinal compositions for inhalation and process for producing the same
JP2005279334A (ja) * 2004-03-26 2005-10-13 Kao Corp 複合化粒子の製造方法
US8475845B2 (en) 2005-07-15 2013-07-02 Map Pharmaceuticals, Inc. Method of particle formation
EP1757361A1 (en) * 2005-08-23 2007-02-28 Feyecon Development & Implementation B.V. Process for the preparation of encapsulates through precipitation
CN101143131B (zh) * 2006-09-15 2012-03-07 国家纳米技术与工程研究院 一种利用超临界流体技术制备人胰岛素吸入干粉的方法
PL2061427T3 (pl) * 2006-09-15 2011-12-30 Echo Pharmaceuticals Bv Granulat zawierający substancję farmaceutycznie aktywną i emulgator oraz sposób jego wytwarzania
JP5575489B2 (ja) * 2007-03-23 2014-08-20 ゲノ エルエルシー 二酸化窒素（ｎｏ２）から酸化窒素（ｎｏ）への変換
KR101102834B1 (ko) * 2010-02-24 2012-01-05 충남대학교산학협력단 신규한 리포좀 제조 방법 및 장치
JP5672554B2 (ja) * 2010-08-19 2015-02-18 Ｊｃｒファーマ株式会社 皮下又は経皮吸収用組成物
CN102872027B (zh) * 2012-09-18 2014-03-12 刘晓忠 一种治疗肺部疾病的药物颗粒的制备和吸入式复方气雾剂的制备

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04222662A (ja) * 1990-12-25 1992-08-12 Nippon Steel Chem Co Ltd 固体表面へのポリマー皮膜形成方法
EP0706821A1 (en) * 1994-10-06 1996-04-17 Centre De Microencapsulation Method of coating particles
WO1996029998A1 (en) * 1995-03-28 1996-10-03 Fidia Advanced Biopolymers S.R.L. Nanospheres comprising a biocompatible polysaccharide
FR2753639B1 (fr) * 1996-09-25 1998-12-11 Procede de preparation de microcapsules de matieres actives enrobees par un polymere et nouvelles microcapsules notamment obtenues selon le procede
US5766637A (en) * 1996-10-08 1998-06-16 University Of Delaware Microencapsulation process using supercritical fluids
WO1998031346A1 (en) * 1997-01-16 1998-07-23 Massachusetts Institute Of Technology Preparation of particles for inhalation
JPH1147681A (ja) * 1997-08-05 1999-02-23 Kira Keshohin Kk 超臨界流体を用いた微粒子のコーティング方法及び塗装物
JPH11197494A (ja) * 1998-01-13 1999-07-27 Kenji Mishima 超臨界流体を用いた微小粒子コーティング

Also Published As

Publication number Publication date
AU784168B2 (en) 2006-02-16
CN1461211A (zh) 2003-12-10
ZA200201109B (en) 2002-10-30
FR2797398A1 (fr) 2001-02-16
HUP0202545A3 (en) 2004-05-28
CN1220484C (zh) 2005-09-28
KR20020038719A (ko) 2002-05-23
CA2380883A1 (fr) 2001-02-22
IL148063A0 (en) 2002-09-12
JP2003506479A (ja) 2003-02-18
NO20020555L (no) 2002-04-09
FR2797398B1 (fr) 2002-10-18
AU7010400A (en) 2001-03-13
WO2001012160A1 (fr) 2001-02-22
NO20020555D0 (no) 2002-02-04
EP1204409A1 (fr) 2002-05-15
MXPA02001520A (es) 2003-07-21

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees