HU217443B - Heterociklusos imino-bisz-metilén-biszfoszfonsav-származékok, eljárás előállításukra, és ezeket hatóanyagként tartalmazó gyógyszerkészítmények - Google Patents
Heterociklusos imino-bisz-metilén-biszfoszfonsav-származékok, eljárás előállításukra, és ezeket hatóanyagként tartalmazó gyógyszerkészítmények Download PDFInfo
- Publication number
- HU217443B HU217443B HU9401070A HU9401070A HU217443B HU 217443 B HU217443 B HU 217443B HU 9401070 A HU9401070 A HU 9401070A HU 9401070 A HU9401070 A HU 9401070A HU 217443 B HU217443 B HU 217443B
- Authority
- HU
- Hungary
- Prior art keywords
- formula
- heterocyclic
- methylene
- iminobis
- bisphosphonic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C07F9/3817—Acids containing the structure (RX)2P(=X)-alk-N...P (X = O, S, Se)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5087692A JPH06298779A (ja) | 1993-04-15 | 1993-04-15 | ヘテロ環イミノビスメチレンビスホスホン酸誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9401070D0 HU9401070D0 (en) | 1994-07-28 |
| HUT68774A HUT68774A (en) | 1995-07-28 |
| HU217443B true HU217443B (hu) | 2000-01-28 |
Family
ID=13921987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9401070A HU217443B (hu) | 1993-04-15 | 1994-04-14 | Heterociklusos imino-bisz-metilén-biszfoszfonsav-származékok, eljárás előállításukra, és ezeket hatóanyagként tartalmazó gyógyszerkészítmények |
Country Status (9)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4435496A1 (de) * | 1994-10-04 | 1996-04-11 | Hoechst Ag | Imidobisphosphorsäuren, Verfahren zu ihrer Herstellung und Verwendung derselben |
| ZA975198B (en) | 1996-06-13 | 1997-12-15 | Smithkline Beecham Corp | Improved process for preparing potassium clavulanate. |
| WO1998039342A1 (en) | 1997-03-07 | 1998-09-11 | Metabasis Therapeutics, Inc. | Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase |
| EP1402895A1 (en) * | 1997-03-07 | 2004-03-31 | Metabasis Therapeutics, Inc. | Benzimidazole inhibitors of fructose 1,6-biphosphatase |
| AU6452098A (en) | 1997-03-07 | 1998-09-22 | Metabasis Therapeutics, Inc. | Novel purine inhibitors of fructose-1,6-bisphosphatase |
| ATE253073T1 (de) * | 1997-03-07 | 2003-11-15 | Metabasis Therapeutics Inc | Neue benzimidazol inhibitoren der fructose-1,6- bisphosphatase |
| SK286080B6 (sk) | 1998-09-09 | 2008-03-05 | Metabasis Therapeutics, Inc. | Heterocyklické aromatické zlúčeniny obsahujúce fosfonátovú skupinu, ich použitie a farmaceutická kompozícia obsahujúca uvedené zlúčeniny |
| FR2793796A1 (fr) * | 1999-04-14 | 2000-11-24 | Hoechst Marion Roussel Inc | Nouveaux derives d'imidazoles, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant |
| US6315566B1 (en) | 1999-05-18 | 2001-11-13 | 3M Innovative Properties Company | Dental materials |
| US6143919A (en) * | 1999-05-18 | 2000-11-07 | 3M Innovative Properties Company | Polymerizable acidic compounds and methods of preparation |
| US7563774B2 (en) | 2000-06-29 | 2009-07-21 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes |
| CN100358906C (zh) * | 2005-09-28 | 2008-01-02 | 南京大学 | N-(2-苯并咪唑基甲基)亚氨基双甲基膦酸的合成方法 |
| WO2012172271A1 (fr) * | 2011-06-17 | 2012-12-20 | Centre National De La Recherche Scientifique | Chélatants bifonctionnels phosphonates |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3674804A (en) * | 1968-10-17 | 1972-07-04 | Petrolite Corp | Imidazoline phosphonic acids |
| DE2224516A1 (de) * | 1972-05-19 | 1973-12-06 | Henkel & Cie Gmbh | Zahnsteinbildung verhindernde mundund zahnpflegemittel |
| JPS5952805A (ja) * | 1982-09-20 | 1984-03-27 | Konishiroku Photo Ind Co Ltd | 処理済み強磁性粉末 |
| DE3428524A1 (de) * | 1984-08-02 | 1986-02-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| US5057505A (en) * | 1986-11-21 | 1991-10-15 | Ciba-Geigy Corporation | Substituted aminomethanediphosphonic acids and use in medicaments |
| EP0317505A1 (de) * | 1987-11-13 | 1989-05-24 | Ciba-Geigy Ag | Neue Azacycloalkylalkandiphosphonsäuren |
| US5190930A (en) * | 1987-12-11 | 1993-03-02 | Ciba-Geigy Corporation | Araliphatylaminoalkanediphosphonic acids |
| DE3822650A1 (de) * | 1988-07-05 | 1990-02-01 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US4990503A (en) * | 1988-08-12 | 1991-02-05 | Yamanouchi Pharmaceutical Co., Ltd. | Heterocyclic bisphosphonic acid derivatives |
| US4917737A (en) * | 1989-03-13 | 1990-04-17 | Betz Laboratories, Inc. | Sealing composition and method for iron and zinc phosphating process |
| EP0491374B1 (en) * | 1990-12-19 | 1996-01-31 | Takeda Chemical Industries, Ltd. | Bisphosphonic acid derivatives, their production and use |
| TW222637B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1991-12-12 | 1994-04-21 | Hoechst Ag |
-
1993
- 1993-04-15 JP JP5087692A patent/JPH06298779A/ja active Pending
-
1994
- 1994-04-11 EP EP94105550A patent/EP0620227A1/en not_active Withdrawn
- 1994-04-13 AU AU59432/94A patent/AU673895B2/en not_active Ceased
- 1994-04-13 US US08/227,351 patent/US5441945A/en not_active Expired - Fee Related
- 1994-04-13 FI FI941712A patent/FI941712A7/fi unknown
- 1994-04-14 HU HU9401070A patent/HU217443B/hu not_active IP Right Cessation
- 1994-04-14 CA CA002121313A patent/CA2121313A1/en not_active Abandoned
- 1994-04-14 NO NO941336A patent/NO303120B1/no unknown
- 1994-04-25 TW TW083103655A patent/TW279164B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| FI941712L (fi) | 1994-10-16 |
| NO941336L (no) | 1994-10-17 |
| JPH06298779A (ja) | 1994-10-25 |
| FI941712A7 (fi) | 1994-10-16 |
| HUT68774A (en) | 1995-07-28 |
| FI941712A0 (fi) | 1994-04-13 |
| HU9401070D0 (en) | 1994-07-28 |
| TW279164B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1996-06-21 |
| EP0620227A1 (en) | 1994-10-19 |
| NO303120B1 (no) | 1998-06-02 |
| US5441945A (en) | 1995-08-15 |
| NO941336D0 (no) | 1994-04-14 |
| AU673895B2 (en) | 1996-11-28 |
| CA2121313A1 (en) | 1994-10-16 |
| AU5943294A (en) | 1994-10-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HU217443B (hu) | Heterociklusos imino-bisz-metilén-biszfoszfonsav-származékok, eljárás előállításukra, és ezeket hatóanyagként tartalmazó gyógyszerkészítmények | |
| HU209305B (en) | Process for producing 1h-imidazo(4,5-b)quinolinyl oxyalkanecarboxylic acid amides having increased water solubility, as well as pharmaceutical compositions comprising same | |
| AU2020414151A1 (en) | Protein degradation agent compound preparation method and application | |
| EP1400521B1 (en) | Piperazine compounds | |
| HUT61984A (en) | Process for producing condensed imidazole derivatives and pharmaceutical compositions comprising same | |
| HUT51637A (en) | Process for producing heterocyclic derivatives of biphosphonic acid | |
| BG51046A3 (bg) | Метод за получаване на пиридо(1,2-а)пиразинови производни | |
| HUT61306A (en) | Process for producing new chelating agents and pharmaceutical compositions comprising same as active ingredient | |
| AU616391B2 (en) | Novel heterocycle-substituted diphosphonate compounds pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism | |
| HU212133B (en) | Therapeutic agents | |
| US5071840A (en) | Certain heterocyclic substituted diphosphonate compounds pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism | |
| HUT61994A (en) | Process for producing dihydropyridine derivatives and pharmaceutical compositions with antitumoral effect comprising same | |
| US4166859A (en) | 2-Bromo-6-fluoro-N-(2-imidazolidinylidene)-benzamine and salts thereof and the use to treat hypertension | |
| DE69329385T2 (de) | Thiazolin-derivate | |
| GB2083474A (en) | N-(4-3-substituted pyridyl piperazino) alkyl azaspirodecanediones | |
| EP0273514A1 (en) | Novel bicyclic diphosphonate compounds and pharmaceutical compositions | |
| GB2214181A (en) | 1,2-ethylene diamine compounds | |
| EP0994884A1 (en) | Diphosphonic acid salts for the treatment of osteoporosis | |
| US5574037A (en) | Amino 1,3,5-triazine derivatives as agents for cardiovascular system | |
| US4410698A (en) | Oxadiazolopyrimidine derivatives | |
| EP0139993A2 (de) | Chinazolinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel | |
| JPS61204186A (ja) | ピリダジノピロロイソキノリン誘導体 | |
| JP2023529047A (ja) | 組織損傷の治療に使用するための作用剤 | |
| MXPA02005866A (es) | Derivados de heterociclo y drogas. | |
| US5272159A (en) | Adjuncts in cancer chemotherapy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HMM4 | Cancellation of final prot. due to non-payment of fee |