HUE030253T2 - Készítmények és eljárások telomeráz aktivitás növelésére - Google Patents
Készítmények és eljárások telomeráz aktivitás növelésére Download PDFInfo
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- HUE030253T2 HUE030253T2 HUE10778210A HUE10778210A HUE030253T2 HU E030253 T2 HUE030253 T2 HU E030253T2 HU E10778210 A HUE10778210 A HU E10778210A HU E10778210 A HUE10778210 A HU E10778210A HU E030253 T2 HUE030253 T2 HU E030253T2
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Claims (12)
- Készítmények és kijárások tdomeráz aktivitás névmásét« Szabadalmi Igénypontok • í *ahol X: koto, hidroxl éscsoportok közül. választott; ahol X" koto, bidroxh éscsoportok kozta választok; ahol X; keto, hiarozí, éscsoportok közét választott; ahol X\ XX és X" közűi legalább egycsoport; ahol XI vagy R2 egymástól laggcticnül -011(01-¾)¾ és -011(01:¾iOByCtO csoportok körtől választott; és gyógyászati lag elfogadható sói.
- 2, Az 1, igénypont szerinti vegyalet.. ahol X: -Ô€(Ô)CHfXRlCl-!(01:¾p es X'' es X; OR
- 3, Az 1. igén y pont szerinti vegyit le t ahol X!csoport, ahol R! -011(01¾¾ vagy -01-1(01-¾)0100¾ csoportok közül választott.
- 4, Az !, igénypont szerint- vegyüict, ahol X"csoport, ahoi R2 -01-1(0-¾¾ vagy -01:1(01-0)01:001-¾ csoport közöl választott,
- 5, Az 1, Igénypont szentül vegyidet, ahol X'csoport,
- 6, Az I. igénypont szerinti vegyölet, ahol X\ X" vagy X': közül legalább egycsoport ?. Λ/. I, Igénypont szeriüti vegyüleg ahol X: vagy X" közül legalább egy XX:(0)€II('NIiXC:e(GII.)ClisClK csoport.
- 8. Az L Igooypcs'ü szerinti vegyülök ahol Xs -ÖCiOtCblCXtGáCBtCHGCl'GCI'iv csoport, és X2 és X3 -Olt X2' 4X:(0)CH'(Nej)€:e(CIi3)2:. cm^M és X* és X3 Olt vagy X2 XíCiOlClICNIésjCHiCIá^jCliXilX emport és Xs és X3 OH.
- 9. Az 1.. IgéoypotE szenet! vegyükt melyközül, választóik és gjégyászaöiag elfogadható soi. ΙΌ; Az L igeavgom szedőik alábbiak közül választok vegvCileiek: 2-íL)'ümmo~3'meü )-vajsav 6α, iöp-dibidroxi·· ! ?-j 57 J meüj-eâO-2-metü- lerraníTYn~3i3-b észter; m«IIIM!V2“m«áHetf^df0«'teató41i^v^Í3J:44§^i3etil-íie>^áekpÉÍ#ö^llíf©F^^:»I^|~: cik1operstaisj;er?arstren-3B''ii észter; 2-(l3--amín<>--3~rr5etit--vajsaY. 30,1 6 p dllÄoxi-·17-[ 5-(1 ••hidroxi-l-metnet.u)-2-metii” teaÄdröfersB-S··; I] -4,4, ϊ:3>:. ] d-retrsaíetil-tetrsxlekákrdré-elk! ápropaf 9N ! dieIklopeata!a|-:i;#aetr^6ö4I észter; MhwitámrB --meíll-peMinsae 6a, ! 6ß~di hiüroxk ! 7-15-(1 --Mdrext'- b-meüb-etblV-meti ! -tetréhttfrö-ásrataá- tij-4,4, 13, 10]cik!opeata[aj- feaaatred'-3!5i1:: észíer; IHLVarn iao-3~meti i-vajsav. lóp-hidroxi-l 7-| 5-C ! -hi<iroxi-! -metBetO}“2-metiÍ -leirtdddm·-furan-z-U 1-4,4-, ! 3, ! 4-tetr&a;erű-3 ~exo-tetradekák!:dro~e!klo|Z;0:paí7:, ! Ojeikioperuai a] ieaarttreít-6et~ll észter; 2H!.d"^4!Be7-pmü:-peatáBsek f>&42*an&riö*5:Ypetl}:^éataB0Íoxí)~'l#pm Mdtmi-! 743-(1 dndrpxi-- !4,13, tetfzdekaÍ4dro-e|kioprepap,:Ítij;erklöperka|a1lé»e^trgp-3:p^l!::észter;. S-CL^í^áiso-S-m^í^'^say. 3jXSa·· dlhl<feaxj-ÍT-í5^1 -hldrexi-t-meik-eiHí-a-metü-tetra b i dro-1 ur au - 2 -·! ! ] -4:4,13, !4Hetrameditetradekanidro-äk!opropai9,10jcik!operüa[ap tenaotrén:--15p~§ észter; és gfàgyésmiii&g: eirogadiato sóik,0. , Egy 141. igénypontok bádtteiyiké szanrrb vegyidet teiomeráz :akt;vttás növelésére egy sejtett vagy szövetben,
- 12, Vegyidet all, igénypont szerinti allsttnkzé*^: alto! a seit vagy szövet növel; teionreráz aktivitást igénylőként azonosított
- 13, Gyógyászati készítmény, mely az MO. igéttypoáték bánrtelytkeszerinti vegyidétől tartalmaz, egy gyögyászatilag edctgtdható vivöanyagban.
- 14, Gyógyászati készítmény, mely az t -1 (>. igénypontok Mondylke Szerinti vegyük! töpiklds kidaMtasii t&rtalPtazza. 1 $, B H áfás se| ick rcpiikaév aktivitásának or vivo növelésem, melynek sorát; a sei teke! az 1-10, igénypontok bármelyike szerinti vegyulcuel hozzuk érintkezésbe, a sebekben a telorneráz aktivitás növeléséhez hatásos mennyiségben. ib. A. 15. igénypont szerinti: eljárás, ahoi a sejtek egy betegtől nyert expiant séf tele
- 17, Egy 1 " 10. Igénypontok bármelyike szerinti vegyiket séf lek reolikativ kapacitásának növelésére IS, Egy 1-10 igénypontok bármelyike szerinti: vegyinél betegség kezelésében történő alkalmazásra.
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| Application Number | Priority Date | Filing Date | Title |
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| US17930509P | 2009-05-18 | 2009-05-18 |
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| EP (1) | EP2437606B1 (hu) |
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| CA (1) | CA2795981C (hu) |
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| DK (1) | DK2437606T3 (hu) |
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| PT (1) | PT2437606T (hu) |
| SI (1) | SI2437606T1 (hu) |
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| CA2795981C (en) | 2009-05-18 | 2017-06-27 | Geron Corporation | Compositions and methods for increasing telomerase activity |
| WO2015029340A1 (ja) | 2013-08-29 | 2015-03-05 | パナソニック株式会社 | テロメラーゼ活性測定方法 |
| CN108498521B (zh) * | 2017-02-24 | 2020-05-05 | 北京大学 | 环黄芪醇在制备抑制腹主动脉瘤的药物中的应用 |
| TR201714942A2 (tr) * | 2017-10-04 | 2019-04-22 | Ege Ueniversitesi Rektoerluegue | Telomeraz akti̇vatörleri̇ni̇n üreti̇m yöntemi̇ ve bu yöntemle elde edi̇len telomeraz akti̇vatörleri̇ |
| JP7320302B2 (ja) | 2018-10-02 | 2023-08-03 | ステムオン インコーポレーテッド | 細胞のテロメアを伸長させる組成物およびその製造方法 |
| WO2020071652A1 (ko) | 2018-10-02 | 2020-04-09 | 주식회사 스템온 | 세포의 텔로미어를 신장시키는 방법 |
| KR102209234B1 (ko) * | 2018-10-02 | 2021-02-01 | 주식회사 스템온 | 세포의 텔로미어를 신장시키는 방법 |
| CN109342619A (zh) * | 2018-11-14 | 2019-02-15 | 神威药业集团有限公司 | 芪黄通秘软胶囊中黄芪甲苷含量的测定方法 |
| MX2019006749A (es) | 2019-06-10 | 2022-11-28 | Univ Mexico Nac Autonoma | Compuestos activadores de senescencia celular. |
| CN112457362B (zh) * | 2019-09-06 | 2023-09-19 | 上海青东生物科技有限公司 | 一种卤代四环三萜衍生物及其制备与应用 |
| CN117247339B (zh) * | 2023-11-16 | 2024-03-12 | 潍坊富邦药业有限公司 | 一种烷基胺衍生物的制备方法 |
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| Publication number | Publication date |
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| EP2437606A1 (en) | 2012-04-11 |
| HRP20161324T1 (hr) | 2016-11-18 |
| WO2010135247A1 (en) | 2010-11-25 |
| LT2437606T (lt) | 2016-10-10 |
| PT2437606T (pt) | 2016-09-22 |
| EP2437606B1 (en) | 2016-07-27 |
| US8481721B2 (en) | 2013-07-09 |
| ES2596631T3 (es) | 2017-01-11 |
| US9403866B2 (en) | 2016-08-02 |
| CY1118073T1 (el) | 2017-06-28 |
| US20160318973A1 (en) | 2016-11-03 |
| CN102448308B (zh) | 2014-08-06 |
| US9913851B2 (en) | 2018-03-13 |
| SI2437606T1 (sl) | 2016-10-28 |
| US20180280413A1 (en) | 2018-10-04 |
| CN102448308A (zh) | 2012-05-09 |
| CA2795981A1 (en) | 2010-11-25 |
| SMT201600332B (it) | 2016-11-10 |
| JP2012532092A (ja) | 2012-12-13 |
| PL2437606T3 (pl) | 2017-07-31 |
| DK2437606T3 (en) | 2016-09-12 |
| US20100292197A1 (en) | 2010-11-18 |
| EP2437606A4 (en) | 2012-11-28 |
| CN104447936A (zh) | 2015-03-25 |
| JP5830013B2 (ja) | 2015-12-09 |
| US20140088055A1 (en) | 2014-03-27 |
| CA2795981C (en) | 2017-06-27 |
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