HUP0002069A2 - Aktív részecskék új liposzómavektorai - Google Patents
Aktív részecskék új liposzómavektoraiInfo
- Publication number
- HUP0002069A2 HUP0002069A2 HU0002069A HUP0002069A HUP0002069A2 HU P0002069 A2 HUP0002069 A2 HU P0002069A2 HU 0002069 A HU0002069 A HU 0002069A HU P0002069 A HUP0002069 A HU P0002069A HU P0002069 A2 HUP0002069 A2 HU P0002069A2
- Authority
- HU
- Hungary
- Prior art keywords
- class
- substances
- carrageenan
- active ingredient
- gel
- Prior art date
Links
- 239000002502 liposome Substances 0.000 title abstract 5
- 239000013598 vector Substances 0.000 title abstract 4
- 239000000126 substance Substances 0.000 abstract 6
- 150000002632 lipids Chemical class 0.000 abstract 4
- 239000004480 active ingredient Substances 0.000 abstract 3
- 239000000679 carrageenan Substances 0.000 abstract 3
- 235000010418 carrageenan Nutrition 0.000 abstract 3
- 229920001525 carrageenan Polymers 0.000 abstract 3
- 229940113118 carrageenan Drugs 0.000 abstract 3
- 239000000499 gel Substances 0.000 abstract 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 abstract 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- 230000002441 reversible effect Effects 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 229920001353 Dextrin Polymers 0.000 abstract 1
- 239000004375 Dextrin Substances 0.000 abstract 1
- IECPWNUMDGFDKC-UHFFFAOYSA-N Fusicsaeure Natural products C12C(O)CC3C(=C(CCC=C(C)C)C(O)=O)C(OC(C)=O)CC3(C)C1(C)CCC1C2(C)CCC(O)C1C IECPWNUMDGFDKC-UHFFFAOYSA-N 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 239000003613 bile acid Substances 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 239000001913 cellulose Substances 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 150000001840 cholesterol esters Chemical class 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 235000019425 dextrin Nutrition 0.000 abstract 1
- 210000002249 digestive system Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- IECPWNUMDGFDKC-MZJAQBGESA-N fusidic acid Chemical compound O[C@@H]([C@@H]12)C[C@H]3\C(=C(/CCC=C(C)C)C(O)=O)[C@@H](OC(C)=O)C[C@]3(C)[C@@]2(C)CC[C@@H]2[C@]1(C)CC[C@@H](O)[C@H]2C IECPWNUMDGFDKC-MZJAQBGESA-N 0.000 abstract 1
- 229960004675 fusidic acid Drugs 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 150000004668 long chain fatty acids Chemical class 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 239000008279 sol Substances 0.000 abstract 1
- 230000007704 transition Effects 0.000 abstract 1
- 150000003626 triacylglycerols Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány hatóanyagot tartalmazó, közelebbről emésztőrendszerbenés/vagy vérsavóban végbemenő lebomlásra érzékeny, például fehérjéttartalmazó, por formájú liposzómavektorokra, ezek előállítására ésgyógyszerként történő alkalmazására vonatkozik. A hatóanyagottartalmazó liposzómavektor az alábbiakat tartalmazza: - egy porszerűkészítményt, amely lényegében egy külső lipidfázist tartalmaz, amely4. osztályba tartozó lipidet (foszfolipidek) tartalmaz, adott esetben2. osztályba tartozó anyagokkal (hosszú szénláncú trigliceridek,koleszterin-észterek), 3. osztályba tartozó anyagokkal (koleszterin,nem ionizált hosszú szénláncú zsírsavak) és/vagy 5. osztályba tartozóanyagokkal (epesavsók, fuszidsavszármazékok) kombinálva, továbbá egybelső vizes magot tartalmaz, amely egy hőmérséklet-reverzíbilis vizesgélt alkot, amely kisugároz a külső lipidfázisba, amely belső vizesmag lényegében legalább két különböző G1 és G2 nem polimerizálhatókocsonyásodó anyag M keverékét tartalmazza, amelynek gél-szol fázisátalakulási pontja 37 °C vagy ennél nagyobb, ahol a G1 kocsonyásodóanyag zselatin vagy karragenán, és a G2 kocsonyásodó anyag olyankarragenán, amelynek tulajdonságai különböznek a G1 karragenántól,vagy cellulóz, amelynek liposzómaátmérője 20 nm és 1 mm közötti,előnyösen 20 nm és 500 nm közötti, és 10 mm és 1000 mm közötti közepesátmérőjű részecske egység formában van, amelyet mátrixként egydehidratált hőmérséklet-reverzíbilis vizes gél vesz körül, amely gélazonos a fenti belső magban lévő vizes géllel, vagy dextrin vagy ezekkeveréke, amely por 1 g-ja átlagosan 1016 és 1018 közötti mennyiségűliposzómát tartalmaz, és - legalább egy hatóanyagot tartalmaz az adottegyedtől függően a kocsonyás belső magban vagy a külső lipidfázisban.A találmány kiterjed a fenti vektorok előállítására is. Ó
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9707255A FR2764508B1 (fr) | 1997-06-11 | 1997-06-11 | Nouveaux vecteurs liposomaux de principes actifs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0002069A2 true HUP0002069A2 (hu) | 2000-12-28 |
| HUP0002069A3 HUP0002069A3 (en) | 2001-01-29 |
Family
ID=9507868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0002069A HUP0002069A3 (en) | 1997-06-11 | 1998-06-11 | Novel liposome vectors of active principles |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6656497B2 (hu) |
| EP (1) | EP0999827A1 (hu) |
| JP (1) | JP2002511078A (hu) |
| KR (1) | KR20010013665A (hu) |
| CN (1) | CN1264297A (hu) |
| AU (1) | AU738809C (hu) |
| BR (1) | BR9810258A (hu) |
| FR (1) | FR2764508B1 (hu) |
| HU (1) | HUP0002069A3 (hu) |
| NZ (1) | NZ501795A (hu) |
| PL (1) | PL337757A1 (hu) |
| RU (1) | RU2203649C2 (hu) |
| WO (1) | WO1998056352A1 (hu) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006017179A1 (en) * | 2004-07-09 | 2006-02-16 | Robert Sabin | Compositions and methods of use for treatment of mammalian diseases |
| US20070185066A1 (en) * | 2005-12-20 | 2007-08-09 | Verus Pharmaceuticals, Inc. | Systems and methods for the delivery of corticosteroids |
| US20070249572A1 (en) * | 2005-12-20 | 2007-10-25 | Verus Pharmaceuticals, Inc. | Systems and methods for the delivery of corticosteroids |
| US20070160542A1 (en) * | 2005-12-20 | 2007-07-12 | Verus Pharmaceuticals, Inc. | Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile |
| US20070197486A1 (en) * | 2005-12-20 | 2007-08-23 | Verus Pharmaceuticals, Inc. | Methods and systems for the delivery of corticosteroids |
| EP1988880A2 (en) * | 2006-02-15 | 2008-11-12 | Tika Läkemedel AB | Stable mixture of corticosteroids |
| PT103495B (pt) * | 2006-06-05 | 2017-05-12 | Faculdade De Farmácia Da Univ De Lisboa | Pró-fármacos de ácidos orgânicos e composições farmacêuticas contendo os referidos pró-fármacos |
| US20140072617A1 (en) * | 2007-09-26 | 2014-03-13 | Lvmh Recherche | Method for preventing or slowing down the appearance of the effects of skin ageing using a tocopheryl phosphate in liposomes |
| US8962015B2 (en) * | 2007-09-28 | 2015-02-24 | Sdg, Inc. | Orally bioavailable lipid-based constructs |
| CA2705031A1 (en) * | 2007-11-15 | 2009-05-22 | Lipodur Pharmaceutical Inc. | Gel-stabilized liposome compositions, methods for their preparation and uses thereof |
| CN103167868B (zh) * | 2010-10-14 | 2016-08-03 | 株式会社爱茉莉太平洋 | 包覆有脂质的水凝胶粒子及其制备方法 |
| US9775803B2 (en) | 2011-10-19 | 2017-10-03 | Samsung Electronics Co., Ltd. | Liposome comprising elastin-like polypeptide and tumor cell targeting material and use thereof |
| EP3154520B1 (en) * | 2014-06-13 | 2020-04-29 | HEIDELTEC GmbH | Matrix stabilized liposomes |
| CN112138202A (zh) * | 2019-06-10 | 2020-12-29 | 戴建英 | 温度敏感型消化道粘膜保护胶 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8522963D0 (en) * | 1985-09-17 | 1985-10-23 | Biocompatibles Ltd | Microcapsules |
| GB8522964D0 (en) * | 1985-09-17 | 1985-10-23 | Biocompatibles Ltd | Aerosol |
| US5464629A (en) * | 1993-11-16 | 1995-11-07 | Georgetown University | Method of forming hydrogel particles having a controlled size using liposomes |
| FR2718369B1 (fr) * | 1994-04-12 | 1996-06-21 | Lipogel Sarl | Microsphères gélifiées, leur procédé de préparation et leurs applications. |
| EP0927025A4 (en) * | 1996-09-18 | 2001-07-25 | Dragoco Inc | DRY POWDER COMPOSITION WITH ACTIVE INGREDIENT ENCLOSED IN LIPOSOMES |
-
1997
- 1997-06-11 FR FR9707255A patent/FR2764508B1/fr not_active Expired - Fee Related
-
1998
- 1998-06-11 WO PCT/FR1998/001204 patent/WO1998056352A1/fr not_active Application Discontinuation
- 1998-06-11 HU HU0002069A patent/HUP0002069A3/hu unknown
- 1998-06-11 EP EP98930820A patent/EP0999827A1/fr not_active Withdrawn
- 1998-06-11 RU RU2000100937/14A patent/RU2203649C2/ru not_active IP Right Cessation
- 1998-06-11 BR BR9810258-3A patent/BR9810258A/pt not_active IP Right Cessation
- 1998-06-11 NZ NZ501795A patent/NZ501795A/en unknown
- 1998-06-11 PL PL98337757A patent/PL337757A1/xx unknown
- 1998-06-11 KR KR19997011677A patent/KR20010013665A/ko not_active Application Discontinuation
- 1998-06-11 AU AU81123/98A patent/AU738809C/en not_active Ceased
- 1998-06-11 CN CN98807283A patent/CN1264297A/zh active Pending
- 1998-06-11 JP JP50178499A patent/JP2002511078A/ja not_active Ceased
- 1998-06-11 US US09/445,444 patent/US6656497B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PL337757A1 (en) | 2000-09-11 |
| KR20010013665A (ko) | 2001-02-26 |
| FR2764508B1 (fr) | 2000-10-20 |
| AU738809B2 (en) | 2001-09-27 |
| HUP0002069A3 (en) | 2001-01-29 |
| CN1264297A (zh) | 2000-08-23 |
| FR2764508A1 (fr) | 1998-12-18 |
| BR9810258A (pt) | 2000-09-19 |
| JP2002511078A (ja) | 2002-04-09 |
| AU738809C (en) | 2002-10-24 |
| EP0999827A1 (fr) | 2000-05-17 |
| NZ501795A (en) | 2001-11-30 |
| US6656497B2 (en) | 2003-12-02 |
| WO1998056352A1 (fr) | 1998-12-17 |
| RU2203649C2 (ru) | 2003-05-10 |
| US20020146447A1 (en) | 2002-10-10 |
| AU8112398A (en) | 1998-12-30 |
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