HUP0201311A3 - 1-(p-thienylbenzyl)-imidazoles as angiotensin-(1-7)receptor agonists, method for the production and the use thereof and pharmaceutical preparations containing said compounds - Google Patents

1-(p-thienylbenzyl)-imidazoles as angiotensin-(1-7)receptor agonists, method for the production and the use thereof and pharmaceutical preparations containing said compounds

Info

Publication number
HUP0201311A3
HUP0201311A3 HU0201311A HUP0201311A HUP0201311A3 HU P0201311 A3 HUP0201311 A3 HU P0201311A3 HU 0201311 A HU0201311 A HU 0201311A HU P0201311 A HUP0201311 A HU P0201311A HU P0201311 A3 HUP0201311 A3 HU P0201311A3
Authority
HU
Hungary
Prior art keywords
thienylbenzyl
angiotensin
imidazoles
compounds
production
Prior art date
Application number
HU0201311A
Other languages
English (en)
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999120815 external-priority patent/DE19920815A1/de
Priority claimed from DE1999161686 external-priority patent/DE19961686A1/de
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of HUP0201311A2 publication Critical patent/HUP0201311A2/hu
Publication of HUP0201311A3 publication Critical patent/HUP0201311A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU0201311A 1999-05-05 2000-04-29 1-(p-thienylbenzyl)-imidazoles as angiotensin-(1-7)receptor agonists, method for the production and the use thereof and pharmaceutical preparations containing said compounds HUP0201311A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1999120815 DE19920815A1 (de) 1999-05-05 1999-05-05 1-(p-Thienylbenzyl)-Imidazole als Agonisten von Angiotensin-(1-7)-Rezeptoren, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE1999161686 DE19961686A1 (de) 1999-12-21 1999-12-21 1-(p-Thienylbenzyl)-Imidazole als Agonisten von Angiotensin-1(1-7)-Rezeptoren, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate

Publications (2)

Publication Number Publication Date
HUP0201311A2 HUP0201311A2 (en) 2002-10-28
HUP0201311A3 true HUP0201311A3 (en) 2003-03-28

Family

ID=26053245

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0201311A HUP0201311A3 (en) 1999-05-05 2000-04-29 1-(p-thienylbenzyl)-imidazoles as angiotensin-(1-7)receptor agonists, method for the production and the use thereof and pharmaceutical preparations containing said compounds

Country Status (25)

Country Link
US (3) US6235766B1 (hu)
EP (1) EP1185527B1 (hu)
JP (1) JP2002544130A (hu)
KR (1) KR20020012207A (hu)
CN (1) CN1158279C (hu)
AR (1) AR023837A1 (hu)
AT (1) ATE300535T1 (hu)
AU (1) AU775244B2 (hu)
BR (1) BR0010248A (hu)
CA (1) CA2373010A1 (hu)
CZ (1) CZ20013907A3 (hu)
DE (1) DE50010835D1 (hu)
EE (1) EE200100572A (hu)
HK (1) HK1045519B (hu)
HR (1) HRP20010814A2 (hu)
HU (1) HUP0201311A3 (hu)
IL (1) IL146198A0 (hu)
NO (1) NO20015309L (hu)
NZ (1) NZ515242A (hu)
PL (1) PL351609A1 (hu)
RU (1) RU2247121C2 (hu)
SK (1) SK15942001A3 (hu)
TR (1) TR200103171T2 (hu)
WO (1) WO2000068226A1 (hu)
YU (1) YU78601A (hu)

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US6630498B2 (en) * 1997-08-06 2003-10-07 Smithkline Beecham Corporation Eprosartan arginyl charge-neutralization-complex and a process for its preparation and formulation
US6329159B1 (en) * 1999-03-11 2001-12-11 Millennium Pharmaceuticals, Inc. Anti-GPR-9-6 antibodies and methods of identifying agents which modulate GPR-9-6 function
DE10112041A1 (de) 2001-03-14 2002-09-26 Aventis Pharma Gmbh p-Thienylbenzyl-Amide als Agonisten von Angiotensin-(1-7)-Rezeptoren, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
AU2002257970B2 (en) * 2001-05-31 2007-08-02 Vicore Pharma Ab Tricyclic compounds useful as angiotensin II agonists
JP4707321B2 (ja) * 2001-05-31 2011-06-22 ヴィコール・ファルマ・アーベー アンギオテンシンｉｉアゴニストとして有用な三環式化合物
US6610726B2 (en) * 2001-06-29 2003-08-26 North Shore-Long Island Jewish Research Institute Compositions and agents for modulating cellular proliferation and angiogenesis
CA2464561A1 (en) * 2001-10-25 2003-05-01 Depomed, Inc. Methods of treatment using a gastric retained losartan dosage
EP1485116A4 (en) * 2002-02-27 2006-06-07 Univ Wake Forest ANGIOTENSIN- (1-7) AND AGONISTS OF ANGIOTENSIN- (1-7) FOR THE INHIBITION OF GROWTH OF CANCER CELLS
EP1348440A1 (en) * 2002-03-28 2003-10-01 Citeq B.V. Use of angiotensin 1-7 for enhancing cardiac function
NL1021048C2 (nl) 2002-07-11 2004-01-13 Weir Netherlands B V Zuigermembraanpomp.
AU2003302027A1 (en) * 2002-11-21 2004-06-15 Vicore Pharma Ab New tricyclic angiotensin ii agonists
AU2003302106A1 (en) * 2002-11-21 2004-06-15 Vicore Pharma Ab New tricyclic angiotensin ii agonists
WO2004085420A1 (en) * 2003-03-24 2004-10-07 Vicore Pharma Ab Bicyclic compounds useful as angiotensin ii agonists
US7176261B2 (en) 2004-10-21 2007-02-13 Medtronic, Inc. Angiotensin-(1-7) eluting polymer-coated medical device to reduce restenosis and improve endothelial cell function
AU2006235698B2 (en) * 2005-04-12 2012-03-29 Vicore Pharma Ab New tricyclic angiotensin II agonists
BRPI0502497A (pt) * 2005-06-28 2007-02-06 Univ Minas Gerais uso de agonistas e antagonistas do receptor acoplado a proteìna g, mas, como moduladores de atividade apoptótica para o estudo, a prevenção e o tratamento de doenças
BRPI0602366B1 (pt) * 2006-04-26 2017-12-12 Universidade Federal De Minas Gerais Use of agonists of the receptor coupled to protein g, but, in the treatment of metabolic syndrome, its components and their complications
WO2008052179A2 (en) * 2006-10-27 2008-05-02 Medtronic, Inc. Angiotensin (1-7) eluting stent
KR100885197B1 (ko) * 2008-09-25 2009-02-24 박창수 다면다각형상 구현이 용이한 엘이디조명 램프용 인쇄회로기판
ES2393455T3 (es) 2008-09-12 2012-12-21 Charité-Universitátsmedizin Berlin (Charité) Uso de un agonista del receptor Ang-(1-7) en lesiones pulmonares agudas
JP2015504870A (ja) * 2011-12-16 2015-02-16 タリックス ファーマシューティカルズ リミテッド 線維症を処置するためのアンジオテンシン
CN104394878A (zh) * 2012-02-10 2015-03-04 塔瑞克斯制药有限公司 用于治疗周围血管疾病的组合物和方法
US8557958B1 (en) * 2012-06-18 2013-10-15 Tarix Pharmaceuticals Ltd. Compositions and methods for treatment of diabetes
US8633158B1 (en) 2012-10-02 2014-01-21 Tarix Pharmaceuticals Ltd. Angiotensin in treating brain conditions
AU2014269028A1 (en) * 2013-04-19 2015-10-22 Tarix Orphan, Llc. Angiotensins in muscular dystrophy
JP2016520592A (ja) 2013-05-24 2016-07-14 タリックス ファーマシューティカルズ リミテッド マルファン症候群および関連障害の処置におけるアンジオテンシンペプチド
US9333233B2 (en) 2014-02-25 2016-05-10 Tarix Pharmaceuticals Ltd. Methods and compositions for the delayed treatment of stroke
CA2953064C (en) 2014-07-17 2023-06-20 University Of Southern California Methods, compounds, and compositions for the treatment of musculoskeletal diseases
MA43230A (fr) 2015-10-14 2021-04-14 Tarix Pharmaceuticals Ltd Méthodes et compositions pour le traitement d'une épidermolyse bulleuse
CA3029630A1 (en) 2016-06-29 2018-01-04 Universite De Montreal Biarylmethyl heterocycles
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
GB201913603D0 (en) * 2019-09-20 2019-11-06 Vicore Pharma Ab New compounds
EP4117703A1 (en) 2020-03-13 2023-01-18 Constant Therapeutics LLC Methods and compositions for treatment of coronavirus infection

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5140037A (en) * 1990-03-20 1992-08-18 E. I. Du Pont De Nemours And Company Treatment of central nervous system disorders with imidazole angiotensin-ii receptor antagonists
CA2058198A1 (en) * 1991-01-04 1992-07-05 Adalbert Wagner Azole derivatives, process for their preparation, and their use
US5177074A (en) 1991-03-26 1993-01-05 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan
US5252574A (en) 1991-04-26 1993-10-12 Merck & Co., Inc. Angiotensin II antagonists incorporating a substituted thiophene or furan
US5198438A (en) * 1991-05-07 1993-03-30 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan
US5256667A (en) 1991-09-25 1993-10-26 Merck & Co., Inc. Quinazolinones and pyridopyrimidinones
WO1994027597A1 (en) * 1993-05-21 1994-12-08 Smithkline Beecham Corporation Imidazolyl-alkenoic acid angiotensin ii receptor antagonists
US5444067A (en) 1993-08-30 1995-08-22 Merck & Co., Inc. Pharmaceutical treatment methods using angiotensin II receptor agonists bearing a thiophene moiety
FR2716882B1 (fr) * 1994-03-04 1996-04-05 Roussel Uclaf Utilisation de dérivés de l'imidazole au traitement d'affections impliquant les récepteurs AT1 et AT2 de l'Angiotensine, certains de ces produits, leur préparation, compositions pharmaceutiques.

Also Published As

Publication number Publication date
KR20020012207A (ko) 2002-02-15
HUP0201311A2 (en) 2002-10-28
HK1045519A1 (en) 2002-11-29
AU775244B2 (en) 2004-07-22
EP1185527B1 (de) 2005-07-27
NO20015309D0 (no) 2001-10-30
US20020077344A1 (en) 2002-06-20
TR200103171T2 (tr) 2002-06-21
YU78601A (sh) 2005-07-19
PL351609A1 (en) 2003-05-05
US6235766B1 (en) 2001-05-22
SK15942001A3 (sk) 2002-04-04
CA2373010A1 (en) 2000-11-16
HK1045519B (zh) 2005-04-22
DE50010835D1 (de) 2005-09-01
IL146198A0 (en) 2002-07-25
CN1158279C (zh) 2004-07-21
CZ20013907A3 (cs) 2002-02-13
NO20015309L (no) 2001-12-28
AU4753600A (en) 2000-11-21
HRP20010814A2 (en) 2003-02-28
BR0010248A (pt) 2002-02-13
ATE300535T1 (de) 2005-08-15
US6429222B2 (en) 2002-08-06
JP2002544130A (ja) 2002-12-24
RU2247121C2 (ru) 2005-02-27
EP1185527A1 (de) 2002-03-13
CN1349530A (zh) 2002-05-15
EE200100572A (et) 2003-02-17
AR023837A1 (es) 2002-09-04
NZ515242A (en) 2003-11-28
WO2000068226A1 (de) 2000-11-16
US20010018449A1 (en) 2001-08-30

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees