HUP0001780A2 - Stabilizált tibolont tartalmazó készítmények és eljárás előállításukra - Google Patents

Stabilizált tibolont tartalmazó készítmények és eljárás előállításukra

Info

Publication number
HUP0001780A2
HUP0001780A2 HU0001780A HUP0001780A HUP0001780A2 HU P0001780 A2 HUP0001780 A2 HU P0001780A2 HU 0001780 A HU0001780 A HU 0001780A HU P0001780 A HUP0001780 A HU P0001780A HU P0001780 A2 HUP0001780 A2 HU P0001780A2
Authority
HU
Hungary
Prior art keywords
preparation
stabilized
compositions
weight
tibolone compositions
Prior art date
Application number
HU0001780A
Other languages
English (en)
Inventor
Theodora Antonia Maria Lambregts-De Hurk
Ryoichi Morita
Adrianus Cornelis Petrus Rovers
Jocominus Antonius Maria Zwinkels
Pieter De Haan
Original Assignee
Akzo Nobel N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel N.V. filed Critical Akzo Nobel N.V.
Publication of HUP0001780A2 publication Critical patent/HUP0001780A2/hu
Publication of HUP0001780A3 publication Critical patent/HUP0001780A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgya gyógyszerészeti dózisegység, amely 0,1-10 tömeg%tibolont és gyógyszerészetileg elfogadható hordozót tartalmaz, amelyhordozó vízben nem oldható keményítőterméket tartalmaz több mint 10tömeg% mennyiségben. Ó
HU0001780A 1997-04-22 1998-04-20 Stabilized tibolone compositions and process for their preparation HUP0001780A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97201180 1997-04-22

Publications (2)

Publication Number Publication Date
HUP0001780A2 true HUP0001780A2 (hu) 2000-12-28
HUP0001780A3 HUP0001780A3 (en) 2001-02-28

Family

ID=8228228

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001780A HUP0001780A3 (en) 1997-04-22 1998-04-20 Stabilized tibolone compositions and process for their preparation

Country Status (26)

Country Link
US (6) US6399594B2 (hu)
EP (1) EP0975348B1 (hu)
JP (1) JPH10316573A (hu)
KR (1) KR100580855B1 (hu)
CN (2) CN1146424C (hu)
AR (1) AR012480A1 (hu)
AT (1) ATE281836T1 (hu)
AU (1) AU742037B2 (hu)
BR (1) BR9809268A (hu)
CA (1) CA2288070A1 (hu)
DE (1) DE69827484T2 (hu)
DK (1) DK0975348T3 (hu)
ES (1) ES2232949T3 (hu)
HK (1) HK1023508A1 (hu)
HU (1) HUP0001780A3 (hu)
ID (1) ID22763A (hu)
IL (1) IL123984A (hu)
NO (1) NO995127L (hu)
NZ (1) NZ338028A (hu)
PL (1) PL190227B1 (hu)
PT (1) PT975348E (hu)
RU (1) RU2207133C2 (hu)
TR (1) TR199902530T2 (hu)
TW (1) TW570798B (hu)
WO (1) WO1998047517A1 (hu)
ZA (1) ZA983169B (hu)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL141850A (en) * 1998-10-16 2005-11-20 Akzo Nobel Nv High purity composition comprising (7alpha,17alpha)-17-hydroxy-7-methyl-19-nor-17-pregn-5(10)-3n-20-yn-3-one
US7763276B1 (en) * 1999-02-26 2010-07-27 Shionogi & Co., Ltd. Chewable soft capsules having improved administration properties and process for producing the same
US20040229854A1 (en) * 2000-11-28 2004-11-18 Pieter Haan De Immediate release dosage form for HRT
KR100979877B1 (ko) * 2001-09-28 2010-09-02 뉴트라슈틱스 인코포레이티드 생물학적 성분의 전달 시스템
US20070098784A1 (en) 2001-09-28 2007-05-03 Nutraceutix, Inc. Delivery system for biological component
GB0125061D0 (en) * 2001-10-18 2001-12-12 Norton Healthcare Ltd Pharmaceutical composition
TW200418525A (en) * 2002-11-20 2004-10-01 Akzo Nobel Nv Coated pharmaceutical tablets containing Tibolone
CN1324041C (zh) * 2003-04-01 2007-07-04 上海迪赛诺医药科技开发有限公司 替勃龙晶型i的制备方法
CA2523883C (en) * 2003-04-29 2012-01-03 Akzo Nobel N.V. Antisolvent solidification process
ES2243919T3 (es) * 2003-05-23 2005-12-01 Akzo Nobel N.V. Formulacion solida farmaceutica que contiene tibolona.
WO2005105278A2 (en) * 2004-05-05 2005-11-10 Akzo Nobel N.V. Antisolvent emulsion solidification process
WO2005117899A1 (en) * 2004-06-02 2005-12-15 Cipla Limited Pharmaceutical composition comprising tibolone and process for procuding the same
WO2005120517A1 (en) * 2004-06-07 2005-12-22 Strides Arcolab Limited Stable liquid suspension formulation comprising synthetic steroids and process for producing the same
CZ300465B6 (cs) * 2007-07-25 2009-05-27 Zentiva, A. S. Zpusob výroby komprimované farmaceutické formulace s obsahem tibolonu
CN102085193B (zh) * 2009-12-08 2013-11-06 北京以岭生物工程技术有限公司 一种替勃龙口腔崩解片及其制备方法
CN104345098B (zh) * 2013-08-05 2016-04-13 华润紫竹药业有限公司 一种测定替勃龙片剂中抗氧剂含量的方法
BR112018072371B1 (pt) 2016-05-04 2024-04-30 Novalon S.A. Uso de um açúcar-álcool, composição farmacêutica, método para preparar uma forma de dosagem sólida compreendendo tibolona e uso de uma composição farmacêutica

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4701450A (en) * 1984-03-21 1987-10-20 Akzo N.V. Steroids for use as immunomodulators
CH676470A5 (hu) * 1988-02-03 1991-01-31 Nestle Sa
IE63051B1 (en) 1989-03-18 1995-03-22 Akzo Nv Pharmaceutical composition which contains a pharmaceutically suitable carrier and the compound having the structure (7alpha, 17alpha)-17-Hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn- 3-one
AU671706B2 (en) * 1993-03-05 1996-09-05 Akzo N.V. Use of a Pregnane Derivative
ATE227122T1 (de) * 1993-09-03 2002-11-15 Smithkline Beecham Corp Stabilisierte tablettenformulierung
IL115445A (en) * 1994-10-17 1999-08-17 Akzo Nobel Nv Solid pharmaceutical compositions comprising low dosage active ingredient oil and excipient capable of binding water and their preparation

Also Published As

Publication number Publication date
US20010005513A1 (en) 2001-06-28
CA2288070A1 (en) 1998-10-29
US6514958B1 (en) 2003-02-04
NO995127D0 (no) 1999-10-21
PL336658A1 (en) 2000-07-03
PT975348E (pt) 2005-01-31
HK1023508A1 (en) 2000-09-15
US20040142030A1 (en) 2004-07-22
NO995127L (no) 1999-10-21
WO1998047517A1 (en) 1998-10-29
KR20010020163A (ko) 2001-03-15
CN1253503A (zh) 2000-05-17
ES2232949T3 (es) 2005-06-01
IL123984A (en) 2004-09-27
AU8014698A (en) 1998-11-13
TW570798B (en) 2004-01-11
AU742037B2 (en) 2001-12-13
US20030119801A1 (en) 2003-06-26
DK0975348T3 (da) 2005-03-07
US20040142028A1 (en) 2004-07-22
ID22763A (id) 1999-12-09
JPH10316573A (ja) 1998-12-02
DE69827484T2 (de) 2005-03-17
HUP0001780A3 (en) 2001-02-28
ZA983169B (en) 1998-10-20
DE69827484D1 (de) 2004-12-16
PL190227B1 (pl) 2005-11-30
NZ338028A (en) 2001-10-26
AR012480A1 (es) 2000-10-18
TR199902530T2 (xx) 2000-05-22
US6399594B2 (en) 2002-06-04
EP0975348A1 (en) 2000-02-02
CN1146424C (zh) 2004-04-21
CN1494908A (zh) 2004-05-12
ATE281836T1 (de) 2004-11-15
EP0975348B1 (en) 2004-11-10
RU2207133C2 (ru) 2003-06-27
KR100580855B1 (ko) 2006-05-17
BR9809268A (pt) 2000-06-27
US20040142031A1 (en) 2004-07-22

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Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: N.V. ORGANON, NL

Free format text: FORMER OWNER(S): AKZO NOBEL N.V., NL