HUP0000759A2 - R- és S-enantiomereket különálló részekben tartalmazó dózisformák - Google Patents

R- és S-enantiomereket különálló részekben tartalmazó dózisformák

Info

Publication number
HUP0000759A2
HUP0000759A2 HU0000759A HUP0000759A HUP0000759A2 HU P0000759 A2 HUP0000759 A2 HU P0000759A2 HU 0000759 A HU0000759 A HU 0000759A HU P0000759 A HUP0000759 A HU P0000759A HU P0000759 A2 HUP0000759 A2 HU P0000759A2
Authority
HU
Hungary
Prior art keywords
enantiomers
dosage form
dosage forms
separate portions
different
Prior art date
Application number
HU0000759A
Other languages
English (en)
Inventor
Hazel Judith Bardsley
Julian Clive Gilbert
Andrew John Mcglashan Richards
Original Assignee
Darwin Discovery Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9704978.7A external-priority patent/GB9704978D0/en
Priority claimed from GBGB9719261.1A external-priority patent/GB9719261D0/en
Application filed by Darwin Discovery Limited filed Critical Darwin Discovery Limited
Publication of HUP0000759A2 publication Critical patent/HUP0000759A2/hu
Publication of HUP0000759A3 publication Critical patent/HUP0000759A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

A találmány olyan gyógyszerészeti dózisformára vonatkozik, amely adózisforma egyik részében egy verapamiltól eltérő királis hatóanyaglényegében tiszta (+)-enantiomerét, és egy másik, elkülönítettrészében a hatóanyag lényegében tiszta (-)-enantiomerét tartalmazza,ahol a dózisforma alkalmazása során az eltérő enantiomerek különbözősebességgel szabadulnak fel a dózisformából. Ó
HU0000759A 1997-03-11 1998-03-11 Dosage forms comprising separate portions of r- and s-enantiomers HUP0000759A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9704978.7A GB9704978D0 (en) 1997-03-11 1997-03-11 Dosage forms
GBGB9719261.1A GB9719261D0 (en) 1997-09-10 1997-09-10 Dosage forms
US09/038,873 US6056968A (en) 1997-03-11 1998-03-11 Pharmaceutical drug dosage forms providing different release rates
PCT/GB1998/000726 WO1998040053A1 (en) 1997-03-11 1998-03-11 Dosage forms comprising separate portions of r- and s-enantiomers

Publications (2)

Publication Number Publication Date
HUP0000759A2 true HUP0000759A2 (hu) 2000-10-28
HUP0000759A3 HUP0000759A3 (en) 2000-11-28

Family

ID=27268767

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0000759A HUP0000759A3 (en) 1997-03-11 1998-03-11 Dosage forms comprising separate portions of r- and s-enantiomers

Country Status (15)

Country Link
US (2) US6056968A (hu)
EP (1) EP0969818B1 (hu)
JP (1) JP2001514651A (hu)
CN (1) CN1251987A (hu)
AT (1) ATE275394T1 (hu)
AU (1) AU741821B2 (hu)
BR (1) BR9808325A (hu)
CA (1) CA2285407C (hu)
DE (1) DE69826113T2 (hu)
ES (1) ES2227814T3 (hu)
HU (1) HUP0000759A3 (hu)
IL (1) IL131713A (hu)
NO (1) NO994412L (hu)
PL (1) PL335619A1 (hu)
WO (1) WO1998040053A1 (hu)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262115B1 (en) * 1995-05-22 2001-07-17 Alza Coporation Method for the management of incontinence
US5912268A (en) * 1995-05-22 1999-06-15 Alza Corporation Dosage form and method for treating incontinence
HUP0104420A2 (en) * 1998-12-02 2002-08-28 Darwin Discovery Ltd Therapeutic composition containing a new form of tramadol and its use
WO2000043003A1 (en) * 1999-01-21 2000-07-27 Darwin Discovery Limited The therapeutic use of r-warfarin as anticoagulant
US20030170181A1 (en) * 1999-04-06 2003-09-11 Midha Kamal K. Method for preventing abuse of methylphenidate
PE20010623A1 (es) * 1999-10-05 2001-07-07 Gruenenthal Chemie Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria
WO2001034125A2 (en) * 1999-11-09 2001-05-17 Darwin Discovery Limited Therapeutic use and formulation of (-)-tramadol
DE10004926A1 (de) 2000-02-04 2001-08-09 Gruenenthal Gmbh Verfahren zur enzymatischen Racematspaltung von Aminomethyl-Aryl-Cyclohexanol-Derivaten
US20030119916A1 (en) 2000-03-01 2003-06-26 David Fowler Treatment of functional gastrointestinal disorders
US20010036959A1 (en) * 2000-04-03 2001-11-01 Gabel Rolf Dieter Carvedilol-hydrophilic solutions
WO2002028383A1 (en) * 2000-10-03 2002-04-11 Penwest Pharmaceuticals Company Delivery system for multi-pharmaceutical active materials at various release rates
WO2002065834A2 (en) * 2000-10-24 2002-08-29 Smithkline Beecham Corporation Novel formulations of carvedilol
US6562871B1 (en) * 2000-11-06 2003-05-13 Boehringer Ingelheim Pharmaceuticals, Inc. Dry granulation of pharmaceutical formulation comprising mexiletine
DE10108122A1 (de) * 2001-02-21 2002-10-02 Gruenenthal Gmbh Arzneimittel auf Basis von Tramadol
IN191028B (hu) * 2001-05-17 2003-09-13 Sun Pharmaceutical Ind Ltd
US8101209B2 (en) * 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
WO2003048113A1 (en) 2001-11-30 2003-06-12 Sepracor Inc. Tramadol analogs and uses thereof
US8128957B1 (en) 2002-02-21 2012-03-06 Valeant International (Barbados) Srl Modified release compositions of at least one form of tramadol
US20050182056A9 (en) * 2002-02-21 2005-08-18 Seth Pawan Modified release formulations of at least one form of tramadol
US20040151772A1 (en) * 2002-11-08 2004-08-05 Egalet A/S Controlled release carvedilol compositions
AU2003288608A1 (en) * 2002-12-20 2004-07-14 Ranbaxy Laboratories Limited Controlled release, multiple unit drug delivery systems
AU2004210671A1 (en) * 2003-02-10 2004-08-26 Shire Canada Inc. Enantiomeric amphetamine compositions for the treatment of ADHD
WO2004103361A2 (en) * 2003-05-20 2004-12-02 Ranbaxy Laboratories Limited A pharmaceutical dosage form of citalopram
US8263126B2 (en) * 2003-06-06 2012-09-11 Ethypharm Orally-dispersible multilayer tablet
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
US20050175695A1 (en) * 2003-11-25 2005-08-11 Catherine Castan Carvedilol free base, salts, anhydrous forms or solvates thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods
US20050169994A1 (en) * 2003-11-25 2005-08-04 Burke Matthew D. Carvedilol free base, salts, anhydrous forms or solvates thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods
JP5254616B2 (ja) 2004-09-13 2013-08-07 クロノ セラピューティクス、インコーポレイテッド 生物学的同調性（ｂｉｏｓｙｎｃｈｒｏｎｏｕｓ）経皮的薬物送達
EP1795207A1 (en) * 2004-10-01 2007-06-13 Nippon Zoki Pharmaceutical Co. Ltd. Solid pharmaceutical preparation
KR101655455B1 (ko) 2005-09-09 2016-09-07 안젤리니 라보팜 엘엘씨 일일 1회 투여를 위한 트라조돈 조성물
EP1976488A4 (en) * 2006-01-12 2010-02-10 Wockhardt Ltd ALFUZOSIN PROLONGED RELEASE PREPARATIONS
WO2007114376A1 (ja) * 2006-03-30 2007-10-11 Nippon Zoki Pharmaceutical Co., Ltd. 固形医薬製剤
CN101657101B (zh) * 2007-02-12 2013-12-11 Dmi生物科学公司 并存早泄和勃起功能障碍的治疗
EP2114147B9 (en) * 2007-02-12 2013-04-10 DMI Biosciences, Inc. Reducing side effects of tramadol
US7718677B2 (en) 2007-04-02 2010-05-18 Parkinson's Institute Methods and compositions for reduction of side effects of therapeutic treatments
EP3250258A4 (en) 2015-01-28 2018-09-05 Chrono Therapeutics, Inc. Drug delivery methods and systems
AU2018205529B2 (en) 2017-01-06 2023-08-10 Morningside Venture Investments Limited Transdermal drug delivery devices and methods
JP7420797B2 (ja) 2018-05-29 2024-01-23 モーニングサイド ベンチャー インベストメンツ リミテッド 薬剤送達の方法及びシステム

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818541A (en) * 1987-08-19 1989-04-04 Schering Corporation Transdermal delivery of enantiomers of phenylpropanolamine
US5145866A (en) * 1991-04-22 1992-09-08 Hoechst-Roussel Pharmaceuticals Incorporated Method of treating anxiety with the aid of r(+)-3-amino-1-hydroxy-pyrrolidin-2-one
US5204116A (en) * 1991-05-01 1993-04-20 Alza Corporation Dosage form providing immediate therapy followed by prolonged therapy
NZ260408A (en) * 1993-05-10 1996-05-28 Euro Celtique Sa Controlled release preparation comprising tramadol
DE4319438C1 (de) * 1993-06-11 1994-06-01 Gerd Dr Dr Geislinger Arzneimittel auf der Grundlage von Ketoprofen zur Bekämpfung von Schmerzen und/oder Entzündungen und/oder Fieber an Menschen und Tieren
GB9412689D0 (en) * 1994-06-23 1994-08-10 Chiroscience Ltd Cytotoxic agent and its use

Also Published As

Publication number Publication date
HUP0000759A3 (en) 2000-11-28
NO994412L (no) 1999-10-20
IL131713A0 (en) 2001-03-19
JP2001514651A (ja) 2001-09-11
DE69826113T2 (de) 2005-01-20
DE69826113D1 (de) 2004-10-14
CN1251987A (zh) 2000-05-03
NO994412D0 (no) 1999-09-10
ES2227814T3 (es) 2005-04-01
BR9808325A (pt) 2000-05-16
EP0969818A1 (en) 2000-01-12
US6221394B1 (en) 2001-04-24
WO1998040053A1 (en) 1998-09-17
CA2285407A1 (en) 1998-09-17
CA2285407C (en) 2006-08-01
IL131713A (en) 2004-08-31
US6056968A (en) 2000-05-02
ATE275394T1 (de) 2004-09-15
AU741821B2 (en) 2001-12-13
PL335619A1 (en) 2000-05-08
EP0969818B1 (en) 2004-09-08
AU6508998A (en) 1998-09-29

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