HUP0003394A2 - Pirido[2,3-b][1,5]benzodiazepin-származékok, alkalmazásuk, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények - Google Patents

Pirido[2,3-b][1,5]benzodiazepin-származékok, alkalmazásuk, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0003394A2
HUP0003394A2 HU0003394A HUP0003394A HUP0003394A2 HU P0003394 A2 HUP0003394 A2 HU P0003394A2 HU 0003394 A HU0003394 A HU 0003394A HU P0003394 A HUP0003394 A HU P0003394A HU P0003394 A2 HUP0003394 A2 HU P0003394A2
Authority
HU
Hungary
Prior art keywords
optionally substituted
compounds
preparation
disorders
group
Prior art date
Application number
HU0003394A
Other languages
English (en)
Inventor
Amedeo Arturo Failli
Jay Scott Shumsky
Robert John Steffan
Original Assignee
American Home Products Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp. filed Critical American Home Products Corp.
Publication of HUP0003394A2 publication Critical patent/HUP0003394A2/hu
Publication of HUP0003394A3 publication Critical patent/HUP0003394A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A találmány kívánt esetben szubsztituált (I) általános képletűvegyületekre és farmakológiailag elfogadható sóikra, továbbá avegyületeket tartalmazó gyógyászati készítményekre, valamint avegyületek előállítására vonatkozik. A képletben W jelentéseoxigénatom vagy NH csoport, A és B jelentése szén- vagy nitorgénatom,R1 jelentése adott esetben szubsztituált metinil- vagy alkanoilcsoportvagy egy 1-4 nitrogén- és/vagy oxigénatomot tartalmazó, adott esetbenszubsztituált heterociklusos csoport, X, Y és Z jelentése hidrogén-vagy halogénatom, adott esetben szubsztituált alkil-, cikloalkil-,alkoxicsoport. A találmány szerinti vegyületek vazopresszin agonistahatásuk révén alkalmasak különböző rendellenességek gyógyítására vagyenyhítésére, ilyen rendellenességek például diabetes insipidus,éjszakai ágybavizelés, éjszakai vizelés, vizeleti inkontinencia,vérzési és véralvadási rendellenességek, valamint a vizelés időlegeskésleltetése képtelenségének kezelésére. Ó
HU0003394A 1997-07-30 1998-07-24 Pyrido[2,3-b][1,5]benzodiazepine derivatives, their use, process for their preparation and pharmaceutical compositions containing them HUP0003394A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94170797A 1997-07-30 1997-07-30
US90337097A 1997-07-30 1997-07-30
PCT/US1998/015487 WO1999006403A1 (en) 1997-07-30 1998-07-24 Tricyclic vasopressin agonists

Publications (2)

Publication Number Publication Date
HUP0003394A2 true HUP0003394A2 (hu) 2001-08-28
HUP0003394A3 HUP0003394A3 (en) 2003-04-28

Family

ID=27129361

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003394A HUP0003394A3 (en) 1997-07-30 1998-07-24 Pyrido[2,3-b][1,5]benzodiazepine derivatives, their use, process for their preparation and pharmaceutical compositions containing them

Country Status (17)

Country Link
EP (1) EP1000059B1 (hu)
JP (1) JP2001512120A (hu)
KR (1) KR20010022397A (hu)
CN (1) CN1162429C (hu)
AT (1) ATE277926T1 (hu)
AU (1) AU8592598A (hu)
BR (1) BR9811559A (hu)
CA (1) CA2297407A1 (hu)
DE (1) DE69826677T2 (hu)
DK (1) DK1000059T3 (hu)
ES (1) ES2229523T3 (hu)
HU (1) HUP0003394A3 (hu)
IL (1) IL133787A0 (hu)
NO (1) NO20000241L (hu)
NZ (1) NZ502448A (hu)
PT (1) PT1000059E (hu)
WO (1) WO1999006403A1 (hu)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7326701B2 (en) 2000-12-01 2008-02-05 Ajinomoto Co., Inc. Lactam compounds and pharmaceutical use thereof

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2358895A1 (en) * 1999-02-04 2000-08-10 Wyeth Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists
DK1149096T3 (da) * 1999-02-04 2003-04-07 Wyeth Corp Tricykliske pyridin-N-oxider som vasopressinagonister
GB0000079D0 (en) * 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents
GB0015601D0 (en) 2000-06-26 2000-08-16 Ferring Bv Novel antidiuretic agents
ATE512951T1 (de) 2003-04-28 2011-07-15 Astellas Pharma Inc 4,4-difluor-1,2,3,4-tetrahydro-5h-1- benzazepinderivat oder salz davon
GB201005623D0 (en) 2010-04-01 2010-05-19 Vantia Ltd New polymorph
AR094929A1 (es) 2013-02-28 2015-09-09 Bristol Myers Squibb Co Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
WO2014134391A1 (en) 2013-02-28 2014-09-04 Bristol-Myers Squibb Company Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1251767B (de) * 1964-02-28 1968-04-18 Dr Karl Thomae Gesellschaft mit beschrankter Haftung Biberach/Riß Verfahren zur Herstellung von neuen m 6 Stellung substituierten 5 6 Dihydro-5oxo HH pyrido[2,3-b] [l,5]benzodiazepinen
US5512563A (en) * 1993-07-29 1996-04-30 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5420270A (en) * 1993-10-07 1995-05-30 G. D. Searle & Co. Aryl substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
AR002459A1 (es) * 1995-01-17 1998-03-25 American Cyanamid Co Antagonistas de vasopresina de benzacepina triciclicos, una composicion farmaceutica que los contiene, un metodo para tratar enfermedades y unprocedimiento para su preparacion.
TW359669B (en) * 1995-12-15 1999-06-01 Otsuka Pharma Co Ltd Benzazepine derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7326701B2 (en) 2000-12-01 2008-02-05 Ajinomoto Co., Inc. Lactam compounds and pharmaceutical use thereof
US7632830B2 (en) 2000-12-01 2009-12-15 Ajinomoto Co., Inc. Lactam compounds and pharmaceutical use thereof

Also Published As

Publication number Publication date
KR20010022397A (ko) 2001-03-15
EP1000059A1 (en) 2000-05-17
JP2001512120A (ja) 2001-08-21
WO1999006403A1 (en) 1999-02-11
CA2297407A1 (en) 1999-02-11
EP1000059B1 (en) 2004-09-29
CN1162429C (zh) 2004-08-18
HUP0003394A3 (en) 2003-04-28
DE69826677T2 (de) 2005-02-10
ATE277926T1 (de) 2004-10-15
ES2229523T3 (es) 2005-04-16
NO20000241L (no) 2000-03-06
DK1000059T3 (da) 2005-01-10
PT1000059E (pt) 2004-12-31
NO20000241D0 (no) 2000-01-18
IL133787A0 (en) 2001-04-30
BR9811559A (pt) 2000-09-12
DE69826677D1 (de) 2004-11-04
NZ502448A (en) 2002-12-20
CN1272110A (zh) 2000-11-01
AU8592598A (en) 1999-02-22

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