HUP0001389A2 - Pyrazolopyrimidinones, process for their preparation, use thereof, pharmaceutical compositions containing them - Google Patents
Pyrazolopyrimidinones, process for their preparation, use thereof, pharmaceutical compositions containing themInfo
- Publication number
- HUP0001389A2 HUP0001389A2 HU0001389A HUP0001389A HUP0001389A2 HU P0001389 A2 HUP0001389 A2 HU P0001389A2 HU 0001389 A HU0001389 A HU 0001389A HU P0001389 A HUP0001389 A HU P0001389A HU P0001389 A2 HUP0001389 A2 HU P0001389A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- alkoxy
- optionally substituted
- piperazinyl
- linked
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- DOTPSQVYOBAWPQ-UHFFFAOYSA-N pyrazolo[4,3-d]pyrimidin-3-one Chemical class N1=CN=C2C(=O)N=NC2=C1 DOTPSQVYOBAWPQ-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000003545 alkoxy group Chemical group 0.000 abstract 6
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002757 morpholinyl group Chemical group 0.000 abstract 2
- 125000003386 piperidinyl group Chemical group 0.000 abstract 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 2
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- WAJNANMQOPCIPO-UHFFFAOYSA-N pyrazolo[4,3-d]pyrimidin-7-one Chemical class O=C1N=CN=C2C=NN=C12 WAJNANMQOPCIPO-UHFFFAOYSA-N 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000565 sulfonamide group Chemical group 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Pyrazolo (4,3-d) pyrimidin-7-ones of formula (I) and their salts and solvates are new. Ring A is of formula (a) or (b); R1 = 1-3C alkyl substituted by 3-6C cycloalkyl, CONR5R6 or N-linked heterocycle selected from pyrazolyl, imidazolyl, triazolyl, pyrrolidinyl, piperidinyl, morpholinyl and 4-R9-piperazinyl; (CH2)nHet; or (CH2)nAr; R2 = 1-6C alkyl; R3 = 1-6C alkyl (optionally substituted by alkoxy); R4 = SO2NR7R8; R5, R6 = H or alkyl (optionally substituted by alkoxy); or NR5R6 = pyrrolidinyl, piperidinyl, morpholinyl or 4-R9-piperazinyl; NR7R8 = 4-R10-piperazinyl; R9 = alkyl; R10 = H or alkyl (optionally substituted by OH, alkoxy or CONH2); Het = C-linked 6-membered heterocycle containing 1 or 2 N (optionally as a mono-N-oxide) or C-linked 5-membered heterocycle containing 1-4 heteroatoms selected from N, O and S, both optionally substituted by 1 or 2 of alkyl (optionally substituted by alkoxy), alkoxy, halo and NH2; Ar = phenyl (optionally substituted by 1 or 2 of alkyl, alkoxy, halo, CN, CONH2, NO2, NH2, NHSO2- alkyl and SO2NH2); n = 0 to 1; alkyl moieties have 1-4C unless specified otherwise.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9722954.6A GB9722954D0 (en) | 1997-10-30 | 1997-10-30 | Therapeutic agents |
| PCT/EP1998/002257 WO1998049166A1 (en) | 1997-04-25 | 1998-04-10 | PYRAZOLOPYRIMIDINONES WHICH INHIBIT TYPE 5 CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE (cGMP PDE5) FOR THE TREATMENT OF SEXUAL DYSFUNCTION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0001389A2 true HUP0001389A2 (en) | 2000-09-28 |
| HUP0001389A3 HUP0001389A3 (en) | 2001-04-28 |
Family
ID=10821332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0001389A HUP0001389A3 (en) | 1997-10-30 | 1998-04-10 | Pyrazolopyrimidinones, process for their preparation, use thereof, pharmaceutical compositions containing them |
Country Status (2)
| Country | Link |
|---|---|
| GB (1) | GB9722954D0 (en) |
| HU (1) | HUP0001389A3 (en) |
-
1997
- 1997-10-30 GB GBGB9722954.6A patent/GB9722954D0/en not_active Ceased
-
1998
- 1998-04-10 HU HU0001389A patent/HUP0001389A3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0001389A3 (en) | 2001-04-28 |
| GB9722954D0 (en) | 1998-01-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |