HUE040063T2 - Tumor õssejtek tumorképzõ potenciáljának gátlása BMP-4 segítségével - Google Patents

Tumor õssejtek tumorképzõ potenciáljának gátlása BMP-4 segítségével

Info

Publication number
HUE040063T2
HUE040063T2 HUE06795317A HUE06795317A HUE040063T2 HU E040063 T2 HUE040063 T2 HU E040063T2 HU E06795317 A HUE06795317 A HU E06795317A HU E06795317 A HUE06795317 A HU E06795317A HU E040063 T2 HUE040063 T2 HU E040063T2
Authority
HU
Hungary
Prior art keywords
bmp
inhibition
stem cells
tumor stem
tumorigenic potential
Prior art date
Application number
HUE06795317A
Other languages
English (en)
Hungarian (hu)
Inventor
Angelo Luigi Vescovi
Brent Allan Reynolds
Original Assignee
Stemgen S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stemgen S P A filed Critical Stemgen S P A
Publication of HUE040063T2 publication Critical patent/HUE040063T2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2093—Leukaemia inhibitory factor [LIF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
HUE06795317A 2005-07-19 2006-07-19 Tumor õssejtek tumorképzõ potenciáljának gátlása BMP-4 segítségével HUE040063T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70085905P 2005-07-19 2005-07-19

Publications (1)

Publication Number Publication Date
HUE040063T2 true HUE040063T2 (hu) 2019-02-28

Family

ID=37420973

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE06795317A HUE040063T2 (hu) 2005-07-19 2006-07-19 Tumor õssejtek tumorképzõ potenciáljának gátlása BMP-4 segítségével
HUE16171392A HUE042197T2 (hu) 2005-07-19 2006-07-19 Tumor õssejtek tumorképzõ potenciáljának gátlása LIF segítségével

Family Applications After (1)

Application Number Title Priority Date Filing Date
HUE16171392A HUE042197T2 (hu) 2005-07-19 2006-07-19 Tumor õssejtek tumorképzõ potenciáljának gátlása LIF segítségével

Country Status (13)

Country Link
US (2) US9220756B2 (https=)
EP (2) EP1904093B1 (https=)
JP (3) JP5189977B2 (https=)
KR (2) KR101311061B1 (https=)
AU (1) AU2006271308B2 (https=)
CA (2) CA2615491C (https=)
DK (2) DK1904093T3 (https=)
ES (2) ES2686093T3 (https=)
HR (1) HRP20181379T1 (https=)
HU (2) HUE040063T2 (https=)
NZ (2) NZ565172A (https=)
PL (2) PL1904093T3 (https=)
WO (1) WO2007010394A2 (https=)

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PL1904093T3 (pl) * 2005-07-19 2018-12-31 Stemgen S.P.A. Hamowanie przez bmp-4 zdolności do tworzenia guzów przez komórki macierzyste guza
WO2009101012A1 (en) * 2008-02-13 2009-08-20 Dkfz Deutsches Krebsforschungszentrum, Stiftung Des Öffentlichen Rechts Methods for treating and preventing brain tumors based on bone morphogenetic proteins
IL298067A (en) 2015-08-25 2023-01-01 Histide Ag Compounds for inducing tissue formation and their uses
WO2017046226A2 (en) * 2015-09-17 2017-03-23 Histide Ag Pharmaceutical association for converting a neoplastic cell into a non-neoplastic cell and uses thereof.
KR20180050744A (ko) * 2015-09-17 2018-05-23 히스티드 아게 신생물성 세포를 비-신생물성 세포로 전환시키기 위한 약제학적 회합물 및 이것의 용도
US20190330290A1 (en) * 2015-09-17 2019-10-31 Histide Ag Pharmaceutical association of growth factor receptor agonist and adhesion protein inhibitor for converting a neoplastic cell into a non-neoplastic cell and uses thereof
JP6890836B2 (ja) * 2015-09-17 2021-06-18 ヒスタイド アクツィエンゲゼルシャフト 腫瘍細胞を非腫瘍細胞に変換するための医薬的連合体及びその使用
CN109715195A (zh) * 2015-09-17 2019-05-03 伊斯迪德股份公司 用于将赘生性细胞转化为非赘生性细胞的药物结合物及其用途
JP7457331B2 (ja) * 2018-12-28 2024-03-28 国立大学法人 東京大学 神経膠腫の治療および予防剤、脳腫瘍の悪性度のマーカーおよび脳腫瘍の予後マーカー、脳腫瘍の悪性度および予後の判定方法並びに腫瘍増殖を抑制する抗体
WO2026022122A1 (en) * 2024-07-23 2026-01-29 Eos Research Sa Checkpoint inhibitors in the treatment of glioblastoma multiforme

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US5324519A (en) * 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
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Also Published As

Publication number Publication date
NZ598031A (en) 2013-11-29
AU2006271308B2 (en) 2012-12-20
KR101311061B1 (ko) 2013-09-25
DK3117833T3 (en) 2019-03-18
PL3117833T3 (pl) 2019-06-28
ES2686093T3 (es) 2018-10-16
HRP20181379T1 (hr) 2018-11-16
US9737589B2 (en) 2017-08-22
NZ565172A (en) 2012-12-21
KR101338533B1 (ko) 2013-12-12
PL1904093T3 (pl) 2018-12-31
JP2009502771A (ja) 2009-01-29
CA2790675A1 (en) 2007-01-25
KR20080082595A (ko) 2008-09-11
EP3117833A1 (en) 2017-01-18
DK1904093T3 (en) 2018-09-03
JP2012107063A (ja) 2012-06-07
EP1904093A2 (en) 2008-04-02
ES2710601T3 (es) 2019-04-26
EP3117833B1 (en) 2019-01-23
US20100167999A1 (en) 2010-07-01
CA2790675C (en) 2016-12-20
AU2006271308A1 (en) 2007-01-25
CA2615491A1 (en) 2007-01-25
JP5891068B2 (ja) 2016-03-22
KR20120125990A (ko) 2012-11-19
EP1904093B1 (en) 2018-06-13
US20160228511A1 (en) 2016-08-11
WO2007010394A3 (en) 2007-08-30
JP2015057452A (ja) 2015-03-26
HUE042197T2 (hu) 2019-06-28
WO2007010394A2 (en) 2007-01-25
CA2615491C (en) 2016-11-29
JP5189977B2 (ja) 2013-04-24
US9220756B2 (en) 2015-12-29

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