HUP9700105A2 - 5-phenyl-1,3,4-thiadiazole derivatives, process for producing them, and pharmaceutical composition containing them as active component - Google Patents
5-phenyl-1,3,4-thiadiazole derivatives, process for producing them, and pharmaceutical composition containing them as active componentInfo
- Publication number
- HUP9700105A2 HUP9700105A2 HU9700105A HUP9700105A HUP9700105A2 HU P9700105 A2 HUP9700105 A2 HU P9700105A2 HU 9700105 A HU9700105 A HU 9700105A HU P9700105 A HUP9700105 A HU P9700105A HU P9700105 A2 HUP9700105 A2 HU P9700105A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- phenyl
- optionally substituted
- alkoxy
- producing
- Prior art date
Links
- ZMJRUUBDMPKHJS-UHFFFAOYSA-N 2-phenyl-1,3,4-thiadiazole Chemical class S1C=NN=C1C1=CC=CC=C1 ZMJRUUBDMPKHJS-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000005059 halophenyl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
2-(Amino-1,2,4-triazol-1-yl)-5-aminoalkoxyphenyl-1,3,4-thiadiazole derivatives of formula (I) and their salts are new. R1 = H, 1-4C alkyl, phenyl (optionally substituted by 1-3 halo, OH, NO2, 1-4C alkoxy or mono- or di- (1-4C alkyl)amino) or phenyl (substituted by Z and (1-6C alkylene)NR4R5); Z = H or 1-4C alkoxy; R4, R5 = H, 2-6C alkenyl or 1-8C alkyl (optionally substituted by OH, mono- or di- (1-4C alkyl)amino, phenyl (optionally substituted by 1-3 1-4C alkoxy) or Het1); or NR4R5 = 5-10 membered saturated heterocyclyl (optionally containing further N and/or O or S and optionally substituted by 1-4C alkyl or phenyl (optionally substituted by 1-4C alkoxy)); Het1 = 5 or 6 membered saturated heterocyclyl (optionally substituted by 1-4C alkyl) containing N atoms or an N and an O, and linked via the N atom; one of R2, R3 = NH2; and the other is NH2 or 5-10-membered heterocyclyl (optionally substituted by 1-4C alkyl, Ph or halophenyl) and containing at least one N and/or O and/or S and linked via its N; or it is SR and optionally one or both amino groups are substituted by 1 or 2 1-6C alkyl, 2-6C alkenyl, phenyl(1-4C alkyl) or halophenyl(1-4C alkyl); R = 1-8C alkyl (optionally substituted by phenyl or halophenyl), 2-6C alkenyl or 2-6C alkynyl.
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9700105A HUP9700105A3 (en) | 1997-01-14 | 1997-01-14 | 5-phenyl-1,3,4-thiadiazole derivatives, process for producing them, and pharmaceutical composition containing them as active component |
JP53068198A JP2001524072A (en) | 1997-01-14 | 1998-01-13 | C. N. S. 2- (1,2,4-triazol-1-yl) -1,3,4-thiadiazole derivative effective for heart and heart |
RU99118591/04A RU2180903C2 (en) | 1997-01-14 | 1998-01-13 | Derivatives of 2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole, method of their synthesis, pharmaceutical composition and intermediate compound |
PL98334570A PL334570A1 (en) | 1997-01-14 | 1998-01-13 | Derivatives of 2-(1,2,4-triazol-1-yl)-1,3,4-thiadiazole acting on central nervous system and hearth |
AU57751/98A AU5775198A (en) | 1997-01-14 | 1998-01-13 | 2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivatives having an effect on the c.n.s. and the heart |
US09/341,362 US6191152B1 (en) | 1997-01-14 | 1998-01-13 | 2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivatives having an effect on the C.N.S. and the heart |
PCT/HU1998/000005 WO1998030561A1 (en) | 1997-01-14 | 1998-01-13 | 2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivatives having an effect on the c.n.s. and the heart |
EP98901423A EP0958294A1 (en) | 1997-01-14 | 1998-01-13 | 2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivatives having an effect on the c.n.s. and the heart |
SK938-99A SK93899A3 (en) | 1997-01-14 | 1998-01-13 | 2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivatives having an effect on the c.n.s. and the heart |
KR1019997006389A KR20000070163A (en) | 1997-01-14 | 1998-01-13 | 2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivatives having an effect on the c.n.s. and the heart |
CA002276720A CA2276720A1 (en) | 1997-01-14 | 1998-01-13 | 2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivatives having an effect on the c.n.s. and the heart |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9700105A HUP9700105A3 (en) | 1997-01-14 | 1997-01-14 | 5-phenyl-1,3,4-thiadiazole derivatives, process for producing them, and pharmaceutical composition containing them as active component |
Publications (3)
Publication Number | Publication Date |
---|---|
HU9700105D0 HU9700105D0 (en) | 1997-02-28 |
HUP9700105A2 true HUP9700105A2 (en) | 1999-06-28 |
HUP9700105A3 HUP9700105A3 (en) | 1999-07-28 |
Family
ID=89994628
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9700105A HUP9700105A3 (en) | 1997-01-14 | 1997-01-14 | 5-phenyl-1,3,4-thiadiazole derivatives, process for producing them, and pharmaceutical composition containing them as active component |
Country Status (1)
Country | Link |
---|---|
HU (1) | HUP9700105A3 (en) |
-
1997
- 1997-01-14 HU HU9700105A patent/HUP9700105A3/en unknown
Also Published As
Publication number | Publication date |
---|---|
HU9700105D0 (en) | 1997-02-28 |
HUP9700105A3 (en) | 1999-07-28 |
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