IL146198A0 - 1-(p-thienylbenzyl)-imidazoles as angiotensin-(1-7) receptor agonists, method for the production and the utilization thereof and pharmaceutical preparations containing said compounds - Google Patents

1-(p-thienylbenzyl)-imidazoles as angiotensin-(1-7) receptor agonists, method for the production and the utilization thereof and pharmaceutical preparations containing said compounds

Info

Publication number
IL146198A0
IL146198A0 IL14619800A IL14619800A IL146198A0 IL 146198 A0 IL146198 A0 IL 146198A0 IL 14619800 A IL14619800 A IL 14619800A IL 14619800 A IL14619800 A IL 14619800A IL 146198 A0 IL146198 A0 IL 146198A0
Authority
IL
Israel
Prior art keywords
thienylbenzyl
angiotensin
imidazoles
utilization
compounds
Prior art date
Application number
IL14619800A
Other languages
English (en)
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999120815 external-priority patent/DE19920815A1/de
Priority claimed from DE1999161686 external-priority patent/DE19961686A1/de
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of IL146198A0 publication Critical patent/IL146198A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL14619800A 1999-05-05 2000-04-29 1-(p-thienylbenzyl)-imidazoles as angiotensin-(1-7) receptor agonists, method for the production and the utilization thereof and pharmaceutical preparations containing said compounds IL146198A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1999120815 DE19920815A1 (de) 1999-05-05 1999-05-05 1-(p-Thienylbenzyl)-Imidazole als Agonisten von Angiotensin-(1-7)-Rezeptoren, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE1999161686 DE19961686A1 (de) 1999-12-21 1999-12-21 1-(p-Thienylbenzyl)-Imidazole als Agonisten von Angiotensin-1(1-7)-Rezeptoren, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
PCT/EP2000/003891 WO2000068226A1 (de) 1999-05-05 2000-04-29 1-(p-thienylbenzyl)-imidazole als agonisten von angiotensin-(1-7)-rezeptoren, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende pharmazeutische präparate

Publications (1)

Publication Number Publication Date
IL146198A0 true IL146198A0 (en) 2002-07-25

Family

ID=26053245

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14619800A IL146198A0 (en) 1999-05-05 2000-04-29 1-(p-thienylbenzyl)-imidazoles as angiotensin-(1-7) receptor agonists, method for the production and the utilization thereof and pharmaceutical preparations containing said compounds

Country Status (25)

Country Link
US (3) US6235766B1 (xx)
EP (1) EP1185527B1 (xx)
JP (1) JP2002544130A (xx)
KR (1) KR20020012207A (xx)
CN (1) CN1158279C (xx)
AR (1) AR023837A1 (xx)
AT (1) ATE300535T1 (xx)
AU (1) AU775244B2 (xx)
BR (1) BR0010248A (xx)
CA (1) CA2373010A1 (xx)
CZ (1) CZ20013907A3 (xx)
DE (1) DE50010835D1 (xx)
EE (1) EE200100572A (xx)
HK (1) HK1045519B (xx)
HR (1) HRP20010814A2 (xx)
HU (1) HUP0201311A3 (xx)
IL (1) IL146198A0 (xx)
NO (1) NO20015309L (xx)
NZ (1) NZ515242A (xx)
PL (1) PL351609A1 (xx)
RU (1) RU2247121C2 (xx)
SK (1) SK15942001A3 (xx)
TR (1) TR200103171T2 (xx)
WO (1) WO2000068226A1 (xx)
YU (1) YU78601A (xx)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6630498B2 (en) * 1997-08-06 2003-10-07 Smithkline Beecham Corporation Eprosartan arginyl charge-neutralization-complex and a process for its preparation and formulation
US6329159B1 (en) * 1999-03-11 2001-12-11 Millennium Pharmaceuticals, Inc. Anti-GPR-9-6 antibodies and methods of identifying agents which modulate GPR-9-6 function
DE10112041A1 (de) 2001-03-14 2002-09-26 Aventis Pharma Gmbh p-Thienylbenzyl-Amide als Agonisten von Angiotensin-(1-7)-Rezeptoren, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
JP4707321B2 (ja) * 2001-05-31 2011-06-22 ヴィコール・ファルマ・アーベー アンギオテンシンｉｉアゴニストとして有用な三環式化合物
DE60222409T2 (de) 2001-05-31 2008-09-25 Vicore Pharma Ab Trizyklische verbindungen, nützlich als angiotensin ii agonisten
US6610726B2 (en) * 2001-06-29 2003-08-26 North Shore-Long Island Jewish Research Institute Compositions and agents for modulating cellular proliferation and angiogenesis
CA2464561A1 (en) * 2001-10-25 2003-05-01 Depomed, Inc. Methods of treatment using a gastric retained losartan dosage
WO2003072059A2 (en) * 2002-02-27 2003-09-04 Wake Forest University Angiotensin-(1-7) and angiotensin-(1-7) agonists for inhibition of cancer cell growth
EP1348440A1 (en) * 2002-03-28 2003-10-01 Citeq B.V. Use of angiotensin 1-7 for enhancing cardiac function
NL1021048C2 (nl) 2002-07-11 2004-01-13 Weir Netherlands B V Zuigermembraanpomp.
WO2004046137A1 (en) * 2002-11-21 2004-06-03 Vicore Pharma Ab New tricyclic angiotensin ii agonists
AU2003302106A1 (en) * 2002-11-21 2004-06-15 Vicore Pharma Ab New tricyclic angiotensin ii agonists
AU2003219291A1 (en) * 2003-03-24 2004-10-18 Vicore Pharma Ab Bicyclic compounds useful as angiotensin ii agonists
EP1802361B1 (en) * 2004-10-21 2009-11-18 Medtronic, Inc. Angiotensin-(1-7) eluting polymer-coated medical device to reduce restenosis and improve endothelial cell function
EP1869023B1 (en) * 2005-04-12 2012-01-11 Vicore Pharma AB New tricyclic angiotensin ii agonists
BRPI0502497A (pt) * 2005-06-28 2007-02-06 Univ Minas Gerais uso de agonistas e antagonistas do receptor acoplado a proteìna g, mas, como moduladores de atividade apoptótica para o estudo, a prevenção e o tratamento de doenças
BRPI0602366B1 (pt) * 2006-04-26 2017-12-12 Universidade Federal De Minas Gerais Use of agonists of the receptor coupled to protein g, but, in the treatment of metabolic syndrome, its components and their complications
EP2114479A2 (en) * 2006-10-27 2009-11-11 Medtronic, Inc. Angiotensin (1-7) eluting stent
KR100885197B1 (ko) * 2008-09-25 2009-02-24 박창수 다면다각형상 구현이 용이한 엘이디조명 램프용 인쇄회로기판
ES2393455T3 (es) 2008-09-12 2012-12-21 Charité-Universitátsmedizin Berlin (Charité) Uso de un agonista del receptor Ang-(1-7) en lesiones pulmonares agudas
WO2013090833A1 (en) * 2011-12-16 2013-06-20 Tarix Pharmaceuticals Ltd. Angiotensins for treatment of fibrosis
EP2819687A4 (en) * 2012-02-10 2015-09-30 Tarix Pharmaceuticals Ltd COMPOSITIONS AND METHODS FOR TREATING PERIPHERAL VASCULAR DISEASE
US8557958B1 (en) * 2012-06-18 2013-10-15 Tarix Pharmaceuticals Ltd. Compositions and methods for treatment of diabetes
US8633158B1 (en) * 2012-10-02 2014-01-21 Tarix Pharmaceuticals Ltd. Angiotensin in treating brain conditions
US9943509B2 (en) 2013-03-15 2018-04-17 University Of Southern California Methods, compounds, and compositions for the treatment of musculoskeletal diseases
CA2909002A1 (en) * 2013-04-19 2014-11-27 University Of Iowa Research Foundation Angiotensins in muscular dystrophy
JP2016520592A (ja) 2013-05-24 2016-07-14 タリックス ファーマシューティカルズ リミテッド マルファン症候群および関連障害の処置におけるアンジオテンシンペプチド
US9333233B2 (en) 2014-02-25 2016-05-10 Tarix Pharmaceuticals Ltd. Methods and compositions for the delayed treatment of stroke
JP2018530590A (ja) 2015-10-14 2018-10-18 タリックス ファーマシューティカルズ リミテッド 表皮水疱症の処置のための方法及び組成物
EA039493B1 (ru) 2016-06-29 2022-02-02 Университе Де Монреаль Биарилметильные гетероциклы
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
GB201913603D0 (en) * 2019-09-20 2019-11-06 Vicore Pharma Ab New compounds
EP4117703A1 (en) 2020-03-13 2023-01-18 Constant Therapeutics LLC Methods and compositions for treatment of coronavirus infection

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5140037A (en) * 1990-03-20 1992-08-18 E. I. Du Pont De Nemours And Company Treatment of central nervous system disorders with imidazole angiotensin-ii receptor antagonists
CA2058198A1 (en) * 1991-01-04 1992-07-05 Adalbert Wagner Azole derivatives, process for their preparation, and their use
US5177074A (en) 1991-03-26 1993-01-05 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan
US5252574A (en) 1991-04-26 1993-10-12 Merck & Co., Inc. Angiotensin II antagonists incorporating a substituted thiophene or furan
US5198438A (en) * 1991-05-07 1993-03-30 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan
US5256667A (en) 1991-09-25 1993-10-26 Merck & Co., Inc. Quinazolinones and pyridopyrimidinones
WO1994027597A1 (en) * 1993-05-21 1994-12-08 Smithkline Beecham Corporation Imidazolyl-alkenoic acid angiotensin ii receptor antagonists
US5444067A (en) 1993-08-30 1995-08-22 Merck & Co., Inc. Pharmaceutical treatment methods using angiotensin II receptor agonists bearing a thiophene moiety
FR2716882B1 (fr) * 1994-03-04 1996-04-05 Roussel Uclaf Utilisation de dérivés de l'imidazole au traitement d'affections impliquant les récepteurs AT1 et AT2 de l'Angiotensine, certains de ces produits, leur préparation, compositions pharmaceutiques.

Also Published As

Publication number Publication date
KR20020012207A (ko) 2002-02-15
NO20015309D0 (no) 2001-10-30
JP2002544130A (ja) 2002-12-24
EE200100572A (et) 2003-02-17
BR0010248A (pt) 2002-02-13
US20010018449A1 (en) 2001-08-30
US6235766B1 (en) 2001-05-22
SK15942001A3 (sk) 2002-04-04
US6429222B2 (en) 2002-08-06
HK1045519A1 (en) 2002-11-29
NZ515242A (en) 2003-11-28
HRP20010814A2 (en) 2003-02-28
HK1045519B (zh) 2005-04-22
EP1185527A1 (de) 2002-03-13
HUP0201311A2 (en) 2002-10-28
NO20015309L (no) 2001-12-28
AU4753600A (en) 2000-11-21
TR200103171T2 (tr) 2002-06-21
YU78601A (sh) 2005-07-19
US20020077344A1 (en) 2002-06-20
WO2000068226A1 (de) 2000-11-16
CN1158279C (zh) 2004-07-21
EP1185527B1 (de) 2005-07-27
AU775244B2 (en) 2004-07-22
CZ20013907A3 (cs) 2002-02-13
AR023837A1 (es) 2002-09-04
ATE300535T1 (de) 2005-08-15
HUP0201311A3 (en) 2003-03-28
RU2247121C2 (ru) 2005-02-27
CN1349530A (zh) 2002-05-15
PL351609A1 (en) 2003-05-05
DE50010835D1 (de) 2005-09-01
CA2373010A1 (en) 2000-11-16

Similar Documents

Publication Publication Date Title
IL146198A0 (en) 1-(p-thienylbenzyl)-imidazoles as angiotensin-(1-7) receptor agonists, method for the production and the utilization thereof and pharmaceutical preparations containing said compounds
HUP9900625A3 (en) Benzimidazole derivatives, pharmaceutical compositions containing them and process for preparing the compounds
HUP0103567A3 (en) 2-substituted-1-piperidyl benzimidazole compounds as orl1-receptor agonists, process for their preparation and pharmaceutical compositions containing the same
HUP0003859A3 (en) Imidazole fused heterocyclic compounds, process for their preparation, pharmaceutical compositions containing the same and their use
HUP0002050A3 (en) Substituted imidazole compounds, process for producing them, pharmaceutical compositions containing them and their use
HUP0203766A3 (en) 5-pyridyl-1,3-azole compounds, process for producing the same and use thereof and pharmaceutical compositions containing them
PL350522A1 (en) Bicyclic heterocycles, pharmaceutical compositions containing these compounds, and processes for preparing them
AU1924699A (en) Compounds of heteroaryl substituted imidazole, their pharmaceutical compositionsand uses
HUP0203403A3 (en) New imidazole derivatives, pharmaceutical compositions containing them and their use
IL138568A0 (en) 1-[(1-substituted-4-piperidinyl) methyl] -4- piperidine derivative, process for the preparation thereof, pharmaceutical composition containing the same and intermediate therefor
HUP0203496A3 (en) Novel cyclopropane derivatives, pharmaceutical compositions containing them and method for the production thereof
HK1052510A1 (en) Novel hydantoin, thiohydantoin, pyrimidinedione and thioxopyrimidinone derivatives, preparation method and use as medicines.
MXPA03007635A (es) P-tienilbencilamidas que sirven como agonistas de receptores para angiotensina-(1-7), metodo para su produccion, su uso y preparaciones farmaceuticas que las contienen.
AU7961200A (en) Urea derivative, process for producing the same, and medicine containing the urea derivative
IL144370A0 (en) Epothilon derivatives, method for the production and the use thereof as pharmaceuticals
HUP0201571A2 (en) Il-8 receptor antagonist phenyl urea derivatives, process for the preparation thereof and pharmaceutical compositions containing them
HUP0202736A3 (en) Substituted aromatic-ring compounds, process for producing the same, and pharmaceutical compositions containing them and use thereof
HUP0400549A3 (en) Novel imidazole derivatives, production method thereof and pharmaceutical compositions containing them
EP1539718A4 (en) 1,2,4-TRIAZOL DERIVATIVE, METHOD FOR THE PRODUCTION THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF
HUP9802257A3 (en) Selective beta3 adrenergic agonists, process for preparing them and pharmaceutical compositions containing the said compounds
HUP9702341A3 (en) New imidazoline compounds, process for preparing them and pharmaceutical compositions containing them
HUP0202379A3 (en) New compounds, process for producing them and pharmaceutical compositions containing them
HUP0200928A3 (en) Pyrido-thieno-diazepines, method for the production thereof and pharmaceutical compositions containing said pyrido-thieno-diazepines
HUP0301008A3 (en) New imidazole derivatives, process for their preparation, their use and pharmaceutical compositions containing them
HUP0200376A3 (en) Thiaoloindolinone compounds, process for their preparation and pharmaceutical composions containing them and their use