PL1833810T3 - Krystaliczne modyfikacje N-alfa-(2,4,6-triizopropylofenylosulfonylo)-3-hydroksyamidyno-(L)- fenyloalanino-4-etoksykarbonylopiperazydu i/lub jego soli - Google Patents

Krystaliczne modyfikacje N-alfa-(2,4,6-triizopropylofenylosulfonylo)-3-hydroksyamidyno-(L)- fenyloalanino-4-etoksykarbonylopiperazydu i/lub jego soli

Info

Publication number
PL1833810T3
PL1833810T3 PL05808401T PL05808401T PL1833810T3 PL 1833810 T3 PL1833810 T3 PL 1833810T3 PL 05808401 T PL05808401 T PL 05808401T PL 05808401 T PL05808401 T PL 05808401T PL 1833810 T3 PL1833810 T3 PL 1833810T3
Authority
PL
Poland
Prior art keywords
ethoxycarbonylpiperazide
triisopropylphenylsulfonyl
hydroxyamidino
phenylalanine
alpha
Prior art date
Application number
PL05808401T
Other languages
English (en)
Inventor
Alfons Grunenberg
Jana Lenz
Original Assignee
Wilex Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wilex Ag filed Critical Wilex Ag
Publication of PL1833810T3 publication Critical patent/PL1833810T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
PL05808401T 2004-11-26 2005-11-24 Krystaliczne modyfikacje N-alfa-(2,4,6-triizopropylofenylosulfonylo)-3-hydroksyamidyno-(L)- fenyloalanino-4-etoksykarbonylopiperazydu i/lub jego soli PL1833810T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004057195A DE102004057195A1 (de) 2004-11-26 2004-11-26 Kristalline Modifikationen von N-Alpha-(2,4,6-Triisopropylphenylsulfonyl)-3-hydroxyamidino-(L)-phenylalanin-4-ethoxycarbonylpiperazid und/oder Salzen davon
EP05808401.3A EP1833810B1 (de) 2004-11-26 2005-11-24 Kristalline modifikationen von n-alpha-(2,4,6-triisopropylphenylsulfonyl)-3-hydroxyamidino-(l)-phenylalanin-4-ethoxycarbonylpiperazid und/oder salzen davon
PCT/EP2005/012589 WO2006056448A1 (de) 2004-11-26 2005-11-24 KRISTALLINE MODIFIKATIONEN VON N-α-(2,4,6-TRIISOPROPYLPHENYLSULFONYL)-3-HYDROXYAMIDINO-(L)-PHENYLALANIN-4-ETHOXYCARBONYLPIPERAZID UND/ODER SALZEN DAVON

Publications (1)

Publication Number Publication Date
PL1833810T3 true PL1833810T3 (pl) 2018-01-31

Family

ID=35811673

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05808401T PL1833810T3 (pl) 2004-11-26 2005-11-24 Krystaliczne modyfikacje N-alfa-(2,4,6-triizopropylofenylosulfonylo)-3-hydroksyamidyno-(L)- fenyloalanino-4-etoksykarbonylopiperazydu i/lub jego soli

Country Status (17)

Country Link
US (2) US7713980B2 (pl)
EP (1) EP1833810B1 (pl)
JP (1) JP5054538B2 (pl)
KR (2) KR101455788B1 (pl)
CN (1) CN1989118B (pl)
AU (1) AU2005308977B2 (pl)
BR (1) BRPI0514823A (pl)
CA (1) CA2581959C (pl)
DE (1) DE102004057195A1 (pl)
DK (1) DK1833810T3 (pl)
ES (1) ES2645567T3 (pl)
HU (1) HUE037259T2 (pl)
MX (1) MX2007001420A (pl)
PL (1) PL1833810T3 (pl)
PT (1) PT1833810T (pl)
RU (1) RU2388754C2 (pl)
WO (1) WO2006056448A1 (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103040815B (zh) * 2011-10-13 2014-12-10 中国科学院上海药物研究所 一类2，4，6-三异丙基苯类化合物在制备治疗糖尿病的药物中的用途
CN105566327A (zh) * 2014-10-09 2016-05-11 江苏恒瑞医药股份有限公司 一种jak激酶抑制剂的硫酸氢盐的i型结晶及其制备方法
MX2018004309A (es) * 2015-10-06 2018-05-22 Redhill Biopharma Ltd Terapias combinadas para tratar el cancer.
CA3117559C (en) * 2018-10-31 2023-09-26 Les Laboratoires Servier Hydrogen sulfate salt of a bcl-2 inhibitor, related crystalline form,method for preparing the same and pharmaceutical compositions containing the same
WO2021181157A1 (en) 2020-03-10 2021-09-16 Redhill Biopharma Ltd. Treatment of coronavirus infection
US11471448B2 (en) 2020-12-15 2022-10-18 Redhill Biopharma Ltd. Sphingosine kinase 2 inhibitor for treating coronavirus infection in moderately severe patients with pneumonia

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002074756A2 (de) 2001-03-21 2002-09-26 Pentapharm Ag Urokinase-inhibitoren
SI21137A (sl) 2002-01-24 2003-08-31 LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. Derivati azafenilalanina
CH695999A5 (de) 2002-02-28 2006-11-15 Wilex Ag Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten.
WO2004011449A2 (de) 2002-07-25 2004-02-05 Wilex Ag Verfahren zur herstellung von phenylalanin-derivaten
DE10323898A1 (de) 2003-05-26 2004-12-23 Wilex Ag Hydroxyamidin- und Hydroxyguanidin-Verbindungen als Urokinase-Hemmstoffe
DE102004045720A1 (de) * 2004-09-21 2006-03-23 Wilex Ag Stabile Dosierungsform von Phenylalanin-Derivaten

Also Published As

Publication number Publication date
PT1833810T (pt) 2017-12-11
US20080058346A1 (en) 2008-03-06
WO2006056448A1 (de) 2006-06-01
JP5054538B2 (ja) 2012-10-24
DE102004057195A1 (de) 2006-06-01
US8492385B2 (en) 2013-07-23
AU2005308977B2 (en) 2011-09-15
US20100266679A1 (en) 2010-10-21
KR101311329B1 (ko) 2013-09-25
HUE037259T2 (hu) 2018-08-28
RU2007123712A (ru) 2009-01-10
DK1833810T3 (da) 2017-12-04
BRPI0514823A (pt) 2008-06-24
KR20070083507A (ko) 2007-08-24
MX2007001420A (es) 2007-04-19
JP2008521764A (ja) 2008-06-26
EP1833810B1 (de) 2017-08-30
AU2005308977A1 (en) 2006-06-01
CN1989118B (zh) 2012-11-14
CN1989118A (zh) 2007-06-27
EP1833810A1 (de) 2007-09-19
RU2388754C2 (ru) 2010-05-10
KR20130066700A (ko) 2013-06-20
CA2581959A1 (en) 2006-06-01
US7713980B2 (en) 2010-05-11
CA2581959C (en) 2013-08-06
KR101455788B1 (ko) 2014-11-04
ES2645567T3 (es) 2017-12-05

Similar Documents

Publication Publication Date Title
IL192241A (en) A process for making 4 - (benzimidazolylmethylamino) - benzamides and their salts
TWI349666B (en) Substituted morpholine and thiomorpholine derivatives
TWI372752B (en) Pyrazinecarboxamide derivatives and plant disease controlling agents containing the same
IL184059A0 (en) Crystal and salt of 1-cyclopropylmethyl-4-[2-(3,3,5,5)-tetramethylcyclohexylphenyl]piperazine
TWI349649B (en) Structurally modified titanium dioxides
IL195346A0 (en) Novel heterocyclic compound or salt thereof and intermediate thereof
HUE056718T2 (hu) Hatóanyag (delafloxacin) meglumin sója és ennek kristályos formái
IL180905A0 (en) Lercanidipine salts
IL175123A0 (en) Crystalline ammonium salts of rosuvastatin
PL378587A1 (pl) Sposób wytwarzania (S)-(-)-2-amino-6-n-propyloamino-4,5,6,7-tetrahydrobenzotiazolu i/lub jego soli
ZA200702380B (en) Substituted heterocyclic compounds and uses thereof
IL178461A0 (en) Substituted 4-alkyl -and 4-alkanoyl-piperidine derivatives and their use as neurokinin antagonists
EP1773339A4 (en) CRYSTALLINE FORM OF DONEPEZIL HYDROCHLORIDE
PL1833810T3 (pl) Krystaliczne modyfikacje N-alfa-(2,4,6-triizopropylofenylosulfonylo)-3-hydroksyamidyno-(L)- fenyloalanino-4-etoksykarbonylopiperazydu i/lub jego soli
EP1898755A4 (en) PILLAR PINE SELECTION AND POVERTY EVALUATION
EP1767531A4 (en) MEDICINAL COMPOSITIONS CONTAINING 6-HYDROXYBENZBROMARONE OR SALTS THEREOF
EP1852432A4 (en) NITROGENIC HETEROCYCLIC COMPOUND AND THEIR MEDICAL USE
EP1623972A4 (en) SOLID N-ACYLALANINE OR SALTS THEREOF
ZA200804816B (en) Pyrazinecarboxamide derivatives and plant disease controlling agents containing the same
IL186221A0 (en) Crystalline rosuvastatin intermediate
HK1127862A1 (en) Piperazine compound and pyridine compound
AU2003232062A8 (en) Heterocyclic amine diol compounds and their biocidal derivatives
IL180702A0 (en) Dimeric piperidine derivatives
HU0401551D0 (en) Polisulfated glycosides and salts thereof
SI1877390T1 (sl) Spojine benzizoksazol piperazina in metode uporabe le teh