HU9902376D0 - Novel process for producing n-(1,1-dimethyl)-4-[[s'-ethoxi-4-cis-[2-(4-morpholino)-ethoxi]-2'-oxospiro[cyclohexane-1,3'-[3h]indole]-1'(2'h)yl]-sulfonyl]-3-methoxybenzamide and its salts - Google Patents

Novel process for producing n-(1,1-dimethyl)-4-[[s'-ethoxi-4-cis-[2-(4-morpholino)-ethoxi]-2'-oxospiro[cyclohexane-1,3'-[3h]indole]-1'(2'h)yl]-sulfonyl]-3-methoxybenzamide and its salts

Info

Publication number
HU9902376D0
HU9902376D0 HU9902376A HUP9902376A HU9902376D0 HU 9902376 D0 HU9902376 D0 HU 9902376D0 HU 9902376 A HU9902376 A HU 9902376A HU P9902376 A HUP9902376 A HU P9902376A HU 9902376 D0 HU9902376 D0 HU 9902376D0
Authority
HU
Hungary
Prior art keywords
ethoxi
salts
dimethyl
oxospiro
methoxybenzamide
Prior art date
Application number
HU9902376A
Other languages
English (en)
Inventor
Csaba Goenczi
Gergely Heja
Lajos Nagy
Eva Csikos
Tiborne Szomor
Gyoergyne Szvoboda
Csutor Andrea Santane
Peter Sarosi
Dr Takacs Tuende Eroesne
Judit Halasz
Istvan Hermecz
Csilla Majlath
Kalman Simon
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Priority to HU9902376A priority Critical patent/HUP9902376A3/hu
Publication of HU9902376D0 publication Critical patent/HU9902376D0/hu
Priority to CNB008103143A priority patent/CN1174969C/zh
Priority to SI200030399T priority patent/SI1196381T1/xx
Priority to PCT/HU2000/000078 priority patent/WO2001005791A2/en
Priority to BR0012425-7A priority patent/BR0012425A/pt
Priority to JP2001511450A priority patent/JP2003505389A/ja
Priority to PL00352465A priority patent/PL195787B1/pl
Priority to SK46-2002A priority patent/SK285818B6/sk
Priority to AT00949822T priority patent/ATE264842T1/de
Priority to CZ2002145A priority patent/CZ2002145A3/cs
Priority to US10/030,647 priority patent/US6600039B1/en
Priority to MXPA01013344A priority patent/MXPA01013344A/es
Priority to CA002378087A priority patent/CA2378087C/en
Priority to AU63081/00A priority patent/AU6308100A/en
Priority to HU0201548A priority patent/HUP0201548A3/hu
Priority to EP00949822A priority patent/EP1196381B1/en
Priority to DE60010083T priority patent/DE60010083T2/de
Priority to ES00949822T priority patent/ES2216927T3/es
Publication of HUP9902376A2 publication Critical patent/HUP9902376A2/hu
Priority to HR20020142A priority patent/HRP20020142B1/xx
Publication of HUP9902376A3 publication Critical patent/HUP9902376A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
HU9902376A 1999-07-15 1999-07-15 Process for producing n-(1,1-dimethyl)-4-[[s'-ethoxi-4-cis-[2-(4-morpholino)-ethoxi]-2'-oxospiro[cyclohexane-1,3'-[3h]indole]-1'(2'h)yl]-sulfonyl]-3-methoxybenzamide and its salts HUP9902376A3 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
HU9902376A HUP9902376A3 (en) 1999-07-15 1999-07-15 Process for producing n-(1,1-dimethyl)-4-[[s'-ethoxi-4-cis-[2-(4-morpholino)-ethoxi]-2'-oxospiro[cyclohexane-1,3'-[3h]indole]-1'(2'h)yl]-sulfonyl]-3-methoxybenzamide and its salts
ES00949822T ES2216927T3 (es) 1999-07-15 2000-07-13 Proceso para la preparacion de n-(1,1-dimetiletil)-4-((5'-etoxi-4-ci 2-(4-morfolino)etoxi)-2'-oxospiro(ciclohexan-1,3'-(3 h)indol)-1'(2'h)-il)-sulfonil)-3-metoxibenzamida y sus sales.
AT00949822T ATE264842T1 (de) 1999-07-15 2000-07-13 Verfahren zur herstellung von n-(1,1- dimethylethyl)-4-((5'-ethoxy-4-cis-(2-(4- morpholino)ethoxy)-2'-oxospiro(cyclohexan-1,3'- (3h)indol-1'(2h)-yl-sulfonyl)-3-methoxybenzamid und deren salzen
US10/030,647 US6600039B1 (en) 1999-07-15 2000-07-13 Process for the preparation of n-(1,1-dimethylethyl)-4-[[5′-ethoxy-4-cis[2-(4-morpholino)ethoxy]-2′-oxospiro[cyclohexan-1,3′[h]indol]1′(2′-h)-yl]-sulfonyl]-3-methoxybenzamide and its salts
PCT/HU2000/000078 WO2001005791A2 (en) 1999-07-15 2000-07-13 NEW PROCESS FOR THE PREPARATION OF N-(1,1-DIMETHYLETHYL)-4-[[5'-ETHOXY-4-cis-[2-(4-MORFOLINO)ETHOXY]-2'-OXOSPIRO[CYCLOHEXAN-1,3'-[H]INDOL]-1'(2'H)-yl]-SULFONYL]-3-METHOXYBENZAMIDE AND ITS SALTS
BR0012425-7A BR0012425A (pt) 1999-07-15 2000-07-13 Processo para a preparação de n-(1,1-dimetiletil)-4-[[5'-etoxi-4-cis[2-(4-morfolino)etoxi] -2'-oxospiro[ciclohexan-1,3'-[3h]indol]-1'(2'h)-il]-sulfoni l]-3-metoxibenzamida e seus sais
JP2001511450A JP2003505389A (ja) 1999-07-15 2000-07-13 Ｎ−（１，１−ジメチルエチル）−４−［［５’−エトキシ−４−シス−［２−（４−モルホリノ）エトキシ］−２’−オキソスピロ［シクロヘキサン−１，３’−［３ｈ］インドル］−１’（２’ｈ）−イル］−スルホニル］−３−メトキシベンズアミド及びその塩の新規製造方法
PL00352465A PL195787B1 (pl) 1999-07-15 2000-07-13 Sposób wytwarzania N-(1,1-dimetyloetylo)-4-[[5'-etoksy-4-cis-[2-(4-morfolino)etoksy]-2'-oksospiro[cykloheksan-1,3'-[3H]indol]-1'(2'H)-ilo]-sulfonylo]-3-metoksybenzamidu i jego soli
SK46-2002A SK285818B6 (sk) 1999-07-15 2000-07-13 Spôsob prípravy N-(1,1-dimetyletyl)-4-[[5'-etoxy-4-cis-[2-(4- morfolino)etoxy]-2'-oxospiro[cyklohexán-1,3'[3H]indol]-1'(2'H)- yl]-sulfonyl]-3-metoxybenzamidu a jeho solí
CNB008103143A CN1174969C (zh) 1999-07-15 2000-07-13 N-(1,1-二甲基乙基)-4-[[5′-乙氧基-4-顺-[2-(4-吗啉代)乙氧基]-2′-氧代螺[环己烷-1，3′-[3h]吲哚-1′（2′h）基]-磺酰基]-3-甲氧基苯甲酰胺及其盐的新制备方法
CZ2002145A CZ2002145A3 (cs) 1999-07-15 2000-07-13 Nový způsob přípravy N-(1,1-dimethylethyl)-4-[[5´-ethoxy-4-cis-[2-(4-morfolino)ethoxy]-2´-oxospiro[cyklohexan-1,3´-[3H]indol]-1´(2´H)-yl]sulfonyl]-3-methoxybenzamidu a jeho solí
SI200030399T SI1196381T1 (en) 1999-07-15 2000-07-13 Process for the preparation of n-(1,1-dimethylethyl)-4-((5'-ethoxy-4-cis-(2-(4-morpholino)ethoxy)-2'-oxospiro(cyclohexan-1,3'-(3h)indol)-1'(2'h)-yl)-sulfonyl)-3-methoxybenzamide and its salts
MXPA01013344A MXPA01013344A (es) 1999-07-15 2000-07-13 Proceso novedoso para la preparacion de n-(1,1-dimetiletil) -4-((5'etoxi-4-cis -(2-(4-morfolino) etoxi) -2'-oxoespiro (ciclohexan-1,3' -(h)indol) -1'(2-h)-il) -sulfonil) -3- metoxibenzamida y sus sales.
CA002378087A CA2378087C (en) 1999-07-15 2000-07-13 New process for the preparation of n-(1,1-dimethylethyl)-4-[[5'-ethoxy-4-cis-[2-(4-morfolino)ethoxy]-2'-oxospiro[cyclohexan-1,3'-[h]indol]-1'(2'h)-yl]-sulfonyl]-3-methoxybenzamideand its salts
AU63081/00A AU6308100A (en) 1999-07-15 2000-07-13 New process for the preparation of n-(1,1-dimethylethyl)-4-((5'-ethoxy-4-cis-(2-(4-morfolino)et oxy)-2'-oxospiro(cyclohexan-1,3'-(h)indol)-1'(2'h)-yl)-sulfo yl)-3-methoxybenzamide and its salts
HU0201548A HUP0201548A3 (en) 1999-07-15 2000-07-13 Process for the preparation of n-(1,1-dimethylethyl)-4-[[5'-ethoxy-4-cis[2-(4-morfolino)ethoxy]-2'-oxospiro[cyclohexan-1,3'[h]indol]1'(2'h)-yl]-sulfonyl]-3-methoxybenzamide and its salts
EP00949822A EP1196381B1 (en) 1999-07-15 2000-07-13 Process for the preparation of n-(1,1-dimethylethyl)-4-((5'-ethoxy-4-cis-(2-(4-morpholino)ethoxy)-2'-oxospiro(cyclohexan-1,3'-(3h)indol)-1'(2'h)-yl)-sulfonyl)-3-methoxybenzamide and its salts
DE60010083T DE60010083T2 (de) 1999-07-15 2000-07-13 Verfahren zur herstellung von n-(1,1-dimethylethyl)-4-((5'-ethoxy-4-cis-(2-(4-morpholino)-ethoxy)-2'-oxospiro(cyclohexan-1,3'-(3h)indol-1'(2h)-yl-sulfonyl)-3-methoxybenzamid und deren salzen
HR20020142A HRP20020142B1 (en) 1999-07-15 2002-02-14 Process for the preparation of n-(1,1-dimethylethyl)-4-[[5'-ethoxy-4-cis-[2-(4-morfolino)ethoxy]-2'-oxospiro[cyklohexan-1,3'-[h]indol]-1'(2'h)-yl]-sulfonyl]-3-methoxybenzamide and its salts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9902376A HUP9902376A3 (en) 1999-07-15 1999-07-15 Process for producing n-(1,1-dimethyl)-4-[[s'-ethoxi-4-cis-[2-(4-morpholino)-ethoxi]-2'-oxospiro[cyclohexane-1,3'-[3h]indole]-1'(2'h)yl]-sulfonyl]-3-methoxybenzamide and its salts

Publications (3)

Publication Number Publication Date
HU9902376D0 true HU9902376D0 (en) 1999-10-28
HUP9902376A2 HUP9902376A2 (hu) 2001-05-28
HUP9902376A3 HUP9902376A3 (en) 2002-11-28

Family

ID=89998742

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9902376A HUP9902376A3 (en) 1999-07-15 1999-07-15 Process for producing n-(1,1-dimethyl)-4-[[s'-ethoxi-4-cis-[2-(4-morpholino)-ethoxi]-2'-oxospiro[cyclohexane-1,3'-[3h]indole]-1'(2'h)yl]-sulfonyl]-3-methoxybenzamide and its salts

Country Status (17)

Country Link
US (1) US6600039B1 (hu)
EP (1) EP1196381B1 (hu)
JP (1) JP2003505389A (hu)
CN (1) CN1174969C (hu)
AT (1) ATE264842T1 (hu)
AU (1) AU6308100A (hu)
BR (1) BR0012425A (hu)
CA (1) CA2378087C (hu)
CZ (1) CZ2002145A3 (hu)
DE (1) DE60010083T2 (hu)
ES (1) ES2216927T3 (hu)
HR (1) HRP20020142B1 (hu)
HU (1) HUP9902376A3 (hu)
MX (1) MXPA01013344A (hu)
PL (1) PL195787B1 (hu)
SK (1) SK285818B6 (hu)
WO (1) WO2001005791A2 (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4823614A (en) * 1986-04-28 1989-04-25 Dahlin Erik B Coriolis-type mass flowmeter
DE60204154T2 (de) * 2001-07-31 2006-01-19 Sanofi-Aventis Verfahren zur herstellung von 3 spiro'cyclohexan-1,3'-'3h!indolin-2'-on!derivaten

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2740136B1 (fr) 1995-10-24 1998-01-09 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant
FR2757157B1 (fr) * 1996-12-13 1999-12-31 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
EP1196381A2 (en) 2002-04-17
BR0012425A (pt) 2002-06-11
DE60010083T2 (de) 2005-03-31
ATE264842T1 (de) 2004-05-15
WO2001005791A2 (en) 2001-01-25
MXPA01013344A (es) 2002-08-20
WO2001005791A3 (en) 2001-07-19
CN1420868A (zh) 2003-05-28
PL352465A1 (en) 2003-08-25
CZ2002145A3 (cs) 2002-11-13
ES2216927T3 (es) 2004-11-01
CA2378087C (en) 2007-12-18
US6600039B1 (en) 2003-07-29
EP1196381B1 (en) 2004-04-21
SK285818B6 (sk) 2007-09-06
PL195787B1 (pl) 2007-10-31
AU6308100A (en) 2001-02-05
CA2378087A1 (en) 2001-01-25
HRP20020142A2 (en) 2003-12-31
SK462002A3 (en) 2003-03-04
HUP9902376A3 (en) 2002-11-28
DE60010083D1 (de) 2004-05-27
JP2003505389A (ja) 2003-02-12
HUP9902376A2 (hu) 2001-05-28
CN1174969C (zh) 2004-11-10
HRP20020142B1 (en) 2010-09-30

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FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished