HUP0000320A2 - Biológiailag aktív peptidek,és eljárás előállításukra - Google Patents
Biológiailag aktív peptidek,és eljárás előállításukraInfo
- Publication number
- HUP0000320A2 HUP0000320A2 HU0000320A HUP0000320A HUP0000320A2 HU P0000320 A2 HUP0000320 A2 HU P0000320A2 HU 0000320 A HU0000320 A HU 0000320A HU P0000320 A HUP0000320 A HU P0000320A HU P0000320 A2 HUP0000320 A2 HU P0000320A2
- Authority
- HU
- Hungary
- Prior art keywords
- peptide
- leű
- nval
- ile
- tyr
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
- 238000000034 method Methods 0.000 title abstract 2
- 230000000694 effects Effects 0.000 abstract 3
- AGPKZVBTJJNPAG-RFZPGFLSSA-N D-Isoleucine Chemical compound CC[C@@H](C)[C@@H](N)C(O)=O AGPKZVBTJJNPAG-RFZPGFLSSA-N 0.000 abstract 2
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 2
- OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical compound OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 abstract 2
- KZSNJWFQEVHDMF-SCSAIBSYSA-N D-valine Chemical compound CC(C)[C@@H](N)C(O)=O KZSNJWFQEVHDMF-SCSAIBSYSA-N 0.000 abstract 2
- SNDPXSYFESPGGJ-UHFFFAOYSA-N L-norVal-OH Natural products CCCC(N)C(O)=O SNDPXSYFESPGGJ-UHFFFAOYSA-N 0.000 abstract 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
- 241000700199 Cavia porcellus Species 0.000 abstract 1
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 abstract 1
- 229960002684 aminocaproic acid Drugs 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 235000019253 formic acid Nutrition 0.000 abstract 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000004957 immunoregulator effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000004904 shortening Methods 0.000 abstract 1
- 210000002536 stromal cell Anatomy 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 231100000563 toxic property Toxicity 0.000 abstract 1
- 210000005239 tubule Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány tárgya új, biőlógiailag aktív, közelebbről imműnszabályőzóhatású peptid és ennek előállítása. Ez a peptid biőlógiai aktivitásakövetkeztében az ember- és állatgyógyászatban, valamint a kísérletibiőkémiában használható. A peptid szerkezete megfelel az X-Glű-Trp-Yáltalánős képletnek, ahől X jelentése hidrőgénatőm vagy Gly, Ala, Leű, Ile, Val, NVal, Prő, Tyr,Phe, Trp, D-Ala, D-Leű, D-Ile, D-Val, D-NVal, D-Prő, D-Tyr, D-Phe, D-Trp, g-aminő-vajsav vagy z-aminő-kaprőnsav; és Y jelentése Gly, Ala, Leű, Ile, Val, NVal, Prő, Tyr, Phe, Trp, D-Ala,D-Leű, D-Ile, D-Val, D-NVal, D-Prő, D-Tyr, D-Phe, D-Trp, g-aminő-vajsav, z-aminő-kaprőnsav, OH-csőpőrt, vagy 1-3szénatőmős csőpőrttalmőnő- vagy diszűbsztitűált amidcsőpőrt. A peptid szintézisét őldatbanvégzik lánchősszabbítással a mőlekűla C-terminálisától kezdve, afűnkciós csőpőrtők maximális védelmének stratégiájával; az aminősav-alkil-észterből indűlnak ki, az észtereket aktiválják, és a vegyesanhidridek módszerét alkalmazzák. Az így kapőtt terméket hangyasavvalkezelve, átkristályősítás űtán főrdítőtt fázisú krőmatőgráfiávaltisztítják. A találmány szerinti peptid hatását a tengerimalacőklimfőcitáinak hőzamára kifejtett hatásűkkal tesztelték; kiműtatták,hőgy a találmány szerinti peptid hatása ezerszer nagyőbb, mint másismert vegyületeké, és e peptidnek tőxikűs sajátságai nincsenek. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU95102461A RU2107691C1 (ru) | 1995-03-02 | 1995-03-02 | Пептид и способ его получения |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0000320A2 true HUP0000320A2 (hu) | 2000-08-28 |
| HUP0000320A3 HUP0000320A3 (en) | 2000-10-30 |
Family
ID=20164981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0000320A HUP0000320A3 (en) | 1995-03-02 | 1996-02-28 | Peptide and a method of obtaining it |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6051683A (hu) |
| EP (1) | EP0818462B1 (hu) |
| JP (1) | JP3902226B2 (hu) |
| CN (1) | CN1161373C (hu) |
| AT (1) | ATE306495T1 (hu) |
| AU (1) | AU708084B2 (hu) |
| BR (1) | BR9607901A (hu) |
| CA (1) | CA2214410C (hu) |
| CZ (1) | CZ288418B6 (hu) |
| DE (1) | DE69635272T2 (hu) |
| DK (1) | DK0818462T3 (hu) |
| ES (1) | ES2250984T3 (hu) |
| HK (1) | HK1012859A1 (hu) |
| HU (1) | HUP0000320A3 (hu) |
| LT (1) | LT4393B (hu) |
| LV (1) | LV11993B (hu) |
| RU (1) | RU2107691C1 (hu) |
| SK (1) | SK282604B6 (hu) |
| UA (1) | UA51647C2 (hu) |
| WO (1) | WO1996026955A1 (hu) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6159940A (en) * | 1996-02-28 | 2000-12-12 | Immunotech Developments Inc. | Method for modulating hemopoiesis |
| DE19712633A1 (de) * | 1997-03-26 | 1998-10-08 | Laves Arzneimittel | Verwendung von gamma-Aminobuttersäure als Interleukinbildungsstimulans |
| IL137820A (en) * | 2000-08-10 | 2009-06-15 | S I S Shulov Inst For Science | Pharmaceutical composition for topical administration comprising an analgesic peptide |
| US20020098999A1 (en) * | 2000-10-06 | 2002-07-25 | Gallop Mark A. | Compounds for sustained release of orally delivered drugs |
| AU2002211863A1 (en) * | 2000-10-06 | 2002-04-15 | Xenoport, Inc. | Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration |
| AU2002239257A1 (en) * | 2000-11-17 | 2002-06-03 | Xenoport, Inc. | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues |
| EP1412324A4 (en) * | 2001-06-11 | 2004-09-29 | Xenoport Inc | AMINO ACID CONJUGATES THAT RESULT IN GABA ANALOGA LASTING SYSTEMIC CONCENTRATIONS |
| US7919468B2 (en) | 2005-04-07 | 2011-04-05 | Centre National De La Recherche Scientifique (C.N.R.S.) | Compounds useful as modulators of the proteasome activity |
| CA2571645A1 (en) | 2006-12-19 | 2008-06-19 | Apotex Technologies Inc. | Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture |
| MX2010005597A (es) * | 2007-11-20 | 2010-10-25 | Immunotech Dev Inc | Péptidos inmunoreguladores novedosos, composiciones y usos de los mismos. |
| EP2464379B1 (en) | 2009-08-10 | 2014-07-30 | Immunotech Developments Inc. | Vaccine having a peptide adjuvant for eliciting a specific immune response to treat influenza viral infection |
| RU2458935C1 (ru) * | 2011-02-18 | 2012-08-20 | Общество с ограниченной ответственностью "ЦитоНИР" (ООО "ЦитоНИР") | Средство для коррекции метаболического синдрома |
| EP2818477B1 (de) * | 2012-05-18 | 2016-05-04 | Obshestvo S Organichennoj Otvetstvennostju "CytoNIR" | L-lysyl-l-glutamyl-l-tryptophan zur korrektur des stoffwechselsyndroms |
| RU2540496C1 (ru) * | 2014-01-20 | 2015-02-10 | Общество с ограниченной ответственностью "ПРОМОМЕД" | Композиция для назального применения, лекарственное средство на его основе и способ его пременения |
| EA025690B1 (ru) * | 2014-07-15 | 2017-01-30 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Ранозаживляющее средство, обладающее иммуностимулирующим и антиоксидантным эффектами |
| RU2672888C1 (ru) | 2018-04-18 | 2018-11-20 | Пивипи Лабс Пте. Лтд. | Противовирусное иммунотропное средство для лечения ОРВИ |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3100974A1 (de) * | 1980-01-18 | 1982-01-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Thymosin(alpha)(pfeil abwaerts)1(pfeil abwaerts)-fragmente enthaltende arzneimittel mit immunregulierender wirkung, und thymosin(alpha)(pfeil abwaerts)1(pfeil abwaerts)-fragmente |
| HU185263B (en) * | 1981-06-12 | 1984-12-28 | Richter Gedeon Vegyeszet | Process for producing peptides effective on the immuncontroll analogous with the tp5 |
| JPS609182Y2 (ja) * | 1981-06-18 | 1985-04-02 | アルファレコ−ド株式会社 | カセツトテ−プケ−スマガジン |
| HU184481B (en) * | 1981-10-02 | 1984-08-28 | Richter Gedeon Vegyeszet | Process for producing tripeptides for diminishing appetite |
| US4699897A (en) * | 1983-06-04 | 1987-10-13 | Amgen | Biologically active peptides structurally related to regions within growth hormones |
| US4603121A (en) * | 1983-10-06 | 1986-07-29 | G. D. Searle & Co. | Enkephalin analogs |
| IT1172391B (it) * | 1983-12-23 | 1987-06-18 | Polifarma Spa | Composti tirpeptidici contenenti acido piroglutaminico e triptofano,procedimentio di produzione ed applicazioni terapeutiche |
| CH659586A5 (de) | 1985-07-02 | 1987-02-13 | Le G Ped I | Arzneimittel aus dem thymus und verfahren zu dessen herstellung. |
| US5070076A (en) * | 1985-07-02 | 1991-12-03 | Leningradsky Gosudarstvenny Pedagogichesky Institut | Thymus-gland preparation and method for producing same |
| US4751216A (en) * | 1985-12-26 | 1988-06-14 | Imreg, Inc. | Methods for treating AIDS and ARC |
| CA1286989C (en) | 1985-12-26 | 1991-07-30 | A. Arthur Gottlieb | Immunoamplifiers and related compositions |
| IT1216908B (it) * | 1987-03-19 | 1990-03-14 | Eniricerche Spa | Analoghi retro-inversi della timopentina e dei suoi frammenti, il metodo per la loro sintesi ed il loro impiego per la preparazionedi composizioni farmaceutiche. |
| JP2511159B2 (ja) * | 1987-12-30 | 1996-06-26 | オブシェストボ エス オグラニチェンノイ オトベツベンノスチュ “ツィトメド―ペプトス” | 免疫欠損状態の治療のための医薬製剤 |
| HU201095B (en) * | 1988-06-14 | 1990-09-28 | Richter Gedeon Vegyeszet | New peptides inhibiting the activity of the immune system and pharmaceutical compositions comprising same, as well as process for producing these peptides and compositions |
| GB2231051B (en) * | 1989-05-05 | 1992-12-16 | Erba Carlo Spa | Bombesin antagonists |
| AU9140891A (en) * | 1990-11-23 | 1992-06-25 | Immunodynamics, Inc. | Synthetic immunoactive peptides having immunomodulating and therapeutic activities |
| ATE188219T1 (de) * | 1991-10-28 | 2000-01-15 | Cytran Ltd | Pharmazeutische dipeptid zusammensetzungen und verwendungsmethoden. |
| IT1264129B1 (it) * | 1993-04-09 | 1996-09-16 | Codev S A | Peptidi ad attivita' immunomodulatoria derivati da frammenti di leucochinina |
| WO1995003067A1 (en) * | 1993-07-21 | 1995-02-02 | Khavinson Vladimir Khatskelevi | Pharmaceutical with immunomodulating activity |
| RU2107692C1 (ru) * | 1995-06-07 | 1998-03-27 | Дейгин Владислав Исакович | Пептид и способ его получения |
| RU2067000C1 (ru) * | 1994-06-29 | 1996-09-27 | Владислав Исакович Дейгин | Пептид и способ его получения |
-
1995
- 1995-03-02 RU RU95102461A patent/RU2107691C1/ru active
-
1996
- 1996-02-28 DE DE69635272T patent/DE69635272T2/de not_active Expired - Lifetime
- 1996-02-28 BR BR9607901-0A patent/BR9607901A/pt not_active Application Discontinuation
- 1996-02-28 SK SK1180-97A patent/SK282604B6/sk not_active IP Right Cessation
- 1996-02-28 JP JP52618596A patent/JP3902226B2/ja not_active Expired - Fee Related
- 1996-02-28 CZ CZ19972703A patent/CZ288418B6/cs not_active IP Right Cessation
- 1996-02-28 UA UA97104869A patent/UA51647C2/uk unknown
- 1996-02-28 CA CA002214410A patent/CA2214410C/en not_active Expired - Fee Related
- 1996-02-28 EP EP96906117A patent/EP0818462B1/en not_active Expired - Lifetime
- 1996-02-28 DK DK96906117T patent/DK0818462T3/da active
- 1996-02-28 CN CNB961923172A patent/CN1161373C/zh not_active Expired - Fee Related
- 1996-02-28 AU AU49594/96A patent/AU708084B2/en not_active Ceased
- 1996-02-28 WO PCT/RU1996/000046 patent/WO1996026955A1/ru active IP Right Grant
- 1996-02-28 AT AT96906117T patent/ATE306495T1/de active
- 1996-02-28 ES ES96906117T patent/ES2250984T3/es not_active Expired - Lifetime
- 1996-02-28 HU HU0000320A patent/HUP0000320A3/hu unknown
- 1996-02-28 US US08/894,963 patent/US6051683A/en not_active Expired - Lifetime
-
1997
- 1997-10-02 LV LVP-97-186A patent/LV11993B/lv unknown
- 1997-10-02 LT LT97-158A patent/LT4393B/lt not_active IP Right Cessation
-
1998
- 1998-12-10 HK HK98113125A patent/HK1012859A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2214410C (en) | 2001-05-29 |
| JPH11505515A (ja) | 1999-05-21 |
| CN1161373C (zh) | 2004-08-11 |
| AU708084B2 (en) | 1999-07-29 |
| LV11993A (lv) | 1998-03-20 |
| UA51647C2 (uk) | 2002-12-16 |
| HK1012859A1 (en) | 1999-08-13 |
| DE69635272T2 (de) | 2006-07-20 |
| EP0818462A1 (en) | 1998-01-14 |
| DK0818462T3 (da) | 2006-02-27 |
| CA2214410A1 (en) | 1996-09-06 |
| BR9607901A (pt) | 1999-09-08 |
| WO1996026955A1 (fr) | 1996-09-06 |
| EP0818462A4 (en) | 2000-05-31 |
| DE69635272D1 (de) | 2006-02-23 |
| RU95102461A (ru) | 1996-12-20 |
| CN1185160A (zh) | 1998-06-17 |
| RU2107691C1 (ru) | 1998-03-27 |
| US6051683A (en) | 2000-04-18 |
| CZ288418B6 (en) | 2001-06-13 |
| LV11993B (lv) | 1998-05-20 |
| EP0818462B1 (en) | 2005-10-12 |
| HUP0000320A3 (en) | 2000-10-30 |
| AU4959496A (en) | 1996-09-18 |
| SK118097A3 (en) | 1998-04-08 |
| JP3902226B2 (ja) | 2007-04-04 |
| LT4393B (lt) | 1998-10-26 |
| CZ270397A3 (cs) | 1998-05-13 |
| SK282604B6 (sk) | 2002-10-08 |
| LT97158A (en) | 1998-05-25 |
| ATE306495T1 (de) | 2005-10-15 |
| ES2250984T3 (es) | 2006-04-16 |
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