HUP0104822A2 - Dehidroepiandroszteron klarátjai és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
Dehidroepiandroszteron klarátjai és az ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0104822A2 HUP0104822A2 HU0104822A HUP0104822A HUP0104822A2 HU P0104822 A2 HUP0104822 A2 HU P0104822A2 HU 0104822 A HU0104822 A HU 0104822A HU P0104822 A HUP0104822 A HU P0104822A HU P0104822 A2 HUP0104822 A2 HU P0104822A2
- Authority
- HU
- Hungary
- Prior art keywords
- dehydroepiandrosterone
- clathrates
- clarate
- acid
- pharmaceutical compositions
- Prior art date
Links
- FMGSKLZLMKYGDP-USOAJAOKSA-N dehydroepiandrosterone Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 FMGSKLZLMKYGDP-USOAJAOKSA-N 0.000 title abstract 2
- FMGSKLZLMKYGDP-UHFFFAOYSA-N Dehydroepiandrosterone Natural products C1C(O)CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CC=C21 FMGSKLZLMKYGDP-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229960002847 prasterone Drugs 0.000 title 1
- 239000011159 matrix material Substances 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 2
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 abstract 1
- 206010001367 Adrenal insufficiency Diseases 0.000 abstract 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 abstract 1
- 206010058359 Hypogonadism Diseases 0.000 abstract 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- 208000017515 adrenocortical insufficiency Diseases 0.000 abstract 1
- 229940024606 amino acid Drugs 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 abstract 1
- 239000001768 carboxy methyl cellulose Substances 0.000 abstract 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 abstract 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 abstract 1
- 239000001913 cellulose Substances 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 235000010980 cellulose Nutrition 0.000 abstract 1
- 229960000913 crospovidone Drugs 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229940057838 polyethylene glycol 4000 Drugs 0.000 abstract 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 abstract 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000001384 succinic acid Substances 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Nanotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Ophthalmology & Optometry (AREA)
- Pregnancy & Childbirth (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány dehidroepiandroszteron (DHEA) vagy szulfát formája a-, <-vagy g-ciklodextrin mátrixban kialakuló klarátjára vonatkozik, amelymátrix egy ko-szolubilizálószert, mégpedig egy aminosavat,kroszpovidont, polietilén-glikol 4000-t, cellulózt,karboximetilcellulózt, keményítőt, bórkősavat, borostyánkősavat vagyglutársavat tartalmaz. A találmány kiterjed a fenti klarátgyógyszerkészítmény előállítására történő alkalmazására, valamintmagára a gyógyszerkészítményre is, amely főleg a mellékvesekéregelégtelenségéből, illetve hipogonadizmus eredő rendellenességekkezelésére használható. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1998MI002745A IT1304190B1 (it) | 1998-12-18 | 1998-12-18 | Clatrati di deidroepiandrosterone e relative composizionifarmaceutiche |
| PCT/EP1999/010010 WO2000037109A2 (en) | 1998-12-18 | 1999-12-16 | Clathrates of dehydroepiandrosterone and corresponding pharmaceutical compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0104822A2 true HUP0104822A2 (hu) | 2002-05-29 |
| HUP0104822A3 HUP0104822A3 (en) | 2002-08-28 |
| HU225414B1 HU225414B1 (en) | 2006-11-28 |
Family
ID=11381280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0104822A HU225414B1 (en) | 1998-12-18 | 1999-12-16 | Clathrates of dehydroepiandrosterone and pharmaceutical compositions thereof |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1140110B1 (hu) |
| JP (1) | JP2002532565A (hu) |
| KR (1) | KR100693514B1 (hu) |
| CN (1) | CN1198620C (hu) |
| AR (1) | AR021663A1 (hu) |
| AT (1) | ATE243517T1 (hu) |
| AU (1) | AU759979B2 (hu) |
| BR (1) | BR9916288A (hu) |
| CA (1) | CA2355148A1 (hu) |
| CO (1) | CO5231137A1 (hu) |
| DE (1) | DE69909128T2 (hu) |
| DK (1) | DK1140110T3 (hu) |
| EA (1) | EA003304B1 (hu) |
| ES (1) | ES2203232T3 (hu) |
| HU (1) | HU225414B1 (hu) |
| IL (2) | IL143776A0 (hu) |
| IT (1) | IT1304190B1 (hu) |
| NZ (1) | NZ512795A (hu) |
| PE (1) | PE20001379A1 (hu) |
| PT (1) | PT1140110E (hu) |
| TR (1) | TR200101766T2 (hu) |
| TW (1) | TWI225791B (hu) |
| WO (1) | WO2000037109A2 (hu) |
| ZA (1) | ZA200105223B (hu) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2815860B1 (fr) * | 2000-10-26 | 2003-12-12 | Oreal | Composition, notamment cosmetique, comprenant la dhea et/ou precurseur ou derive de celle-ci et au moins un agent myorelaxant |
| EP1285927A3 (de) * | 2001-08-16 | 2005-06-29 | Schering Aktiengesellschaft | Verwendung von Glucocorticoid-Rezeptorantagonisten zur Vorbeugung und Behandlung von Erkrankungen des männlichen Reproduktionssystems |
| ITMI20021074A1 (it) * | 2002-05-20 | 2003-11-20 | Actimex S R L | Composizione ternaria comprendente una sostanza attiva e processo di comacinazione per la sua preparazione |
| ITMI20022549A1 (it) * | 2002-12-02 | 2004-06-03 | Actimex S R L | Composizione quaternaria comprendente come sostanza attiva la propolis. |
| US20070191404A1 (en) | 2004-04-01 | 2007-08-16 | Pierre Bartsch | Pharmaceutical compositions of pyrimidine-2,4,6-triones |
| WO2006137433A1 (ja) * | 2005-06-21 | 2006-12-28 | Wakamoto Pharmaceutical Co., Ltd. | レボカバスチンを可溶化させた水性薬剤 |
| ITPD20050224A1 (it) * | 2005-07-19 | 2007-01-20 | Actimex Srl | Composizioni contenenti micronutrienti aventi in particolare attivita' antiossidante e loro impiego |
| US8268806B2 (en) * | 2007-08-10 | 2012-09-18 | Endorecherche, Inc. | Pharmaceutical compositions |
| ES2545337T3 (es) * | 2011-07-19 | 2015-09-10 | Pantarhei Bioscience B.V. | Comprimido que contiene dehidroepiandrosterona (DHEA) |
| DE102012101680A1 (de) * | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat |
| EP2986634B1 (en) * | 2013-04-19 | 2019-11-20 | University of Houston System | Cocrystalline dhea formulations |
| EP3505154B1 (en) | 2017-12-26 | 2022-04-06 | Industrial Technology Research Institute | Composition for improving the solubility of poorly soluble substances, use thereof and complex formulation containing thereof |
| EP3666260A1 (en) | 2018-12-13 | 2020-06-17 | Laboratorios Leon Farma SA | Ethinyl estradiol-beta-cyclodextrin complex and process for preparing thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2647343B1 (fr) * | 1989-05-24 | 1994-05-06 | Rhone Poulenc Sante | Nouvelle forme pharmaceutique poreuse et sa preparation |
| US4978532A (en) * | 1989-08-11 | 1990-12-18 | Pharmedic Co. | Dosage form for administration of dehydroepiandrosterone |
| US5120720A (en) * | 1990-09-20 | 1992-06-09 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Preparation of lipophile:hydroxypropylcyclodextrin complexes by a method using co-solubilizers |
| WO1994004155A1 (en) * | 1992-08-19 | 1994-03-03 | Health Resource Institute, Ltd. | Dehydroepiandrosterone therapy for the treatment of eye disorders |
| WO1995015746A1 (en) * | 1993-12-10 | 1995-06-15 | The School Of Pharmacy | Liposome delivery systems |
| CN1201397A (zh) * | 1995-11-13 | 1998-12-09 | 萨珀根公司 | 甾族化合物给药的改进配方 |
-
1998
- 1998-12-18 IT IT1998MI002745A patent/IT1304190B1/it active
-
1999
- 1999-12-14 AR ARP990106362A patent/AR021663A1/es not_active Application Discontinuation
- 1999-12-14 CO CO99077980A patent/CO5231137A1/es not_active Application Discontinuation
- 1999-12-14 TW TW088121876A patent/TWI225791B/zh not_active IP Right Cessation
- 1999-12-16 WO PCT/EP1999/010010 patent/WO2000037109A2/en active IP Right Grant
- 1999-12-16 CN CNB998157716A patent/CN1198620C/zh not_active Expired - Fee Related
- 1999-12-16 AT AT99963559T patent/ATE243517T1/de not_active IP Right Cessation
- 1999-12-16 KR KR1020017007454A patent/KR100693514B1/ko not_active IP Right Cessation
- 1999-12-16 DK DK99963559T patent/DK1140110T3/da active
- 1999-12-16 DE DE69909128T patent/DE69909128T2/de not_active Expired - Fee Related
- 1999-12-16 BR BR9916288-1A patent/BR9916288A/pt not_active IP Right Cessation
- 1999-12-16 TR TR2001/01766T patent/TR200101766T2/xx unknown
- 1999-12-16 AU AU19810/00A patent/AU759979B2/en not_active Ceased
- 1999-12-16 ES ES99963559T patent/ES2203232T3/es not_active Expired - Lifetime
- 1999-12-16 HU HU0104822A patent/HU225414B1/hu not_active IP Right Cessation
- 1999-12-16 EA EA200100674A patent/EA003304B1/ru not_active IP Right Cessation
- 1999-12-16 PT PT99963559T patent/PT1140110E/pt unknown
- 1999-12-16 IL IL14377699A patent/IL143776A0/xx not_active IP Right Cessation
- 1999-12-16 PE PE1999001262A patent/PE20001379A1/es not_active Application Discontinuation
- 1999-12-16 JP JP2000589219A patent/JP2002532565A/ja active Pending
- 1999-12-16 EP EP99963559A patent/EP1140110B1/en not_active Expired - Lifetime
- 1999-12-16 NZ NZ512795A patent/NZ512795A/en unknown
- 1999-12-16 CA CA002355148A patent/CA2355148A1/en not_active Abandoned
-
2001
- 2001-06-14 IL IL143776A patent/IL143776A/en unknown
- 2001-06-25 ZA ZA200105223A patent/ZA200105223B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000037109A3 (en) | 2000-09-14 |
| PT1140110E (pt) | 2003-11-28 |
| ITMI982745A1 (it) | 2000-06-18 |
| AU1981000A (en) | 2000-07-12 |
| TWI225791B (en) | 2005-01-01 |
| ZA200105223B (en) | 2002-09-25 |
| IT1304190B1 (it) | 2001-03-08 |
| DE69909128T2 (de) | 2004-05-06 |
| DK1140110T3 (da) | 2003-10-20 |
| TR200101766T2 (tr) | 2001-12-21 |
| ES2203232T3 (es) | 2004-04-01 |
| CN1333686A (zh) | 2002-01-30 |
| HU225414B1 (en) | 2006-11-28 |
| BR9916288A (pt) | 2001-10-16 |
| AR021663A1 (es) | 2002-07-31 |
| NZ512795A (en) | 2003-08-29 |
| IL143776A (en) | 2007-03-08 |
| WO2000037109A2 (en) | 2000-06-29 |
| KR20010086109A (ko) | 2001-09-07 |
| CO5231137A1 (es) | 2002-12-27 |
| CA2355148A1 (en) | 2000-06-29 |
| EA200100674A1 (ru) | 2001-12-24 |
| IL143776A0 (en) | 2002-04-21 |
| EP1140110B1 (en) | 2003-06-25 |
| AU759979B2 (en) | 2003-05-01 |
| CN1198620C (zh) | 2005-04-27 |
| PE20001379A1 (es) | 2000-11-25 |
| EP1140110A2 (en) | 2001-10-10 |
| HUP0104822A3 (en) | 2002-08-28 |
| JP2002532565A (ja) | 2002-10-02 |
| ATE243517T1 (de) | 2003-07-15 |
| DE69909128D1 (de) | 2003-07-31 |
| KR100693514B1 (ko) | 2007-03-14 |
| EA003304B1 (ru) | 2003-04-24 |
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