HU9502869D0 - Chelators of type xn1s1x' for radioactive isotopes, their metal complexes and their diagnostic and therapeutical uses - Google Patents
Chelators of type xn1s1x' for radioactive isotopes, their metal complexes and their diagnostic and therapeutical usesInfo
- Publication number
- HU9502869D0 HU9502869D0 HU9502869A HU9502869A HU9502869D0 HU 9502869 D0 HU9502869 D0 HU 9502869D0 HU 9502869 A HU9502869 A HU 9502869A HU 9502869 A HU9502869 A HU 9502869A HU 9502869 D0 HU9502869 D0 HU 9502869D0
- Authority
- HU
- Hungary
- Prior art keywords
- pct
- diagnostic
- compounds
- xn1s1x
- chelators
- Prior art date
Links
- 239000002738 chelating agent Substances 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 239000002184 metal Substances 0.000 title 1
- 230000002285 radioactive effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000001588 bifunctional effect Effects 0.000 abstract 2
- 150000001787 chalcogens Chemical group 0.000 abstract 2
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000012217 radiopharmaceutical Substances 0.000 abstract 1
- 229940121896 radiopharmaceutical Drugs 0.000 abstract 1
- 230000002799 radiopharmaceutical effect Effects 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4310999A DE4310999C2 (de) | 1993-03-31 | 1993-03-31 | Bifunktionelle chalkogenatom-unterbrochene Chelatbildner vom Typ XN¶1¶S¶1¶X' für radioaktive Isotope und deren Metallkomplexe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Mittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HU9502869D0 true HU9502869D0 (en) | 1995-11-28 |
| HUT73489A HUT73489A (en) | 1996-08-28 |
Family
ID=6484671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9502869A HUT73489A (en) | 1993-03-31 | 1994-03-29 | Chelators of type xn1s1x' braked with twovalent calcogene atom for radioactive isotopes, their metal complexes and their diagnostic and therpeutical uses, and pharmaceutical compositions containing them, and process for producing them |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5961954A (hu) |
| EP (1) | EP0692981B1 (hu) |
| JP (1) | JPH08511237A (hu) |
| KR (1) | KR960700762A (hu) |
| AT (1) | ATE179078T1 (hu) |
| AU (1) | AU692154B2 (hu) |
| CA (1) | CA2156619A1 (hu) |
| DE (2) | DE4310999C2 (hu) |
| HU (1) | HUT73489A (hu) |
| NO (1) | NO953868L (hu) |
| NZ (1) | NZ263795A (hu) |
| WO (1) | WO1994022493A1 (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4311022C2 (de) * | 1993-03-31 | 1996-07-11 | Diagnostikforschung Inst | Bifunktionelle chalkogenatom-unterbrochene Chelatbildner vom Typ S¶3¶N¶2¶ für radioaktive Isotope und deren Metallkomplexe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Mittel |
| DE19536781A1 (de) * | 1995-09-21 | 1997-03-27 | Diagnostikforschung Inst | Bifunktionelle sulfidhaltige Sulfonamid-Chelatbildner vom Typ XSNS für radioaktive Isotope |
| DE19536785A1 (de) * | 1995-09-21 | 1997-03-27 | Diagnostikforschung Inst | Bifunktionelle sulfidhaltige Sulfonamid-Chelatbildner vom Typ S¶2¶NY für radioaktive Isotope |
| DE19652374A1 (de) * | 1996-12-04 | 1998-06-10 | Schering Ag | Verwendung von Endothelin-Konjugaten in der Therapie, neue Endothelin-Konjugate, diese enthaltende Mittel, sowie Verfahren zu deren Herstellung |
| CA2484345C (en) * | 2002-05-06 | 2015-09-29 | Endocyte, Inc. | Folate-targeted imaging agents |
| US20080058674A1 (en) * | 2006-08-29 | 2008-03-06 | Lex Jansen | Tissue extraction device and method of using the same |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0063946A1 (en) * | 1981-04-21 | 1982-11-03 | AMERSHAM INTERNATIONAL plc | Diagnosis of kidney function |
| EP0089143A1 (en) * | 1982-03-16 | 1983-09-21 | AMERSHAM INTERNATIONAL plc | Diagnosis of kidney function |
| US4980147A (en) * | 1984-06-25 | 1990-12-25 | University Of Utah Research Foundation | Radiolabeled technetium chelates for use in renal function determinations |
| ATE66469T1 (de) * | 1985-01-14 | 1991-09-15 | Neorx Corp | Metall-radionuklid markiertes protein fuer diagnose und therapie. |
| ES2017088B3 (es) * | 1986-05-28 | 1991-01-01 | Mallinckrodt Inc (A Missouri Corporation) | Quelatos de tecnecio a utilizar para determinar la funcion renal. |
| US4861869A (en) * | 1986-05-29 | 1989-08-29 | Mallinckrodt, Inc. | Coupling agents for joining radionuclide metal ions with biologically useful proteins |
| WO1989000557A1 (en) * | 1987-07-16 | 1989-01-26 | Cockbain, Julian, Roderick, Michaelson | Aminopolycarboxylic acids and derivatives thereof |
| AU1995392A (en) * | 1991-05-08 | 1992-12-21 | Mallinckrodt Medical, Inc. | Technetium chelates to be used for determining the renal function |
| JPH0570484A (ja) * | 1991-09-12 | 1993-03-23 | Hitachi Chem Co Ltd | ペプチドおよびその塩 |
| CA2129036A1 (en) * | 1992-02-06 | 1993-08-19 | Mallinckrodt Inc. | Ligands for improving metal chelate formation kinetics |
| DE4311022C2 (de) * | 1993-03-31 | 1996-07-11 | Diagnostikforschung Inst | Bifunktionelle chalkogenatom-unterbrochene Chelatbildner vom Typ S¶3¶N¶2¶ für radioaktive Isotope und deren Metallkomplexe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Mittel |
| DE4311021A1 (de) * | 1993-03-31 | 1994-10-27 | Diagnostikforschung Inst | Bifunktionelle Chelatbildner, deren Technetium- und Rhenium-Komplexe, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Mittel |
| DE4311023C2 (de) * | 1993-03-31 | 1996-05-02 | Diagnostikforschung Inst | Bifunktionelle chalkogenatom-unterbrochene Chelatbildner von Typ XN¶1¶S¶1¶O¶1¶ für radioaktive Isotope, deren Metallkomplexe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Mittel |
-
1993
- 1993-03-31 DE DE4310999A patent/DE4310999C2/de not_active Expired - Lifetime
-
1994
- 1994-03-29 EP EP94912442A patent/EP0692981B1/de not_active Expired - Lifetime
- 1994-03-29 JP JP6521543A patent/JPH08511237A/ja active Pending
- 1994-03-29 US US08/530,326 patent/US5961954A/en not_active Expired - Fee Related
- 1994-03-29 AU AU65018/94A patent/AU692154B2/en not_active Ceased
- 1994-03-29 AT AT94912442T patent/ATE179078T1/de not_active IP Right Cessation
- 1994-03-29 DE DE59408144T patent/DE59408144D1/de not_active Expired - Lifetime
- 1994-03-29 HU HU9502869A patent/HUT73489A/hu unknown
- 1994-03-29 WO PCT/DE1994/000372 patent/WO1994022493A1/de active IP Right Grant
- 1994-03-29 CA CA002156619A patent/CA2156619A1/en not_active Abandoned
- 1994-03-29 NZ NZ263795A patent/NZ263795A/en unknown
- 1994-03-29 KR KR1019950703670A patent/KR960700762A/ko not_active Application Discontinuation
-
1995
- 1995-09-29 NO NO953868A patent/NO953868L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE179078T1 (de) | 1999-05-15 |
| KR960700762A (ko) | 1996-02-24 |
| NZ263795A (en) | 1997-01-29 |
| WO1994022493A1 (de) | 1994-10-13 |
| AU692154B2 (en) | 1998-06-04 |
| JPH08511237A (ja) | 1996-11-26 |
| DE4310999C2 (de) | 1996-07-18 |
| CA2156619A1 (en) | 1994-10-13 |
| DE59408144D1 (de) | 1999-05-27 |
| EP0692981A1 (de) | 1996-01-24 |
| DE4310999A1 (de) | 1994-10-06 |
| EP0692981B1 (de) | 1999-04-21 |
| NO953868D0 (no) | 1995-09-29 |
| HUT73489A (en) | 1996-08-28 |
| NO953868L (no) | 1995-11-23 |
| AU6501894A (en) | 1994-10-24 |
| US5961954A (en) | 1999-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DFD9 | Temporary protection cancelled due to non-payment of fee |