HUP0003394A2 - Pirido[2,3-b][1,5]benzodiazepin-származékok, alkalmazásuk, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
Pirido[2,3-b][1,5]benzodiazepin-származékok, alkalmazásuk, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0003394A2 HUP0003394A2 HU0003394A HUP0003394A HUP0003394A2 HU P0003394 A2 HUP0003394 A2 HU P0003394A2 HU 0003394 A HU0003394 A HU 0003394A HU P0003394 A HUP0003394 A HU P0003394A HU P0003394 A2 HUP0003394 A2 HU P0003394A2
- Authority
- HU
- Hungary
- Prior art keywords
- optionally substituted
- compounds
- preparation
- disorders
- group
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- NJVCEFNGEYMKSL-UHFFFAOYSA-N 11h-pyrido[2,3-b][1,5]benzodiazepine Chemical class N1=CC2=CC=CN=C2NC2=CC=CC=C21 NJVCEFNGEYMKSL-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 230000027939 micturition Effects 0.000 abstract 2
- 230000000422 nocturnal effect Effects 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 229940083335 Vasopressin agonist Drugs 0.000 abstract 1
- 102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000000740 bleeding effect Effects 0.000 abstract 1
- 208000015294 blood coagulation disease Diseases 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010064 diabetes insipidus Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 208000031169 hemorrhagic disease Diseases 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 208000005346 nocturnal enuresis Diseases 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A találmány kívánt esetben szubsztituált (I) általános képletűvegyületekre és farmakológiailag elfogadható sóikra, továbbá avegyületeket tartalmazó gyógyászati készítményekre, valamint avegyületek előállítására vonatkozik. A képletben W jelentéseoxigénatom vagy NH csoport, A és B jelentése szén- vagy nitorgénatom,R1 jelentése adott esetben szubsztituált metinil- vagy alkanoilcsoportvagy egy 1-4 nitrogén- és/vagy oxigénatomot tartalmazó, adott esetbenszubsztituált heterociklusos csoport, X, Y és Z jelentése hidrogén-vagy halogénatom, adott esetben szubsztituált alkil-, cikloalkil-,alkoxicsoport. A találmány szerinti vegyületek vazopresszin agonistahatásuk révén alkalmasak különböző rendellenességek gyógyítására vagyenyhítésére, ilyen rendellenességek például diabetes insipidus,éjszakai ágybavizelés, éjszakai vizelés, vizeleti inkontinencia,vérzési és véralvadási rendellenességek, valamint a vizelés időlegeskésleltetése képtelenségének kezelésére. Ó
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94170797A | 1997-07-30 | 1997-07-30 | |
| US90337097A | 1997-07-30 | 1997-07-30 | |
| PCT/US1998/015487 WO1999006403A1 (en) | 1997-07-30 | 1998-07-24 | Tricyclic vasopressin agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0003394A2 true HUP0003394A2 (hu) | 2001-08-28 |
| HUP0003394A3 HUP0003394A3 (en) | 2003-04-28 |
Family
ID=27129361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0003394A HUP0003394A3 (en) | 1997-07-30 | 1998-07-24 | Pyrido[2,3-b][1,5]benzodiazepine derivatives, their use, process for their preparation and pharmaceutical compositions containing them |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1000059B1 (hu) |
| JP (1) | JP2001512120A (hu) |
| KR (1) | KR20010022397A (hu) |
| CN (1) | CN1162429C (hu) |
| AT (1) | ATE277926T1 (hu) |
| AU (1) | AU8592598A (hu) |
| BR (1) | BR9811559A (hu) |
| CA (1) | CA2297407A1 (hu) |
| DE (1) | DE69826677T2 (hu) |
| DK (1) | DK1000059T3 (hu) |
| ES (1) | ES2229523T3 (hu) |
| HU (1) | HUP0003394A3 (hu) |
| IL (1) | IL133787A0 (hu) |
| NO (1) | NO20000241L (hu) |
| NZ (1) | NZ502448A (hu) |
| PT (1) | PT1000059E (hu) |
| WO (1) | WO1999006403A1 (hu) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7326701B2 (en) | 2000-12-01 | 2008-02-05 | Ajinomoto Co., Inc. | Lactam compounds and pharmaceutical use thereof |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1149097A2 (en) * | 1999-02-04 | 2001-10-31 | American Home Products Corporation | Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists |
| DE60001054T2 (de) * | 1999-02-04 | 2003-07-24 | Wyeth, Madison | Trizyclische pyridin n-oxide vasopressin agonisten |
| GB0000079D0 (en) * | 2000-01-05 | 2000-02-23 | Ferring Bv | Novel antidiuretic agents |
| GB0015601D0 (en) * | 2000-06-26 | 2000-08-16 | Ferring Bv | Novel antidiuretic agents |
| AU2004234258B2 (en) | 2003-04-28 | 2009-04-09 | Tacurion | 4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivative or salt thereof |
| GB201005623D0 (en) | 2010-04-01 | 2010-05-19 | Vantia Ltd | New polymorph |
| TW201444798A (zh) | 2013-02-28 | 2014-12-01 | 必治妥美雅史谷比公司 | 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物 |
| EP2961746B1 (en) | 2013-02-28 | 2018-01-03 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1251767B (de) * | 1964-02-28 | 1968-04-18 | Dr Karl Thomae Gesellschaft mit beschrankter Haftung Biberach/Riß | Verfahren zur Herstellung von neuen m 6 Stellung substituierten 5 6 Dihydro-5oxo HH pyrido[2,3-b] [l,5]benzodiazepinen |
| US5512563A (en) * | 1993-07-29 | 1996-04-30 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| US5420270A (en) * | 1993-10-07 | 1995-05-30 | G. D. Searle & Co. | Aryl substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use |
| AR002459A1 (es) * | 1995-01-17 | 1998-03-25 | American Cyanamid Co | Antagonistas de vasopresina de benzacepina triciclicos, una composicion farmaceutica que los contiene, un metodo para tratar enfermedades y unprocedimiento para su preparacion. |
| TW359669B (en) * | 1995-12-15 | 1999-06-01 | Otsuka Pharma Co Ltd | Benzazepine derivatives |
-
1998
- 1998-07-24 PT PT98937144T patent/PT1000059E/pt unknown
- 1998-07-24 EP EP98937144A patent/EP1000059B1/en not_active Expired - Lifetime
- 1998-07-24 IL IL13378798A patent/IL133787A0/xx unknown
- 1998-07-24 AU AU85925/98A patent/AU8592598A/en not_active Abandoned
- 1998-07-24 BR BR9811559-6A patent/BR9811559A/pt active Search and Examination
- 1998-07-24 KR KR1020007000976A patent/KR20010022397A/ko not_active Application Discontinuation
- 1998-07-24 NZ NZ502448A patent/NZ502448A/xx unknown
- 1998-07-24 DE DE69826677T patent/DE69826677T2/de not_active Expired - Fee Related
- 1998-07-24 CA CA002297407A patent/CA2297407A1/en not_active Abandoned
- 1998-07-24 JP JP2000505161A patent/JP2001512120A/ja active Pending
- 1998-07-24 HU HU0003394A patent/HUP0003394A3/hu unknown
- 1998-07-24 CN CNB988096420A patent/CN1162429C/zh not_active Expired - Fee Related
- 1998-07-24 AT AT98937144T patent/ATE277926T1/de not_active IP Right Cessation
- 1998-07-24 ES ES98937144T patent/ES2229523T3/es not_active Expired - Lifetime
- 1998-07-24 WO PCT/US1998/015487 patent/WO1999006403A1/en active IP Right Grant
- 1998-07-24 DK DK98937144T patent/DK1000059T3/da active
-
2000
- 2000-01-18 NO NO20000241A patent/NO20000241L/no not_active Application Discontinuation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7326701B2 (en) | 2000-12-01 | 2008-02-05 | Ajinomoto Co., Inc. | Lactam compounds and pharmaceutical use thereof |
| US7632830B2 (en) | 2000-12-01 | 2009-12-15 | Ajinomoto Co., Inc. | Lactam compounds and pharmaceutical use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1272110A (zh) | 2000-11-01 |
| WO1999006403A1 (en) | 1999-02-11 |
| AU8592598A (en) | 1999-02-22 |
| CA2297407A1 (en) | 1999-02-11 |
| DE69826677T2 (de) | 2005-02-10 |
| IL133787A0 (en) | 2001-04-30 |
| HUP0003394A3 (en) | 2003-04-28 |
| JP2001512120A (ja) | 2001-08-21 |
| NZ502448A (en) | 2002-12-20 |
| NO20000241D0 (no) | 2000-01-18 |
| BR9811559A (pt) | 2000-09-12 |
| ATE277926T1 (de) | 2004-10-15 |
| CN1162429C (zh) | 2004-08-18 |
| ES2229523T3 (es) | 2005-04-16 |
| EP1000059B1 (en) | 2004-09-29 |
| NO20000241L (no) | 2000-03-06 |
| DE69826677D1 (de) | 2004-11-04 |
| KR20010022397A (ko) | 2001-03-15 |
| PT1000059E (pt) | 2004-12-31 |
| DK1000059T3 (da) | 2005-01-10 |
| EP1000059A1 (en) | 2000-05-17 |
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