HUP0103858A2 - Lamivudin és adefovir tartalmú vírusellenes kombinációkat tartalmazó gyógyászati készítmények és alkalmazásuk - Google Patents

Lamivudin és adefovir tartalmú vírusellenes kombinációkat tartalmazó gyógyászati készítmények és alkalmazásuk

Info

Publication number
HUP0103858A2
HUP0103858A2 HU0103858A HUP0103858A HUP0103858A2 HU P0103858 A2 HUP0103858 A2 HU P0103858A2 HU 0103858 A HU0103858 A HU 0103858A HU P0103858 A HUP0103858 A HU P0103858A HU P0103858 A2 HUP0103858 A2 HU P0103858A2
Authority
HU
Hungary
Prior art keywords
adefovir
lamivudine
pharmaceutical compositions
compositions containing
hbv
Prior art date
Application number
HU0103858A
Other languages
English (en)
Inventor
Nathaniel A. Brown
Lynn D. Condreay
Douglas Fraser Gray
Marc Rubin
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of HUP0103858A2 publication Critical patent/HUP0103858A2/hu
Publication of HUP0103858A3 publication Critical patent/HUP0103858A3/hu
Publication of HU227677B1 publication Critical patent/HU227677B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Jelen találmány olyan, hepatitis B vírus ellenes (HBV) aktivitássalrendelkező terápiás kombinációkra vonatkozik, amelyek (2R,cisz)- 4-amino-1-(2-hidroximetil-1,3-oxatiolán-5-il)pirimidin-2-ont (lamivudin)és második terápiás hatóanyagként a 9-[(R)-2-(foszfonometoxi)etil]adenint (PMEA vagy adefovir) vagy abisz(pivaloiloximetil)-9-[(R)-2-(foszfonometoxi)etil]adenint (a PMEAorális előanyaga, adefovir-dipivoxil) tartalmaznak. A találmánygyógyszerészeti készítményekre is vonatkozik, amelyek az említettkombinációkat tartalmazzák, valamint azok alkalmazására a HBVfertőzések kezelésére, beleértve a nukleozid és/vagy nem-nukleozidgátlókra rezisztens HBV mutánsok által előidézett fertőzéseket is. Ó
HU0103858A 1998-09-18 1999-09-17 Antiviral combinations of lamivudine and adefovir HU227677B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9820420.9A GB9820420D0 (en) 1998-09-18 1998-09-18 Antiviral combinations
PCT/EP1999/006886 WO2000016755A2 (en) 1998-09-18 1999-09-17 Antiviral combinations of lamivudine and adefovir

Publications (3)

Publication Number Publication Date
HUP0103858A2 true HUP0103858A2 (hu) 2002-05-29
HUP0103858A3 HUP0103858A3 (en) 2004-03-01
HU227677B1 HU227677B1 (en) 2011-11-28

Family

ID=10839133

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0103858A HU227677B1 (en) 1998-09-18 1999-09-17 Antiviral combinations of lamivudine and adefovir

Country Status (23)

Country Link
EP (1) EP1113802B1 (hu)
JP (1) JP2002526441A (hu)
KR (1) KR100413312B1 (hu)
CN (1) CN1178660C (hu)
AR (1) AR023661A1 (hu)
AT (1) ATE270106T1 (hu)
AU (1) AU755633B2 (hu)
BR (1) BR9913791A (hu)
CA (1) CA2344172A1 (hu)
CZ (1) CZ2001977A3 (hu)
DE (1) DE69918447T2 (hu)
ES (1) ES2223183T3 (hu)
GB (1) GB9820420D0 (hu)
HK (1) HK1035670A1 (hu)
HU (1) HU227677B1 (hu)
IL (1) IL141844A0 (hu)
NO (1) NO20011358L (hu)
NZ (1) NZ510380A (hu)
PL (1) PL358988A1 (hu)
TR (1) TR200101486T2 (hu)
TW (1) TW555559B (hu)
WO (1) WO2000016755A2 (hu)
ZA (1) ZA200101920B (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA986614B (en) 1997-07-25 1999-01-27 Gilead Sciences Nucleotide analog composition
SI1267880T2 (sl) 2000-02-29 2010-04-30 Bristol Myers Squibb Co Formulacija z nizko dozo entekavirja in uporaba
CN1303089C (zh) * 2002-11-19 2007-03-07 天津药物研究院 阿德福韦酯结晶形态及其制备方法
EP3025718A1 (en) 2003-01-14 2016-06-01 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
UA93354C2 (ru) * 2004-07-09 2011-02-10 Гилиад Сайенсиз, Инк. Местный противовирусный препарат
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
RU2008128424A (ru) * 2005-12-14 2010-01-20 Сипла Лимитед (In) Фармацевтическая комбинация, включающая нуклеотидный и нуклеозидный ингибиторы обратной транскриптазы (такие как тенофовир и ламивудин) в различных частях дозы
CA2785461A1 (en) * 2009-12-31 2011-07-07 Xiao-jian ZHOU Compositions and methods for treating hepatitis b virus infection
WO2012062835A1 (en) * 2010-11-12 2012-05-18 Glaxo Wellcome Manufacturing Pte Ltd Novel pharmaceutical compositions
CN113880898B (zh) * 2020-10-30 2023-07-25 杭州拉林智能科技有限公司 黄酮苷-有机胺类抗微生物剂复盐化合物及其制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA00012842A (es) * 1998-06-24 2004-06-22 Univ Emory Uso de 3'-azido-2',3'-didesoxiuridina en combinacion de drogas adicionales contra el vih para la manufactura de un medicamento para el tratamiento del vih.

Also Published As

Publication number Publication date
HU227677B1 (en) 2011-11-28
WO2000016755A3 (en) 2000-05-25
ATE270106T1 (de) 2004-07-15
CZ2001977A3 (cs) 2001-08-15
KR100413312B1 (ko) 2004-01-03
BR9913791A (pt) 2001-05-29
NZ510380A (en) 2003-07-25
AU6085199A (en) 2000-04-10
CN1178660C (zh) 2004-12-08
AU755633B2 (en) 2002-12-19
AR023661A1 (es) 2002-09-04
TR200101486T2 (tr) 2001-12-21
CN1326349A (zh) 2001-12-12
TW555559B (en) 2003-10-01
JP2002526441A (ja) 2002-08-20
HK1035670A1 (hu) 2001-12-07
NO20011358L (no) 2001-04-17
PL358988A1 (en) 2004-08-23
DE69918447T2 (de) 2005-08-04
NO20011358D0 (no) 2001-03-16
CA2344172A1 (en) 2000-03-30
EP1113802B1 (en) 2004-06-30
DE69918447D1 (de) 2004-08-05
ES2223183T3 (es) 2005-02-16
EP1113802A2 (en) 2001-07-11
KR20010075192A (ko) 2001-08-09
ZA200101920B (en) 2002-03-07
WO2000016755A2 (en) 2000-03-30
GB9820420D0 (en) 1998-11-11
IL141844A0 (en) 2002-03-10
HUP0103858A3 (en) 2004-03-01

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Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: GLAXO GROUP LIMITED, GB

Free format text: FORMER OWNER(S): GLAXO GROUP LIMITED, GB

MM4A Lapse of definitive patent protection due to non-payment of fees