HUE052470T2 - ROR-gamma (RORy) modulátorok - Google Patents

ROR-gamma (RORy) modulátorok

Info

Publication number
HUE052470T2
HUE052470T2 HUE17826439A HUE17826439A HUE052470T2 HU E052470 T2 HUE052470 T2 HU E052470T2 HU E17826439 A HUE17826439 A HU E17826439A HU E17826439 A HUE17826439 A HU E17826439A HU E052470 T2 HUE052470 T2 HU E052470T2
Authority
HU
Hungary
Prior art keywords
rory
ror
modulators
gamma
Prior art date
Application number
HUE17826439A
Other languages
English (en)
Inventor
Joseph Maria Gerardus Barbara Cals
David Machnik
Sander Bernardus Nabuurs
Jean-François Sabuco
Original Assignee
Lead Pharma B V
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lead Pharma B V, Sanofi Sa filed Critical Lead Pharma B V
Publication of HUE052470T2 publication Critical patent/HUE052470T2/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/44Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C317/50Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/095Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10Sulfides; Sulfoxides; Sulfones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/26Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/44Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/44Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Radiation-Therapy Devices (AREA)
  • Plural Heterocyclic Compounds (AREA)
HUE17826439A 2016-12-05 2017-12-05 ROR-gamma (RORy) modulátorok HUE052470T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16202175 2016-12-05

Publications (1)

Publication Number Publication Date
HUE052470T2 true HUE052470T2 (hu) 2022-02-28

Family

ID=57482312

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE17826439A HUE052470T2 (hu) 2016-12-05 2017-12-05 ROR-gamma (RORy) modulátorok

Country Status (34)

Country Link
US (3) US10196350B2 (hu)
EP (1) EP3548016B1 (hu)
JP (1) JP6955563B2 (hu)
KR (1) KR102554776B1 (hu)
CN (1) CN110352054B (hu)
AR (1) AR110481A1 (hu)
AU (1) AU2017373593B2 (hu)
BR (1) BR112019010461A2 (hu)
CA (1) CA3045946A1 (hu)
CL (1) CL2019001406A1 (hu)
CO (1) CO2019007186A2 (hu)
CR (1) CR20190321A (hu)
DK (1) DK3548016T3 (hu)
DO (1) DOP2019000119A (hu)
EA (1) EA201991373A1 (hu)
EC (1) ECSP19047767A (hu)
ES (1) ES2830759T3 (hu)
HU (1) HUE052470T2 (hu)
IL (1) IL267045B (hu)
LT (1) LT3548016T (hu)
MA (1) MA46965B1 (hu)
MX (1) MX2019006517A (hu)
MY (1) MY194174A (hu)
NZ (1) NZ755105A (hu)
PE (1) PE20191545A1 (hu)
PH (1) PH12019501231A1 (hu)
PL (1) PL3548016T3 (hu)
PT (1) PT3548016T (hu)
RS (1) RS60964B1 (hu)
TW (1) TWI705958B (hu)
UA (1) UA123751C2 (hu)
UY (1) UY37507A (hu)
WO (1) WO2018104288A1 (hu)
ZA (1) ZA201902288B (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3101009A1 (en) 2015-06-05 2016-12-07 Lead Pharma Cel Models IP B.V. Ror gamma (rory) modulators
AR110481A1 (es) 2016-12-05 2019-04-03 Lead Pharma Holding Bv MODULADORES DE ROR g (RORg)
WO2023232870A1 (en) 2022-05-31 2023-12-07 Immunic Ag Rorg/rorgt modulators for the treatment of virus infections like covid-19

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006007486A2 (en) 2004-07-01 2006-01-19 New York University COMPOSITIONS AND METHODS FOR MODULATION OF RORϜt
WO2011115892A1 (en) * 2010-03-15 2011-09-22 Griffin Patrick R Modulators of the retinoic acid receptor-related orphan receptors
WO2013029338A1 (en) * 2011-09-01 2013-03-07 Glaxo Group Limited Novel compounds
WO2013169864A2 (en) 2012-05-08 2013-11-14 Lycera Corporation TETRAHYDRO[1,8]NAPHTHYRIDINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORƴ AND THE TREATMENT OF DISEASE
WO2013171729A2 (en) * 2013-01-08 2013-11-21 Glenmark Pharmaceuticals S.A. Aryl and heteroaryl amide compounds as rorgamat modulator
US9359315B2 (en) 2013-09-10 2016-06-07 Arrien Pharmaceuticals Llc Substituted 2,3-dihydro-1H-inden-1-one retinoic acid-related orphan nuclear receptor antagonists for treating multiple sclerosis
AU2014359324B2 (en) 2013-12-05 2019-02-21 Lead Pharma Holding B.V. ROR gamma (RORy) modulators
TW201605797A (zh) 2013-12-10 2016-02-16 葛蘭馬克製藥公司 作為ror伽馬調節物的雙環雜芳基化合物
AU2014365915C1 (en) 2013-12-19 2019-04-04 Merck Patent Gmbh Tetrahydro-tetrazolo[1,5-a]pyrazines as ROR-gamma inhibitors
WO2015101928A1 (en) 2013-12-31 2015-07-09 Aurigene Discovery Technologies Limited Fused thiophene and thiazole derivatives as ror gamma modulators
PL3102576T3 (pl) 2014-02-03 2019-12-31 Vitae Pharmaceuticals, Llc Dihydropirolopirydynowe inhibitory ror-gamma
WO2015145371A1 (en) * 2014-03-27 2015-10-01 Piramal Enterprises Limited Ror-gamma modulators and uses thereof
CN106132965B (zh) 2014-04-14 2020-02-07 勃林格殷格翰国际有限公司 作为RORγ调节剂的化合物
RS62016B1 (sr) 2015-05-15 2021-07-30 Aurigene Discovery Tech Ltd Supstituisana jedinjenja tetrahidrohinolina kao modulatori ror gama receptora
EP3101005A1 (en) 2015-06-05 2016-12-07 Lead Pharma Cel Models IP B.V. Ror gamma (rory) modulators
EP3101007A1 (en) 2015-06-05 2016-12-07 Lead Pharma Cel Models IP B.V. Ror gamma (rory) modulators
EP3101006A1 (en) 2015-06-05 2016-12-07 Lead Pharma Cel Models IP B.V. Ror gamma (rory) modulators
EP3101009A1 (en) 2015-06-05 2016-12-07 Lead Pharma Cel Models IP B.V. Ror gamma (rory) modulators
EP3101008A1 (en) 2015-06-05 2016-12-07 Lead Pharma Cel Models IP B.V. Ror gamma (rory) modulators
ES2791496T3 (es) 2015-08-03 2020-11-04 Glenmark Pharmaceuticals Sa Compuestos novedosos como moduladores de ROR gamma
WO2017213137A1 (ja) 2016-06-09 2017-12-14 アグロカネショウ株式会社 新規化合物およびこれを有効成分とする農園芸用薬剤
AR110481A1 (es) 2016-12-05 2019-04-03 Lead Pharma Holding Bv MODULADORES DE ROR g (RORg)
JP2019026575A (ja) 2017-07-27 2019-02-21 アグロカネショウ株式会社 新規化合物およびこれを有効成分とする農園芸用殺菌剤

Also Published As

Publication number Publication date
AU2017373593B2 (en) 2022-04-07
UY37507A (es) 2018-06-29
UA123751C2 (uk) 2021-05-26
PH12019501231A1 (en) 2019-09-23
AU2017373593A1 (en) 2019-07-25
PL3548016T3 (pl) 2021-02-08
CN110352054A (zh) 2019-10-18
JP2020500886A (ja) 2020-01-16
EA201991373A1 (ru) 2019-11-29
KR102554776B1 (ko) 2023-07-11
PT3548016T (pt) 2020-10-08
PE20191545A1 (es) 2019-10-24
ES2830759T3 (es) 2021-06-04
CR20190321A (es) 2019-09-11
WO2018104288A1 (en) 2018-06-14
IL267045A (en) 2019-07-31
ECSP19047767A (es) 2019-08-30
CL2019001406A1 (es) 2019-10-18
AR110481A1 (es) 2019-04-03
US20200190028A1 (en) 2020-06-18
US10196350B2 (en) 2019-02-05
US11299456B2 (en) 2022-04-12
LT3548016T (lt) 2021-01-11
DOP2019000119A (es) 2019-09-30
US20180162808A1 (en) 2018-06-14
DK3548016T3 (da) 2020-11-16
MA46965B1 (fr) 2020-12-31
ZA201902288B (en) 2020-10-28
TWI705958B (zh) 2020-10-01
IL267045B (en) 2021-07-29
CA3045946A1 (en) 2018-06-14
CO2019007186A2 (es) 2019-08-20
JP6955563B2 (ja) 2021-10-27
RS60964B1 (sr) 2020-11-30
MX2019006517A (es) 2019-08-22
CN110352054B (zh) 2022-11-01
BR112019010461A2 (pt) 2019-09-10
US20190119204A1 (en) 2019-04-25
NZ755105A (en) 2023-01-27
TW201835038A (zh) 2018-10-01
EP3548016A1 (en) 2019-10-09
MY194174A (en) 2022-11-17
EP3548016B1 (en) 2020-09-02
KR20190096365A (ko) 2019-08-19

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