HUP0105281A2 - Rákellenes hatású benzaldehidszármazékok és gyógyászati alkalmazásuk - Google Patents

Rákellenes hatású benzaldehidszármazékok és gyógyászati alkalmazásuk

Info

Publication number
HUP0105281A2
HUP0105281A2 HU0105281A HUP0105281A HUP0105281A2 HU P0105281 A2 HUP0105281 A2 HU P0105281A2 HU 0105281 A HU0105281 A HU 0105281A HU P0105281 A HUP0105281 A HU P0105281A HU P0105281 A2 HUP0105281 A2 HU P0105281A2
Authority
HU
Hungary
Prior art keywords
benzaldehyde derivatives
anticancer
pharmaceutical use
compounds
production
Prior art date
Application number
HU0105281A
Other languages
English (en)
Inventor
Bernt Borretzen
Camilla Bruno Dunsaed
Rolf Olaf Larsen
Vidar Moen
Erik Olai Pettersen
Geir Sagvolden
Original Assignee
Norsk Hydro Asa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norsk Hydro Asa filed Critical Norsk Hydro Asa
Publication of HUP0105281A2 publication Critical patent/HUP0105281A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány benzaldehidszármazékokra és rákellenes szerekként történőgyógyászati alkalmazásukra vonatkozik. Néhány találmányunk szerintivegyület önmagában új. A találmány kiterjed a vegyületeket tartalmazógyógyszerkészítményekre és azok előállítására is. A találmány szerintibenzaldehidszármazékok májrák, veserák vagy hasnyálmirigyrákmegelőzésére és/vagy kezelésére szolgáló terápiás szerek előállításáraalkalmazhatók. Ó
HU0105281A 1999-02-19 2000-02-18 Rákellenes hatású benzaldehidszármazékok és gyógyászati alkalmazásuk HUP0105281A2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NO990814A NO309305B1 (no) 1999-02-19 1999-02-19 Anvendelse av benzaldehydderivater ved fremstilling av farmasöytiske preparater for forebygging og/eller behandling av kreft, samt visse nye benzaldehydderivater

Publications (1)

Publication Number Publication Date
HUP0105281A2 true HUP0105281A2 (hu) 2002-05-29

Family

ID=19902986

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0105281A HUP0105281A2 (hu) 1999-02-19 2000-02-18 Rákellenes hatású benzaldehidszármazékok és gyógyászati alkalmazásuk
HU0105280A HUP0105280A2 (hu) 1999-02-19 2000-02-18 Benzaldehidszármazékok és gyógyászati alkalmazásuk és a vegyületeket tartalmazó gyógyszerkészítmények

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU0105280A HUP0105280A2 (hu) 1999-02-19 2000-02-18 Benzaldehidszármazékok és gyógyászati alkalmazásuk és a vegyületeket tartalmazó gyógyszerkészítmények

Country Status (15)

Country Link
EP (2) EP1150689A1 (hu)
JP (2) JP2002537264A (hu)
CN (2) CN1347323A (hu)
AU (2) AU2834200A (hu)
BR (2) BR0008297A (hu)
CA (2) CA2363670A1 (hu)
CZ (2) CZ20012966A3 (hu)
HU (2) HUP0105281A2 (hu)
IL (2) IL144895A0 (hu)
MX (2) MXPA01008347A (hu)
NO (1) NO309305B1 (hu)
PL (2) PL350519A1 (hu)
RU (2) RU2001123124A (hu)
SK (2) SK11602001A3 (hu)
WO (2) WO2000048610A1 (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002096921A1 (fr) * 2001-05-30 2002-12-05 Nisshin Seifun Group Inc. Nouveau derive glucose induisant l'apoptose, procede de production et utilisation comme medicament
DE10261807A1 (de) * 2002-12-19 2004-07-01 Turicum Drug Development Ag Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel
WO2007012651A1 (en) * 2005-07-26 2007-02-01 Nycomed Gmbh Isotopically substituted pantoprazole
KR101358509B1 (ko) * 2005-07-26 2014-02-05 다케다 게엠베하 동위 원소 치환된 양성자 펌프 억제제
US7598273B2 (en) * 2005-10-06 2009-10-06 Auspex Pharmaceuticals, Inc Inhibitors of the gastric H+, K+-ATPase with enhanced therapeutic properties
CN101157711B (zh) * 2007-09-28 2010-12-08 西安交通大学 一种具有抗肿瘤活性的化合物及其用途
EP2271350A4 (en) * 2008-04-03 2011-05-18 Cognate3 Llc COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY
CN101735284B (zh) * 2008-11-24 2012-05-23 上海医药工业研究院 一种4,6-o-苄叉-d-吡喃葡萄糖的制备方法
ES2893621T3 (es) 2013-12-03 2022-02-09 Intra Cellular Therapies Inc Métodos para el tratamiento de los síntomas residuales de la esquizofrenia
US10077267B2 (en) * 2014-04-04 2018-09-18 Intra-Cellular Therapies, Inc. Organic compounds
JP6898072B2 (ja) * 2015-08-27 2021-07-07 秀行 佐谷 １４−３−３タンパク質活性調節剤
JP6686168B2 (ja) 2016-03-25 2020-04-22 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 有機化合物
WO2018071233A1 (en) 2016-10-12 2018-04-19 Intra-Cellular Therapies, Inc. Amorphous solid dispersions
CN116327770A (zh) 2017-03-24 2023-06-27 细胞内治疗公司 新组合物和方法
KR20210052472A (ko) 2018-08-31 2021-05-10 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규한 방법
EP3843738A4 (en) 2018-08-31 2022-06-01 Intra-Cellular Therapies, Inc. NEW METHODS

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB811510A (en) * 1954-12-20 1959-04-08 Gyogyszeripari Ki New nitrogen-containing derivatives of polyhydroxy compounds and process for the preparation thereof
JPS6112623A (ja) * 1984-06-28 1986-01-21 Kaken Pharmaceut Co Ltd エンケフアリナ−ゼ阻害剤
JPS6256423A (ja) * 1985-09-06 1987-03-12 Kaken Pharmaceut Co Ltd 悪液質治療改善剤
US4874780A (en) * 1987-03-11 1989-10-17 Norsk Hydro A.S. Anticancer compounds
JPH07145191A (ja) * 1993-11-24 1995-06-06 Japan Tobacco Inc ガラクトシルホスフォネート誘導体

Also Published As

Publication number Publication date
JP2002537263A (ja) 2002-11-05
MXPA01008347A (es) 2004-03-10
CN1347322A (zh) 2002-05-01
CA2362306A1 (en) 2000-08-24
AU2834100A (en) 2000-09-04
BR0008297A (pt) 2002-05-28
RU2001123124A (ru) 2004-02-20
SK11602001A3 (sk) 2002-02-05
PL350519A1 (en) 2002-12-16
MXPA01008346A (es) 2003-06-06
CZ20012966A3 (cs) 2002-03-13
WO2000048609A1 (en) 2000-08-24
PL350520A1 (en) 2002-12-16
SK11612001A3 (sk) 2002-04-04
BR0008302A (pt) 2002-08-27
RU2001123035A (ru) 2004-03-20
IL144896A0 (en) 2002-06-30
EP1150689A1 (en) 2001-11-07
NO990814L (no) 2000-08-21
JP2002537264A (ja) 2002-11-05
AU2834200A (en) 2000-09-04
NO990814D0 (no) 1999-02-19
HUP0105280A2 (hu) 2002-04-29
WO2000048610A1 (en) 2000-08-24
IL144895A0 (en) 2002-06-30
NO309305B1 (no) 2001-01-15
EP1150690A1 (en) 2001-11-07
CZ20012965A3 (cs) 2002-03-13
CN1347323A (zh) 2002-05-01
CA2363670A1 (en) 2000-08-24

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