SG11201706335TA - Host cell protein modification - Google Patents
Host cell protein modificationInfo
- Publication number
- SG11201706335TA SG11201706335TA SG11201706335TA SG11201706335TA SG11201706335TA SG 11201706335T A SG11201706335T A SG 11201706335TA SG 11201706335T A SG11201706335T A SG 11201706335TA SG 11201706335T A SG11201706335T A SG 11201706335TA SG 11201706335T A SG11201706335T A SG 11201706335TA
- Authority
- SG
- Singapore
- Prior art keywords
- host cell
- cell protein
- protein modification
- modification
- host
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562126213P | 2015-02-27 | 2015-02-27 | |
| US201662298869P | 2016-02-23 | 2016-02-23 | |
| PCT/US2016/019915 WO2016138467A1 (en) | 2015-02-27 | 2016-02-26 | Host cell protein modification |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201706335TA true SG11201706335TA (en) | 2017-09-28 |
Family
ID=55538620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201706335TA SG11201706335TA (en) | 2015-02-27 | 2016-02-26 | Host cell protein modification |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20160251411A1 (en) |
| EP (1) | EP3262168B1 (en) |
| JP (1) | JP6751402B2 (en) |
| KR (1) | KR20170120126A (en) |
| CN (1) | CN107406831A (en) |
| AU (1) | AU2016224988A1 (en) |
| BR (1) | BR112017018149A2 (en) |
| CA (1) | CA2976669A1 (en) |
| DK (1) | DK3262168T3 (en) |
| EA (1) | EA201791918A1 (en) |
| ES (1) | ES2751670T3 (en) |
| HK (1) | HK1248272A1 (en) |
| HU (1) | HUE045862T2 (en) |
| IL (1) | IL253863A0 (en) |
| MX (1) | MX2017011012A (en) |
| MY (1) | MY180896A (en) |
| SG (1) | SG11201706335TA (en) |
| TW (1) | TW201702380A (en) |
| WO (1) | WO2016138467A1 (en) |
| ZA (1) | ZA201705712B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018039499A1 (en) * | 2016-08-24 | 2018-03-01 | Regeneron Pharmaceuticals, Inc. | Host cell protein modification |
| CN116327963A (en) | 2016-11-21 | 2023-06-27 | 济世-伊沃泰克生物制品有限公司 | Ophthalmic preparation and application thereof |
| CA3067735A1 (en) | 2017-08-17 | 2019-02-21 | Just Biotherapeutics, Inc. | Method of purifying glycosylated protein from host cell galectins and other contaminants |
| JP2021521873A (en) * | 2018-05-04 | 2021-08-30 | シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニーＳｉｇｍａ−Ａｌｄｒｉｃｈ Ｃｏ． ＬＬＣ | Manipulated cells with modified host cell protein profile |
| SG11202009499VA (en) * | 2018-05-04 | 2020-11-27 | Sigma Aldrich Co Llc | Producing recombinant proteins with reduced levels of host cell proteins |
| US20210096130A1 (en) * | 2019-09-12 | 2021-04-01 | Lonza Ltd | Compositions, methods, and kits for detection of lipolytic activity |
| MX2022004311A (en) | 2019-10-15 | 2022-05-10 | Lilly Co Eli | Recombinantly engineered, lipase/esterase-deficient mammalian cell lines. |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69734936T2 (en) * | 1996-09-19 | 2006-08-24 | Novozymes A/S | HOST CELLS AND METHODS FOR PRODUCING PROTEINS |
| EP2150617B1 (en) | 2007-06-04 | 2014-10-22 | Regeneron Pharmaceuticals, Inc. | Enhanced expression and stability regions |
| GB201000587D0 (en) * | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
| CN104066439A (en) * | 2011-07-29 | 2014-09-24 | 十一生物治疗股份有限公司 | Purified proteins |
| US8697359B1 (en) * | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| WO2015038888A1 (en) | 2013-09-13 | 2015-03-19 | Genentech, Inc. | Methods and compositions comprising purified recombinant polypeptides |
| RU2016107435A (en) * | 2013-09-13 | 2017-10-18 | Дженентек, Инк. | COMPOSITIONS AND METHODS FOR DETECTING AND QUANTITATIVE DETERMINATION OF THE PROTEIN OF CELLS-OWNERS IN CELL LINES AND RECOMBINANT POLYPEPTIDE PRODUCTS |
| US9932591B2 (en) * | 2013-12-18 | 2018-04-03 | University Of Delaware | Reduction of lipase activity in product formulations |
-
2016
- 2016-02-25 TW TW105105690A patent/TW201702380A/en unknown
- 2016-02-26 CN CN201680012054.7A patent/CN107406831A/en active Pending
- 2016-02-26 MY MYPI2017702862A patent/MY180896A/en unknown
- 2016-02-26 DK DK16710378.7T patent/DK3262168T3/en active
- 2016-02-26 KR KR1020177025651A patent/KR20170120126A/en unknown
- 2016-02-26 EA EA201791918A patent/EA201791918A1/en unknown
- 2016-02-26 MX MX2017011012A patent/MX2017011012A/en unknown
- 2016-02-26 EP EP16710378.7A patent/EP3262168B1/en not_active Revoked
- 2016-02-26 US US15/055,034 patent/US20160251411A1/en not_active Abandoned
- 2016-02-26 HU HUE16710378A patent/HUE045862T2/en unknown
- 2016-02-26 BR BR112017018149A patent/BR112017018149A2/en not_active Application Discontinuation
- 2016-02-26 CA CA2976669A patent/CA2976669A1/en not_active Abandoned
- 2016-02-26 AU AU2016224988A patent/AU2016224988A1/en not_active Abandoned
- 2016-02-26 ES ES16710378T patent/ES2751670T3/en active Active
- 2016-02-26 WO PCT/US2016/019915 patent/WO2016138467A1/en active Application Filing
- 2016-02-26 JP JP2017545231A patent/JP6751402B2/en not_active Expired - Fee Related
- 2016-02-26 SG SG11201706335TA patent/SG11201706335TA/en unknown
-
2017
- 2017-08-07 IL IL253863A patent/IL253863A0/en unknown
- 2017-08-22 ZA ZA2017/05712A patent/ZA201705712B/en unknown
-
2018
- 2018-06-09 HK HK18107524.0A patent/HK1248272A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA201791918A1 (en) | 2017-12-29 |
| CA2976669A1 (en) | 2016-09-01 |
| MX2017011012A (en) | 2017-10-20 |
| HUE045862T2 (en) | 2020-01-28 |
| JP6751402B2 (en) | 2020-09-02 |
| MY180896A (en) | 2020-12-11 |
| EP3262168A1 (en) | 2018-01-03 |
| WO2016138467A1 (en) | 2016-09-01 |
| TW201702380A (en) | 2017-01-16 |
| KR20170120126A (en) | 2017-10-30 |
| HK1248272A1 (en) | 2018-10-12 |
| DK3262168T3 (en) | 2019-10-07 |
| AU2016224988A1 (en) | 2017-09-07 |
| EP3262168B1 (en) | 2019-08-21 |
| BR112017018149A2 (en) | 2018-04-10 |
| IL253863A0 (en) | 2017-09-28 |
| JP2018506295A (en) | 2018-03-08 |
| CN107406831A (en) | 2017-11-28 |
| ES2751670T3 (en) | 2020-04-01 |
| US20160251411A1 (en) | 2016-09-01 |
| ZA201705712B (en) | 2020-01-29 |
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