HUP0101346A2 - Kalcilitikus vegyületek - Google Patents
Kalcilitikus vegyületekInfo
- Publication number
- HUP0101346A2 HUP0101346A2 HU0101346A HUP0101346A HUP0101346A2 HU P0101346 A2 HUP0101346 A2 HU P0101346A2 HU 0101346 A HU0101346 A HU 0101346A HU P0101346 A HUP0101346 A HU P0101346A HU P0101346 A2 HUP0101346 A2 HU P0101346A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- covalent bond
- alkylene
- alkyl
- optionally substituted
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 230000001126 calcilytic effect Effects 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004450 alkenylene group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000005002 aryl methyl group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
- -1 oxy- Chemical class 0.000 abstract 2
- 229940123613 Calcium receptor antagonist Drugs 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 125000005677 ethinylene group Chemical group [*:2]C#C[*:1] 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 abstract 1
- 125000005553 heteroaryloxy group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000005156 substituted alkylene group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/33—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/22—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány (I) általános képletű vegyületekre - amelyek képletében Y1kovalens kötés, adott esetben szubsztituált alkilén- vagyalkeniléncsoport, vagy oxicsoport; Y2 adott esetben szubsztituáltmetiléncsoport; Y3 kovalens kötés, oxi-, tio-, N(RIV), -(alkilén)-O-,-(alkilén)-S- vagy -(alkilén)-N(RIV)- csoport; R3 és R4 egymástólfüggetlenül metil- vagy etilcsoport, vagy R3 és R4 együttciklopropilcsoportot képez; R5 adott esetben szubsztituált aril- vagykondenzált aril-, kondenzált dihidro- vagy tetrahidroarilcsoport; RIVhidrogénatom, alkil- vagy cikloalkilcsoport; vagy R5 adott esetbenszubsztituált heteroaril- vagy kondenzált heteroaril-csoport; Gkovalens kötés, CH-R6 vagy C=R6 csoport, ahol R6 hidrogénatom,hidroxicsoport vagy oxocsoport; R7 hidrogénatom, hidroxi- vagyalkoxicsoport; R8 hidrogénatom vagy alkilcsoport; vagy R7 és R8 együttkarbonilcsoportot képez; A és B kovalens kötés, metilén-, imino-,oxi-, tio- vagy karbonilcsoport; azzal a megkötéssel, hogy vagy A,vagy pedig B jelentése metilén- vagy iminocsoport; vagy A és B együttkovalens kötést képez; vagy A-B vinilén- vagy etiniléncsoport; X1 és X5 hidrogén-, halogénatom,ciano-, nitro-, alkil-, cikloalkil-, aril-metil- vagy heteroaril-metil-csoport; azzal a megkötéssel, hogy X1 és X5 egyikének ajelentése hidrogénatom; X2, X3 és X4 hidrogén-, halogénatom, alkoxi-,aril-oxi-, heteroaril-oxi-, aril-metil-, heteroaril-metil-, alkil-,aril-karbonil-, heteroaril-karbonil-csoport, aril-CH(OH)- vagyheteroaril -CH(OH)- képletű csoport; és J-K általános képletű csoport;J kovalens kötés, adott esetben szubsztituált alkilén-, -O-alkilénvagy alkeniléncsoport; K -CO2RIV általános képletű csoport, hidroxi-vagy cianocsoport -, a vegyületeket tartalmazógyógyszerkészítményekre, valamint a vegyületek kalciumreceptor-antagonistákként történő alkalmazására vonatkozik. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8109398P | 1998-04-08 | 1998-04-08 | |
PCT/US1999/007722 WO1999051569A1 (en) | 1998-04-08 | 1999-04-08 | Calcilytic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0101346A2 true HUP0101346A2 (hu) | 2001-08-28 |
HUP0101346A3 HUP0101346A3 (en) | 2003-03-28 |
Family
ID=22162059
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0101346A HUP0101346A3 (en) | 1998-04-08 | 1999-04-08 | Calcilytic compounds |
Country Status (34)
Country | Link |
---|---|
US (1) | US6395919B1 (hu) |
EP (1) | EP1070048B1 (hu) |
JP (1) | JP2002510671A (hu) |
KR (1) | KR20010042526A (hu) |
CN (1) | CN1304401A (hu) |
AP (1) | AP1271A (hu) |
AR (1) | AR018177A1 (hu) |
AT (1) | ATE303358T1 (hu) |
AU (1) | AU752389B2 (hu) |
BG (1) | BG104916A (hu) |
BR (1) | BR9909486A (hu) |
CA (1) | CA2327279A1 (hu) |
CO (1) | CO5031246A1 (hu) |
DE (1) | DE69927008T2 (hu) |
DZ (1) | DZ2751A1 (hu) |
EA (1) | EA200001039A1 (hu) |
EG (1) | EG24178A (hu) |
ES (1) | ES2247795T3 (hu) |
HK (1) | HK1034243A1 (hu) |
HU (1) | HUP0101346A3 (hu) |
ID (1) | ID27004A (hu) |
IL (1) | IL138918A0 (hu) |
MX (1) | MXPA00009844A (hu) |
MY (1) | MY121054A (hu) |
NO (1) | NO20005006L (hu) |
NZ (1) | NZ507288A (hu) |
OA (1) | OA11499A (hu) |
PE (1) | PE20000415A1 (hu) |
PL (1) | PL343357A1 (hu) |
SK (1) | SK14852000A3 (hu) |
TR (1) | TR200002896T2 (hu) |
UA (1) | UA58586C2 (hu) |
WO (1) | WO1999051569A1 (hu) |
ZA (1) | ZA200005369B (hu) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ECSP003590A (es) * | 1999-07-31 | 2002-02-25 | Smithkline Beecham Corp | Compuestos calcioliticos |
MY159417A (en) * | 2000-01-24 | 2017-01-13 | Smithkline Beecham Corp | Calcilytic compounds |
US20030018203A1 (en) | 2002-07-17 | 2003-01-23 | Largo Maria Amparo | Calcilytic compounds |
FR2812875B1 (fr) | 2000-08-08 | 2003-12-12 | Centre Nat Rech Scient | Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation |
DE60136187D1 (de) * | 2000-08-11 | 2008-11-27 | Japan Tobacco Inc | Calciumrezeptor-antagonisten |
WO2002034204A2 (en) * | 2000-10-25 | 2002-05-02 | Smithkline Beecham Corporation | Calcilytic compounds |
MY143244A (en) | 2002-11-26 | 2011-04-15 | Smithkline Beecham Corp | Calcilytic compounds |
US7105537B2 (en) | 2003-01-28 | 2006-09-12 | Bristol-Myers Squibb Company | 2-substituted cyclic amines as calcium sensing receptor modulators |
US7205322B2 (en) | 2003-02-12 | 2007-04-17 | Bristol-Myers Squibb Company | Thiazolidine compounds as calcium sensing receptor modulators |
MY138734A (en) | 2003-04-23 | 2009-07-31 | Japan Tobacco Inc | Casr antagonist |
US7265145B2 (en) | 2003-05-28 | 2007-09-04 | Bristol-Myers Squibb Company | Substituted piperidines and pyrrolidines as calcium sensing receptor modulators and method |
EP1630157A4 (en) | 2003-05-28 | 2007-05-23 | Japan Tobacco Inc | ANTAGONIST OF CASR |
WO2005077886A1 (en) * | 2004-02-06 | 2005-08-25 | Smithkline Beecham Corporation | Calcilytic compounds |
US7648965B2 (en) * | 2004-05-14 | 2010-01-19 | Unigene Laboratories Inc. | Method for fostering bone formation and preservation |
US7531518B2 (en) | 2004-05-14 | 2009-05-12 | Unigene Laboratories Inc. | Method for fostering bone formation and preservation |
US20060293667A1 (en) * | 2005-05-19 | 2006-12-28 | Agnes Vignery | Bone implant device and methods of using same |
JP5244597B2 (ja) | 2005-09-02 | 2013-07-24 | アムジエン・インコーポレーテツド | カルシリティック化合物またはカルシウム模倣性化合物を用いて腸液バランスを調節する方法 |
US8093299B2 (en) * | 2007-03-30 | 2012-01-10 | Amgen Inc. | Methods of treating bowel disorders |
SG172141A1 (en) * | 2008-12-24 | 2011-07-28 | Daiichi Sankyo Co Ltd | Indanyl compounds |
WO2010103429A1 (en) | 2009-03-10 | 2010-09-16 | Pfizer Inc. | 1,1-(Dimethyl-Ethylamino)-2-Hydroxy-Propoxy]-Ethyl}-3-Methyl-Biphenyl-4- Carboxylic Acid Derivatives As Calcium Receptor Antagonists |
GB201217330D0 (en) | 2012-09-28 | 2012-11-14 | Univ Cardiff | Therapeutic for treating inflammatory lung disorders |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2533210A1 (fr) * | 1982-09-17 | 1984-03-23 | Lyon I Universite Claude | Edulcorants de synthese |
DE3301198A1 (de) * | 1983-01-15 | 1984-07-19 | Hoechst Ag, 6230 Frankfurt | N-arylalkylamin-3-propoxypyridin-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische praeparate und deren verwendung |
US5541204A (en) * | 1994-12-02 | 1996-07-30 | Bristol-Myers Squibb Company | Aryloxypropanolamine β 3 adrenergic agonists |
BR9610481A (pt) | 1995-09-21 | 1999-05-11 | Lilly Co Eli | Agonistas adrenérgicos beta seletivos |
DE69733649T2 (de) | 1996-04-09 | 2006-05-18 | NPS Pharmaceuticals, Inc., Salt Lake City | Calcylitische verbindungen |
-
1999
- 1999-04-06 PE PE1999000275A patent/PE20000415A1/es not_active Application Discontinuation
- 1999-04-06 AR ARP990101554A patent/AR018177A1/es unknown
- 1999-04-06 MY MYPI99001327A patent/MY121054A/en unknown
- 1999-04-07 DZ DZ990052A patent/DZ2751A1/xx active
- 1999-04-07 EG EG36999A patent/EG24178A/xx active
- 1999-04-08 ZA ZA200005369A patent/ZA200005369B/xx unknown
- 1999-04-08 DE DE69927008T patent/DE69927008T2/de not_active Expired - Lifetime
- 1999-04-08 WO PCT/US1999/007722 patent/WO1999051569A1/en not_active Application Discontinuation
- 1999-04-08 KR KR1020007011166A patent/KR20010042526A/ko not_active Application Discontinuation
- 1999-04-08 TR TR2000/02896T patent/TR200002896T2/xx unknown
- 1999-04-08 BR BR9909486-0A patent/BR9909486A/pt not_active Application Discontinuation
- 1999-04-08 ES ES99916516T patent/ES2247795T3/es not_active Expired - Lifetime
- 1999-04-08 HU HU0101346A patent/HUP0101346A3/hu unknown
- 1999-04-08 AU AU34819/99A patent/AU752389B2/en not_active Ceased
- 1999-04-08 CO CO99020604A patent/CO5031246A1/es unknown
- 1999-04-08 ID IDW20002001A patent/ID27004A/id unknown
- 1999-04-08 CA CA002327279A patent/CA2327279A1/en not_active Abandoned
- 1999-04-08 US US09/647,793 patent/US6395919B1/en not_active Expired - Lifetime
- 1999-04-08 EP EP99916516A patent/EP1070048B1/en not_active Expired - Lifetime
- 1999-04-08 SK SK1485-2000A patent/SK14852000A3/sk unknown
- 1999-04-08 MX MXPA00009844A patent/MXPA00009844A/es unknown
- 1999-04-08 JP JP2000542291A patent/JP2002510671A/ja not_active Withdrawn
- 1999-04-08 AP APAP/P/2000/001931A patent/AP1271A/en active
- 1999-04-08 IL IL13891899A patent/IL138918A0/xx unknown
- 1999-04-08 NZ NZ507288A patent/NZ507288A/en not_active IP Right Cessation
- 1999-04-08 EA EA200001039A patent/EA200001039A1/ru unknown
- 1999-04-08 CN CN99807083A patent/CN1304401A/zh active Pending
- 1999-04-08 PL PL99343357A patent/PL343357A1/xx not_active Application Discontinuation
- 1999-04-08 AT AT99916516T patent/ATE303358T1/de not_active IP Right Cessation
- 1999-08-04 UA UA2000105670A patent/UA58586C2/uk unknown
-
2000
- 2000-10-04 NO NO20005006A patent/NO20005006L/no not_active Application Discontinuation
- 2000-10-06 OA OA1200000277A patent/OA11499A/en unknown
- 2000-11-07 BG BG104916A patent/BG104916A/xx unknown
-
2001
- 2001-07-09 HK HK01104722A patent/HK1034243A1/xx not_active IP Right Cessation
Also Published As
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Publication | Publication Date | Title |
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