HUE054691T2 - Eljárás 3,7-bisz(dimetilamino)fenotiazin-5-ílium-jodid elõállítására - Google Patents
Eljárás 3,7-bisz(dimetilamino)fenotiazin-5-ílium-jodid elõállításáraInfo
- Publication number
- HUE054691T2 HUE054691T2 HUE18712446A HUE18712446A HUE054691T2 HU E054691 T2 HUE054691 T2 HU E054691T2 HU E18712446 A HUE18712446 A HU E18712446A HU E18712446 A HUE18712446 A HU E18712446A HU E054691 T2 HUE054691 T2 HU E054691T2
- Authority
- HU
- Hungary
- Prior art keywords
- phenothiazine
- dimethylamino
- bis
- preparation
- ylium iodide
- Prior art date
Links
- ZBODYMOTCHLNHV-UHFFFAOYSA-N 3-N,3-N,7-N,7-N-tetramethyl-10H-phenothiazin-5-ium-3,7-diamine iodide Chemical compound [I-].CN(C=1C=CC=2NC3=CC=C(C=C3[SH+]C=2C=1)N(C)C)C ZBODYMOTCHLNHV-UHFFFAOYSA-N 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1751700A FR3063495B1 (fr) | 2017-03-02 | 2017-03-02 | Procede de preparation de l’iodure de 3,7-bis(dimethylamino)phenothiazine-5-ylium |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE054691T2 true HUE054691T2 (hu) | 2021-09-28 |
Family
ID=59031095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE18712446A HUE054691T2 (hu) | 2017-03-02 | 2018-02-16 | Eljárás 3,7-bisz(dimetilamino)fenotiazin-5-ílium-jodid elõállítására |
Country Status (17)
Country | Link |
---|---|
US (2) | US11078169B2 (hu) |
EP (1) | EP3589622B1 (hu) |
JP (2) | JP2020509019A (hu) |
KR (2) | KR102558527B1 (hu) |
CN (2) | CN110382472B (hu) |
AU (1) | AU2018228816B2 (hu) |
BR (1) | BR112019018208A2 (hu) |
CA (1) | CA3054659A1 (hu) |
DK (1) | DK3589622T3 (hu) |
ES (1) | ES2877117T3 (hu) |
FR (1) | FR3063495B1 (hu) |
HU (1) | HUE054691T2 (hu) |
MX (1) | MX2019010266A (hu) |
PL (1) | PL3589622T3 (hu) |
PT (1) | PT3589622T (hu) |
RU (1) | RU2768139C2 (hu) |
WO (1) | WO2018158520A1 (hu) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2021226188A1 (en) * | 2020-02-28 | 2022-11-10 | Dishman Carbogen Amcis Ltd | A process for the preparation of methylene blue |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2373787A (en) | 2001-03-08 | 2002-10-02 | Univ Central Lancashire | Phenothiazinium derivatives and their use to reduce pathogenic contaminants |
CA2379211A1 (fr) | 2002-03-28 | 2003-09-28 | Institut De Cardiologie De Montreal | Utilisation du bleu de methylene pour renverser la reaction hemodynamique exageree induite par la combinaison d'un derive nitre et du sildenafil ou d'une molecule de meme classe (inhibiteur de la phosphodiesterase) |
RU2233274C1 (ru) * | 2002-12-25 | 2004-07-27 | Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" | Способ получения 10-(3-диметиламино-2-метилпропил)-2-метоксифенотиазина |
GB0327672D0 (en) * | 2003-11-28 | 2003-12-31 | Photopharmica Ltd | Developments in biologically active methylene blue derivatives (phenothiazines) |
AU2004295148A1 (en) * | 2003-11-28 | 2005-06-16 | Photopharmica Limited | Developments in biologically active methylene blue derivatives (2) |
WO2006032879A2 (en) | 2004-09-23 | 2006-03-30 | Wista Laboratories Ltd. | Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (mtc) |
CN103735554B (zh) * | 2006-03-29 | 2018-03-20 | 维斯塔实验室有限公司 | 蛋白聚集抑制剂 |
CN101511803B (zh) * | 2006-07-11 | 2012-10-31 | 维斯塔实验室有限公司 | 二氨基吩噻嗪*化合物的合成和/或纯化方法 |
FR2903696B1 (fr) | 2006-07-12 | 2011-02-11 | Provence Technologies | Procede de purification de composes diaminophenothiazium |
AU2016220096B2 (en) * | 2015-02-17 | 2020-01-30 | Arizona Board Of Regents On Behalf Of Arizona State University | Phenothiazine analogues as mitochondrial therapeutic agents |
-
2017
- 2017-03-02 FR FR1751700A patent/FR3063495B1/fr not_active Expired - Fee Related
-
2018
- 2018-02-16 CN CN201880014923.9A patent/CN110382472B/zh active Active
- 2018-02-16 WO PCT/FR2018/050372 patent/WO2018158520A1/fr active Application Filing
- 2018-02-16 DK DK18712446.6T patent/DK3589622T3/da active
- 2018-02-16 CA CA3054659A patent/CA3054659A1/fr active Pending
- 2018-02-16 EP EP18712446.6A patent/EP3589622B1/fr active Active
- 2018-02-16 JP JP2019547078A patent/JP2020509019A/ja active Pending
- 2018-02-16 AU AU2018228816A patent/AU2018228816B2/en active Active
- 2018-02-16 PT PT187124466T patent/PT3589622T/pt unknown
- 2018-02-16 RU RU2019126407A patent/RU2768139C2/ru active
- 2018-02-16 MX MX2019010266A patent/MX2019010266A/es unknown
- 2018-02-16 KR KR1020197028165A patent/KR102558527B1/ko active IP Right Grant
- 2018-02-16 KR KR1020237017170A patent/KR20230074848A/ko not_active Application Discontinuation
- 2018-02-16 CN CN202310407746.3A patent/CN116410155A/zh active Pending
- 2018-02-16 BR BR112019018208-0A patent/BR112019018208A2/pt unknown
- 2018-02-16 ES ES18712446T patent/ES2877117T3/es active Active
- 2018-02-16 US US16/490,480 patent/US11078169B2/en active Active
- 2018-02-16 HU HUE18712446A patent/HUE054691T2/hu unknown
- 2018-02-16 PL PL18712446T patent/PL3589622T3/pl unknown
-
2021
- 2021-06-29 US US17/362,283 patent/US11891367B2/en active Active
-
2022
- 2022-11-07 JP JP2022178414A patent/JP2023011886A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN110382472A (zh) | 2019-10-25 |
JP2023011886A (ja) | 2023-01-24 |
FR3063495A1 (fr) | 2018-09-07 |
KR102558527B1 (ko) | 2023-07-21 |
CA3054659A1 (fr) | 2018-09-07 |
ES2877117T3 (es) | 2021-11-16 |
EP3589622A1 (fr) | 2020-01-08 |
US20200010438A1 (en) | 2020-01-09 |
RU2768139C2 (ru) | 2022-03-23 |
US11078169B2 (en) | 2021-08-03 |
RU2019126407A (ru) | 2021-04-02 |
CN116410155A (zh) | 2023-07-11 |
FR3063495B1 (fr) | 2019-04-05 |
DK3589622T3 (da) | 2021-06-21 |
EP3589622B1 (fr) | 2021-03-31 |
US11891367B2 (en) | 2024-02-06 |
RU2019126407A3 (hu) | 2021-04-27 |
US20210323937A1 (en) | 2021-10-21 |
JP2020509019A (ja) | 2020-03-26 |
CN110382472B (zh) | 2023-05-09 |
AU2018228816B2 (en) | 2021-09-30 |
KR20230074848A (ko) | 2023-05-31 |
PT3589622T (pt) | 2021-06-03 |
MX2019010266A (es) | 2019-10-14 |
WO2018158520A1 (fr) | 2018-09-07 |
KR20190125366A (ko) | 2019-11-06 |
BR112019018208A2 (pt) | 2020-06-23 |
PL3589622T3 (pl) | 2021-10-18 |
AU2018228816A1 (en) | 2019-09-12 |
JP2022068343A (ja) | 2022-05-09 |
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