HUE025949T2 - Izofoszforamid-mustár sói és annak analógjai - Google Patents
Izofoszforamid-mustár sói és annak analógjai Download PDFInfo
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- HUE025949T2 HUE025949T2 HUE08727299A HUE08727299A HUE025949T2 HU E025949 T2 HUE025949 T2 HU E025949T2 HU E08727299 A HUE08727299 A HU E08727299A HU E08727299 A HUE08727299 A HU E08727299A HU E025949 T2 HUE025949 T2 HU E025949T2
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- 229960000281 trometamol Drugs 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
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- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- HHJUWIANJFBDHT-KOTLKJBCSA-N vindesine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(N)=O)N4C)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 HHJUWIANJFBDHT-KOTLKJBCSA-N 0.000 description 1
- 229960004355 vindesine Drugs 0.000 description 1
- GBABOYUKABKIAF-IELIFDKJSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-IELIFDKJSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Seasonings (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Oil, Petroleum & Natural Gas (AREA)
Claims (10)
- Szabadalmi igénypontok 1 * Kristályos vegyület amely (I) képletü IRM analógot foglal magábanahol a képletben A* jelentése egy hidroxilezeit alifás amin savas konjugáitja; és X és Y jelentése egymástól függetlenül távozó csoport, amelyet a halogének közül választunk; az IRM analóg és az ammóniurn származékok 1:1 arányban vannak jelen; és a kristályos vegyidet olvadáspontja 103 - 1Ö8':'C
- 2. Az 1, igénypont szerinti kristályos vegyidet, A* jelentését a következők savas konjugáltjai közül választjuk: mono-, bisz- vagy trisz-(2-hldfOxi~etil)-amín S-hidroxi-terc-butif-amin, N,N-dlmetsl-N~(2~hídroxl-etll)-amln, és trlsz(hidröxi~metíf-ami~ no-metán (Tris), adott esetben Tris.
- 3. Az 1. vagy 2. igénypont szerinti kristályos vegyület ahol X és Y jelentése azonos, mint például mind X és mind Y jelentése Cl. 4« Az 1, igénypont szerinti kristályos vegyület, ahol a kristályos vegyület olvadáspontja 105 -106*0.
- 5, Az 1-4, igénypontok bármelyike szerinti kristályos vegyület, ahol a kristályos vegyület egy kristály egyetlen polimorf alakja.
- 6, Az 1-5. igénypontok bármelyike szerinti kristályos vegyület, ahol a vegyület stabilis szobahőmérsékleten víz jelenlétében legalább egy napig, adott esetben legalább három napig, mint például legalább hat napig,
- 7, Eljárás gyógyszerkészítmény előállítására, amely magában foglalja az 1-6. igénypontok bármelyike szerinti kristályos vegyület feloldását egy sőoldatban. ahol adott esetben a) az oldat stabilis szobahőmérsékleten legalább 120 peroíg; b) a kristályos vegyület oldékonysága legalább 50 mg/ml; és/vagy c) a gyógyszerkészítmény orális, topikális, transzdermáiis, vagy parenterálís adagoláshoz, mint például parenterálís adagoláshoz vagy orális adagoláshoz formuláit.
- 8, Az 1-6. igénypontok bármelyike szerinti kristályos vegyüíeí a) egy hiperproliferatív rendellenesség:, mint például akut leukémia, krónikus leukémia, polioitémia vera, iimfóma, Hodgkin kór, nem-Rodgkin limloma, mieióma multiplex, Waldenström makrogíobulinémia, nehézlánc betegség, mielodiszpláziás szindróma, hajas sejtes leukémia, mielodíszpiázia, szakómák és karcinómák, szinovioma, mezotelíoma, Ewing-tumor, leiomioszarkóma, rabdomloszarkóma, vastagbél karcinóma, a nyirok rosszindulatú betegségei, hasnyálmírigyrák, mell· rák, tüdőrákok, petefészekrák, prosztatarák, rosszindulatú májsejt daganat, lap-hámsejtes rák, bazálsejtes karcinóma, mirigysejtes karcinóma. verejtékmirigy karcinóma, faggyúmshgy karcinóma, papilláris karcinóma, papilláris adenokarcinómák, meduliáris karcinóma, tüdő karcinóma, vesesejt karcinóma, hepatőma, epevezeték karcinóma, korlokareinóma, Wilm-tumor. méhnyakrák, hererák, hólyagrák és CNS tumorok, vagy b) egy CPA rezisztens állapot kezelésére történő alkalmazásra.
- 9, Orális adagoláshoz kialakított gyógyszerkészitmény, amely egy gyógy-szerészetileg elfogadható nigftot vagy kötőanyagot és egy 1-6. igénypontok bármelyike szerinti vegyületet foglal magában.
- 18. Egy 1-6. igénypontok bármelyike szerinti vegyület alkalmazása egy kemoterápiás szerrel együtt adagolva a kemoterápiás hatás hatékonyságának javítására szolgáló gyógyszerkészítmény előállítására.
- 11. Egy 1-6. igénypontok bármelyike szerinti vegyület egy kemoterápiás szerrel együtt adagolva a kemoterápiás szer hatékonyságának javítására szolgáló alkalmazásra.
Applications Claiming Priority (4)
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| US92214807P | 2007-04-06 | 2007-04-06 | |
| US92736307P | 2007-05-02 | 2007-05-02 | |
| US93491407P | 2007-06-15 | 2007-06-15 | |
| US123707P | 2007-10-30 | 2007-10-30 |
Publications (1)
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| HUE025949T2 true HUE025949T2 (hu) | 2016-05-30 |
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| HUE08727299A HUE025949T2 (hu) | 2007-04-06 | 2008-04-04 | Izofoszforamid-mustár sói és annak analógjai |
Country Status (22)
| Country | Link |
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| US (2) | US8604007B2 (hu) |
| EP (2) | EP2581367B1 (hu) |
| JP (1) | JP5659010B2 (hu) |
| KR (3) | KR20150139620A (hu) |
| CN (2) | CN102942589B (hu) |
| AU (1) | AU2008236684B2 (hu) |
| BR (1) | BRPI0809999A2 (hu) |
| CA (1) | CA2684747A1 (hu) |
| CY (1) | CY1116596T1 (hu) |
| DK (2) | DK2155682T3 (hu) |
| ES (1) | ES2547302T3 (hu) |
| HU (1) | HUE025949T2 (hu) |
| IL (2) | IL201424A (hu) |
| MX (1) | MX2009010820A (hu) |
| NZ (1) | NZ580341A (hu) |
| PL (1) | PL2155682T3 (hu) |
| PT (2) | PT2155682E (hu) |
| RU (1) | RU2527531C2 (hu) |
| SI (1) | SI2155682T1 (hu) |
| TW (2) | TWI490226B (hu) |
| WO (1) | WO2008124097A2 (hu) |
| ZA (1) | ZA200907722B (hu) |
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| PT1805192E (pt) * | 2004-10-25 | 2013-01-23 | Dekk Tec Inc | Sais de mostarda de isofosforamida e análogos da mesma como agentes antitumorais |
| US7964583B2 (en) * | 2006-02-17 | 2011-06-21 | Ziopharm Oncology, Inc. | Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents |
| RU2527531C2 (ru) | 2007-04-06 | 2014-09-10 | Зайофарм Онколоджи, Инк. | Соли изофосфорамидного иприта и его аналогов |
| WO2010014841A1 (en) * | 2008-07-31 | 2010-02-04 | Ziopharm Oncology, Inc. | Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof |
| EP2401285B1 (en) * | 2009-02-24 | 2012-10-10 | Dekk-Tec, Inc. | Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents |
| US20130196000A1 (en) * | 2012-01-31 | 2013-08-01 | Ziopharm Oncology, Inc. | Combination therapy including isophosphoramide mustard, analogs, or salts thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
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| SU427945A1 (ru) | 1972-07-24 | 1974-05-15 | Институт элементоорганических соединений | СПОСОБ ПОЛУЧЕНИЯа ПОЛИФТОРАЛКИЛЗАМЕЩЕННЫХБЕНЗИЛДИХЛОРФОСФАТОВ |
| JPS5159886A (hu) | 1974-11-20 | 1976-05-25 | Shionogi Seiyaku Kk | |
| US4537883A (en) * | 1982-11-12 | 1985-08-27 | Mead Johnson & Company | Lyophilized cyclophosphamide |
| US5091552A (en) | 1986-06-30 | 1992-02-25 | Board Of Regents, The University Of Texas System | Novel antitumor aldophosphamide analogs |
| US5055459A (en) * | 1986-06-30 | 1991-10-08 | Board Of Regents, The University Of Texas | Selective elimination of malignant cells from bone marrow by bis (acyloxy) propylphosphoramidates |
| US5204335A (en) * | 1986-10-31 | 1993-04-20 | Asta Pharma Aktiengesellschaft | Ifosfamide lyophilisate and process for its preparation |
| JPH07505887A (ja) | 1992-04-17 | 1995-06-29 | アボツト・ラボラトリーズ | タキソール誘導体 |
| US5468499A (en) * | 1993-11-15 | 1995-11-21 | Ohio State University | Liposomes containing the salt of phosphoramide mustard and related compounds |
| US5659061A (en) * | 1995-04-20 | 1997-08-19 | Drug Innovation & Design, Inc. | Tumor protease activated prodrugs of phosphoramide mustard analogs with toxification and detoxification functionalities |
| DK0795334T3 (da) * | 1996-03-12 | 2006-06-06 | Sanofi Aventis Deutschland | Nye prodrugs til behandling af tumorer og betændelsessygdomme |
| US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| AU773061B2 (en) | 1999-05-24 | 2004-05-13 | Southern Research Institute | Isophosphoramide mustard analogs and use thereof |
| CO5280224A1 (es) | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
| MXPA02010089A (es) | 2000-04-13 | 2004-08-19 | Hsc Res Dev Lp | Compuestos para modular la proliferacion celular. |
| EP1506203B1 (en) | 2002-08-23 | 2007-01-03 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| PT1805192E (pt) * | 2004-10-25 | 2013-01-23 | Dekk Tec Inc | Sais de mostarda de isofosforamida e análogos da mesma como agentes antitumorais |
| RU2527531C2 (ru) | 2007-04-06 | 2014-09-10 | Зайофарм Онколоджи, Инк. | Соли изофосфорамидного иприта и его аналогов |
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