HUE035082T2 - Interferon alfa receptor 1 antitestek és felhasználásuk - Google Patents

Interferon alfa receptor 1 antitestek és felhasználásuk Download PDF

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HUE035082T2
HUE035082T2 HUE13162333A HUE13162333A HUE035082T2 HU E035082 T2 HUE035082 T2 HU E035082T2 HU E13162333 A HUE13162333 A HU E13162333A HU E13162333 A HUE13162333 A HU E13162333A HU E035082 T2 HUE035082 T2 HU E035082T2
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antibodies
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ifnar
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Josephine M Cardarelli
Alison Witte
Mohan Srinivasan
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Squibb & Sons Llc
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Claims (6)

  1. Sznbatkhnh igénypomnk 1. talált monokíonális antitest. vagy annak ttnrigénkötö része. ahol az antitest, vagy annak tintigéttkötö részA keresztlsén versenyez emberi interlőtön áléi receptor i kötéséért rsfáréóíoo antitesttel V1 í ,!, ;t>; 'i ‘<if > <> vv \ ! \ v i v i i t ii ’ti \ iii része, amely kt vatt választva a következőkből ál lé csoportból: ZS ZÍSt:5e.;5, öt'g) ,00:, A anögéok OD ρ'νΛ, SO'S N S tíí.ŐÜS.t,·.; 3 OV'heZ ktnv'it V.ntvsblbS iCgüZÍ, SOsA íárinlmzzza az airilppsttv székvéneiai jÁQ ID Nö:2á. és könnyn.láóéú variábilis .régiét, amely bsrtálmazza az annom.av szekveociát SEQ I© NOAk bt antitest, vagy aitaak áhtiöénkötő része, kétely táttalntaz nehéz láncé várhíhllis régiek amely tartalmazza az arnmesac szekvenciát SLQ iÖ NO:7k, és köimyü láncé variábilis régiét kétely tartalmazza az atninosav szekvenciát SbQ ID Nöttk ahöl a keresztben veresenyzé antitest vagy annak tmtlgénkőtő része tartalmaz.: 1) nehéz iérteéi variábilis régiót CpEA amely tartahnazza az ammosav szekvenciái SkQ iD NŐD, es könnyé táPéő variabíhs régiét Cpgg. sméiy iartákriaaza ;;z smnmsav szokverteiát: A’á ISA NO:2|. avagy tn '1' C ' i v- ibN rn \t 2 ' \ itt t v ,m t{,\ p. \ >>, ,< su't H ' NO:12, és könnyé kbteé variábilis régiéi CPUs., amely tarlalmazzá az ámthosáv szekvenciát AZ> IP NO: 24.
  2. 2. Az b igénypont szerinti kérésziéért versenyző antitest vagy annak autigértkörö része, améiy tartalmaz: a) nehéz láncú variábilis régió; CDR2, amely tartalmazza az atninosav szekvenciát SEO ID NÖ:S, és könnyű láhe-ó variábilis régiói CDR2, amely tartalmazza áz atninoSáv szekvenciát SEQ ÍD NO: 17; vágy b) nehéz láncé variábilis régiét ΟΡΙΑ, amely tartalmazza az ámínősav szekvenciát ShQ IP NO;é, és könnyé iancá variábilis réziól é'Dkz. mneiv taríalm&amp;zzn az aminosay szekvenélál $bQ ID NO:2Ö,
  3. 3. Az i vagy 2, Igénypont szerinti keresztben versenyző antitest vagy annak antigénkötb része., amely tartalmaz: á) nehéz láncú variábilis régivé CDE.L amely tartalmazza zz atmaoszv szekvenciát 'Ά; 10 Nt.> ás könnye láncé variábilis régiótADRI, a-naiy tartalmazza ttz asninosav szekvenciái SbQ ID ΝΟΝΟ; S’agy h) nehéz láncé variábilis régiót CDRI, amely tartalmazza az nroinos&amp;v szekvenciát SbQ ID N0:4, és könnyb lánc a variábilis régiót CDiéi, amely tartálmaxza az am;?msav szekyenclá· A IP ND: 16.
  4. 4. Λζ I, igénypont Szérirtii késeszthen versenyző antitest vagy annak aftísgértkötö része, amely emberi antitest vágy annak része. á. Az í. igénypont: szerinti keresztben versenyző amAes; vagy annak amigénkötö része, amely human izéit antitest, vagy annak része. ő, Az I. igénypont szerinti kemsztbett versenyző- aníitésí vagy annak amtgónkőíő része, amely kánéra antitest vagy armak része, 7. iaummkoumgá;, ansely tartalmazza az IA igénypontok bármelyike szernttl keresztben versenyző antitestet, vagy annak aongmköm u./vt. atneiy teOpiai s.vrimz van kapcsolva 8. A 7, igénypont ;·;z<·;·?;; imossntkoaioigb, ahol sí terápiás szer eiíotozio vagy radioaktív izmán, ő. Sispseibkas moiekoin, amely reríalasazza az t m. igénypontok őázsmdyike szerinti keresztben versenyző aptitestet vágy arsnak antigénkblb részét, anmiy másmiik fbokesonábs részhez 'kapv-soládik, gípéíynék köiánbőző kőié spéci f is hasa van, «rini a keresztben versenyző antitestnek, vagy annak iánigépköső részenek lö. tkompo/K'<o amen saönmmzzm a- az i'á. igénypostsok bármelyike szerinti keresztben verssenyzte aniiiesset. vagy annak antigétekőtő sészég vagy á) a. ?. vagy 8, igénypont széfiöíi -anoninkonf-ngatot, vagy » >1 '. ' V \v \i S ' « k li i és gybgyszorészetiieg eitbgadhatö bordozbaoyagoi, íi. Izolált nakieinsav nnsisktrla, saséi? kódolja az 1Ά, -igénypontok bármelyike szerinti keresztben v<.· vseb?rá m η n ex v;, vagy nanak arsigéókötö resZái, 1.2, bvpívvvziö vektor, á-noíy íartáhnazáaa 11. igénypont szerinti ngkiéitesssv rsaiektbái.
  5. 13, Host seít, amely íartaimazzst a 12. igénypont szerinti expresszié vektort 14, franszgén egét amely tsrtainsaz emben inonunogioteuíin nehéz és könnyű iéneő ífaoszgéoeket, ahöl az egér expresszálja az 1-4. Igénypamok bármelyike szerinte keresztben versényzö ianhéstot. 15, tObribonia, amely a bt. igénypont szerinti egérből van eloáiütva. ahol a híbiidómst siőáöája az antitestet lé, la i;p? eli-n-ts apa 1 nam-bo-n émk-gno aktív itassunk iubsbimimaru sepost, οηκ·1\ evi>rcss,x<ljo iptgrtbran alia receptor Het, aibeiy tartanoazzn a sejt kratíakiálayát az i·n. igénypontok itáooeiyike szerinti kerészibeti veresenyzö antitesttel, vagy annak anbgeokbtb részévei, ágy hog? a tipas 1 imerlero» biológia; skbvááss mlobnáivz vsa.
  6. 17. Az 1 -b. igénypont bármelyike szerinti kereszmen versenyző ember·, vagy annak aotigénkötö OÁze, félhasznáiésra eljárásban típus i interferon által közvetített betegség vagy rendeiienesség kezelésére, iá A keresztben versenyző antitest vagy annak sobgénkörö része a 17, Igénypont. szerinti íeibasznátásra, aboi a rams 1 ioíorleroa aita; krizyotiteit betegség íoterferon alfa áiial kozvetöeít betegség; vagy, ahol a betegség vagy t-ende!tettesség ki van választva a következők közöl; szisztémás lapos erythsiőatbsas, gizoíinigggő diábéiesz meiiints, gyosiadásos bői béiégség, sélérpsts multiplex, psoriasis, ,'tib'!, tti'i!'! itemmdd's tkti!'V>'"t ,i ibt.it' dnm mim volaeí , lb\ xömes \ít>'' u,tox,pkm aia n kilökődés, és amit verses bosl betegség.
HUE13162333A 2004-06-21 2005-06-20 Interferon alfa receptor 1 antitestek és felhasználásuk HUE035082T2 (hu)

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