HUE031877T2 - Eljárás vorikonazol és analógjai elõállítására - Google Patents
Eljárás vorikonazol és analógjai elõállítására Download PDFInfo
- Publication number
- HUE031877T2 HUE031877T2 HUE13795583A HUE13795583A HUE031877T2 HU E031877 T2 HUE031877 T2 HU E031877T2 HU E13795583 A HUE13795583 A HU E13795583A HU E13795583 A HUE13795583 A HU E13795583A HU E031877 T2 HUE031877 T2 HU E031877T2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- bis
- chloro
- minutes
- added
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (2)
- é ΛΛ :.4¾ W g! /¾. S* « £, > > >· > -¾ £. à ο. νΐ ,¾ I. Ë ·;: ·;·· I >ι I I ι 1: s· « s f s ® % i: * :ί> '< '·:;·: '·:' £' . " ν>: t t s: 1 a ti' 1 &: s % :< " â % ftf » S £ 0 V :** 4* ST- ’"v *·< 1 I t i £ 1 g; < % :>t-: 4 g # S. * ?? t| χ .§· f f >-/ - « &: «=. '· % X fí' f?· .3- w fi. :¾ ?r g ä 'Z ZZ. ή'·· ·.·«' Λ Æ1 XX s? i;<ï Wi ÍS £ 'Si- 4 x: f: «£ g -fcr t^r‘ ££· >- ci ^ ** y. j η-Í· 1·. ,; '* /.> <*i O; ^ f#> λ: ^ ;î ., ·<· % - 2. .£ i K! f ':. %· I I % « :;:· S ? e Ί ;;: f I i: I f: 11 I I § 1 :?.. £ 3 Si' ?! 2; 2 XV 2. f 1' S 3 « % I f I * r fr: S :â. Sx: I a % S t ^ f: :ïï m t $ ^ ;f 1 ï ÿ 2 ! 1 S I I f Í ί ï I ! i I S •V. S 4 4 4 z- Sx N V.ï. -;.'· î»: ÍV- /¾ .< '..λ . -y-y· yf B* fvi: :r:- ·;,' £, X « {,. £. w ;;; a 1 £ ä i;: i |; R H- § -s a a ··;·. * ·χ - w ?:' “ £, .X .c: & < g: |. -s I I -r ^ I ä Æ f ” f 1, I -f Sr ,y S S: ‘ 1 ï;.· X* 4e/· <1 ·Α· a 5, gCßyBmU SáCCgi sb|íái, sh»! à ksíaiiaá-or a (! «sF« PPh·. ·; «miand ·*.?:«;·>á; vagy Cu F( PFí:·,}; aíaruF :;:í;í S va;
- 7, A a aiikö igcavpmam· bánndyska ::-agí!mj Cjsráy. «M s bpadgip «a (a;· I Cí-SaHk-fk-(iiiiaak íoa;'ni'Kí)t'F«in fbíroaesni : Síiisna; C5-bu-a (írsOgörrksiii)íébFIiÇsaig. :s. .Aa eiôaà :genyyont«k kánueiy ike SMiigií diám. ahol & fS<|yká|Ssa®r iböiJsSiÄ 7; At sî«ko lg«Çyps>uiok b«jrgi§|yjbé saefgg; «bégig, aggka mkeió ivvmm\n;e kb. ·Ά;:Γ SO. Λ a alúaó igánvpomi: hanndyike sasribb Ciam. ahoi a $ç.rmck vorikoaayoi vagy g ®nP«kbi íovabbsiaksikik agy vagy íCbb ÍSpééb«B, Çs így vsgkgBSkgU állnunk «IÇ. 1 ;. vegya iák ameiy a 4 vkjga-5 ·· fém à·# : vs r> í sgi f jm lib iá; $-Huííí '-FvíBigann;|pm:; vagy 74: iíMaé-fi sJO!>4-:Vífblpl gin iá in.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261713761P | 2012-10-15 | 2012-10-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE031877T2 true HUE031877T2 (hu) | 2017-08-28 |
Family
ID=49641810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE13795583A HUE031877T2 (hu) | 2012-10-15 | 2013-10-08 | Eljárás vorikonazol és analógjai elõállítására |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US9388167B2 (hu) |
| EP (1) | EP2906555B1 (hu) |
| JP (1) | JP6180533B2 (hu) |
| KR (1) | KR101706488B1 (hu) |
| CN (1) | CN104884450B (hu) |
| AU (1) | AU2013333534B2 (hu) |
| BR (1) | BR112015007821B1 (hu) |
| CA (1) | CA2888127A1 (hu) |
| CY (1) | CY1118451T1 (hu) |
| DK (1) | DK2906555T3 (hu) |
| ES (1) | ES2615743T3 (hu) |
| HK (1) | HK1213891A1 (hu) |
| HU (1) | HUE031877T2 (hu) |
| IL (1) | IL238209A (hu) |
| IN (1) | IN2015DN02877A (hu) |
| MX (1) | MX358245B (hu) |
| NZ (1) | NZ706764A (hu) |
| PL (1) | PL2906555T3 (hu) |
| PT (1) | PT2906555T (hu) |
| RU (1) | RU2619928C2 (hu) |
| SG (1) | SG11201502237RA (hu) |
| SI (1) | SI2906555T1 (hu) |
| WO (1) | WO2014060900A1 (hu) |
| ZA (1) | ZA201501904B (hu) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ706764A (en) * | 2012-10-15 | 2017-11-24 | Pfizer Ireland Pharmaceuticals | Process for the preparation of voriconazole and analogues thereof |
| CN106432198B (zh) * | 2016-09-08 | 2022-10-21 | 浙江华海药业股份有限公司 | 一种制备伏立康唑拆分中间体的方法 |
| CN112898273B (zh) * | 2021-03-30 | 2022-05-31 | 海南锦瑞制药有限公司 | 伏立康唑的合成方法及应用 |
| CN113185465B (zh) * | 2021-05-26 | 2022-09-27 | 无锡捷化医药科技有限公司 | 一种4-乙基-5-氨基嘧啶的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8819308D0 (en) | 1988-08-13 | 1988-09-14 | Pfizer Ltd | Triazole antifungal agents |
| GB9002375D0 (en) * | 1990-02-02 | 1990-04-04 | Pfizer Ltd | Triazole antifungal agents |
| GB9516121D0 (en) * | 1995-08-05 | 1995-10-04 | Pfizer Ltd | Organometallic addition to ketones |
| CA2590687C (en) * | 2004-12-14 | 2013-09-10 | Dr. Reddy's Laboratories Ltd. | Process for preparing voriconazole |
| US8067591B2 (en) | 2005-01-10 | 2011-11-29 | Agouron Pharmaceuticals, Inc. | Pyrrolopyrazole, potent kinase inhibitors |
| KR100889937B1 (ko) * | 2007-08-06 | 2009-03-20 | 한미약품 주식회사 | 보리코나졸의 제조방법 |
| WO2011045807A2 (en) * | 2009-10-14 | 2011-04-21 | Neuland Laboratories Ltd. | A novel process to manufacture (2r,3s)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl)butan-2-ol |
| CN102827073A (zh) * | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| CN103814020B (zh) * | 2011-06-17 | 2017-07-14 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| EP2900665B1 (en) * | 2012-09-28 | 2018-01-03 | Merck Sharp & Dohme Corp. | Triazolyl derivatives as syk inhibitors |
| NZ706764A (en) * | 2012-10-15 | 2017-11-24 | Pfizer Ireland Pharmaceuticals | Process for the preparation of voriconazole and analogues thereof |
| JO3383B1 (ar) | 2013-03-14 | 2019-03-13 | Lilly Co Eli | مثبطات cdc7 |
-
2013
- 2013-10-08 NZ NZ706764A patent/NZ706764A/en not_active IP Right Cessation
- 2013-10-08 PT PT137955837T patent/PT2906555T/pt unknown
- 2013-10-08 US US14/431,319 patent/US9388167B2/en active Active
- 2013-10-08 SG SG11201502237RA patent/SG11201502237RA/en unknown
- 2013-10-08 JP JP2015536261A patent/JP6180533B2/ja active Active
- 2013-10-08 EP EP13795583.7A patent/EP2906555B1/en active Active
- 2013-10-08 DK DK13795583.7T patent/DK2906555T3/en active
- 2013-10-08 KR KR1020157009365A patent/KR101706488B1/ko active IP Right Grant
- 2013-10-08 IN IN2877DEN2015 patent/IN2015DN02877A/en unknown
- 2013-10-08 AU AU2013333534A patent/AU2013333534B2/en active Active
- 2013-10-08 RU RU2015113741A patent/RU2619928C2/ru active
- 2013-10-08 SI SI201330487T patent/SI2906555T1/sl unknown
- 2013-10-08 MX MX2015004450A patent/MX358245B/es active IP Right Grant
- 2013-10-08 BR BR112015007821-4A patent/BR112015007821B1/pt active IP Right Grant
- 2013-10-08 CA CA2888127A patent/CA2888127A1/en not_active Abandoned
- 2013-10-08 HU HUE13795583A patent/HUE031877T2/hu unknown
- 2013-10-08 CN CN201380052966.3A patent/CN104884450B/zh active Active
- 2013-10-08 ES ES13795583.7T patent/ES2615743T3/es active Active
- 2013-10-08 PL PL13795583T patent/PL2906555T3/pl unknown
- 2013-10-08 WO PCT/IB2013/059202 patent/WO2014060900A1/en active Application Filing
-
2015
- 2015-03-19 ZA ZA2015/01904A patent/ZA201501904B/en unknown
- 2015-04-12 IL IL238209A patent/IL238209A/en active IP Right Grant
-
2016
- 2016-02-19 HK HK16101881.2A patent/HK1213891A1/zh not_active IP Right Cessation
- 2016-04-20 US US15/133,621 patent/US9499520B2/en active Active
-
2017
- 2017-01-18 CY CY20171100072T patent/CY1118451T1/el unknown
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