HUE038741T2 - Folyamatos többlépéses eljárás antitestek tisztítására - Google Patents

Folyamatos többlépéses eljárás antitestek tisztítására

Info

Publication number
HUE038741T2
HUE038741T2 HUE14722194A HUE14722194A HUE038741T2 HU E038741 T2 HUE038741 T2 HU E038741T2 HU E14722194 A HUE14722194 A HU E14722194A HU E14722194 A HUE14722194 A HU E14722194A HU E038741 T2 HUE038741 T2 HU E038741T2
Authority
HU
Hungary
Prior art keywords
multistep process
purifying antibodies
continuous multistep
continuous
antibodies
Prior art date
Application number
HUE14722194A
Other languages
English (en)
Hungarian (hu)
Inventor
Didier Duthe
Celine Hemet
Laure Landric-Burtin
Benoît Mothes
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of HUE038741T2 publication Critical patent/HUE038741T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Water Supply & Treatment (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
HUE14722194A 2013-05-06 2014-05-06 Folyamatos többlépéses eljárás antitestek tisztítására HUE038741T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13305593 2013-05-06

Publications (1)

Publication Number Publication Date
HUE038741T2 true HUE038741T2 (hu) 2018-11-28

Family

ID=48430636

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE17200909A HUE057119T2 (hu) 2013-05-06 2014-05-06 Folyamatos többlépéses eljárás antitestek tisztítására
HUE14722194A HUE038741T2 (hu) 2013-05-06 2014-05-06 Folyamatos többlépéses eljárás antitestek tisztítására

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HUE17200909A HUE057119T2 (hu) 2013-05-06 2014-05-06 Folyamatos többlépéses eljárás antitestek tisztítására

Country Status (19)

Country Link
US (1) US10793622B2 (cg-RX-API-DMAC7.html)
EP (2) EP2994485B1 (cg-RX-API-DMAC7.html)
JP (2) JP6463734B2 (cg-RX-API-DMAC7.html)
KR (1) KR102272851B1 (cg-RX-API-DMAC7.html)
CN (2) CN105358572A (cg-RX-API-DMAC7.html)
AU (1) AU2014264697B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015027812B1 (cg-RX-API-DMAC7.html)
CA (1) CA2911462C (cg-RX-API-DMAC7.html)
CY (1) CY1125281T1 (cg-RX-API-DMAC7.html)
DK (2) DK2994485T3 (cg-RX-API-DMAC7.html)
ES (2) ES2905675T3 (cg-RX-API-DMAC7.html)
HU (2) HUE057119T2 (cg-RX-API-DMAC7.html)
IL (1) IL242408B (cg-RX-API-DMAC7.html)
MX (1) MX368177B (cg-RX-API-DMAC7.html)
NO (1) NO2994485T3 (cg-RX-API-DMAC7.html)
RU (1) RU2662668C2 (cg-RX-API-DMAC7.html)
SG (1) SG11201508968XA (cg-RX-API-DMAC7.html)
TW (2) TWI631132B (cg-RX-API-DMAC7.html)
WO (1) WO2014180852A1 (cg-RX-API-DMAC7.html)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US10967298B2 (en) 2012-03-15 2021-04-06 Flodesign Sonics, Inc. Driver and control for variable impedence load
US9950282B2 (en) 2012-03-15 2018-04-24 Flodesign Sonics, Inc. Electronic configuration and control for acoustic standing wave generation
DK2911759T3 (da) * 2012-10-24 2024-09-16 Genzyme Corp Eluering af biomolekyler fra multimodale harpikser under anvendelse af mes og mops som modifikatorer af den mobile fase
US10519195B2 (en) * 2013-09-17 2019-12-31 Kaneka Corporation Antibody purification method, antibody obtained therefrom, novel antibody purification method using cation exchanger, and antibody obtained therefrom
EP3092049A1 (en) 2014-01-08 2016-11-16 Flodesign Sonics Inc. Acoustophoresis device with dual acoustophoretic chamber
GB201503578D0 (en) * 2015-03-03 2015-04-15 Ge Healthcare Bio Sciences Ab Sanitization method for affinity chromatography matrices
US11021699B2 (en) 2015-04-29 2021-06-01 FioDesign Sonics, Inc. Separation using angled acoustic waves
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
EP3015542A1 (de) * 2015-05-07 2016-05-04 Bayer Technology Services GmbH Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes
US11459540B2 (en) 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
US11474085B2 (en) 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
US20170101437A1 (en) * 2015-10-09 2017-04-13 Hetero Drugs Ltd. Process for purification of darbepoetin alfa
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
US11085035B2 (en) 2016-05-03 2021-08-10 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
US20190211055A1 (en) * 2016-09-14 2019-07-11 Kinbio Ltd. Methods of purifying and qualifying antibodies
CN110494543A (zh) 2016-10-19 2019-11-22 弗洛设计声能学公司 通过声学的亲和细胞提取
US11697672B2 (en) * 2017-03-24 2023-07-11 Council Of Scientific & Industrial Research Process for the purification of recombinant antibody fragments
GB201711481D0 (en) * 2017-07-17 2017-08-30 Ucb Biopharma Sprl Protein purification
JP6957738B2 (ja) * 2017-08-31 2021-11-02 グリーン・クロス・コーポレイションＧｒｅｅｎ Ｃｒｏｓｓ Ｃｏｒｐ． スルファターゼタンパク質を精製する方法
JP2021507561A (ja) 2017-12-14 2021-02-22 フロデザイン ソニックス， インク．Ｆｌｏｄｅｓｉｇｎ Ｓｏｎｉｃｓ， Ｉｎｃ． 音響トランスデューサドライバ及びコントローラ
CN119881293A (zh) 2018-03-21 2025-04-25 沃特世科技公司 基于非抗体高亲和力的样品制备、吸附剂、装置和方法
EP3546475A1 (en) 2018-03-27 2019-10-02 Sanofi Full flow-through process for purifying recombinant proteins
US12071607B2 (en) * 2018-06-01 2024-08-27 Lonza Ltd. Midscale model for organic growth and phasing
KR102337683B1 (ko) 2018-09-21 2021-12-13 주식회사 녹십자 고효율 항-tfpi 항체 조성물
EP3636657A1 (en) 2018-10-08 2020-04-15 Ablynx N.V. Chromatography-free antibody purification method
WO2020084503A1 (en) * 2018-10-26 2020-04-30 Cadila Healthcare Limited A composition comprising antibody with reduced level of basic variants thereof
WO2020183332A1 (en) * 2019-03-11 2020-09-17 Intas Pharmaceuticals Ltd. Purification of adalimumab using tandem chromatography
CA3135611A1 (en) * 2019-04-03 2020-10-08 Genzyme Corporation Continuous production of recombinant proteins
CN114026108B (zh) * 2019-06-28 2024-09-10 夏尔巴生物技术(苏州)有限公司 无缝连续流层析方法
EP4034546A4 (en) * 2019-09-23 2024-01-31 Merck Sharp & Dohme LLC METHODS AND COMPOSITIONS COMPRISING AN ANTI-CTLA4 MONOCLONAL ANTIBODY WITH REDUCED HOST CELL PROTEINS AND INCREASED POLYSORBATE 80 STABILITY
KR102154952B1 (ko) * 2020-02-21 2020-09-10 프레스티지바이오로직스 주식회사 아달리무맙의 Non-Protein A 정제방법
CN112574321B (zh) * 2020-12-30 2023-10-20 上海赛金生物医药有限公司 一种捕获单克隆抗体-肿瘤坏死因子融合蛋白的亲和纯化方法
WO2022234412A1 (en) 2021-05-03 2022-11-10 Lupin Limited A process for purification of fc-fusion proteins

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR930008447B1 (ko) 1987-10-23 1993-09-04 쉐링 코포레이션 단백질 정제방법
UA35599C2 (uk) * 1993-09-21 2001-04-16 Хемосол Інк Спосіб очищення гемоглобіну з сирого розчину
CA2106612C (en) 1993-09-21 2001-02-06 Diana Pliura Displacement chromatography process
US5891741A (en) 1997-05-16 1999-04-06 Coulter International Corp. Antibody-aminodextran-phycobiliprotein conjugates
CN1136317C (zh) 1999-03-12 2004-01-28 中国人民解放军第四军医大学 单克隆抗体双段和单段的制备方法
US20020009445A1 (en) 2000-07-12 2002-01-24 Yansheng Du Human beta-amyloid antibody and use thereof for treatment of alzheimer's disease
US6602855B2 (en) 2001-04-30 2003-08-05 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1449 daltons
CN1504482A (zh) 2002-12-03 2004-06-16 北京优力凯生物技术有限责任公司 无细胞百日咳抗原蛋白的分离纯化方法
PT1745075E (pt) 2004-04-21 2013-06-17 Brigham & Womens Hospital Péptidos de ligação a poli-n-acetilglucosamina (pnag/dpnag) e métodos da sua utilização
EP1807205B1 (en) * 2004-10-21 2012-09-26 GE Healthcare Bio-Sciences AB A method of antibody purification
CA2602375C (en) 2005-03-23 2018-07-24 Genmab A/S Antibodies against cd38 for treatment of multiple myeloma
CN1814775A (zh) 2005-12-06 2006-08-09 中国海洋大学 一种抗病毒活性寡聚肽的制备方法
EP1914242A1 (en) * 2006-10-19 2008-04-23 Sanofi-Aventis Novel anti-CD38 antibodies for the treatment of cancer
AU2008274195B2 (en) * 2007-07-11 2013-09-05 Novo Nordisk A/S Purification of factor VIII using a mixed-mode or multimodal resin
MY158903A (en) 2007-11-16 2016-11-30 Univ Rockefeller Antibodies specific for the protofibril form of beta-amyloid protein
TWI472339B (zh) * 2008-01-30 2015-02-11 Genentech Inc 包含結合至ｈｅｒ２結構域ii之抗體及其酸性變異體的組合物
EP2260054B1 (en) * 2008-02-29 2015-06-03 Biogen Idec MA Inc. Purified immunoglobulin fusion proteins and methods of their purification
EP2281000A2 (en) 2008-05-15 2011-02-09 Novo Nordisk A/S Antibody purification process
WO2010009388A1 (en) * 2008-07-18 2010-01-21 Talecris Biotherapeutics, Inc. Method of preparing alpha-1 proteinase inhibitor
EP2360183B1 (en) 2008-12-19 2016-07-27 Takeda Pharmaceutical Company Limited Antibody purification method by mixed mode chromatography utilizing an arginine-containing loading solution
CN102272146A (zh) 2009-01-13 2011-12-07 通用电气健康护理生物科学股份公司 用带负电的聚合物沉淀生物分子
KR101224468B1 (ko) * 2009-05-20 2013-01-23 주식회사 파멥신 신규한 형태의 이중표적항체 및 그 용도
KR101415660B1 (ko) * 2009-08-07 2014-07-16 이엠디 밀리포어 코포레이션 샘플 중의 1 이상의 불순물로부터 표적 단백질을 정제하는 방법
US9527010B2 (en) * 2009-09-25 2016-12-27 Ge Healthcare Bio-Sciences Corp. Separation system and method
US20120208986A1 (en) * 2009-10-20 2012-08-16 Wenger Marc D Use of mixed mode chromatography for the capture and purification of basic antibody products
WO2011090719A2 (en) 2009-12-29 2011-07-28 Dr. Reddy's Laboratories Ltd. Protein purification by ion exchange
EP2415779B1 (en) 2010-08-02 2015-01-21 ratiopharm GmbH Method of producing and purifying an active soluble sialyltransferase
WO2012125735A1 (en) * 2011-03-15 2012-09-20 Abott Laboratories An integrated approach to the isolation and purification of antibodies
CA2831787A1 (en) 2011-03-29 2012-10-04 Glaxosmithkline Llc Buffer system for protein purification
ES2915263T3 (es) 2011-06-17 2022-06-21 Roche Diagnostics Hematology Inc Solución y procedimiento para el histoprocesamiento de muestras biológicas
WO2013028330A2 (en) 2011-08-19 2013-02-28 Emd Millipore Corporation Methods of reducing level of one of more impurities in a sample during protein purification
EP2578286A1 (en) * 2011-10-04 2013-04-10 Merck Patent GmbH Method and apparatus for chromatographic purification
JP6431372B2 (ja) * 2011-10-25 2018-11-28 プロシーナ バイオサイエンシーズ リミテッド 抗体製剤および方法
WO2013075740A1 (en) * 2011-11-23 2013-05-30 Sanofi Antibody purification method

Also Published As

Publication number Publication date
EP3301115B1 (en) 2021-11-10
CN105358572A (zh) 2016-02-24
JP2016519137A (ja) 2016-06-30
JP2019104735A (ja) 2019-06-27
DK2994485T3 (en) 2018-04-23
MX368177B (es) 2019-09-23
SG11201508968XA (en) 2015-11-27
RU2015151869A (ru) 2017-06-13
AU2014264697B2 (en) 2019-08-22
TWI631132B (zh) 2018-08-01
CA2911462A1 (en) 2014-11-13
US20160083454A1 (en) 2016-03-24
EP2994485A1 (en) 2016-03-16
TWI675041B (zh) 2019-10-21
US10793622B2 (en) 2020-10-06
HUE057119T2 (hu) 2022-04-28
MX2015015482A (es) 2016-03-21
NO2994485T3 (cg-RX-API-DMAC7.html) 2018-06-09
CY1125281T1 (el) 2023-06-09
JP6463734B2 (ja) 2019-02-06
BR112015027812A2 (pt) 2017-07-25
EP2994485B1 (en) 2018-01-10
BR112015027812B1 (pt) 2021-03-30
ES2905675T3 (es) 2022-04-11
EP3301115A1 (en) 2018-04-04
CN116003579A (zh) 2023-04-25
RU2662668C2 (ru) 2018-07-26
CA2911462C (en) 2021-04-06
IL242408B (en) 2020-04-30
WO2014180852A1 (en) 2014-11-13
KR20160005047A (ko) 2016-01-13
ES2665645T3 (es) 2018-04-26
TW201908331A (zh) 2019-03-01
AU2014264697A1 (en) 2015-11-26
DK3301115T3 (da) 2022-01-31
KR102272851B1 (ko) 2021-07-02
TW201522363A (zh) 2015-06-16

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