HUP0202520A2 - Szubsztituált benzil-tiazolidin-2,4-dion-származékok és az azokat tartalmazó gyógyszerkészítmények - Google Patents
Szubsztituált benzil-tiazolidin-2,4-dion-származékok és az azokat tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0202520A2 HUP0202520A2 HU0202520A HUP0202520A HUP0202520A2 HU P0202520 A2 HUP0202520 A2 HU P0202520A2 HU 0202520 A HU0202520 A HU 0202520A HU P0202520 A HUP0202520 A HU P0202520A HU P0202520 A2 HUP0202520 A2 HU P0202520A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- optionally substituted
- dione derivatives
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- JIMXJAFZPUUCAD-UHFFFAOYSA-N 3-benzyl-1,3-thiazolidine-2,4-dione Chemical class O=C1CSC(=O)N1CC1=CC=CC=C1 JIMXJAFZPUUCAD-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Chemical class 0.000 title 1
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 abstract 2
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
A találmány tárgyát új (1) általános képletű szubsztituált benzil-tiazolidin-2,4-dion-származékok - a képletben A jelentése -CH2CONH-, -NHCONH-, -CH2CH2CO- vagy -NHCOCH2-, és B jelentése 1-4 szénatomosrövid szénláncú alkilcsoport, 1-3 szénatomos rövid szénláncúalkoxicsoport, halogénatom, trifluormetilcsoport,trifluormetoxicsoport, adott esetben szubsztituált fenilcsoport, adottesetben szubsztituált fenoxicsoport vagy adott esetben szubsztituáltbenziloxicsoport és gyógyászatilag elfogadható sóik és hidrátjaik képezik, amelyekligandumként a humán peroxiszóma proliferátoraktivált receptorhoz(PPAR) kötődve aktiválják azt, és vércukor-csökkentő hatással éslipidcsökkentő hatással rendelkeznek. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP23552799 | 1999-08-23 | ||
JP2000242706 | 2000-08-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0202520A2 true HUP0202520A2 (hu) | 2002-11-28 |
HUP0202520A3 HUP0202520A3 (en) | 2004-11-29 |
Family
ID=26532180
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0202520A HUP0202520A3 (en) | 1999-08-23 | 2000-08-18 | Substituted benzylthiazolidine-2,4-dione derivatives and pharmaceutical compositions containing them |
Country Status (10)
Country | Link |
---|---|
US (1) | US6730687B1 (hu) |
EP (1) | EP1213287B1 (hu) |
KR (1) | KR100738245B1 (hu) |
CN (1) | CN1155586C (hu) |
AT (1) | ATE296294T1 (hu) |
AU (1) | AU778720B2 (hu) |
CA (1) | CA2382574A1 (hu) |
DE (1) | DE60020381T2 (hu) |
HU (1) | HUP0202520A3 (hu) |
WO (1) | WO2001014349A1 (hu) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7407978B2 (en) * | 1999-04-06 | 2008-08-05 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
TWI262185B (en) * | 1999-10-01 | 2006-09-21 | Eisai Co Ltd | Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives |
WO2002046161A1 (fr) * | 2000-12-05 | 2002-06-13 | Kyorin Pharmaceutical Co., Ltd. | Derives de l'acide carboxylique substitues |
EP1911462A3 (en) | 2001-01-26 | 2011-11-30 | Schering Corporation | Compositions comprising a sterol absorption inhibitor |
US6908939B2 (en) | 2001-12-21 | 2005-06-21 | Galderma Research & Development S.N.C. | Biaromatic ligand activators of PPARγ receptors |
FR2833949B1 (fr) * | 2001-12-21 | 2005-08-05 | Galderma Res & Dev | NOUVEAUX LIGANDS ACTIVATEURS DES RECEPTEURS PPARy, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE |
FR2836683B1 (fr) * | 2002-03-01 | 2006-06-23 | Galderma Res & Dev | NOUVEAUX LIGANDS ACTIVATEURS DES RECEPTEURS PPARy, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE |
US7521465B2 (en) * | 2003-01-17 | 2009-04-21 | Bexel Pharmaceuticals, Inc. | Diphenyl ether derivatives |
US7781464B2 (en) * | 2003-01-17 | 2010-08-24 | Bexel Pharmaceuticals, Inc. | Heterocyclic diphenyl ethers |
US6794401B2 (en) * | 2003-01-17 | 2004-09-21 | Bexel Pharmaceuticals, Inc. | Amino acid phenoxy ethers |
US7087576B2 (en) | 2003-10-07 | 2006-08-08 | Bexel Pharmaceuticals, Inc. | Dipeptide phenyl ethers |
WO2005058813A2 (en) * | 2003-12-17 | 2005-06-30 | Ranbaxy Laboratories Limited | Thiodiazolidinedione, oxazolidinedione and diazolidinedione derivatives and their use as antidiabetic agents |
TW200827343A (en) * | 2006-09-11 | 2008-07-01 | Fuji Yakuhin Co Ltd | Novel phenylacetic acid derivative |
UY31952A (es) * | 2008-07-02 | 2010-01-29 | Astrazeneca Ab | 5-metilideno-1,3-tiazolidina-2,4-dionas sustituidas como inhibidores de quinasa pim |
US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
CN116217511B (zh) * | 2023-03-22 | 2024-04-19 | 沈阳药科大学 | 一种双靶点化合物及其制备方法和在制备sEH抑制剂与PPARs激动剂中的应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5061717A (en) | 1988-03-08 | 1991-10-29 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
US5223522A (en) * | 1988-03-08 | 1993-06-29 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
JP3144624B2 (ja) * | 1995-06-02 | 2001-03-12 | 杏林製薬株式会社 | N−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
JP3929512B2 (ja) | 1995-06-02 | 2007-06-13 | 杏林製薬株式会社 | N−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
JP3906935B2 (ja) | 1995-12-18 | 2007-04-18 | 杏林製薬株式会社 | N−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
AU2231397A (en) * | 1996-03-08 | 1997-09-22 | Torii Pharmaceutical Co., Ltd. | Thiazolidine-2,4-dione derivatives |
IL120443A (en) | 1996-03-18 | 2000-07-16 | Sankyo Co | Use of an insulin sensitizer for the manufacture of a medicament for the treatment or prophylaxis of pancreatitis |
JPH09301963A (ja) | 1996-05-17 | 1997-11-25 | Kyorin Pharmaceut Co Ltd | N−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
JP3982645B2 (ja) | 1996-09-06 | 2007-09-26 | 杏林製薬株式会社 | N−置換ジオキソチアゾリジルベンズアミド誘導体の製造中間体 |
GB0127805D0 (en) | 2001-11-20 | 2002-01-09 | Smithkline Beecham Plc | Pharmaceutical composition |
-
2000
- 2000-08-18 CN CNB008147086A patent/CN1155586C/zh not_active Expired - Fee Related
- 2000-08-18 EP EP00953475A patent/EP1213287B1/en not_active Expired - Lifetime
- 2000-08-18 DE DE60020381T patent/DE60020381T2/de not_active Expired - Fee Related
- 2000-08-18 HU HU0202520A patent/HUP0202520A3/hu unknown
- 2000-08-18 AT AT00953475T patent/ATE296294T1/de not_active IP Right Cessation
- 2000-08-18 US US10/049,645 patent/US6730687B1/en not_active Expired - Fee Related
- 2000-08-18 AU AU65945/00A patent/AU778720B2/en not_active Ceased
- 2000-08-18 KR KR1020027001998A patent/KR100738245B1/ko not_active IP Right Cessation
- 2000-08-18 CA CA002382574A patent/CA2382574A1/en not_active Abandoned
- 2000-08-18 WO PCT/JP2000/005519 patent/WO2001014349A1/ja active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
HUP0202520A3 (en) | 2004-11-29 |
ATE296294T1 (de) | 2005-06-15 |
DE60020381T2 (de) | 2006-01-26 |
EP1213287A1 (en) | 2002-06-12 |
CA2382574A1 (en) | 2001-03-01 |
KR20020040774A (ko) | 2002-05-30 |
KR100738245B1 (ko) | 2007-07-12 |
CN1155586C (zh) | 2004-06-30 |
US6730687B1 (en) | 2004-05-04 |
AU6594500A (en) | 2001-03-19 |
DE60020381D1 (de) | 2005-06-30 |
EP1213287A4 (en) | 2002-09-18 |
EP1213287B1 (en) | 2005-05-25 |
WO2001014349A1 (fr) | 2001-03-01 |
AU778720B2 (en) | 2004-12-16 |
CN1382129A (zh) | 2002-11-27 |
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