HUE037259T2 - N-alfa(2,4,6-triizopropil-fenil-szulfonil)-3-hidroxi-amidino-(L)-fenilalanin-4-etoxi-karbonilpiperazid és/vagy sóinak kristályos módosulatai - Google Patents

N-alfa(2,4,6-triizopropil-fenil-szulfonil)-3-hidroxi-amidino-(L)-fenilalanin-4-etoxi-karbonilpiperazid és/vagy sóinak kristályos módosulatai

Info

Publication number
HUE037259T2
HUE037259T2 HUE05808401A HUE05808401A HUE037259T2 HU E037259 T2 HUE037259 T2 HU E037259T2 HU E05808401 A HUE05808401 A HU E05808401A HU E05808401 A HUE05808401 A HU E05808401A HU E037259 T2 HUE037259 T2 HU E037259T2
Authority
HU
Hungary
Prior art keywords
ethoxycarbonylpiperazide
triisopropylphenylsulfonyl
hydroxyamidino
phenylalanine
alpha
Prior art date
Application number
HUE05808401A
Other languages
English (en)
Inventor
Alfons Grunenberg
Jana Lenz
Original Assignee
Wilex Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wilex Ag filed Critical Wilex Ag
Publication of HUE037259T2 publication Critical patent/HUE037259T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
HUE05808401A 2004-11-26 2005-11-24 N-alfa(2,4,6-triizopropil-fenil-szulfonil)-3-hidroxi-amidino-(L)-fenilalanin-4-etoxi-karbonilpiperazid és/vagy sóinak kristályos módosulatai HUE037259T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004057195A DE102004057195A1 (de) 2004-11-26 2004-11-26 Kristalline Modifikationen von N-Alpha-(2,4,6-Triisopropylphenylsulfonyl)-3-hydroxyamidino-(L)-phenylalanin-4-ethoxycarbonylpiperazid und/oder Salzen davon

Publications (1)

Publication Number Publication Date
HUE037259T2 true HUE037259T2 (hu) 2018-08-28

Family

ID=35811673

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE05808401A HUE037259T2 (hu) 2004-11-26 2005-11-24 N-alfa(2,4,6-triizopropil-fenil-szulfonil)-3-hidroxi-amidino-(L)-fenilalanin-4-etoxi-karbonilpiperazid és/vagy sóinak kristályos módosulatai

Country Status (17)

Country Link
US (2) US7713980B2 (hu)
EP (1) EP1833810B1 (hu)
JP (1) JP5054538B2 (hu)
KR (2) KR101311329B1 (hu)
CN (1) CN1989118B (hu)
AU (1) AU2005308977B2 (hu)
BR (1) BRPI0514823A (hu)
CA (1) CA2581959C (hu)
DE (1) DE102004057195A1 (hu)
DK (1) DK1833810T3 (hu)
ES (1) ES2645567T3 (hu)
HU (1) HUE037259T2 (hu)
MX (1) MX2007001420A (hu)
PL (1) PL1833810T3 (hu)
PT (1) PT1833810T (hu)
RU (1) RU2388754C2 (hu)
WO (1) WO2006056448A1 (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103040815B (zh) * 2011-10-13 2014-12-10 中国科学院上海药物研究所 一类2，4，6-三异丙基苯类化合物在制备治疗糖尿病的药物中的用途
CN105566327A (zh) * 2014-10-09 2016-05-11 江苏恒瑞医药股份有限公司 一种jak激酶抑制剂的硫酸氢盐的i型结晶及其制备方法
EP3359255A4 (en) * 2015-10-06 2019-06-12 Redhill Biopharma Ltd. POLYTHERAPIES FOR THE TREATMENT OF CANCER
KR20210092750A (ko) * 2018-10-31 2021-07-26 르 라보레또레 쎄르비에르 Bcl-2 억제제의 신규 염, 관련 결정질 형태, 이의 제조 방법 및 이를 함유하는 약학적 조성물
WO2021181157A1 (en) 2020-03-10 2021-09-16 Redhill Biopharma Ltd. Treatment of coronavirus infection
US11471448B2 (en) 2020-12-15 2022-10-18 Redhill Biopharma Ltd. Sphingosine kinase 2 inhibitor for treating coronavirus infection in moderately severe patients with pneumonia

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4414652B2 (ja) * 2001-03-21 2010-02-10 ヴィレックス アクチェンゲゼルシャフト ウロキナーゼ阻害剤
SI21137A (sl) 2002-01-24 2003-08-31 LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. Derivati azafenilalanina
CH695999A5 (de) * 2002-02-28 2006-11-15 Wilex Ag Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten.
WO2004011449A2 (de) 2002-07-25 2004-02-05 Wilex Ag Verfahren zur herstellung von phenylalanin-derivaten
DE10323898A1 (de) * 2003-05-26 2004-12-23 Wilex Ag Hydroxyamidin- und Hydroxyguanidin-Verbindungen als Urokinase-Hemmstoffe
DE102004045720A1 (de) * 2004-09-21 2006-03-23 Wilex Ag Stabile Dosierungsform von Phenylalanin-Derivaten

Also Published As

Publication number Publication date
JP5054538B2 (ja) 2012-10-24
KR101455788B1 (ko) 2014-11-04
CN1989118A (zh) 2007-06-27
KR20130066700A (ko) 2013-06-20
US20080058346A1 (en) 2008-03-06
WO2006056448A1 (de) 2006-06-01
KR101311329B1 (ko) 2013-09-25
EP1833810B1 (de) 2017-08-30
MX2007001420A (es) 2007-04-19
ES2645567T3 (es) 2017-12-05
US7713980B2 (en) 2010-05-11
RU2007123712A (ru) 2009-01-10
CA2581959C (en) 2013-08-06
BRPI0514823A (pt) 2008-06-24
CN1989118B (zh) 2012-11-14
DE102004057195A1 (de) 2006-06-01
DK1833810T3 (da) 2017-12-04
RU2388754C2 (ru) 2010-05-10
EP1833810A1 (de) 2007-09-19
JP2008521764A (ja) 2008-06-26
PL1833810T3 (pl) 2018-01-31
AU2005308977A1 (en) 2006-06-01
US8492385B2 (en) 2013-07-23
KR20070083507A (ko) 2007-08-24
CA2581959A1 (en) 2006-06-01
AU2005308977B2 (en) 2011-09-15
US20100266679A1 (en) 2010-10-21
PT1833810T (pt) 2017-12-11

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