HUP0002353A3 - 1-cycloalkyl-1,8-naphthyridin-4-one derivatives with phoshodiesterase iv inhibitory activity and pharmaceutical compositions containing them - Google Patents

1-cycloalkyl-1,8-naphthyridin-4-one derivatives with phoshodiesterase iv inhibitory activity and pharmaceutical compositions containing them

Info

Publication number
HUP0002353A3
HUP0002353A3 HU0002353A HUP0002353A HUP0002353A3 HU P0002353 A3 HUP0002353 A3 HU P0002353A3 HU 0002353 A HU0002353 A HU 0002353A HU P0002353 A HUP0002353 A HU P0002353A HU P0002353 A3 HUP0002353 A3 HU P0002353A3
Authority
HU
Hungary
Prior art keywords
phoshodiesterase
naphthyridin
cycloalkyl
derivatives
pharmaceutical compositions
Prior art date
Application number
HU0002353A
Other languages
English (en)
Original Assignee
Daiichi Asubio Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Asubio Pharma Co Ltd filed Critical Daiichi Asubio Pharma Co Ltd
Publication of HUP0002353A2 publication Critical patent/HUP0002353A2/hu
Publication of HUP0002353A3 publication Critical patent/HUP0002353A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HU0002353A 1998-01-29 1999-01-29 1-cycloalkyl-1,8-naphthyridin-4-one derivatives with phoshodiesterase iv inhibitory activity and pharmaceutical compositions containing them HUP0002353A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1700998 1998-01-29
PCT/JP1999/000404 WO1999038867A1 (fr) 1998-01-29 1999-01-29 Derives de 1-cycloalkyle-1,8-naphthyridine-4-one presentant une activite inhibitrice de la phosphodiesterase iv

Publications (2)

Publication Number Publication Date
HUP0002353A2 HUP0002353A2 (hu) 2001-05-28
HUP0002353A3 true HUP0002353A3 (en) 2001-11-28

Family

ID=11932014

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0002353A HUP0002353A3 (en) 1998-01-29 1999-01-29 1-cycloalkyl-1,8-naphthyridin-4-one derivatives with phoshodiesterase iv inhibitory activity and pharmaceutical compositions containing them

Country Status (8)

Country Link
US (1) US6331548B1 (hu)
EP (1) EP0978516A4 (hu)
KR (1) KR20010005830A (hu)
CN (1) CN1156476C (hu)
AU (1) AU763636C (hu)
CA (1) CA2285352A1 (hu)
HU (1) HUP0002353A3 (hu)
WO (1) WO1999038867A1 (hu)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7217722B2 (en) * 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
CN1398258A (zh) 2000-03-21 2003-02-19 法玛西雅厄普约翰美国公司 用作抗病毒剂的4－羟基噌啉－3－甲酰胺化合物
US6413958B2 (en) * 2000-03-21 2002-07-02 Pharmacia & Upjohn Company 4-hydroxy-1,8-naphthyridine-3-carboxamides as antiviral agents
MXPA02009249A (es) 2000-03-21 2003-03-12 Upjohn Co 4-oxo-1,4-dihidro(1,8)naftiridin-3-carboxamidas como agentes antivirales.
NZ521524A (en) 2000-03-21 2004-04-30 Upjohn Co 4-oxo-1,4-dihydro-3-cinnolinecarboxamides as antiviral agents
GB0011802D0 (en) * 2000-05-16 2000-07-05 Smithkline Beecham Method for enhancing cognitive function
DE60205899T2 (de) 2001-05-24 2006-06-29 Merck Frosst Canada & Co, Kirkland 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren
JO2311B1 (en) 2001-08-29 2005-09-12 ميرك فروست كندا ليمتد Alkyl inhibitors Ariel phosphodiesterase-4
IL160707A0 (en) 2001-09-26 2004-08-31 Bayer Pharmaceuticals Corp 1, 8-naphthyridine derivatives as antidiabetics
KR101064227B1 (ko) 2002-11-06 2011-09-14 아스카 세이야쿠 가부시키가이샤 피라졸로나프티리딘 유도체
US20060258668A1 (en) * 2003-05-29 2006-11-16 Scolnick Edward M Use of phosphatase inhibitors as adjunct therapy for psychiatric disorders
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
CA2622605A1 (en) * 2005-09-15 2007-03-22 Aska Pharmaceutical Co., Ltd. Heterocycle compound, and production process and application thereof
EP2377530A3 (en) 2005-10-21 2012-06-20 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
WO2007053596A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
JP2009536669A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド アンジオテンシン調節による神経新生
EP2026813A2 (en) 2006-05-09 2009-02-25 Braincells, Inc. 5 ht receptor mediated neurogenesis
WO2008026687A1 (fr) * 2006-09-01 2008-03-06 Kyorin Pharmaceutical Co., Ltd. Dérivé de pyrazolopyridine carboxamide et inhibiteur de phosphodiestérase (pde) comprenant le dérivé
KR20090064418A (ko) * 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 4-아실아미노피리딘 유도체 포함 조합물
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
FR2917413B1 (fr) 2007-06-13 2009-08-21 Sanofi Aventis Sa Derives de 7-alkynyl-1,8-naphthyridones, leur preparation et leur application en therapeutique
FR2917412B1 (fr) * 2007-06-13 2009-08-21 Sanofi Aventis Sa Derives de 7-alkynyl, 1,8-naphthyridones, leur preparation et leur application en therapeutique
CL2009000904A1 (es) * 2008-04-21 2010-04-30 Shionogi & Co Compuestos derivados de ciclohexil sulfonamidas que tienen actividad antagonista en el receptor npy y5, composicion farmaceutica y formulacion farmaceutica que los comprende.
WO2010041964A1 (en) * 2008-10-09 2010-04-15 Victoria Link Limited Methods for the preparation of alkenylamines, cyclic carbamates or dithiocarbamates, and aminoalcohols or aminothiols
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
CN103183675A (zh) * 2011-12-27 2013-07-03 山东轩竹医药科技有限公司 磷酸二酯酶-4抑制剂
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
AR097279A1 (es) 2013-08-09 2016-03-02 Actelion Pharmaceuticals Ltd Derivados de benzimidazolil-metil urea como agonistas del receptor de alx

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2808070A1 (de) * 1978-02-24 1979-08-30 Bayer Ag Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten
JPS61148179A (ja) * 1984-12-20 1986-07-05 Dainippon Pharmaceut Co Ltd 新規ナフチリジン誘導体、そのエステルおよびその塩
DE3508816A1 (de) * 1985-01-10 1986-07-10 Bayer Ag, 5090 Leverkusen 6,7-disubstituierte 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtyridin-3-carbonsaeuren
JPS6233317A (ja) * 1985-08-06 1987-02-13 Matsushita Electric Ind Co Ltd 薄膜磁気ヘツド
CA2012681A1 (en) * 1989-03-31 1990-09-30 Masayasu Okuhira Quinolone derivatives, preparation processes thereof, and antibacterial agents containing the same
KR950704314A (ko) 1992-12-01 1995-11-17 가와노 다케히코 1,8-나프티리딘-2-온 유도체 및 그 사용 방법(1,8-naphthyridin-2-one derivative and use thereof)
CN1043993C (zh) 1994-08-29 1999-07-07 山之内制药株式会社 萘啶衍生物及其医药组合物
JPH08151377A (ja) * 1994-11-25 1996-06-11 Kyowa Hakko Kogyo Co Ltd キナゾリン誘導体
AU695132B2 (en) 1995-08-02 1998-08-06 Darwin Discovery Limited Quinolones and their therapeutic use
EP0958297A1 (en) 1997-08-06 1999-11-24 Suntory Limited 1-aryl-1,8-naphthylidin-4-one derivative as type iv phosphodiesterase inhibitor

Also Published As

Publication number Publication date
AU763636C (en) 2004-05-27
AU2185699A (en) 1999-08-16
CN1156476C (zh) 2004-07-07
US6331548B1 (en) 2001-12-18
CN1256693A (zh) 2000-06-14
CA2285352A1 (en) 1999-08-05
AU763636B2 (en) 2003-07-31
HUP0002353A2 (hu) 2001-05-28
KR20010005830A (ko) 2001-01-15
EP0978516A1 (en) 2000-02-09
WO1999038867A1 (fr) 1999-08-05
EP0978516A4 (en) 2001-01-10

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees