HUE044154T2 - MIR-15 mikro-RNS, valamint az ezt tartalmazó készítmények kortikotropin-felszabadító hormonhoz kapcsolódó orvosi állapotok kezelésére - Google Patents
MIR-15 mikro-RNS, valamint az ezt tartalmazó készítmények kortikotropin-felszabadító hormonhoz kapcsolódó orvosi állapotok kezeléséreInfo
- Publication number
- HUE044154T2 HUE044154T2 HUE17163200A HUE17163200A HUE044154T2 HU E044154 T2 HUE044154 T2 HU E044154T2 HU E17163200 A HUE17163200 A HU E17163200A HU E17163200 A HUE17163200 A HU E17163200A HU E044154 T2 HUE044154 T2 HU E044154T2
- Authority
- HU
- Hungary
- Prior art keywords
- corticotropin
- micro
- compositions
- treatment
- same
- Prior art date
Links
- 102400000739 Corticotropin Human genes 0.000 title 1
- 101800000414 Corticotropin Proteins 0.000 title 1
- 108091060597 Mir-15 microRNA precursor family Proteins 0.000 title 1
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 title 1
- 229960000258 corticotropin Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161514954P | 2011-08-04 | 2011-08-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE044154T2 true HUE044154T2 (hu) | 2019-09-30 |
Family
ID=46875925
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE17163200A HUE044154T2 (hu) | 2011-08-04 | 2012-08-02 | MIR-15 mikro-RNS, valamint az ezt tartalmazó készítmények kortikotropin-felszabadító hormonhoz kapcsolódó orvosi állapotok kezelésére |
| HUE12759827A HUE033746T2 (en) | 2011-08-04 | 2012-08-02 | MIR-135 and compositions thereof for the treatment of therapeutic conditions associated with serotonin |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE12759827A HUE033746T2 (en) | 2011-08-04 | 2012-08-02 | MIR-135 and compositions thereof for the treatment of therapeutic conditions associated with serotonin |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US9150858B2 (https=) |
| EP (3) | EP2739736B1 (https=) |
| JP (2) | JP6309450B2 (https=) |
| CN (3) | CN107115352B (https=) |
| BR (1) | BR112014002737B1 (https=) |
| CA (2) | CA3107434C (https=) |
| ES (2) | ES2732427T3 (https=) |
| HU (2) | HUE044154T2 (https=) |
| IL (1) | IL230814A (https=) |
| WO (1) | WO2013018060A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9150858B2 (en) | 2011-08-04 | 2015-10-06 | Yeda Research And Development Co. Ltd. | Micro-RNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions |
| CN105934439B (zh) | 2013-11-27 | 2019-09-10 | 西格马-奥尔德里奇有限责任公司 | 从生物流体中分离微小rna |
| WO2015118537A2 (en) | 2014-02-05 | 2015-08-13 | Yeda Research And Development Co. Ltd. | Micro-rnas and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions |
| EP3134552B1 (en) * | 2014-04-22 | 2020-11-18 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | Methods, processes, devices and kits for the measurement of post traumatic stress disorder microrna markers |
| EP3204967B1 (en) * | 2014-10-09 | 2018-07-25 | Consorzio Delta Ti Research | 3d integrated thermoelectric generator operating in an out-of-plane heat flux configuration with internal voids and heat conduction paths conditioning vias |
| CN104826131B (zh) * | 2015-04-15 | 2018-12-18 | 涛康生物科技（上海）有限公司 | miR-17-92基因簇在制备治疗精神类疾病药物中的用途 |
| CN105349643B (zh) * | 2015-11-05 | 2018-09-07 | 中国航天员科研训练中心 | 预测睡眠剥夺后5-羟色胺变化的方法与microRNAs标志物 |
| EP4328324B1 (en) * | 2015-11-18 | 2026-03-25 | Dignity Health | Methods of diagnosing epilepsy |
| CN105709240B (zh) * | 2016-03-23 | 2020-07-07 | 中国人民解放军第四军医大学 | 一种miR-26a抑制剂及其应用 |
| CN105748501B (zh) * | 2016-03-31 | 2017-07-28 | 成都仕康美生物科技有限公司 | 一种miRNA‑182抑制剂及其在制备防治心脏移植免疫排斥反应药物中的应用 |
| US11497762B2 (en) | 2017-11-03 | 2022-11-15 | Interna Technologies B.V. | MiRNA molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation |
| AU2019237514A1 (en) | 2018-03-23 | 2020-10-08 | University Of Massachusetts | Gene therapeutics for treating bone disorders |
| CA3019970A1 (en) * | 2018-10-05 | 2020-04-05 | Fang Liu | Methods for diagnosing or treating post-traumatic stress disorder, and compositions therefor |
| CN112852961B (zh) * | 2021-01-08 | 2022-09-13 | 上海市胸科医院 | 肺腺癌铁死亡敏感性标志物adcy10及其应用 |
| EP4277635A4 (en) * | 2021-01-18 | 2024-12-25 | Yeda Research and Development Co. Ltd | MODIFIED MIR-135, CONJUGATED FORM THEREOF, AND USES THEREOF |
| CN113897435B (zh) * | 2021-11-22 | 2024-08-06 | 山西农业大学 | 一种用于评估黑色素瘤转移风险的miRNA及其应用 |
| WO2023182507A1 (ja) * | 2022-03-24 | 2023-09-28 | 北海道公立大学法人 札幌医科大学 | 薬学的組成物、間葉系幹細胞の三次元培養物の製造方法、エクソソームの製造方法、および薬学的組成物の製造方法 |
| WO2024020376A1 (en) * | 2022-07-22 | 2024-01-25 | University Of Massachusetts | Aav-mediated delivery of osteoblast/osteoclast-regulating mirnas for osteoporosis therapy |
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