HUE032197T2 - Synthetic and purification methods for phosphaplatin compounds and uses thereof - Google Patents
Synthetic and purification methods for phosphaplatin compounds and uses thereof Download PDFInfo
- Publication number
- HUE032197T2 HUE032197T2 HUE13793812A HUE13793812A HUE032197T2 HU E032197 T2 HUE032197 T2 HU E032197T2 HU E13793812 A HUE13793812 A HU E13793812A HU E13793812 A HUE13793812 A HU E13793812A HU E032197 T2 HUE032197 T2 HU E032197T2
- Authority
- HU
- Hungary
- Prior art keywords
- platinum
- complex
- dach
- reaction mixture
- pyrophosphate
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 130
- 150000001875 compounds Chemical class 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 238000000746 purification Methods 0.000 title claims abstract description 18
- 230000015572 biosynthetic process Effects 0.000 title description 22
- 238000003786 synthesis reaction Methods 0.000 title description 22
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 121
- 238000006243 chemical reaction Methods 0.000 claims description 70
- 239000011541 reaction mixture Substances 0.000 claims description 69
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 61
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 51
- 239000000203 mixture Substances 0.000 claims description 48
- 229910052697 platinum Inorganic materials 0.000 claims description 45
- ZZMFAAPZGBNYRP-UHFFFAOYSA-J phosphonato phosphate platinum(4+) Chemical compound [Pt+4].[O-]P([O-])(=O)OP([O-])([O-])=O ZZMFAAPZGBNYRP-UHFFFAOYSA-J 0.000 claims description 42
- 230000008569 process Effects 0.000 claims description 40
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims description 39
- 239000002244 precipitate Substances 0.000 claims description 37
- -1 aliphatic amines Chemical class 0.000 claims description 36
- 229910017604 nitric acid Inorganic materials 0.000 claims description 35
- 235000011180 diphosphates Nutrition 0.000 claims description 31
- 229940048084 pyrophosphate Drugs 0.000 claims description 30
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- 238000003756 stirring Methods 0.000 claims description 24
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- 238000002955 isolation Methods 0.000 description 16
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- VZWGHDYJGOMEKT-UHFFFAOYSA-J sodium pyrophosphate decahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O VZWGHDYJGOMEKT-UHFFFAOYSA-J 0.000 description 12
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- 238000000113 differential scanning calorimetry Methods 0.000 description 1
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- NDBYXKQCPYUOMI-UHFFFAOYSA-N platinum(4+) Chemical compound [Pt+4] NDBYXKQCPYUOMI-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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| US201261651200P | 2012-05-24 | 2012-05-24 |
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| HUE032197T2 true HUE032197T2 (en) | 2017-09-28 |
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| HUE16203851A HUE046327T2 (hu) | 2012-05-24 | 2013-03-15 | Tisztítási eljárás foszfaplatin vegyületekhez |
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| HU (2) | HUE032197T2 (OSRAM) |
| IN (1) | IN2014KN02722A (OSRAM) |
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| SM (2) | SMT201700168T1 (OSRAM) |
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| LT3202769T (lt) * | 2012-05-24 | 2019-12-10 | Phosplatin Therapeutics Llc | Fosfaplatinos junginių gryninimo būdas |
| CA3020166A1 (en) * | 2016-04-06 | 2017-10-12 | Phosplatin Therapeutics Llc | Phosphaplatin liquid formulations |
| TWI791008B (zh) * | 2017-01-06 | 2023-02-01 | 美商弗斯普萊汀治療股份有限公司 | 作為供骨癌或血癌治療用之治療劑的磷酸鉑(phosphaplatin)化合物 |
| EP3679046B1 (en) * | 2017-09-08 | 2023-11-08 | Promontory Therapeutics Inc. | Phosphaplatin compounds as immuno-modulatory agents and therapeutic uses thereof |
| CN113861036B (zh) * | 2021-11-08 | 2024-04-02 | 合肥工业大学 | 一种乙二胺高氯酸铜配合物的制备及用途 |
| US11673904B1 (en) * | 2021-12-09 | 2023-06-13 | L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude | Low pressure process for synthesis of Pt(PF3)4 involving a soluble intermediate and storage of obtained Pt(PF3)4 |
| CN119822568B (zh) * | 2025-02-19 | 2025-08-19 | 扬州宏鑫环保科技有限公司 | 一种高效纯化水制备装置及制备方法 |
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| US4234500A (en) | 1979-03-07 | 1980-11-18 | Engelhard Minerals & Chemicals Corporation | Ethylenediamine platinum(II) and 1,2-diamino-cyclohexane platinum(II) pyrophosphate complexes |
| JP4463274B2 (ja) | 2003-06-27 | 2010-05-19 | 明 小谷 | ビスホスホネート錯体 |
| WO2007085957A1 (en) * | 2006-01-30 | 2007-08-02 | Platco Technologies (Proprietary) Limited | Preparation of platinum (ll) complexes |
| CA2686286A1 (en) * | 2007-05-18 | 2008-11-27 | Tti Ellebeau, Inc. | Transdermal delivery devices assuring an improved release of an active principle through a biological interface |
| DK2173337T3 (da) * | 2007-08-06 | 2014-09-15 | Univ Ohio | Phosphaplatiner og deres anvendelse i behandlingen af cancer, der er resistent over for cisplatin og carboplatin |
| PL2575802T3 (pl) | 2010-06-04 | 2017-04-28 | Ohio University | Fosfaplatyny oraz ich zastosowanie w leczeniu nowotworów |
| EP2763537B1 (en) * | 2011-10-05 | 2018-01-10 | Rathindra N. Bose | Efficient processes for large scale preparation of phosphaplatins antitumor agents |
| LT3202769T (lt) * | 2012-05-24 | 2019-12-10 | Phosplatin Therapeutics Llc | Fosfaplatinos junginių gryninimo būdas |
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