HUE035241T2 - Darunavir combination formulations - Google Patents
Darunavir combination formulations Download PDFInfo
- Publication number
- HUE035241T2 HUE035241T2 HUE12738060A HUE12738060A HUE035241T2 HU E035241 T2 HUE035241 T2 HU E035241T2 HU E12738060 A HUE12738060 A HU E12738060A HU E12738060 A HUE12738060 A HU E12738060A HU E035241 T2 HUE035241 T2 HU E035241T2
- Authority
- HU
- Hungary
- Prior art keywords
- darunavir
- amely amely
- oral
- weight
- tablet
- Prior art date
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- CJBJHOAVZSMMDJ-HEXNFIEUSA-N darunavir Chemical compound C([C@@H]([C@H](O)CN(CC(C)C)S(=O)(=O)C=1C=CC(N)=CC=1)NC(=O)O[C@@H]1[C@@H]2CCO[C@@H]2OC1)C1=CC=CC=C1 CJBJHOAVZSMMDJ-HEXNFIEUSA-N 0.000 title description 89
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
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| EP11173067 | 2011-07-07 |
Publications (1)
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| HUE035241T2 true HUE035241T2 (en) | 2018-05-02 |
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| HR (1) | HRP20171889T1 (OSRAM) |
| HU (1) | HUE035241T2 (OSRAM) |
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| LT (1) | LT2729130T (OSRAM) |
| MX (1) | MX343689B (OSRAM) |
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| PL (1) | PL2729130T3 (OSRAM) |
| PT (1) | PT2729130T (OSRAM) |
| RS (1) | RS56667B1 (OSRAM) |
| SI (1) | SI2729130T1 (OSRAM) |
| SM (1) | SMT201700574T1 (OSRAM) |
| WO (1) | WO2013004818A1 (OSRAM) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| PL2729130T3 (pl) | 2011-07-07 | 2018-02-28 | Janssen Sciences Ireland Uc | Preparaty kombinowane darunawiru |
| JP2015508822A (ja) * | 2012-03-01 | 2015-03-23 | ギリアード サイエンシーズ， インコーポレイテッド | 噴霧乾燥製剤 |
| MX344879B (es) | 2012-12-21 | 2017-01-11 | Gilead Sciences Inc | Compuestos de carbamoilpiridona policiclicos y su uso farmaceutico. |
| KR102606625B1 (ko) | 2015-11-09 | 2023-11-27 | 길리애드 사이언시즈, 인코포레이티드 | 인간 면역결핍 바이러스의 치료를 위한 치료 조성물 |
| WO2018029566A1 (en) * | 2016-08-08 | 2018-02-15 | Hetero Labs Limited | A high drug loaded tablet composition for treating hiv |
| US20190175511A1 (en) * | 2016-08-08 | 2019-06-13 | Hetero Labs Limited | A Multi-Class Anti-Retroviral Composition |
| EP3496718A4 (en) | 2016-08-08 | 2020-01-22 | Hetero Labs Limited | ANTIRETROVIRAL COMPOSITIONS |
| WO2018064071A1 (en) * | 2016-09-27 | 2018-04-05 | Gilead Sciences, Inc. | Therapeutic compositions for treatment of human immunodeficiency virus |
| EP3654951A1 (en) | 2017-07-20 | 2020-05-27 | Janssen Sciences Ireland Unlimited Company | Compositions comprising darunavir, cobicistat, emtricitabine and tenofovir alafenamide for use in the treatment of hiv |
| WO2020064980A1 (en) | 2018-09-28 | 2020-04-02 | Janssen Sciences Ireland Unlimited Company | Methods of treating and preventing neuropsychiatric and/or neurocognitive complications in patients infected with hiv |
| WO2021180963A1 (en) | 2020-03-13 | 2021-09-16 | Janssen Sciences Ireland Unlimited Company | A protease inhibitor regimen for treating subjects infected with hiv |
| CN119700779B (zh) * | 2024-11-28 | 2025-11-04 | 安徽贝克生物制药有限公司 | 一种达芦那韦和考比司他复合片剂及其制备方法 |
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| US5968942A (en) | 1992-08-25 | 1999-10-19 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| EP0715618B1 (en) | 1993-08-24 | 1998-12-16 | G.D. Searle & Co. | Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors |
| ATE500823T1 (de) | 1998-06-23 | 2011-03-15 | Us Of America Represented By The Secretary Dept Of Health And Human Services | Arzneimittel zur behandlung von hiv-infizierten säugetieren |
| AR037797A1 (es) | 2001-12-12 | 2004-12-01 | Tibotec Pharm Ltd | Combinacion de inhibidores de proteasa dependientes del citocromo p450 |
| HRP20041061B1 (hr) | 2002-05-16 | 2015-02-27 | Tibotec Pharmaceuticals Ltd. | Pseudopolimorfni oblici inhibitora hiv proteaze |
| TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
| WO2007143422A2 (en) | 2006-05-30 | 2007-12-13 | Janssen Pharmaceutica N.V. | Substituted pyridyl amide compounds as modulators of the histamine h3 receptor |
| US20080039428A1 (en) * | 2006-06-29 | 2008-02-14 | Panacos Pharmaceuticals, Inc. | Antiretroviral combination therapy |
| AR061838A1 (es) | 2006-07-07 | 2008-09-24 | Gilead Sciences Inc | Moduladores de propiedades farmacocineticas de terapeuticos |
| BRPI0718428A2 (pt) * | 2006-10-25 | 2013-11-12 | Mcneil Ppc Inc | Composição de ibuprofeno |
| EP2118082B1 (en) | 2007-02-23 | 2014-10-01 | Gilead Sciences, Inc. | Modulators of pharmacokinetic properties of therapeutics |
| CA2689330A1 (en) * | 2007-06-25 | 2008-12-31 | Tibotec Pharmaceuticals | Combination formulations |
| AR069539A1 (es) * | 2007-07-25 | 2010-02-03 | Tibotec Pharm Ltd | Avances respecto de las formulaciones de comprimidos contra el vih |
| KR101546712B1 (ko) | 2007-11-20 | 2015-08-24 | 얀센 파마슈티카 엔.브이. | 히스타민 ｈ3 수용체의 조절제로서 사이클로알킬옥시- 및 헤테로사이클로알킬옥시피리딘 화합물 |
| PA8809601A1 (es) * | 2007-12-24 | 2009-07-23 | Cipla Ltd | Combinación anti-retroviral |
| AP3089A (en) * | 2008-05-02 | 2015-01-31 | Gilead Sciences Inc | The use of solid carrier particles to improve the processability of a pharmaceutical agent |
| BRPI1008664A2 (pt) * | 2009-02-06 | 2016-03-08 | Gilead Sciences Inc | comprimidos para a terapia de combinação |
| EP2477992B1 (en) * | 2009-09-17 | 2016-12-14 | Mylan Laboratories Limited | Processes for the preparation of darunavir and the amorphous form thereof |
| US20130195978A1 (en) | 2010-05-10 | 2013-08-01 | Hetero Research Foundation | Darunavir Compositions |
| ES2598823T3 (es) | 2011-07-07 | 2017-01-30 | Janssen R&D Ireland | Formulaciones de darunavir |
| PL2729130T3 (pl) | 2011-07-07 | 2018-02-28 | Janssen Sciences Ireland Uc | Preparaty kombinowane darunawiru |
| WO2013115916A1 (en) | 2012-02-03 | 2013-08-08 | Gilead Sciences, Inc. | Combination therapy comprising gs-7340 and cobicistat for use in the treatment of viral infections |
| EP3240793A1 (en) | 2015-01-03 | 2017-11-08 | Mylan Laboratories Ltd. | Processes for the preparation of amorphous tenofovir alafenamide hemifumarate and a premix thereof |
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2012
- 2012-07-06 PL PL12738060T patent/PL2729130T3/pl unknown
- 2012-07-06 SM SM20170574T patent/SMT201700574T1/it unknown
- 2012-07-06 SI SI201231141T patent/SI2729130T1/en unknown
- 2012-07-06 EA EA201490222A patent/EA026587B1/ru unknown
- 2012-07-06 CN CN201280033554.0A patent/CN103826616B/zh active Active
- 2012-07-06 MX MX2013015199A patent/MX343689B/es active IP Right Grant
- 2012-07-06 KR KR1020147000092A patent/KR102058097B1/ko active Active
- 2012-07-06 HR HRP20171889TT patent/HRP20171889T1/hr unknown
- 2012-07-06 JP JP2014517822A patent/JP6122427B2/ja active Active
- 2012-07-06 LT LTEP12738060.8T patent/LT2729130T/lt unknown
- 2012-07-06 WO PCT/EP2012/063249 patent/WO2013004818A1/en not_active Ceased
- 2012-07-06 AU AU2012280198A patent/AU2012280198B2/en active Active
- 2012-07-06 PT PT127380608T patent/PT2729130T/pt unknown
- 2012-07-06 DK DK12738060.8T patent/DK2729130T3/en active
- 2012-07-06 NO NO12738060A patent/NO2729130T3/no unknown
- 2012-07-06 RS RS20171244A patent/RS56667B1/sr unknown
- 2012-07-06 ES ES12738060.8T patent/ES2651212T3/es active Active
- 2012-07-06 US US14/131,282 patent/US20140142070A1/en not_active Abandoned
- 2012-07-06 BR BR112014000290-8A patent/BR112014000290B1/pt active IP Right Grant
- 2012-07-06 EP EP12738060.8A patent/EP2729130B1/en active Active
- 2012-07-06 HU HUE12738060A patent/HUE035241T2/en unknown
- 2012-07-06 CA CA2838659A patent/CA2838659C/en active Active
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2013
- 2013-12-17 IL IL229933A patent/IL229933A/en active IP Right Grant
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2017
- 2017-12-05 CY CY20171101267T patent/CY1121999T1/el unknown
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2019
- 2019-11-27 US US16/697,888 patent/US11654150B2/en active Active
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2023
- 2023-05-05 US US18/313,266 patent/US20230302024A1/en active Pending
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