HUE049228T2 - Új kondenzált pirimidin vegyület vagy annak sója - Google Patents
Új kondenzált pirimidin vegyület vagy annak sójaInfo
- Publication number
- HUE049228T2 HUE049228T2 HUE17756554A HUE17756554A HUE049228T2 HU E049228 T2 HUE049228 T2 HU E049228T2 HU E17756554 A HUE17756554 A HU E17756554A HU E17756554 A HUE17756554 A HU E17756554A HU E049228 T2 HUE049228 T2 HU E049228T2
- Authority
- HU
- Hungary
- Prior art keywords
- salt
- pyrimidine compound
- novel condensed
- condensed pyrimidine
- novel
- Prior art date
Links
- -1 pyrimidine compound Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016031919 | 2016-02-23 | ||
| JP2016140801 | 2016-07-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE049228T2 true HUE049228T2 (hu) | 2020-09-28 |
Family
ID=59685768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE17756554A HUE049228T2 (hu) | 2016-02-23 | 2017-02-22 | Új kondenzált pirimidin vegyület vagy annak sója |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US10155768B2 (hu) |
| EP (1) | EP3269370B1 (hu) |
| JP (1) | JP6273075B1 (hu) |
| KR (1) | KR102356212B1 (hu) |
| CN (1) | CN108697714B (hu) |
| AU (1) | AU2017222908B2 (hu) |
| BR (1) | BR112018016724B1 (hu) |
| CA (1) | CA3015484C (hu) |
| CY (1) | CY1123353T1 (hu) |
| DK (1) | DK3269370T3 (hu) |
| ES (1) | ES2775751T3 (hu) |
| HR (1) | HRP20200352T1 (hu) |
| HU (1) | HUE049228T2 (hu) |
| IL (1) | IL261107B2 (hu) |
| LT (1) | LT3269370T (hu) |
| MD (1) | MD3269370T2 (hu) |
| ME (1) | ME03669B (hu) |
| MX (1) | MX2018010176A (hu) |
| PH (1) | PH12018501716A1 (hu) |
| PL (1) | PL3269370T3 (hu) |
| PT (1) | PT3269370T (hu) |
| RU (1) | RU2770727C2 (hu) |
| SG (1) | SG11201806930PA (hu) |
| SI (1) | SI3269370T1 (hu) |
| TW (1) | TWI687422B (hu) |
| WO (1) | WO2017146116A1 (hu) |
| ZA (2) | ZA201805491B (hu) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE035337T2 (hu) | 2010-05-20 | 2018-05-02 | Array Biopharma Inc | Makrociklusos vegyületek TRK kináz inhibitorokként |
| PL3319959T3 (pl) | 2015-07-06 | 2022-02-14 | Alkermes, Inc. | Hetero-haloinhibitory deacetylazy histonowej |
| EP3319968A1 (en) | 2015-07-06 | 2018-05-16 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| EP3322706B1 (en) | 2015-07-16 | 2020-11-11 | Array Biopharma, Inc. | Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors |
| MA41559A (fr) | 2015-09-08 | 2017-12-26 | Taiho Pharmaceutical Co Ltd | Composé de pyrimidine condensé ou un sel de celui-ci |
| PT3269370T (pt) | 2016-02-23 | 2020-03-05 | Taiho Pharmaceutical Co Ltd | Novo composto de pirimidina condensada ou sal do mesmo |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
| WO2018132533A1 (en) | 2017-01-11 | 2018-07-19 | Rodin Therapeutics, Inc. | Bicyclic inhibitors of histone deacetylase |
| JP6888101B2 (ja) | 2017-01-18 | 2021-06-16 | アレイ バイオファーマ インコーポレイテッド | ＲＥＴキナーゼ阻害剤としての置換ピラゾロ［１，５−ａ］ピラジン化合物 |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| SI3664802T1 (sl) | 2017-08-07 | 2022-10-28 | Alkermes, Inc. | Biciklični zaviralci histon deacetilaze |
| CN111032696B (zh) | 2017-08-21 | 2023-11-03 | 大鹏药品工业株式会社 | Dctn1蛋白质与ret蛋白质的融合蛋白 |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| TWI812649B (zh) | 2017-10-10 | 2023-08-21 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| JP7254078B2 (ja) | 2017-11-27 | 2023-04-07 | ダート・ニューロサイエンス・エルエルシー | Ｐｄｅ１阻害剤としての置換フラノピリミジン化合物 |
| CA3087972C (en) | 2018-01-18 | 2023-01-10 | Array Biopharma Inc. | Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors |
| WO2019143991A1 (en) * | 2018-01-18 | 2019-07-25 | Array Biopharma Inc. | SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS AS RET KINASE INHIBITORS |
| EP3740491A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| US11964988B2 (en) | 2018-09-10 | 2024-04-23 | Array Biopharma Inc. | Fused heterocyclic compounds as RET kinase inhibitors |
| PT3909584T (pt) * | 2019-01-11 | 2024-01-12 | Taiho Pharmaceutical Co Ltd | Composto de pirimidina ou um seu sal |
| US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| KR20220007889A (ko) * | 2019-05-13 | 2022-01-19 | 릴레이 테라퓨틱스, 인크. | Fgfr 저해제 및 이의 사용 방법 |
| JP2023500906A (ja) | 2019-11-08 | 2023-01-11 | インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） | キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| US11373425B2 (en) | 2020-06-02 | 2022-06-28 | The Nielsen Company (U.S.), Llc | Methods and apparatus for monitoring an audience of media based on thermal imaging |
| CN116368136A (zh) | 2020-07-15 | 2023-06-30 | 大鹏药品工业株式会社 | Egfr抑制剂 |
| US20230255972A1 (en) | 2020-07-15 | 2023-08-17 | Taiho Pharmaceutical Co., Ltd. | Pyrimidine compound-containing combination to be used in tumor treatment |
| US11553247B2 (en) | 2020-08-20 | 2023-01-10 | The Nielsen Company (Us), Llc | Methods and apparatus to determine an audience composition based on thermal imaging and facial recognition |
| KR20230110547A (ko) | 2020-11-20 | 2023-07-24 | 헬신 헬쓰케어 에스.에이. | 4-아미노-n-[4-(메톡시메틸)페닐]-7-(1-메틸시클로프로필)-6-(3-모르폴리노프로프-1-인-1-일)-7h-피롤로[2,3-d]피리미딘-5-카르복스아미드의 결정질 형태, 그의 제조 방법 및 용도 |
| CA3199714A1 (en) | 2020-11-20 | 2022-05-27 | Isao Miyazaki | Brain-migrating tumor therapeutic agent containing fused pyrimidine compound as active ingredient |
| WO2022106529A1 (en) * | 2020-11-20 | 2022-05-27 | Helsinn Healthcare Sa | Methods of using 4-amino-n-[4-(methoxymethyl)phenyl]-7-(1-methylcyclopropyl)-6-(3-morpholinoprop-1-yn-1-yl)-7h-pyrrolo[2,3-d]pyrimidine-5-carboxamide for the treatment of tumors |
| WO2023239422A2 (en) | 2021-10-22 | 2023-12-14 | University Of Houston System | Methods and compositions for treating chronic inflammatory injury, metaplasia, dysplasia and cancers of epithelial tissues |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6143749A (en) | 1995-06-07 | 2000-11-07 | Abbott Laboratories | Heterocyclic substituted cyclopentane compounds |
| US5665721A (en) | 1995-06-07 | 1997-09-09 | Abbott Laboratories | Heterocyclic substituted cyclopentane compounds |
| UA80171C2 (en) | 2002-12-19 | 2007-08-27 | Pfizer Prod Inc | Pyrrolopyrimidine derivatives |
| WO2005047289A1 (en) | 2003-11-17 | 2005-05-26 | Pfizer Products Inc. | Pyrrolopyrimidine compounds useful in treatment of cancer |
| CA2550361C (en) | 2003-12-19 | 2014-04-29 | Prabha Ibrahim | Compounds and methods for development of ret modulators |
| BRPI0514094A (pt) * | 2004-08-02 | 2008-05-27 | Osi Pharm Inc | composto, composição, e, método de tratamento de distúrbio hiperproliferativo |
| US20070135387A1 (en) | 2005-12-08 | 2007-06-14 | Michaelides Michael R | Inhibitors of protein kinases |
| WO2011018894A1 (en) | 2009-08-10 | 2011-02-17 | Raqualia Pharma Inc. | Pyrrolopyrimidine derivatives as potassium channel modulators |
| WO2013059740A1 (en) | 2011-10-21 | 2013-04-25 | Foundation Medicine, Inc. | Novel alk and ntrk1 fusion molecules and uses thereof |
| ES2516392T3 (es) * | 2012-01-19 | 2014-10-30 | Taiho Pharmaceutical Co., Ltd. | Compuesto de alquinilbenceno 3,5-disustituido y sal del mismo |
| GB201201566D0 (en) | 2012-01-30 | 2012-03-14 | Vernalis R&D Ltd | New chemical compounds |
| US10031968B2 (en) | 2012-10-11 | 2018-07-24 | Veveo, Inc. | Method for adaptive conversation state management with filtering operators applied dynamically as part of a conversational interface |
| US20160010068A1 (en) | 2013-02-22 | 2016-01-14 | Boris C. Bastian | Fusion polynucleotides and fusion polypeptides associated with cancer and particularly melanoma and their uses as therapeutic and diagnostic targets |
| ES2646019T3 (es) * | 2013-05-14 | 2017-12-11 | Nerviano Medical Sciences S.R.L. | Derivados de 6-amino-7-deaza-purina, proceso para su preparación y su uso como inhibidores de cinasa |
| ES2661733T3 (es) | 2013-08-12 | 2018-04-03 | Taiho Pharmaceutical Co., Ltd. | Compuesto de pirimidina condensado novedoso o sal del mismo |
| WO2015078417A1 (zh) | 2013-11-29 | 2015-06-04 | 四川好医生药业集团有限公司 | 吡咯并嘧啶化合物及其在制备降血糖药物中的用途 |
| KR102075886B1 (ko) * | 2015-09-01 | 2020-02-11 | 다이호야쿠힌고교 가부시키가이샤 | 신규한 피라졸로[3,4-d]피리미딘 화합물 또는 그 염 |
| MA41559A (fr) | 2015-09-08 | 2017-12-26 | Taiho Pharmaceutical Co Ltd | Composé de pyrimidine condensé ou un sel de celui-ci |
| PT3269370T (pt) * | 2016-02-23 | 2020-03-05 | Taiho Pharmaceutical Co Ltd | Novo composto de pirimidina condensada ou sal do mesmo |
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2017
- 2017-02-22 PT PT177565546T patent/PT3269370T/pt unknown
- 2017-02-22 BR BR112018016724-0A patent/BR112018016724B1/pt active Search and Examination
- 2017-02-22 TW TW106105968A patent/TWI687422B/zh active
- 2017-02-22 ME MEP-2020-46A patent/ME03669B/me unknown
- 2017-02-22 PL PL17756554T patent/PL3269370T3/pl unknown
- 2017-02-22 MX MX2018010176A patent/MX2018010176A/es unknown
- 2017-02-22 CN CN201780012909.0A patent/CN108697714B/zh active Active
- 2017-02-22 LT LTEP17756554.6T patent/LT3269370T/lt unknown
- 2017-02-22 ES ES17756554T patent/ES2775751T3/es active Active
- 2017-02-22 HU HUE17756554A patent/HUE049228T2/hu unknown
- 2017-02-22 CA CA3015484A patent/CA3015484C/en active Active
- 2017-02-22 SG SG11201806930PA patent/SG11201806930PA/en unknown
- 2017-02-22 IL IL261107A patent/IL261107B2/en unknown
- 2017-02-22 DK DK17756554.6T patent/DK3269370T3/da active
- 2017-02-22 MD MDE20180076T patent/MD3269370T2/ro unknown
- 2017-02-22 WO PCT/JP2017/006672 patent/WO2017146116A1/ja active Application Filing
- 2017-02-22 KR KR1020187027127A patent/KR102356212B1/ko active IP Right Grant
- 2017-02-22 JP JP2017519012A patent/JP6273075B1/ja active Active
- 2017-02-22 SI SI201730182T patent/SI3269370T1/sl unknown
- 2017-02-22 EP EP17756554.6A patent/EP3269370B1/en active Active
- 2017-02-22 RU RU2018133000A patent/RU2770727C2/ru active
- 2017-02-22 AU AU2017222908A patent/AU2017222908B2/en active Active
- 2017-09-19 US US15/708,917 patent/US10155768B2/en active Active
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2018
- 2018-08-13 PH PH12018501716A patent/PH12018501716A1/en unknown
- 2018-08-16 ZA ZA201805491A patent/ZA201805491B/en unknown
- 2018-11-01 US US16/177,844 patent/US10807986B2/en active Active
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2019
- 2019-08-13 ZA ZA2019/05332A patent/ZA201905332B/en unknown
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2020
- 2020-03-03 HR HRP20200352TT patent/HRP20200352T1/hr unknown
- 2020-03-26 CY CY20201100282T patent/CY1123353T1/el unknown
- 2020-05-13 US US15/930,554 patent/US11046696B2/en active Active
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