HUE027112T2 - Eljárás vérlemezkék elõállítására - Google Patents

Eljárás vérlemezkék elõállítására Download PDF

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Publication number
HUE027112T2
HUE027112T2 HUE09768362A HUE09768362A HUE027112T2 HU E027112 T2 HUE027112 T2 HU E027112T2 HU E09768362 A HUE09768362 A HU E09768362A HU E09768362 A HUE09768362 A HU E09768362A HU E027112 T2 HUE027112 T2 HU E027112T2
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HU
Hungary
Prior art keywords
vwf
platelets
platelet
mks
cells
Prior art date
Application number
HUE09768362A
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English (en)
Inventor
Dominique Baruch
Elisabeth Cramer-Borde
Claire Dunois-Larde
Original Assignee
Inserm (Institut Nat De La Sante Et De La Rech Medicale)
Assist Publique Hôpitaux De Paris
Univ Paris Descartes
L'universite De Versailles Saint Quentin En Yvelines
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Inserm (Institut Nat De La Sante Et De La Rech Medicale), Assist Publique Hôpitaux De Paris, Univ Paris Descartes, L'universite De Versailles Saint Quentin En Yvelines filed Critical Inserm (Institut Nat De La Sante Et De La Rech Medicale)
Publication of HUE027112T2 publication Critical patent/HUE027112T2/hu

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0644—Platelets; Megakaryocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/145—Thrombopoietin [TPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (5)

  1. Eljárás vérámnezkék előállítására Szakaialmi igénypsatok L Ex e^êris xèrlemsakik előállítására, nrelyppk -mást éret laegakmoeMk spts^raó- ját áramoltatunk, mely a vérlemezke képződésre megfelelő nyírási értekei biztosit a GPib-hez kötődő Von Wi 1 iebrand faktorral (VWF), vagy armak íragmensével vagy variánsával vagy analógjával borított szilárd lázi son.
  2. 2. Az L igénypont szerinti eljárás, ahol aVWF fragmense vagy variánsa vagy analógja a VWF 52/48-kDa tnptikas tiagmense; Siapbyloeoectís aureus V-S proieázza! emésztett VWF: terápiás alkalmazásra szolgáló VWF köneeníráttmiok és a 2M típusú von Willebrand betegségért ieleles ¥ W? mutánsok közül választod.
  3. 3. Az 1. vágy 2. igénypont szerinti eljárás, ató:márdtf«ié^ten-oeí^tó: íégaláli !β V1 nyÉóerőnek: tesszük ki.
  4. 4. Az !. igénypont szerinti eljárás, ahol a tenyészetben asejtkeneenirieie CIS és 4xlOc/mL közötti,: vagy legalább 4x Ib¥m'L
  5. 5. Eljárás proplatelet-képzőciés elösegitésére* mélynél során érett ntegákarioeitákat áramoltatunk nylrőero jeleplit#^p':epr''àid^là$iikl»a#^y.Âibâz áramlási kamra YWF-el borított fénék-ialat tartalmaz.
HUE09768362A 2008-12-04 2009-12-04 Eljárás vérlemezkék elõállítására HUE027112T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08305881 2008-12-04

Publications (1)

Publication Number Publication Date
HUE027112T2 true HUE027112T2 (hu) 2016-08-29

Family

ID=40756593

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE09768362A HUE027112T2 (hu) 2008-12-04 2009-12-04 Eljárás vérlemezkék elõállítására

Country Status (17)

Country Link
US (1) US9012221B2 (hu)
EP (1) EP2352815B1 (hu)
JP (1) JP5863459B2 (hu)
CN (2) CN102300984B (hu)
AU (1) AU2009324042B2 (hu)
BR (1) BRPI0922710A8 (hu)
CA (1) CA2745268C (hu)
CY (1) CY1117452T1 (hu)
DK (1) DK2352815T3 (hu)
ES (1) ES2569610T3 (hu)
HK (1) HK1165491A1 (hu)
HR (1) HRP20160404T8 (hu)
HU (1) HUE027112T2 (hu)
PL (1) PL2352815T3 (hu)
SI (1) SI2352815T1 (hu)
SM (1) SMT201600131B (hu)
WO (1) WO2010063823A1 (hu)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012231207B2 (en) * 2011-03-18 2016-06-23 New York Blood Center, Inc. Megakaryocyte and platelet production from stem cells
GB201210857D0 (en) 2012-06-19 2012-08-01 Cambridge Entpr Ltd Transcription factor mediated programming towards megakaryocytes
EP2934555B1 (en) 2012-12-21 2021-09-22 Astellas Institute for Regenerative Medicine Methods for production of platelets from pluripotent stem cells
CN105308452B (zh) * 2013-01-03 2018-02-06 布里格姆女子医院有限公司 仿生流体处理的系统和方法
KR102331655B1 (ko) * 2013-11-19 2021-11-30 플라토드 혈소판 생산용 유체 장치
JP2015181406A (ja) * 2014-03-24 2015-10-22 東レエンジニアリング株式会社 血小板産生装置および血小板産生方法
AU2015241133B2 (en) * 2014-03-31 2019-11-28 Brigham And Women's Hospital, Inc. Systems and methods for biomimetic fluid processing
WO2015179301A1 (en) * 2014-05-19 2015-11-26 Eleftherios Papoutsakis Megakaryocytic particles and microparticles for cell therapy & fate modification of stem and progenitor cells
WO2016180918A1 (en) 2015-05-12 2016-11-17 Platod Combination of pharmacological and microfluidic features for improved platelets production
AU2016278335B2 (en) * 2015-06-16 2021-10-28 Kyoto University Method for producing highly functional platelets
JP6859351B2 (ja) * 2015-09-08 2021-04-14 ブリガム・アンド・ウイミンズ・ホスピタル・インコーポレイテッド 血小板を産生するためのシステムおよび方法
CA2998463A1 (en) * 2015-09-15 2017-03-23 Megakaryon Corporation Method for manufacturing platelets by rotary stirring culture method
KR102689261B1 (ko) * 2015-10-14 2024-07-30 가부시키가이샤 메가카리온 정제 혈소판의 제조 방법
RU2741871C2 (ru) * 2015-11-02 2021-01-29 Мегакарион Корпорейшн Способ получения тромбоцитов с помощью устройства для возвратно-поступательного перемешивания
WO2018237061A1 (en) * 2017-06-20 2018-12-27 Northwestern University PLATELET MICROFLUIDIC BIOREACTOR DEVICE AND SYSTEMS
KR102592176B1 (ko) 2018-01-05 2023-10-20 플레이틀렛 바이오제네시스, 인크. 거핵구 생성을 위한 조성물 및 방법
FR3101885A1 (fr) * 2019-10-11 2021-04-16 Etablissement Français Du Sang Systeme pour la liberation de plaquettes et procede de liberation de plaquettes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4344560A (en) * 1979-11-02 1982-08-17 Asahi Kasei Kogyo Kabushiki Kaisha Container, apparatus and method for separating platelets
DE19956156A1 (de) 1999-11-23 2001-06-13 Univ Eberhard Karls Verfahren zur Aufbereitung eines Präparates von Thrombozyten und Thrombozytenpräparat
EP1369128A1 (en) * 2002-06-07 2003-12-10 Procorde GmbH Inhibitors of glycoprotein VI and their therapeutic use
EP1807507A2 (en) * 2004-11-01 2007-07-18 Wisconsin Alumni Research Foundation Platelets from stem cells
ES2347908T3 (es) * 2005-01-14 2010-11-25 Ablynx N.V. PROCEDIMIENTOS Y ENSAYOS PARA DISTINGUIR ENTRE DIFERENTES FORMAS DE ENFERMEDADES Y TRASTORNOS CARACTERIZADOS POR LA TROMBOCITOPENIA Y/O POR LA INTERACCIÓN ESPONTÁNEA ENTRE EL FACTOR DE VON WILLEBRAND (vWF) Y LAS PLAQUETAS.
JP5419076B2 (ja) * 2008-05-15 2014-02-19 旭化成メディカル株式会社 血小板の誘導方法

Also Published As

Publication number Publication date
BRPI0922710A2 (pt) 2016-01-05
CA2745268A1 (en) 2010-06-10
SMT201600131B (it) 2016-07-01
AU2009324042B2 (en) 2014-12-04
JP2012510804A (ja) 2012-05-17
CA2745268C (en) 2018-11-13
AU2009324042A1 (en) 2011-07-07
WO2010063823A1 (en) 2010-06-10
HRP20160404T1 (hr) 2016-06-17
US9012221B2 (en) 2015-04-21
US20120014933A1 (en) 2012-01-19
SI2352815T1 (sl) 2016-10-28
DK2352815T3 (en) 2016-05-17
BRPI0922710A8 (pt) 2018-06-26
CN102300984B (zh) 2014-06-04
PL2352815T3 (pl) 2016-07-29
CN102300984A (zh) 2011-12-28
EP2352815B1 (en) 2016-02-10
JP5863459B2 (ja) 2016-02-16
HK1165491A1 (en) 2012-10-05
HRP20160404T8 (hr) 2016-07-01
CN104087552A (zh) 2014-10-08
EP2352815A1 (en) 2011-08-10
CY1117452T1 (el) 2017-04-26
ES2569610T3 (es) 2016-05-11

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