HUP0103659A3 - Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives - Google Patents

Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives

Info

Publication number
HUP0103659A3
HUP0103659A3 HU0103659A HUP0103659A HUP0103659A3 HU P0103659 A3 HUP0103659 A3 HU P0103659A3 HU 0103659 A HU0103659 A HU 0103659A HU P0103659 A HUP0103659 A HU P0103659A HU P0103659 A3 HUP0103659 A3 HU P0103659A3
Authority
HU
Hungary
Prior art keywords
cyanomethyl
dioxane
producing
acetic acid
acid derivatives
Prior art date
Application number
HU0103659A
Other languages
English (en)
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Publication of HUP0103659A2 publication Critical patent/HUP0103659A2/hu
Publication of HUP0103659A3 publication Critical patent/HUP0103659A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/14—Preparation of carboxylic acid nitriles by reaction of cyanides with halogen-containing compounds with replacement of halogen atoms by cyano groups
HU0103659A 1998-04-30 1999-04-28 Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives HUP0103659A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12113598 1998-04-30

Publications (2)

Publication Number Publication Date
HUP0103659A2 HUP0103659A2 (en) 2002-06-29
HUP0103659A3 true HUP0103659A3 (en) 2003-01-28

Family

ID=14803747

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0103659A HUP0103659A3 (en) 1998-04-30 1999-04-28 Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives

Country Status (7)

Country Link
US (1) US6344569B1 (hu)
EP (1) EP1077212B1 (hu)
CA (1) CA2329893A1 (hu)
DE (1) DE69910562T2 (hu)
ES (1) ES2207202T3 (hu)
HU (1) HUP0103659A3 (hu)
WO (1) WO1999057109A1 (hu)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227840B1 (en) * 1999-05-06 2012-05-02 Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag Intermediates of atorvastatin synthesis and process for producing them
AU1551701A (en) * 1999-12-03 2001-06-12 Kaneka Corporation Novel carbonyl reductase, gene thereof and method of using the same
GB0011120D0 (en) * 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) * 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
GB0116212D0 (en) * 2001-07-03 2001-08-29 Avecia Ltd Process
US7199261B2 (en) * 2001-07-06 2007-04-03 Teva Pharmaceutical Industries Ltd Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
GB0211715D0 (en) * 2002-05-22 2002-07-03 Phoenix Chemicals Ltd Process
EP1375493A1 (en) 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
DE60336324D1 (de) * 2002-08-09 2011-04-21 Codexis Inc Enzymatische verfahren zur herstellung 4-substituierter 3-hydroxybuttersäure-derivate
KR100529703B1 (ko) * 2002-09-23 2005-11-17 임광민 키랄 중간체의 제조방법 및 그를 이용한 아토바스타틴의제조방법
US7588928B2 (en) * 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
KR20060064617A (ko) * 2003-08-11 2006-06-13 코덱시스, 인코포레이티드 개량된 할로히드린 디할로게나제 및 관련 폴리뉴클레오티드
US7541171B2 (en) * 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
EP1660648B1 (en) * 2003-08-11 2013-10-09 Codexis, Inc. Improved glucose dehydrogenase polypeptides and related polynucleotides
WO2005017135A1 (en) * 2003-08-11 2005-02-24 Codexis, Inc. Improved ketoreductase polypeptides and related polynucleotides
MXPA06001718A (es) 2003-08-11 2006-05-19 Codexis Inc Procedimiento enzimatico para la produccion de derivados de acido 3-hidroxibutirico 4-sustituido y esteres de acido carboxilico sustituido con ciano e hidroxi vecinales.
US7879585B2 (en) 2006-10-02 2011-02-01 Codexis, Inc. Ketoreductase enzymes and uses thereof
EP2198018B1 (en) 2007-09-13 2013-11-20 Codexis, Inc. Ketoreductase polypeptides for the reduction of acetophenones
WO2010080635A2 (en) 2008-12-18 2010-07-15 Codexis, Inc. Recombinant halohydrin dehalogenase polypeptides
WO2011104725A2 (en) 2010-02-23 2011-09-01 Cadila Healthcare Limited Hmg-coa reductase inhibitors and process for the preparation thereof
CN105669637A (zh) * 2014-11-21 2016-06-15 南京博优康远生物医药科技有限公司 一种3,5,6-取代己酸酯衍生物的制备方法
CN105566281A (zh) * 2015-02-13 2016-05-11 江西苏克尔新材料有限公司 一种阿托伐他汀钙侧链中间体的制备方法
CN111978286A (zh) * 2020-08-21 2020-11-24 江苏万年长药业有限公司 一种制备ats-8的方法
CN114181188B (zh) * 2021-12-08 2023-06-27 江苏阿尔法药业股份有限公司 一种阿托伐他汀钙中间体的无溶剂化合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5003080A (en) * 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
US5103024A (en) * 1990-10-17 1992-04-07 Warner-Lambert Company Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5155251A (en) * 1991-10-11 1992-10-13 Warner-Lambert Company Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
US5278313A (en) * 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
GB9512837D0 (en) * 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups

Also Published As

Publication number Publication date
EP1077212B1 (en) 2003-08-20
EP1077212A4 (en) 2001-11-21
HUP0103659A2 (en) 2002-06-29
CA2329893A1 (en) 1999-11-11
ES2207202T3 (es) 2004-05-16
US6344569B1 (en) 2002-02-05
DE69910562D1 (de) 2003-09-25
DE69910562T2 (de) 2004-06-17
EP1077212A1 (en) 2001-02-21
WO1999057109A1 (fr) 1999-11-11

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