CA2200169A1 - Triazole antifungal agents - Google Patents
Triazole antifungal agentsInfo
- Publication number
- CA2200169A1 CA2200169A1 CA002200169A CA2200169A CA2200169A1 CA 2200169 A1 CA2200169 A1 CA 2200169A1 CA 002200169 A CA002200169 A CA 002200169A CA 2200169 A CA2200169 A CA 2200169A CA 2200169 A1 CA2200169 A1 CA 2200169A1
- Authority
- CA
- Canada
- Prior art keywords
- het
- halo
- linked
- alkyl
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
An antifungal compound of formula (1):
(see fig.I) or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of either entity, wherein X is CH or N; R1 is phenyl subsituted with 1 to 3 substituents each independently selected from halo and CF3; R2 is (hydroxy)C1-C4alkyl, CONH2, S(O)m(C1-C4 alkyl), Ar or Het; m is 1 or 2; Ar is phenyl optionally monosubstituted with halo or CF3; and Het is a C-linked 6-membered nitrogen-containing aromatic heterocyclic group containing 1 or 2 nitrogen atoms, or a C- or N-linked 5-membered nitrogen-containing aromatic heterocyclic group containing from 2 to 4 nitrogen atoms, wherein either of said heterocyclic groups is optionally substituted with C1-C4 alkyl or (C1-C4 alkoxy)methyl.
(see fig.I) or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of either entity, wherein X is CH or N; R1 is phenyl subsituted with 1 to 3 substituents each independently selected from halo and CF3; R2 is (hydroxy)C1-C4alkyl, CONH2, S(O)m(C1-C4 alkyl), Ar or Het; m is 1 or 2; Ar is phenyl optionally monosubstituted with halo or CF3; and Het is a C-linked 6-membered nitrogen-containing aromatic heterocyclic group containing 1 or 2 nitrogen atoms, or a C- or N-linked 5-membered nitrogen-containing aromatic heterocyclic group containing from 2 to 4 nitrogen atoms, wherein either of said heterocyclic groups is optionally substituted with C1-C4 alkyl or (C1-C4 alkoxy)methyl.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9605705.4A GB9605705D0 (en) | 1996-03-19 | 1996-03-19 | Therapeutic agents |
| GB9605705.4 | 1996-03-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2200169A1 true CA2200169A1 (en) | 1997-09-19 |
| CA2200169C CA2200169C (en) | 2001-04-03 |
Family
ID=10790616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002200169A Expired - Fee Related CA2200169C (en) | 1996-03-19 | 1997-03-17 | Triazole antifungal agents |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US5981560A (en) |
| EP (1) | EP0796858B1 (en) |
| JP (1) | JP2987339B2 (en) |
| AT (1) | ATE197304T1 (en) |
| CA (1) | CA2200169C (en) |
| DE (1) | DE69703403T2 (en) |
| DK (1) | DK0796858T3 (en) |
| ES (1) | ES2151223T3 (en) |
| GB (1) | GB9605705D0 (en) |
| GR (1) | GR3035029T3 (en) |
| PT (1) | PT796858E (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602005027482D1 (en) * | 2004-11-30 | 2011-05-26 | Sumitomo Chemical Co | PROCESS FOR PREPARING AN EPOXYTRIAZOL DERIVATIVE |
| PT2563771E (en) * | 2010-04-24 | 2016-03-31 | Viamet Pharmaceuticals Inc | Metalloenzyme inhibitor compounds |
| US8809378B2 (en) | 2011-06-19 | 2014-08-19 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| KR20160137619A (en) * | 2014-03-26 | 2016-11-30 | 바스프 에스이 | Substituted [1,2,4]triazole and imidazole compounds as fungicides |
| EP3297998B1 (en) | 2015-05-18 | 2019-12-11 | Viamet Pharmaceuticals (NC), Inc. | Antifungal compounds |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2431407C2 (en) | 1974-06-29 | 1982-12-02 | Bayer Ag, 5090 Leverkusen | 1,2,4-Triazol-1-yl-alkanones and alkanols, processes for their preparation and their use as fungicides |
| GB2078719B (en) | 1980-06-02 | 1984-04-26 | Ici Ltd | Heterocyclic compounds |
| DE3262386D1 (en) | 1981-06-06 | 1985-03-28 | Pfizer Ltd | Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them |
| DE3346123A1 (en) | 1983-12-21 | 1985-06-27 | Janssen Pharmaceutica, N.V., Beerse | PHARMACEUTICAL PREPARATIONS OF SUBSTANCES MEDICAL OR UNSTABLE IN WATER AND METHOD FOR THE PRODUCTION THEREOF |
| EP0440608A1 (en) * | 1987-12-17 | 1991-08-14 | E.I. Du Pont De Nemours And Company | Antifungal carbinols |
| GB8819308D0 (en) * | 1988-08-13 | 1988-09-14 | Pfizer Ltd | Triazole antifungal agents |
| KR0166088B1 (en) | 1990-01-23 | 1999-01-15 | . | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| GB9002375D0 (en) * | 1990-02-02 | 1990-04-04 | Pfizer Ltd | Triazole antifungal agents |
| GB9121456D0 (en) * | 1991-10-10 | 1991-11-27 | Pfizer Ltd | Triazole antifungal agents |
| CA2145458A1 (en) * | 1994-03-28 | 1995-09-29 | Hiroki Kodama | Triazole compound and production process and use thereof |
-
1996
- 1996-03-19 GB GBGB9605705.4A patent/GB9605705D0/en active Pending
-
1997
- 1997-02-06 DK DK97200348T patent/DK0796858T3/en active
- 1997-02-06 EP EP97200348A patent/EP0796858B1/en not_active Expired - Lifetime
- 1997-02-06 ES ES97200348T patent/ES2151223T3/en not_active Expired - Lifetime
- 1997-02-06 DE DE69703403T patent/DE69703403T2/en not_active Expired - Fee Related
- 1997-02-06 AT AT97200348T patent/ATE197304T1/en not_active IP Right Cessation
- 1997-02-06 PT PT97200348T patent/PT796858E/en unknown
- 1997-03-17 CA CA002200169A patent/CA2200169C/en not_active Expired - Fee Related
- 1997-03-18 US US08/828,754 patent/US5981560A/en not_active Expired - Fee Related
- 1997-03-19 JP JP9065657A patent/JP2987339B2/en not_active Expired - Fee Related
-
1999
- 1999-08-02 US US09/365,929 patent/US6124325A/en not_active Expired - Fee Related
- 1999-12-01 US US09/452,492 patent/US6376526B1/en not_active Expired - Fee Related
-
2000
- 2000-12-12 GR GR20000402716T patent/GR3035029T3/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GB9605705D0 (en) | 1996-05-22 |
| US6376526B1 (en) | 2002-04-23 |
| JP2987339B2 (en) | 1999-12-06 |
| CA2200169C (en) | 2001-04-03 |
| DE69703403D1 (en) | 2000-12-07 |
| DK0796858T3 (en) | 2000-12-27 |
| PT796858E (en) | 2001-03-30 |
| EP0796858A1 (en) | 1997-09-24 |
| ATE197304T1 (en) | 2000-11-15 |
| DE69703403T2 (en) | 2001-03-08 |
| GR3035029T3 (en) | 2001-03-30 |
| JPH107663A (en) | 1998-01-13 |
| US5981560A (en) | 1999-11-09 |
| US6124325A (en) | 2000-09-26 |
| EP0796858B1 (en) | 2000-11-02 |
| ES2151223T3 (en) | 2000-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |