HUE045862T2 - Gazdasejt fehérjéjének módosítása - Google Patents
Gazdasejt fehérjéjének módosításaInfo
- Publication number
- HUE045862T2 HUE045862T2 HUE16710378A HUE16710378A HUE045862T2 HU E045862 T2 HUE045862 T2 HU E045862T2 HU E16710378 A HUE16710378 A HU E16710378A HU E16710378 A HUE16710378 A HU E16710378A HU E045862 T2 HUE045862 T2 HU E045862T2
- Authority
- HU
- Hungary
- Prior art keywords
- host cell
- cell protein
- protein modification
- modification
- host
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562126213P | 2015-02-27 | 2015-02-27 | |
| US201662298869P | 2016-02-23 | 2016-02-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE045862T2 true HUE045862T2 (hu) | 2020-01-28 |
Family
ID=55538620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE16710378A HUE045862T2 (hu) | 2015-02-27 | 2016-02-26 | Gazdasejt fehérjéjének módosítása |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20160251411A1 (hu) |
| EP (1) | EP3262168B1 (hu) |
| JP (1) | JP6751402B2 (hu) |
| KR (1) | KR20170120126A (hu) |
| CN (1) | CN107406831A (hu) |
| AU (1) | AU2016224988A1 (hu) |
| BR (1) | BR112017018149A2 (hu) |
| CA (1) | CA2976669A1 (hu) |
| DK (1) | DK3262168T3 (hu) |
| EA (1) | EA201791918A1 (hu) |
| ES (1) | ES2751670T3 (hu) |
| HK (1) | HK1248272A1 (hu) |
| HU (1) | HUE045862T2 (hu) |
| IL (1) | IL253863A0 (hu) |
| MX (1) | MX2017011012A (hu) |
| MY (1) | MY180896A (hu) |
| SG (1) | SG11201706335TA (hu) |
| TW (1) | TW201702380A (hu) |
| WO (1) | WO2016138467A1 (hu) |
| ZA (1) | ZA201705712B (hu) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018039499A1 (en) * | 2016-08-24 | 2018-03-01 | Regeneron Pharmaceuticals, Inc. | Host cell protein modification |
| CN116327963A (zh) | 2016-11-21 | 2023-06-27 | 济世-伊沃泰克生物制品有限公司 | 一种眼科制剂及其用途 |
| CA3067735A1 (en) | 2017-08-17 | 2019-02-21 | Just Biotherapeutics, Inc. | Method of purifying glycosylated protein from host cell galectins and other contaminants |
| JP2021521873A (ja) * | 2018-05-04 | 2021-08-30 | シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニーＳｉｇｍａ−Ａｌｄｒｉｃｈ Ｃｏ． ＬＬＣ | 改変された宿主細胞タンパク質プロファイルを有する操作された細胞 |
| SG11202009499VA (en) * | 2018-05-04 | 2020-11-27 | Sigma Aldrich Co Llc | Producing recombinant proteins with reduced levels of host cell proteins |
| US20210096130A1 (en) * | 2019-09-12 | 2021-04-01 | Lonza Ltd | Compositions, methods, and kits for detection of lipolytic activity |
| MX2022004311A (es) | 2019-10-15 | 2022-05-10 | Lilly Co Eli | Estirpes celulares de mamiferos con deficiencia de lipasa/esterasa modificadas geneticamente de manera recombinante. |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69734936T2 (de) * | 1996-09-19 | 2006-08-24 | Novozymes A/S | Wirtszellen und methoden für die produktion von proteinen |
| EP2150617B1 (en) | 2007-06-04 | 2014-10-22 | Regeneron Pharmaceuticals, Inc. | Enhanced expression and stability regions |
| GB201000587D0 (en) * | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
| CN104066439A (zh) * | 2011-07-29 | 2014-09-24 | 十一生物治疗股份有限公司 | 纯化的蛋白质 |
| US8697359B1 (en) * | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| WO2015038888A1 (en) | 2013-09-13 | 2015-03-19 | Genentech, Inc. | Methods and compositions comprising purified recombinant polypeptides |
| RU2016107435A (ru) * | 2013-09-13 | 2017-10-18 | Дженентек, Инк. | Композиции и способы обнаружения и количественного определения белка клеток-хозяев в клеточных линиях и рекомбинантные полипептидные продукты |
| US9932591B2 (en) * | 2013-12-18 | 2018-04-03 | University Of Delaware | Reduction of lipase activity in product formulations |
-
2016
- 2016-02-25 TW TW105105690A patent/TW201702380A/zh unknown
- 2016-02-26 CN CN201680012054.7A patent/CN107406831A/zh active Pending
- 2016-02-26 MY MYPI2017702862A patent/MY180896A/en unknown
- 2016-02-26 DK DK16710378.7T patent/DK3262168T3/da active
- 2016-02-26 KR KR1020177025651A patent/KR20170120126A/ko unknown
- 2016-02-26 EA EA201791918A patent/EA201791918A1/ru unknown
- 2016-02-26 MX MX2017011012A patent/MX2017011012A/es unknown
- 2016-02-26 EP EP16710378.7A patent/EP3262168B1/en not_active Revoked
- 2016-02-26 US US15/055,034 patent/US20160251411A1/en not_active Abandoned
- 2016-02-26 HU HUE16710378A patent/HUE045862T2/hu unknown
- 2016-02-26 BR BR112017018149A patent/BR112017018149A2/pt not_active Application Discontinuation
- 2016-02-26 CA CA2976669A patent/CA2976669A1/en not_active Abandoned
- 2016-02-26 AU AU2016224988A patent/AU2016224988A1/en not_active Abandoned
- 2016-02-26 ES ES16710378T patent/ES2751670T3/es active Active
- 2016-02-26 WO PCT/US2016/019915 patent/WO2016138467A1/en active Application Filing
- 2016-02-26 JP JP2017545231A patent/JP6751402B2/ja not_active Expired - Fee Related
- 2016-02-26 SG SG11201706335TA patent/SG11201706335TA/en unknown
-
2017
- 2017-08-07 IL IL253863A patent/IL253863A0/en unknown
- 2017-08-22 ZA ZA2017/05712A patent/ZA201705712B/en unknown
-
2018
- 2018-06-09 HK HK18107524.0A patent/HK1248272A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA201791918A1 (ru) | 2017-12-29 |
| CA2976669A1 (en) | 2016-09-01 |
| MX2017011012A (es) | 2017-10-20 |
| JP6751402B2 (ja) | 2020-09-02 |
| MY180896A (en) | 2020-12-11 |
| EP3262168A1 (en) | 2018-01-03 |
| WO2016138467A1 (en) | 2016-09-01 |
| TW201702380A (zh) | 2017-01-16 |
| KR20170120126A (ko) | 2017-10-30 |
| SG11201706335TA (en) | 2017-09-28 |
| HK1248272A1 (zh) | 2018-10-12 |
| DK3262168T3 (da) | 2019-10-07 |
| AU2016224988A1 (en) | 2017-09-07 |
| EP3262168B1 (en) | 2019-08-21 |
| BR112017018149A2 (pt) | 2018-04-10 |
| IL253863A0 (en) | 2017-09-28 |
| JP2018506295A (ja) | 2018-03-08 |
| CN107406831A (zh) | 2017-11-28 |
| ES2751670T3 (es) | 2020-04-01 |
| US20160251411A1 (en) | 2016-09-01 |
| ZA201705712B (en) | 2020-01-29 |
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