HUP0103534A2 - Benzolszulfonil(tio)karbamidok alkalmazása a vegetatív idegrendszer zavarainak kezelésére és megelőzésére és alkalmazásuk béta-receptor blokkolókkal kombinálva és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Benzolszulfonil(tio)karbamidok alkalmazása a vegetatív idegrendszer zavarainak kezelésére és megelőzésére és alkalmazásuk béta-receptor blokkolókkal kombinálva és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0103534A2 HUP0103534A2 HU0103534A HUP0103534A HUP0103534A2 HU P0103534 A2 HUP0103534 A2 HU P0103534A2 HU 0103534 A HU0103534 A HU 0103534A HU P0103534 A HUP0103534 A HU P0103534A HU P0103534 A2 HUP0103534 A2 HU P0103534A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- alkoxy
- hydrogen atom
- atom
- benzenesulfonyl
- Prior art date
Links
- 235000013877 carbamide Nutrition 0.000 title abstract 2
- 210000000653 nervous system Anatomy 0.000 title abstract 2
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- 150000003672 ureas Chemical class 0.000 title abstract 2
- 230000004064 dysfunction Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000011321 prophylaxis Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 239000002876 beta blocker Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004428 fluoroalkoxy group Chemical group 0.000 abstract 1
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
- C07C335/42—Sulfonylthioureas; Sulfonylisothioureas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/54—Silicon-containing compounds
- C08K5/5406—Silicon-containing compounds containing elements other than oxygen or nitrogen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Polymers & Plastics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány tárgya (I) általános képletűbenzolszulfonil(tio)karbamidok, ezek tetszőleges szetereoizomer formáiés ezek tetszőleges arányú elegyei és/vagy fiziológiailag alkalmazhatósói alkalmazása a vegetatív idegrendszer zavarainak kezelésére vagymegelőzésére alkalmas gyógyszerkészítmény előállítására, a képletbenR1 jelentése hidrogénatom, metilcsoport vagy trifluormetilcsoport, R2jelentése hidrogénatom, halogénatom, alkilcsoport, alkoxicsoport,alkoxi-alkoxicsoport, alkoxi-alkoxi-alkoxicsoport, alkiltiocsoport,fluoralkoxicsoport vagy fluoralkilcsoport, E jelentése oxigénatom vagykénatom, Y jelentése -(CR32)n- általános képletű szénhidrogén csoport,ahol R3 jelentése az egyes előfordulási helyeken egymástól függetlenülhidrogénatom vagy alkilcsoport, n értéke 1, 2, 3 vagy 4, X jelentésehidrogénatom, halogénatom vagy alkilcsoport, Z jelentése halogénatom,nitrocsoport, alkoxicsoport vagy alkilcsoport, adott esetben béta-receptor blokkolóval kombinálva. A találmány kiterjed a fentivegyületeket tartalmazó termékekre és gyógyszerkészítményekre. Ó
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1998141534 DE19841534A1 (de) | 1998-09-10 | 1998-09-10 | Verwendung von Benzolsulfonyl(thio)harnstoffen zur Behandlung und Prophylaxe von Dysfunktionen des autonomen Nervensystems und Verwendung von Benzolsulfonyl(thio)harnstoffen in Kombination mit Betarezeptoren-Blockern |
| DE1999101061 DE19901061A1 (de) | 1999-01-14 | 1999-01-14 | Verwendung von Benzolsulfonyl(thio)harnstoffen zur Behandlung von Prophylaxe von Dysfunktionen des autonomen Nervensystems und Verwendung von Benzolsulfonyl(thio)harnstoffen in Kombination mit Betarezeptoren-Blockern |
| PCT/EP1999/006450 WO2000015204A2 (en) | 1998-09-10 | 1999-09-02 | Use of benzenesulfonyl(thio)ureas for the treatment and prophylaxis of dysfunctions of the autonomous nervous system and use of benzenesulfonyl(thio)ureas in combination with beta-receptor blockers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0103534A2 true HUP0103534A2 (hu) | 2002-05-29 |
| HUP0103534A3 HUP0103534A3 (en) | 2003-09-29 |
| HU228988B1 HU228988B1 (hu) | 2013-07-29 |
Family
ID=26048790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0103534A HU228988B1 (hu) | 1998-09-10 | 1999-09-02 | Benzolszulfonil(tio)karbamidok alkalmazása béta-receptor blokkolókkal kombinálva |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6414030B1 (hu) |
| EP (1) | EP1117409B1 (hu) |
| JP (1) | JP4733268B2 (hu) |
| KR (1) | KR100981592B1 (hu) |
| CN (1) | CN1195524C (hu) |
| AR (1) | AR020411A1 (hu) |
| AT (1) | ATE287718T1 (hu) |
| AU (1) | AU762832B2 (hu) |
| BR (1) | BR9913572A (hu) |
| CA (1) | CA2343009C (hu) |
| CZ (1) | CZ301165B6 (hu) |
| DE (1) | DE69923464T2 (hu) |
| DK (1) | DK1117409T3 (hu) |
| ES (1) | ES2235507T3 (hu) |
| HK (1) | HK1040187B (hu) |
| HU (1) | HU228988B1 (hu) |
| ID (1) | ID28854A (hu) |
| IL (2) | IL141414A0 (hu) |
| MY (1) | MY121798A (hu) |
| NO (1) | NO330215B1 (hu) |
| NZ (1) | NZ510424A (hu) |
| PL (1) | PL194986B1 (hu) |
| PT (1) | PT1117409E (hu) |
| RU (1) | RU2247562C2 (hu) |
| TR (1) | TR200100692T2 (hu) |
| TW (1) | TWI238817B (hu) |
| WO (1) | WO2000015204A2 (hu) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19917233A1 (de) * | 1999-04-16 | 2000-10-19 | Aventis Pharma Gmbh | Kristalline Formen des Natriumsalzes des 5-Chlor-2-methoxy-N-(2-(4-methoxy-3-methylaminothiocarbonylaminosulfonyl-phenyl)-ethyl)- benzamids |
| DE19923086A1 (de) | 1999-05-20 | 2000-11-23 | Aventis Pharma Gmbh | Cinnamoylaminoalkyl-substituierte Benzolsulfonamidderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| US7620611B1 (en) * | 1999-07-20 | 2009-11-17 | Trilithic, Inc. | Neural networks for ingress monitoring |
| DE10054482A1 (de) | 2000-11-03 | 2002-05-08 | Aventis Pharma Gmbh | Heteroarylacryloylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE10054481A1 (de) | 2000-11-03 | 2002-05-08 | Aventis Pharma Gmbh | Acylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE10129704A1 (de) * | 2001-06-22 | 2003-01-02 | Aventis Pharma Gmbh | Verwendung von Benzolsulfonyl(thio)harnstoffen in der Behandlung des septischen Schocks |
| CN1330630C (zh) * | 2004-03-10 | 2007-08-08 | 中国药科大学 | 新的磺酰(硫)脲衍生物、其制备方法及含有它们的药物组合物 |
| DE102004061017A1 (de) | 2004-12-18 | 2006-06-22 | Sanofi-Aventis Deutschland Gmbh | Piperidinsulfonylharnstoffe und -thioharnstoffe, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| BRPI0812590A2 (pt) * | 2007-06-05 | 2015-02-18 | Sanofi Aventis | Derivados de di(hetero) aricicloexano, sua preparação, seu uso e composições farmacêuticas compreendendo-os |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1185180B (de) * | 1963-10-19 | 1965-01-14 | Hoechst Ag | Verfahren zur Herstellung von Benzolsulfonylharnstoffen |
| DE1518874C3 (de) * | 1964-10-07 | 1975-03-13 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung |
| DE3009047A1 (de) | 1980-03-08 | 1981-09-24 | C.H. Boehringer Sohn, 6507 Ingelheim | Neue l-(acylamino-aryloxy-)2-hydroxy-3-alkinylaminopropane und verfahren zu ihrer herstellung |
| GB8716972D0 (en) * | 1987-07-17 | 1987-08-26 | Pfizer Ltd | Treatment of cardiac arrhythmias |
| EP0612724B1 (de) * | 1993-02-23 | 1996-12-27 | Hoechst Aktiengesellschaft | Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe- Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika |
| DE19505397A1 (de) * | 1995-02-17 | 1996-08-22 | Hoechst Ag | Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| WO1996028437A1 (en) | 1995-03-10 | 1996-09-19 | Hoechst Marion Roussel, Inc. | Novel process for preparing 2,3-dihydro-benzofuranol derivatives |
| FR2746013B1 (fr) | 1996-03-18 | 1998-05-29 | Sanofi Sa | Utilisation de composes antiarythmiques dans la prevention de la mortalite post infarctus |
-
1999
- 1999-09-02 PL PL347215A patent/PL194986B1/pl unknown
- 1999-09-02 CZ CZ20010858A patent/CZ301165B6/cs not_active IP Right Cessation
- 1999-09-02 KR KR1020017003067A patent/KR100981592B1/ko not_active IP Right Cessation
- 1999-09-02 PT PT99944585T patent/PT1117409E/pt unknown
- 1999-09-02 DK DK99944585T patent/DK1117409T3/da active
- 1999-09-02 JP JP2000569788A patent/JP4733268B2/ja not_active Expired - Fee Related
- 1999-09-02 AT AT99944585T patent/ATE287718T1/de active
- 1999-09-02 AU AU57444/99A patent/AU762832B2/en not_active Ceased
- 1999-09-02 IL IL14141499A patent/IL141414A0/xx active IP Right Grant
- 1999-09-02 WO PCT/EP1999/006450 patent/WO2000015204A2/en active IP Right Grant
- 1999-09-02 DE DE69923464T patent/DE69923464T2/de not_active Expired - Lifetime
- 1999-09-02 EP EP99944585A patent/EP1117409B1/en not_active Expired - Lifetime
- 1999-09-02 RU RU2001109434/15A patent/RU2247562C2/ru not_active IP Right Cessation
- 1999-09-02 BR BR9913572-8A patent/BR9913572A/pt not_active Application Discontinuation
- 1999-09-02 HU HU0103534A patent/HU228988B1/hu not_active IP Right Cessation
- 1999-09-02 TR TR2001/00692T patent/TR200100692T2/xx unknown
- 1999-09-02 NZ NZ510424A patent/NZ510424A/xx not_active IP Right Cessation
- 1999-09-02 ID IDW20010566A patent/ID28854A/id unknown
- 1999-09-02 CA CA2343009A patent/CA2343009C/en not_active Expired - Fee Related
- 1999-09-02 CN CNB998107794A patent/CN1195524C/zh not_active Expired - Fee Related
- 1999-09-02 ES ES99944585T patent/ES2235507T3/es not_active Expired - Lifetime
- 1999-09-08 AR ARP990104515A patent/AR020411A1/es not_active Application Discontinuation
- 1999-09-09 MY MYPI99003906A patent/MY121798A/en unknown
- 1999-11-25 TW TW088115446A patent/TWI238817B/zh not_active IP Right Cessation
-
2001
- 2001-02-13 IL IL141414A patent/IL141414A/en not_active IP Right Cessation
- 2001-03-05 NO NO20011117A patent/NO330215B1/no not_active IP Right Cessation
- 2001-11-09 US US09/986,626 patent/US6414030B1/en not_active Expired - Lifetime
-
2002
- 2002-02-26 HK HK02101438.6A patent/HK1040187B/zh not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |