MX358245B - Proceso para la preparación de voriconazol y análogos del mismo. - Google Patents

Proceso para la preparación de voriconazol y análogos del mismo.

Info

Publication number
MX358245B
MX358245B MX2015004450A MX2015004450A MX358245B MX 358245 B MX358245 B MX 358245B MX 2015004450 A MX2015004450 A MX 2015004450A MX 2015004450 A MX2015004450 A MX 2015004450A MX 358245 B MX358245 B MX 358245B
Authority
MX
Mexico
Prior art keywords
formula
compound
voriconazole
analogues
preparation
Prior art date
Application number
MX2015004450A
Other languages
English (en)
Other versions
MX2015004450A (es
Inventor
James Musgrave Burrell Adam
Mary O'neill Padraig
John Pettman Alan
Original Assignee
Pfizer Ireland Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ireland Pharmaceuticals filed Critical Pfizer Ireland Pharmaceuticals
Publication of MX2015004450A publication Critical patent/MX2015004450A/es
Publication of MX358245B publication Critical patent/MX358245B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención proporciona un proceso para preparar un compuesto de la fórmula: (ver Fórmulas) en donde X, Y, Z, A, B y E son como se definieron en la presente, al hacer reaccionar un compuesto de la fórmula: (ver Fórmula) con un compuesto de la fórmula: (ver Fórmulas) respectivamente, en presencia de un catalizador de metal de transición, un ligando adecuado para uso con el catalizador y un agente de reducción. La invención proporciona también intermediarios novedosos.
MX2015004450A 2012-10-15 2013-10-08 Proceso para la preparación de voriconazol y análogos del mismo. MX358245B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261713761P 2012-10-15 2012-10-15
PCT/IB2013/059202 WO2014060900A1 (en) 2012-10-15 2013-10-08 Process for the preparation of voriconazole and analogues thereof

Publications (2)

Publication Number Publication Date
MX2015004450A MX2015004450A (es) 2015-06-24
MX358245B true MX358245B (es) 2018-08-10

Family

ID=49641810

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015004450A MX358245B (es) 2012-10-15 2013-10-08 Proceso para la preparación de voriconazol y análogos del mismo.

Country Status (24)

Country Link
US (2) US9388167B2 (es)
EP (1) EP2906555B1 (es)
JP (1) JP6180533B2 (es)
KR (1) KR101706488B1 (es)
CN (1) CN104884450B (es)
AU (1) AU2013333534B2 (es)
BR (1) BR112015007821B1 (es)
CA (1) CA2888127A1 (es)
CY (1) CY1118451T1 (es)
DK (1) DK2906555T3 (es)
ES (1) ES2615743T3 (es)
HK (1) HK1213891A1 (es)
HU (1) HUE031877T2 (es)
IL (1) IL238209A (es)
IN (1) IN2015DN02877A (es)
MX (1) MX358245B (es)
NZ (1) NZ706764A (es)
PL (1) PL2906555T3 (es)
PT (1) PT2906555T (es)
RU (1) RU2619928C2 (es)
SG (1) SG11201502237RA (es)
SI (1) SI2906555T1 (es)
WO (1) WO2014060900A1 (es)
ZA (1) ZA201501904B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ706764A (en) * 2012-10-15 2017-11-24 Pfizer Ireland Pharmaceuticals Process for the preparation of voriconazole and analogues thereof
CN106432198B (zh) * 2016-09-08 2022-10-21 浙江华海药业股份有限公司 一种制备伏立康唑拆分中间体的方法
CN112898273B (zh) * 2021-03-30 2022-05-31 海南锦瑞制药有限公司 伏立康唑的合成方法及应用
CN113185465B (zh) * 2021-05-26 2022-09-27 无锡捷化医药科技有限公司 一种4-乙基-5-氨基嘧啶的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8819308D0 (en) 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
GB9516121D0 (en) * 1995-08-05 1995-10-04 Pfizer Ltd Organometallic addition to ketones
CA2590687C (en) * 2004-12-14 2013-09-10 Dr. Reddy's Laboratories Ltd. Process for preparing voriconazole
US8067591B2 (en) 2005-01-10 2011-11-29 Agouron Pharmaceuticals, Inc. Pyrrolopyrazole, potent kinase inhibitors
KR100889937B1 (ko) * 2007-08-06 2009-03-20 한미약품 주식회사 보리코나졸의 제조방법
WO2011045807A2 (en) * 2009-10-14 2011-04-21 Neuland Laboratories Ltd. A novel process to manufacture (2r,3s)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl)butan-2-ol
CN102827073A (zh) * 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
CN103814020B (zh) * 2011-06-17 2017-07-14 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
EP2900665B1 (en) * 2012-09-28 2018-01-03 Merck Sharp & Dohme Corp. Triazolyl derivatives as syk inhibitors
NZ706764A (en) * 2012-10-15 2017-11-24 Pfizer Ireland Pharmaceuticals Process for the preparation of voriconazole and analogues thereof
JO3383B1 (ar) 2013-03-14 2019-03-13 Lilly Co Eli مثبطات cdc7

Also Published As

Publication number Publication date
CA2888127A1 (en) 2014-04-24
CY1118451T1 (el) 2017-07-12
US20150239867A1 (en) 2015-08-27
US20160229842A1 (en) 2016-08-11
CN104884450A (zh) 2015-09-02
IN2015DN02877A (es) 2015-09-11
ES2615743T3 (es) 2017-06-08
WO2014060900A1 (en) 2014-04-24
SG11201502237RA (en) 2015-05-28
PT2906555T (pt) 2017-02-15
JP6180533B2 (ja) 2017-08-16
RU2619928C2 (ru) 2017-05-22
SI2906555T1 (sl) 2017-02-28
PL2906555T3 (pl) 2017-07-31
AU2013333534B2 (en) 2016-04-14
EP2906555A1 (en) 2015-08-19
JP2015536305A (ja) 2015-12-21
EP2906555B1 (en) 2016-12-14
US9388167B2 (en) 2016-07-12
MX2015004450A (es) 2015-06-24
BR112015007821B1 (pt) 2022-02-15
AU2013333534A1 (en) 2015-04-09
RU2015113741A (ru) 2016-12-10
HUE031877T2 (en) 2017-08-28
DK2906555T3 (en) 2017-02-06
IL238209A (en) 2017-07-31
IL238209A0 (en) 2015-06-30
KR20150055009A (ko) 2015-05-20
KR101706488B1 (ko) 2017-02-13
BR112015007821A2 (pt) 2017-07-04
US9499520B2 (en) 2016-11-22
HK1213891A1 (zh) 2016-07-15
ZA201501904B (en) 2017-01-25
CN104884450B (zh) 2017-03-29
NZ706764A (en) 2017-11-24

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