HUP9700104A2 - 1,3,4-thiadiazole derivatives, pharmaceutical compositions containing them as active component and process for producing the active component - Google Patents

1,3,4-thiadiazole derivatives, pharmaceutical compositions containing them as active component and process for producing the active component

Info

Publication number
HUP9700104A2
HUP9700104A2 HU9700104A HUP9700104A HUP9700104A2 HU P9700104 A2 HUP9700104 A2 HU P9700104A2 HU 9700104 A HU9700104 A HU 9700104A HU P9700104 A HUP9700104 A HU P9700104A HU P9700104 A2 HUP9700104 A2 HU P9700104A2
Authority
HU
Hungary
Prior art keywords
alkyl
optionally substituted
active component
phenyl
alkoxy
Prior art date
Application number
HU9700104A
Other languages
Hungarian (hu)
Inventor
József Reiter
Gábor Berecz
József Barkóczy
András Egyed
dr. Megyeri Katalin Ivanicsné
dr. Kovács Anikó Miklósné
Gyula Simig
Gábor Szénási
Sándor Drabant
Szabolcs Kertész
Gyönös Ildikó Nagyné
dr. Hegedűs Mária Szécseyné
János Wellmann
Katalin Pallagi
Éva Schmidt
Károly Tihanyi
Péter Trinka
Margit Csörgő
Original Assignee
EGIS Gyógyszergyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EGIS Gyógyszergyár Rt. filed Critical EGIS Gyógyszergyár Rt.
Priority to HU9700104A priority Critical patent/HUP9700104A3/en
Publication of HU9700104D0 publication Critical patent/HU9700104D0/en
Priority to EP98901423A priority patent/EP0958294A1/en
Priority to AU57751/98A priority patent/AU5775198A/en
Priority to RU99118591/04A priority patent/RU2180903C2/en
Priority to KR1019997006389A priority patent/KR20000070163A/en
Priority to PCT/HU1998/000005 priority patent/WO1998030561A1/en
Priority to CA002276720A priority patent/CA2276720A1/en
Priority to JP53068198A priority patent/JP2001524072A/en
Priority to PL98334570A priority patent/PL334570A1/en
Priority to SK938-99A priority patent/SK93899A3/en
Priority to US09/341,362 priority patent/US6191152B1/en
Publication of HUP9700104A2 publication Critical patent/HUP9700104A2/en
Publication of HUP9700104A3 publication Critical patent/HUP9700104A3/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

2-(Amino-1,2,4-triazol-1-yl)-5-aminoalkoxyphenyl-1,3,4-thiadiazole derivatives of formula (I) and their salts are new. R1 = H, 1-4C alkyl, phenyl (optionally substituted by 1-3 halo, OH, NO2, 1-4C alkoxy or mono- or di- (1-4C alkyl)amino) or phenyl (substituted by Z and (1-6C alkylene)NR4R5); Z = H or 1-4C alkoxy; R4, R5 = H, 2-6C alkenyl or 1-8C alkyl (optionally substituted by OH, mono- or di- (1-4C alkyl)amino, phenyl (optionally substituted by 1-3 1-4C alkoxy) or Het1); or NR4R5 = 5-10 membered saturated heterocyclyl (optionally containing further N and/or O or S and optionally substituted by 1-4C alkyl or phenyl (optionally substituted by 1-4C alkoxy)); Het1 = 5 or 6 membered saturated heterocyclyl (optionally substituted by 1-4C alkyl) containing N atoms or an N and an O, and linked via the N atom; one of R2, R3 = NH2; and the other is NH2 or 5-10-membered heterocyclyl (optionally substituted by 1-4C alkyl, Ph or halophenyl) and containing at least one N and/or O and/or S and linked via its N; or it is SR and optionally one or both amino groups are substituted by 1 or 2 1-6C alkyl, 2-6C alkenyl, phenyl(1-4C alkyl) or halophenyl(1-4C alkyl); R = 1-8C alkyl (optionally substituted by phenyl or halophenyl), 2-6C alkenyl or 2-6C alkynyl.
HU9700104A 1997-01-14 1997-01-14 1,3,4-thiadiazole derivatives, pharmaceutical compositions containing them as active component and process for producing the active component HUP9700104A3 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
HU9700104A HUP9700104A3 (en) 1997-01-14 1997-01-14 1,3,4-thiadiazole derivatives, pharmaceutical compositions containing them as active component and process for producing the active component
US09/341,362 US6191152B1 (en) 1997-01-14 1998-01-13 2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivatives having an effect on the C.N.S. and the heart
KR1019997006389A KR20000070163A (en) 1997-01-14 1998-01-13 2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivatives having an effect on the c.n.s. and the heart
AU57751/98A AU5775198A (en) 1997-01-14 1998-01-13 2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivatives having an effect on the c.n.s. and the heart
RU99118591/04A RU2180903C2 (en) 1997-01-14 1998-01-13 Derivatives of 2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole, method of their synthesis, pharmaceutical composition and intermediate compound
EP98901423A EP0958294A1 (en) 1997-01-14 1998-01-13 2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivatives having an effect on the c.n.s. and the heart
PCT/HU1998/000005 WO1998030561A1 (en) 1997-01-14 1998-01-13 2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivatives having an effect on the c.n.s. and the heart
CA002276720A CA2276720A1 (en) 1997-01-14 1998-01-13 2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivatives having an effect on the c.n.s. and the heart
JP53068198A JP2001524072A (en) 1997-01-14 1998-01-13 C. N. S. 2- (1,2,4-triazol-1-yl) -1,3,4-thiadiazole derivative effective for heart and heart
PL98334570A PL334570A1 (en) 1997-01-14 1998-01-13 Derivatives of 2-(1,2,4-triazol-1-yl)-1,3,4-thiadiazole acting on central nervous system and hearth
SK938-99A SK93899A3 (en) 1997-01-14 1998-01-13 2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivatives having an effect on the c.n.s. and the heart

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9700104A HUP9700104A3 (en) 1997-01-14 1997-01-14 1,3,4-thiadiazole derivatives, pharmaceutical compositions containing them as active component and process for producing the active component

Publications (3)

Publication Number Publication Date
HU9700104D0 HU9700104D0 (en) 1997-02-28
HUP9700104A2 true HUP9700104A2 (en) 1999-06-28
HUP9700104A3 HUP9700104A3 (en) 1999-07-28

Family

ID=89994625

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9700104A HUP9700104A3 (en) 1997-01-14 1997-01-14 1,3,4-thiadiazole derivatives, pharmaceutical compositions containing them as active component and process for producing the active component

Country Status (1)

Country Link
HU (1) HUP9700104A3 (en)

Also Published As

Publication number Publication date
HU9700104D0 (en) 1997-02-28
HUP9700104A3 (en) 1999-07-28

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