HUP0101826A2 - Javított farmakokinetikai tulajdonságokat mutató hibrid polipeptidek - Google Patents
Javított farmakokinetikai tulajdonságokat mutató hibrid polipeptidekInfo
- Publication number
- HUP0101826A2 HUP0101826A2 HU0101826A HUP0101826A HUP0101826A2 HU P0101826 A2 HUP0101826 A2 HU P0101826A2 HU 0101826 A HU0101826 A HU 0101826A HU P0101826 A HUP0101826 A HU P0101826A HU P0101826 A2 HUP0101826 A2 HU P0101826A2
- Authority
- HU
- Hungary
- Prior art keywords
- pharmacokinetic properties
- hybrid polypeptides
- core
- core polypeptide
- polypeptides
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 12
- 229920001184 polypeptide Polymers 0.000 title abstract 10
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 10
- 108700028146 Genetic Enhancer Elements Proteins 0.000 abstract 1
- 101800001690 Transmembrane protein gp41 Proteins 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000007910 cell fusion Effects 0.000 abstract 1
- 239000003623 enhancer Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000001177 retroviral effect Effects 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
A találmány elsődleges tárgya eredetileg különféle retrovírus-burkolatok (gp41) fehérjeszekvenciáiból származó enhancer szekvenciák,amelyek valamely velük összekapcsolt mag-polipeptid farmakokinetikaitulajdonságait javítják. A találmány azon az eredményen alapul, hogyha a találmány szerinti peptidszekvenciákat bármilyen mag-polipeptiddel összekapcsolják, az így kapott hibrid polipeptid jobbfarmakokinetikai tulajdonságokat, például hosszabb felezési időtmutat, mint a mag-polipeptid önmagában. A találmány további tárgyátképezik az ilyen hibrid polipeptidek, ezek előállítási eljárása,továbbá a mag-polipeptidek. A hibrid polipeptidek egy mag-polipeptidből és egy vagy több hozzákapcsolt enhancerpeptidszekvenciából állnak. A találmány szerinti hibrid polipeptidekelőnyösen vírusfertőzések és/vagy vírusok által előidézett sejtfúziósjelenségek gátlására használhatók. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/082,279 US6258782B1 (en) | 1998-05-20 | 1998-05-20 | Hybrid polypeptides with enhanced pharmacokinetic properties |
PCT/US1999/011219 WO1999059615A1 (en) | 1998-05-20 | 1999-05-20 | Hybrid polypeptides with enhanced pharmacokinetic properties |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0101826A2 true HUP0101826A2 (hu) | 2001-09-28 |
HUP0101826A3 HUP0101826A3 (en) | 2005-12-28 |
Family
ID=22170199
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0101826A HUP0101826A3 (en) | 1998-05-20 | 1999-05-20 | Hybrid polypeptides with enhanced pharmacokinetic properties |
Country Status (22)
Country | Link |
---|---|
US (3) | US6258782B1 (hu) |
EP (1) | EP1079846A4 (hu) |
JP (1) | JP2002515449A (hu) |
KR (1) | KR100742789B1 (hu) |
CN (1) | CN1205995C (hu) |
AU (1) | AU766995C (hu) |
BR (1) | BR9910626A (hu) |
CA (1) | CA2332338A1 (hu) |
HK (1) | HK1039747A1 (hu) |
HR (1) | HRP20000789A2 (hu) |
HU (1) | HUP0101826A3 (hu) |
ID (1) | ID29141A (hu) |
IL (2) | IL139702A0 (hu) |
MX (1) | MXPA00011314A (hu) |
NO (1) | NO20005836L (hu) |
NZ (1) | NZ508352A (hu) |
PL (1) | PL344342A1 (hu) |
RU (1) | RU2236865C2 (hu) |
TR (1) | TR200100163T2 (hu) |
WO (1) | WO1999059615A1 (hu) |
YU (1) | YU71800A (hu) |
ZA (1) | ZA200006642B (hu) |
Families Citing this family (89)
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-
1998
- 1998-05-20 US US09/082,279 patent/US6258782B1/en not_active Expired - Fee Related
-
1999
- 1999-05-20 CA CA002332338A patent/CA2332338A1/en not_active Abandoned
- 1999-05-20 RU RU2000132227/15A patent/RU2236865C2/ru not_active IP Right Cessation
- 1999-05-20 IL IL13970299A patent/IL139702A0/xx active IP Right Grant
- 1999-05-20 EP EP99925716A patent/EP1079846A4/en not_active Withdrawn
- 1999-05-20 BR BR9910626-4A patent/BR9910626A/pt not_active Application Discontinuation
- 1999-05-20 TR TR2001/00163T patent/TR200100163T2/xx unknown
- 1999-05-20 US US09/315,304 patent/US6348568B1/en not_active Expired - Fee Related
- 1999-05-20 NZ NZ508352A patent/NZ508352A/xx unknown
- 1999-05-20 AU AU41949/99A patent/AU766995C/en not_active Ceased
- 1999-05-20 WO PCT/US1999/011219 patent/WO1999059615A1/en not_active Application Discontinuation
- 1999-05-20 MX MXPA00011314A patent/MXPA00011314A/es not_active IP Right Cessation
- 1999-05-20 ID IDW20002674A patent/ID29141A/id unknown
- 1999-05-20 PL PL99344342A patent/PL344342A1/xx not_active Application Discontinuation
- 1999-05-20 HU HU0101826A patent/HUP0101826A3/hu unknown
- 1999-05-20 JP JP2000549279A patent/JP2002515449A/ja active Pending
- 1999-05-20 KR KR1020007012887A patent/KR100742789B1/ko not_active IP Right Cessation
- 1999-05-20 CN CNB998089362A patent/CN1205995C/zh not_active Expired - Fee Related
- 1999-05-20 YU YU71800A patent/YU71800A/sh unknown
-
2000
- 2000-11-15 ZA ZA200006642A patent/ZA200006642B/en unknown
- 2000-11-15 IL IL139702A patent/IL139702A/en not_active IP Right Cessation
- 2000-11-17 NO NO20005836A patent/NO20005836L/no not_active Application Discontinuation
- 2000-11-17 HR HR20000789A patent/HRP20000789A2/hr not_active Application Discontinuation
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2001
- 2001-04-13 US US09/834,784 patent/US6562787B1/en not_active Expired - Fee Related
-
2002
- 2002-02-06 HK HK02100923.0A patent/HK1039747A1/zh unknown
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CA2332338A1 (en) | 1999-11-25 |
IL139702A (en) | 2007-10-31 |
ID29141A (id) | 2001-08-02 |
RU2236865C2 (ru) | 2004-09-27 |
YU71800A (sh) | 2004-05-12 |
US6562787B1 (en) | 2003-05-13 |
WO1999059615A9 (en) | 2000-06-22 |
HK1039747A1 (zh) | 2002-06-21 |
NO20005836L (no) | 2001-01-19 |
MXPA00011314A (es) | 2003-04-22 |
HUP0101826A3 (en) | 2005-12-28 |
US6258782B1 (en) | 2001-07-10 |
HRP20000789A2 (en) | 2001-06-30 |
KR100742789B1 (ko) | 2007-07-25 |
AU766995C (en) | 2004-12-02 |
ZA200006642B (en) | 2001-05-28 |
NO20005836D0 (no) | 2000-11-17 |
KR20010043681A (ko) | 2001-05-25 |
TR200100163T2 (tr) | 2001-06-21 |
BR9910626A (pt) | 2006-01-03 |
PL344342A1 (en) | 2001-11-05 |
WO1999059615A1 (en) | 1999-11-25 |
JP2002515449A (ja) | 2002-05-28 |
NZ508352A (en) | 2004-02-27 |
EP1079846A4 (en) | 2003-01-02 |
AU4194999A (en) | 1999-12-06 |
IL139702A0 (en) | 2002-02-10 |
US6348568B1 (en) | 2002-02-19 |
CN1205995C (zh) | 2005-06-15 |
EP1079846A1 (en) | 2001-03-07 |
CN1310626A (zh) | 2001-08-29 |
AU766995B2 (en) | 2003-10-30 |
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