HUP0103925A2 - Formoterolt tartalmazó, stabilan tárolható hatóanyag-koncentrátum - Google Patents

Formoterolt tartalmazó, stabilan tárolható hatóanyag-koncentrátum

Info

Publication number
HUP0103925A2
HUP0103925A2 HU0103925A HUP0103925A HUP0103925A2 HU P0103925 A2 HUP0103925 A2 HU P0103925A2 HU 0103925 A HU0103925 A HU 0103925A HU P0103925 A HUP0103925 A HU P0103925A HU P0103925 A2 HUP0103925 A2 HU P0103925A2
Authority
HU
Hungary
Prior art keywords
free
propellant
formoterol
active substance
pharmaceutically acceptable
Prior art date
Application number
HU0103925A
Other languages
English (en)
Inventor
Dieter Hochrainer
Bernd Zierenberg
Original Assignee
Boehringer Ingelheim Pharma Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19847969A external-priority patent/DE19847969A1/de
Application filed by Boehringer Ingelheim Pharma Kg filed Critical Boehringer Ingelheim Pharma Kg
Publication of HUP0103925A2 publication Critical patent/HUP0103925A2/hu
Publication of HUP0103925A3 publication Critical patent/HUP0103925A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány tárgyát hajtóanyagmentes aeroszolformuláció előállításáraszolgáló, stabilan tárolható, hajtóanyagmentes hatóanyag-koncentrátumképezi, amely hatóanyagként 75 és 500 mg/ml közötti koncentrációjúformoterolt tartalmaz szabad bázis, egy gyógyszerészetileg elfogadhatósója vagy addíciós terméke formájában, egy gyógyszerészetilegelfogadható oldó- vagy szuszpendálószerben. A találmány tárgyát képezitovábbá a fenti hatóanyag-koncentrátum inhalációs célokra valóalkalmazása is, amelynél azt a felhasználás előtt egyhajtóanyagmentes, gyógyszerészetileg elfogadható hígítószerrel úgyhígítják meg, hogy a formoterol koncentrációja 0,9 és 1,5 mg/ml közöttlegyen. Ó
HU0103925A 1998-10-17 1999-10-09 Storable active substance concentrate containing formoterol HUP0103925A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19847969A DE19847969A1 (de) 1998-10-17 1998-10-17 Lagerfähig flüssige Formulierung mit Formoterol
US11238098P 1998-12-14 1998-12-14

Publications (2)

Publication Number Publication Date
HUP0103925A2 true HUP0103925A2 (hu) 2002-05-29
HUP0103925A3 HUP0103925A3 (en) 2003-05-28

Family

ID=26049594

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0103925A HUP0103925A3 (en) 1998-10-17 1999-10-09 Storable active substance concentrate containing formoterol

Country Status (26)

Country Link
EP (1) EP1121112B1 (hu)
JP (2) JP3636430B2 (hu)
KR (1) KR100655100B1 (hu)
CN (1) CN1187044C (hu)
BG (1) BG65350B1 (hu)
BR (1) BR9914507A (hu)
CA (1) CA2343123C (hu)
CZ (1) CZ20011362A3 (hu)
DE (1) DE59901669D1 (hu)
DK (1) DK1121112T3 (hu)
EA (1) EA003960B1 (hu)
EE (1) EE04219B1 (hu)
ES (1) ES2178479T3 (hu)
HK (1) HK1041448B (hu)
HR (1) HRP20010255A2 (hu)
HU (1) HUP0103925A3 (hu)
ID (1) ID29605A (hu)
IL (2) IL142494A0 (hu)
NO (1) NO20011663L (hu)
NZ (1) NZ511225A (hu)
PL (1) PL348434A1 (hu)
PT (1) PT1121112E (hu)
SI (1) SI1121112T1 (hu)
SK (1) SK285382B6 (hu)
TR (1) TR200101096T2 (hu)
WO (1) WO2000023065A2 (hu)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DZ2947A1 (fr) 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
IT1313553B1 (it) 1999-07-23 2002-09-09 Chiesi Farma Spa Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione.
IT1317846B1 (it) 2000-02-22 2003-07-15 Chiesi Farma Spa Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
AU5070100A (en) * 2000-05-22 2001-12-03 Chiesi Farma Spa Stable pharmaceutical solution formulations for pressurised metered dose inhalers
US6667344B2 (en) * 2001-04-17 2003-12-23 Dey, L.P. Bronchodilating compositions and methods
US20030055026A1 (en) 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
EP1595531A1 (en) 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers
ITRM20040268A1 (it) * 2004-05-31 2004-08-31 Italchimici S P A Formulazione farmaceutica di una soluzione stabile di formoterolo per via inalatoria e suo precedimento di preparazione.
ITRM20050022A1 (it) 2005-01-19 2006-07-20 Italchimici S P A Formulazione farmaceutica di una soluzione stabile di glicole propilenico contenente formoterolo per via inalatoria e suo procedimento di preparazione.
WO2007059620A1 (en) * 2005-11-23 2007-05-31 Feanny Stephen J Method for administering formoterol using a nebulizer
DE102006023756A1 (de) * 2006-05-20 2007-11-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ethanolhaltige Aerosolformulierung für die Inhalation
EP2034990A4 (en) * 2006-05-26 2013-03-06 Dey L P DIRTIBLE COMPOSITIONS OF QUATERNARY AMMONIUM MUSCARIN RECEPTOR ANTAGONISTS
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
JP5670421B2 (ja) 2009-03-31 2015-02-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング コンポーネント表面のコーティング方法
EP2432531B1 (de) 2009-05-18 2019-03-06 Boehringer Ingelheim International GmbH Adapter, inhalationseinrichtung und zerstäuber
JP5658268B2 (ja) 2009-11-25 2015-01-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
WO2011064164A1 (en) 2009-11-25 2011-06-03 Boehringer Ingelheim International Gmbh Nebulizer
WO2011160932A1 (en) 2010-06-24 2011-12-29 Boehringer Ingelheim International Gmbh Nebulizer
EP2694220B1 (de) 2011-04-01 2020-05-06 Boehringer Ingelheim International GmbH Medizinisches gerät mit behälter
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
ES2836977T3 (es) 2013-08-09 2021-06-28 Boehringer Ingelheim Int Nebulizador
WO2015169430A1 (en) 2014-05-07 2015-11-12 Boehringer Ingelheim International Gmbh Nebulizer
EA032850B1 (ru) 2014-05-07 2019-07-31 Бёрингер Ингельхайм Интернациональ Гмбх Контейнер, небулайзер и способ изготовления контейнера
PT3139979T (pt) 2014-05-07 2023-09-28 Boehringer Ingelheim Int Unidade, nebulizador e método
CN107362140A (zh) * 2016-05-11 2017-11-21 广东东阳光药业有限公司 喷雾剂以及喷雾组件
WO2020019952A1 (zh) * 2018-07-26 2020-01-30 四川海思科制药有限公司 一种含格隆铵盐及茚达特罗盐的气雾剂药物组合物及其制备方法与应用
CN110755414A (zh) * 2019-11-12 2020-02-07 南京华盖制药有限公司 一种酒石酸阿福特罗气雾剂及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE204743T1 (de) * 1991-12-18 2001-09-15 Minnesota Mining & Mfg Aerosolzusammensetzungen für arzneimittelsuspensionen
GB9612297D0 (en) * 1996-06-11 1996-08-14 Minnesota Mining & Mfg Medicinal aerosol formulations
GB9616237D0 (en) * 1996-08-01 1996-09-11 Norton Healthcare Ltd Aerosol formulations

Also Published As

Publication number Publication date
NZ511225A (en) 2003-08-29
CA2343123C (en) 2008-03-25
TR200101096T2 (tr) 2001-12-21
BG105391A (en) 2001-11-30
EP1121112B1 (de) 2002-06-05
ES2178479T3 (es) 2002-12-16
WO2000023065A2 (de) 2000-04-27
WO2000023065A3 (de) 2000-08-03
SK4942001A3 (en) 2001-09-11
IL142494A (en) 2006-04-10
HK1041448A1 (en) 2002-07-12
NO20011663D0 (no) 2001-04-03
BG65350B1 (bg) 2008-03-31
ID29605A (id) 2001-09-06
EE200100224A (et) 2002-06-17
EE04219B1 (et) 2004-02-16
IL142494A0 (en) 2002-03-10
JP3636430B2 (ja) 2005-04-06
EA003960B1 (ru) 2003-10-30
HK1041448B (zh) 2005-05-13
KR20010075637A (ko) 2001-08-09
NO20011663L (no) 2001-04-03
CN1333682A (zh) 2002-01-30
SI1121112T1 (en) 2002-10-31
HUP0103925A3 (en) 2003-05-28
KR100655100B1 (ko) 2006-12-08
BR9914507A (pt) 2001-06-26
CN1187044C (zh) 2005-02-02
CA2343123A1 (en) 2000-04-27
PL348434A1 (en) 2002-05-20
DE59901669D1 (de) 2002-07-11
JP2002527473A (ja) 2002-08-27
CZ20011362A3 (cs) 2001-09-12
HRP20010255A2 (en) 2002-04-30
DK1121112T3 (da) 2002-09-16
PT1121112E (pt) 2002-11-29
WO2000023065A8 (de) 2001-02-22
SK285382B6 (sk) 2006-12-07
EP1121112A2 (de) 2001-08-08
EA200100439A1 (ru) 2001-10-22
JP2005047933A (ja) 2005-02-24

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees