HUE028088T2 - Aldóz-1-epimerázt expresszáló mikroorganizmus - Google Patents
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- HUE028088T2 HUE028088T2 HUE09773023A HUE09773023A HUE028088T2 HU E028088 T2 HUE028088 T2 HU E028088T2 HU E09773023 A HUE09773023 A HU E09773023A HU E09773023 A HUE09773023 A HU E09773023A HU E028088 T2 HUE028088 T2 HU E028088T2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
- C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/24—Preparation of compounds containing saccharide radicals produced by the action of an isomerase, e.g. fructose
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
- C12P7/08—Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate
- C12P7/10—Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate substrate containing cellulosic material
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
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Claims (3)
- IvXPEESSZÁLÓ ^HKR<)OR<I4XïZXPjS SÍM b Malmi ígMypöftiok J.* Transzformált nnkroorganizmus, amely képes (íj aidópentózt magasabb arányban ketopeniózza alaki-tatai, mint az ekvivalens miknxngantztntts a transzformálás előtt; és/vagv (ti) gyorsabb növekedésre aldopenióz jelenlétében, mint az ekvivalens mikroorganizmus a transzformálás előtt ahol a mikroorganizmus endogén e.kkk~} -epimet azt kódoló mrklcaukl-sxefcvenciához működőképesen kapcsolt beieroióg promóterí tartalmaz és/vagy ahol a mikroorganizmus exogén akióz-i-epimeràxt kódoló «ukkerid-szekveociát expesszábá az aldóz-li-epimerázt, és a nnkmorgMiznms tartalmaz t^y vagy: több, áldópentÓK kefopeníózzá aiéliÂâbsn sxorepöt játszó poli-peptide; kódoló egy vagy több wpgéx péMáMkxM^mtemmíái, ahol az egy v*Ä poiípepüíl aKlÖ-ívlil poiípeptidek alkotta csoportból választott: (i) xtlóz-ízotnerázy. ( i i) arab i í tóz-i zom® áíg (ül ) D-íixóz- izomét áz, (iv) vjbóz.-izotncrdz. (v> xilóz-redíikííVz ésxilulóiote<htktÉ|:lpöi1biigác#|a,· tvi) arahinöz-róduktáz, L-amíéíobd-débídrogeöáz.lekiiniéz-íeduktáz ésÍbxiiniózöMtMáz kontbmációja» ivíl): P-llxóbRíeduktáz és í^^abímtol-éiiy^OganÁK kombinációja és/vagv a nnkrporgatnzinus tartalmaz a kővetkezőkből álló csoportból választott egy vagyjöbb énziípét kódplö légalább egy ágprossziós vektort: ribuiokisáz. ribií1ózdbszfát-4-epimet'áz, xihdokimiz, ÖstibuiokináZi rihöz-S-foszßfo izometáz, nbulóz-Mbszfát.-epiweráz, íntnszakioiáz, transzketoláz és a pentóz-ioszíát anyagcseréin bármely másik enzime, és/vagy a tnikroorganizmus tartalmaz a következőkből áíió csoportból választott agy vagy több enzimet kódoló egy vagy több i^kl^tiâ-s^kver^éb^jœÂdôképçse« kötött heteto!ő| ppmőtert: xiloiokini«» -OxÄl^MÄi-iibóz-S-bssziat-izytneráz, ribolózP-'íoskKkepimeráz, transzaldolàz, transzMteiáz és reüt -bármely másik enzimét «mély feaiasáfá s mtktnorganizmns a promóter nélküli skjáf&ta- aÂéifgtoùât·-mussaí Összehasonlítva fokozottan expresszàija az egy vagy több enzimet, és ahol a mikroorganizmus genetikailag mödosilott éiesztó.2. Az I. igénypont szerinti miksoorgaoizmus, ahol az aldopenióz a xiíóz, arabinóz, ribóz és JíxÓK alkotta csoportból választott. 3» Az előző igéíVypontokMtanclyike szerinti níifeöt^anízmöSj áKíí a kettspeotóz xtiulöz, 4, îâôkôfiiffigat»0i:f4stis^ét^^iô»tôk^«««IpeëîmÂto®^pôt^aôst'&ilÂltô». 5» Tenyészíőközeg. Mely 1-3. igénypontok bármelyike szerinti mikmorgäiüznütst tartalmaz. b, Eljárás tR^zfppg^%ip.kpborgatiizí«öit előállításira,, amely képes (>} {»Äs^rsdetä 'vegyülni; té^sél*· :n|;:^vagy-(i0.aWépc3rté#.^^áfeb arányban ketoperttózzá aiakííanipmM az ekvivalens mikroorganizmus a tfonszforntálás előtt és/vagy Ilii j gyorsabb növekedésre aldopenioz jeiePlétében, mint az ekvivalens mikroorganizmus a transzformálás előd. amely eljárás magfe: foglalja a írapazformlásár kódoló nukleotld- szdrvenc iàvai ékv&gy Meföfog promptért«], amely promoter képessé teszi a nnktoorganizmtisí endogén aldóz-Î -epinunáztsak a prompter nélküli, azoaös mikroorganizmussal össxchasetslítva fokozol: expressmópa, ahoi a trariszformáh aakroorpaizmus képes aid.opentozt pemóxeredetü vegyüietté alakítónk ás a mikroorganizmus tartalmaz egy vagy több, aldópentóz ketopentózzá alakításában szerepet játszó pólipeptkiet kódoló egy vagy több «x<^ifeîîp>li«ôk'îe»ïii#iS^ekv«^ét, alto! m egy vagy íobÍypöÍl|aíp£i4 az (j)-> ívű) polípeptkkk alkotta eseportbói választott: fi) xiioz-izomerlx, fii)· arahisiöz-ixometáz, (isi) D-Uxóz-ixomeráz, (tv) nbóx-izoméfáz>: (yj; 'Íí:ü6^födslíi^#'&iötó«-íedxtí«áz kombinációja, (yi) Ji.»;xsl«Sö»-í'eáöfet&5 és fo-xifolóz-redttkíéz komhlnáiSója, (vii) Ö-lixőz-íedukiáz «s D-arabinifobdeiddropnáx kombinációja ésÁmgy a mikroöígaidzmus famlmaz a köveíkszőkbőiállé esoportbói választott egy vagy több enzimei kódoló legalább ágy expressziés vektort: tfonfoklnáz., rífealdZ'iesKÍát'á-epioieráx, xüulökiaáz, D-ribolöklbáz, rilfox-S-fosziar-izometáz, fibtó^fcs?iábep8»tó,. ttmiszaldÄ, banszkstoMz 4» & pentóz-fosztlf íibpgeserenl bármely másik enzime, és/vagy 8 mikroorganizmus a kővetkezőkből allé csoportból! Vl$9§«fotf égy. vagy több enzimet kódoló egy vagy több nukleoíid-szekveodához működőkópeseo kötött heterológ promptem;! leit transzformálva: xiJulokináz, D-nbuiokiaáz, nbóz-ó-foszfiitAzemeráz, nbiiiüz-S-fosxiat-epimefáx, iransxaldoláz, ttnnsxkekdáx és a penloz-foszfát anyagcserééi bármely másik enzime; amely hatására a mikroorganizmus a promoter nélküli ekvivalens nákroorgardzmnssal összehasonlítva fokozottan expresszáija az egy vagy több enzimet, és ahol a mikroorganizmus mmszformáii élesztő, 7, A 6. igénypont szerinti eljárás, ahol az aidóx-1-epimerázt kódoló >mkÍeot!<bszekvencia azt kódoló expresszié« vektorban van.
- 8, Eljárás pemózeredető vegyölet eioSííitssára, ahol az eljárás tartalípazza 1-3. igénypontok bármelyike szerinti míkroorgmriznms tenyésztését tsnyészközegben,
- 9, Eljárás bioüzemanyag eíoálsMsám ahol m eprás íatlalmaxxó i*f> igéaypmiiek bármelyike szerinti mikroorganizmus tenyésztéséi tenyászközegben, Hk A 9, igénypbhf s;fonMi ejjáfas, afiáéi^ t«nÄä»: t0VábM :«iiöö?^^yág:tíiiptiásii: a tartott* közegből. £& '14. igénypontok feÉrö#lfce ^ntôsseteâ^tswiék eíéliltásá- ra. 1¾ 1-3, igény^bisâ'btei^fe szerinti mikrootgsniznms aíkalmazásálPbiizemányag előállítására,
Applications Claiming Priority (2)
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| GBGB0812318.4A GB0812318D0 (en) | 2008-07-04 | 2008-07-04 | Microorganism |
| US8153508P | 2008-07-17 | 2008-07-17 |
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| US (1) | US8809019B2 (hu) |
| EP (1) | EP2310499B1 (hu) |
| CN (1) | CN102144029B (hu) |
| AU (1) | AU2009265115B2 (hu) |
| BR (1) | BRPI0915704B1 (hu) |
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| PL (1) | PL2310499T3 (hu) |
| WO (1) | WO2010001363A1 (hu) |
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| GB0822937D0 (en) * | 2008-12-16 | 2009-01-21 | Terranol As | Microorganism |
| CN103562216A (zh) * | 2011-01-21 | 2014-02-05 | 伊利诺伊大学董事会 | 纤维糊精和β-D-葡萄糖的增强型发酵 |
| CN112004930A (zh) * | 2018-03-27 | 2020-11-27 | 巴斯夫欧洲公司 | 木糖代谢酵母 |
| CN113330119B (zh) * | 2018-10-10 | 2024-07-12 | 生物领先公司 | 使用源自干酪乳杆菌的半乳糖变旋酶基因启动子用于组成型高表达的表面表达载体及其用途 |
| CN115981384B (zh) * | 2023-02-07 | 2023-09-22 | 淮阴工学院 | 一种智能生物质orc蒸发压力控制设备 |
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| DE3730712A1 (de) | 1987-09-12 | 1989-03-23 | Merck Patent Gmbh | Expression von mutarotase |
| ES2068586T5 (es) | 1990-05-09 | 2004-12-01 | Novozymes A/S | Una preparacion de celulasa que comprende una enzima endoglucanasa. |
| BRPI0306740B1 (pt) | 2002-01-23 | 2019-08-27 | C5 Yeast Company B V | célula hospedeira transformada com um construto de ácido nucléico e processo para a produção de etanol |
| SE0200855D0 (sv) | 2002-03-19 | 2002-03-19 | Forskarpatent I Syd Ab | SACCHAROMYCES cerevisiae MUTANT |
| SE0302421D0 (sv) * | 2003-09-11 | 2003-09-11 | Forskarpatent I Syd Ab | Construction of new xylose utilizing Saccharomyces cerevisiae strain |
| SE0400815D0 (sv) * | 2004-03-26 | 2004-03-26 | Forskarpatent I Syd Ab | Traits in recombinant xylose-growing saccharomyces cerevisiae strains using genome-wide transcription analysis |
| WO2005113774A2 (en) | 2004-05-19 | 2005-12-01 | Biotechnology Research And Development Corporation | Methods for production of xylitol in microorganisms |
| BRPI0513437A (pt) | 2004-07-16 | 2008-05-06 | Univ Delft Tech | célula hospedeira eucariótica com a capacidade para isomerizar diretamente xilose em xilulose, e, processos para produzir etanol e um produto de fermentação |
| CA2602084C (en) * | 2005-03-11 | 2016-08-09 | Forskarpatent I Syd Ab | Arabinose- and xylose-fermenting saccharomyces cerevisiae strains |
| CA2664646C (en) | 2006-10-02 | 2016-09-20 | Dsm Ip Assets B.V. | Metabolic engineering of arabinose- fermenting yeast cells |
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| GB2473586B (en) | 2011-12-21 |
| GB201100689D0 (en) | 2011-03-02 |
| BRPI0915704A2 (pt) | 2017-07-04 |
| ES2587836T3 (es) | 2016-10-27 |
| DK2310499T3 (da) | 2016-08-22 |
| MX2010014529A (es) | 2011-02-25 |
| CN102144029A (zh) | 2011-08-03 |
| WO2010001363A1 (en) | 2010-01-07 |
| EP2310499B1 (en) | 2016-05-04 |
| AU2009265115A1 (en) | 2010-01-07 |
| EP2310499A1 (en) | 2011-04-20 |
| PL2310499T3 (pl) | 2016-12-30 |
| BRPI0915704B1 (pt) | 2020-11-03 |
| AU2009265115B2 (en) | 2014-11-06 |
| US20110099892A1 (en) | 2011-05-05 |
| CA2729871A1 (en) | 2010-01-07 |
| GB0812318D0 (en) | 2008-08-13 |
| CA2729871C (en) | 2018-04-10 |
| CN102144029B (zh) | 2013-03-13 |
| GB2473586A (en) | 2011-03-16 |
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