HU200177B - Process for producing thiazolidinecarboxylic acids and pharmaceutical compositions comprising such compounds - Google Patents

Process for producing thiazolidinecarboxylic acids and pharmaceutical compositions comprising such compounds

Info

Publication number
HU200177B
HU200177B HU852388A HU238885A HU200177B HU 200177 B HU200177 B HU 200177B HU 852388 A HU852388 A HU 852388A HU 238885 A HU238885 A HU 238885A HU 200177 B HU200177 B HU 200177B
Authority
HU
Hungary
Prior art keywords
compounds
producing
pharmaceutical compositions
thiazolidinecarboxylic
acids
Prior art date
Application number
HU852388A
Other languages
English (en)
Other versions
HUT41774A (en
Inventor
Zoltan Gyoergydeak
Rezsoe Bognar
Geza Horvath
Ferenc Pusztai
Istvan Kovacs
Huszka Mariann Feketene
Sandor Jancso
Terezia Mile
Borbely Ildiko Mihokne
Janos Balint
Attila Jakab
Ham Judit Krusperne
Karoly Lapis
Bela Szende
Andras Jenei
Original Assignee
Biogal Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar filed Critical Biogal Gyogyszergyar
Priority to HU852388A priority Critical patent/HU200177B/hu
Priority to IL78942A priority patent/IL78942A0/xx
Priority to DK259386A priority patent/DK259386A/da
Priority to IN416/CAL/86A priority patent/IN165646B/en
Priority to PH33857A priority patent/PH22790A/en
Priority to GR861517A priority patent/GR861517B/el
Priority to US06/874,111 priority patent/US4775675A/en
Priority to PL1986273754A priority patent/PL149453B1/pl
Priority to GB8614616A priority patent/GB2177089B/en
Priority to DD86291335A priority patent/DD259866A5/de
Priority to PT82769A priority patent/PT82769B/pt
Priority to PL1986260106A priority patent/PL148541B1/pl
Priority to ES556135A priority patent/ES8800919A1/es
Priority to NO862408A priority patent/NO862408L/no
Priority to JP61139386A priority patent/JPS6248672A/ja
Priority to BG075405A priority patent/BG46457A3/xx
Priority to KR1019860004835A priority patent/KR870000312A/ko
Priority to SU864027696A priority patent/SU1443800A3/ru
Priority to CN198686104085A priority patent/CN86104085A/zh
Priority to AR86304306A priority patent/AR241532A1/es
Priority to EP86108186A priority patent/EP0206197A1/de
Priority to FI862608A priority patent/FI862608A/fi
Priority to SU864028509A priority patent/SU1475905A1/ru
Publication of HUT41774A publication Critical patent/HUT41774A/hu
Publication of HU200177B publication Critical patent/HU200177B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
HU852388A 1985-06-18 1985-06-18 Process for producing thiazolidinecarboxylic acids and pharmaceutical compositions comprising such compounds HU200177B (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
HU852388A HU200177B (en) 1985-06-18 1985-06-18 Process for producing thiazolidinecarboxylic acids and pharmaceutical compositions comprising such compounds
IL78942A IL78942A0 (en) 1985-06-18 1986-05-27 Thiazolidinecarboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
DK259386A DK259386A (da) 1985-06-18 1986-06-02 Thiazolidincarboxylsyrederivater
IN416/CAL/86A IN165646B (hu) 1985-06-18 1986-06-04
PH33857A PH22790A (en) 1985-06-18 1986-06-05 Thiazolidine carboxylic acid derivatives
GR861517A GR861517B (en) 1985-06-18 1986-06-11 Triazolidino-4(s)- carbonic acid derivatives and preparation process therefor
US06/874,111 US4775675A (en) 1985-06-18 1986-06-13 Thiazolidinecarboxylic acid derivatives and treatment of liver diseases therewith
PL1986273754A PL149453B1 (en) 1985-06-18 1986-06-16 Method of obtaining novel 5,5-dimethyl-2-/indenyl-5'-thiazolidinylcarboxylic-4/s/ acid
GB8614616A GB2177089B (en) 1985-06-18 1986-06-16 Thiazolidinecarboxylic acid derivatives and process for preparing same
DD86291335A DD259866A5 (de) 1985-06-18 1986-06-16 Verfahren zur herstellung von neuen thiozdiolin-4(s)-carbonsaeure-derivaten
PT82769A PT82769B (pt) 1985-06-18 1986-06-16 Processo para a preparacao de derivados de acidos tiazolidino-4(s)-caboxilicos
PL1986260106A PL148541B1 (en) 1985-06-18 1986-06-16 Method of obtaining novel derivatives of triazolydinocarboxylic-4/s/ acid
ES556135A ES8800919A1 (es) 1985-06-18 1986-06-17 Procedimiento para preparar nuevos derivados de acidos tiazolidin-4(s)-carboxilicos
NO862408A NO862408L (no) 1985-06-18 1986-06-17 Fremgangsmaate for fremstilling av thiazolidin-4(s)-karboksylsyrederivater.
JP61139386A JPS6248672A (ja) 1985-06-18 1986-06-17 チアゾリジンカルボン酸誘導体
BG075405A BG46457A3 (en) 1985-06-18 1986-06-18 Method for preparing of replaced thiazolidine- 4(s)- carbonic acids
KR1019860004835A KR870000312A (ko) 1985-06-18 1986-06-18 티아졸리딘-4(s)-카르복실산 유도체의 제조 방법
SU864027696A SU1443800A3 (ru) 1985-06-18 1986-06-18 Способ получени производных тиазолидин-4(S)-карбоновой кислоты или ее солей с щелочными или щелочноземельными металлами,или ее сложных эфиров
CN198686104085A CN86104085A (zh) 1985-06-18 1986-06-18 四氢噻唑羧酸衍生物的制备方法
AR86304306A AR241532A1 (es) 1985-06-18 1986-06-18 Procedimiento para preparar nuevos derivados de acido-tiazolidin-4(s)-carboxilico.
EP86108186A EP0206197A1 (de) 1985-06-18 1986-06-18 5,5-Di-(methyl)-thiazolidin-4(S)-carbonsäurederivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
FI862608A FI862608A (fi) 1985-06-18 1986-06-18 Tiazolin-4(s) -karboxylsyraderivat och foerfarande foer deras framstaellning.
SU864028509A SU1475905A1 (ru) 1985-06-18 1986-11-19 Производные тиазолидин-4S-карбоновой кислоты, обладающие способностью защищать печень

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU852388A HU200177B (en) 1985-06-18 1985-06-18 Process for producing thiazolidinecarboxylic acids and pharmaceutical compositions comprising such compounds

Publications (2)

Publication Number Publication Date
HUT41774A HUT41774A (en) 1987-05-28
HU200177B true HU200177B (en) 1990-04-28

Family

ID=10959103

Family Applications (1)

Application Number Title Priority Date Filing Date
HU852388A HU200177B (en) 1985-06-18 1985-06-18 Process for producing thiazolidinecarboxylic acids and pharmaceutical compositions comprising such compounds

Country Status (21)

Country Link
US (1) US4775675A (hu)
EP (1) EP0206197A1 (hu)
JP (1) JPS6248672A (hu)
KR (1) KR870000312A (hu)
CN (1) CN86104085A (hu)
AR (1) AR241532A1 (hu)
BG (1) BG46457A3 (hu)
DD (1) DD259866A5 (hu)
DK (1) DK259386A (hu)
ES (1) ES8800919A1 (hu)
FI (1) FI862608A (hu)
GB (1) GB2177089B (hu)
GR (1) GR861517B (hu)
HU (1) HU200177B (hu)
IL (1) IL78942A0 (hu)
IN (1) IN165646B (hu)
NO (1) NO862408L (hu)
PH (1) PH22790A (hu)
PL (2) PL149453B1 (hu)
PT (1) PT82769B (hu)
SU (2) SU1443800A3 (hu)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5740492A (en) * 1980-08-22 1982-03-06 Yamanouchi Pharmaceut Co Ltd Novel 2-phenylimidazo 2,1-b benzothiazole derivative
CN1030415A (zh) * 1987-02-20 1989-01-18 山之内制药株式会社 饱和的杂环碳酰胺衍生物和它的制备方法
IT1223565B (it) * 1987-12-21 1990-09-19 Zambon Spa Derivati dell'acido tiazolidin 4 carbossilico ad attivita' farmaceutica
JP2726999B2 (ja) * 1988-06-22 1998-03-11 日研化学株式会社 イミダゾ［２，１−ｂ］ベンゾチアゾール誘導体及び該化合物を有効成分とする抗潰瘍剤
GB9026114D0 (en) * 1990-11-30 1991-01-16 Norsk Hydro As New compounds
ATE144142T1 (de) * 1991-01-10 1996-11-15 Transcend Therapeutics Inc Verwendung von thiazolidin-4-carboxylatderivaten zur behandlung von lungenerkrankungen
US5747459A (en) * 1991-02-04 1998-05-05 Nestec, Ltd. Method for insuring adequate intracellular glutathione in tissue
US5849686A (en) * 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
US5214062A (en) * 1992-04-08 1993-05-25 Clintec Nutrition Co. Method and composition for treating immune disorders, inflammation and chronic infections
US5430045A (en) * 1992-04-23 1995-07-04 Free Radical Sciences, Inc. Method of reducing or preventing bone marrow hypoplasia
US5447712A (en) * 1993-12-09 1995-09-05 Free Radical Sciences Method of reducing cyclophosphamide induced hemorrhagic cystitis
US6083966A (en) * 1998-08-31 2000-07-04 University Of Florida Thiazoline acid derivatives
WO2000016763A2 (en) * 1998-09-21 2000-03-30 University Of Florida Research Foundation, Inc. Antimalarial agents
AU5319700A (en) * 1999-06-02 2000-12-18 S. Mbua Ngale Efange Nicotine receptor ligands
AU6676100A (en) 1999-08-17 2001-03-13 University Of Saskatchewan Technologies Inc. Improved treatment for acute physical insult to the central nervous system
WO2005034949A1 (en) * 2003-09-09 2005-04-21 University Of Florida Desferrithiocin derivatives and their use as iron chelators
DE102004021658A1 (de) * 2004-05-03 2005-12-01 Rudy Dr. Susilo Kombinationspräparate enthaltend 2-Methylthiazolidin-2,4-dicarbonsäure
CA2603385C (en) 2005-04-04 2014-07-15 University Of Florida Research Foundation, Inc. Desferrithiocin polyether analogues and uses thereof for treating metal overload, oxidative stress, and neoplastic and preneoplastic conditions
CN104003955A (zh) 2007-03-15 2014-08-27 佛罗里达大学研究基金公司 去铁硫辛聚醚类似物
CN104114170B (zh) 2011-12-16 2021-07-06 佛罗里达大学研究基金会 4′-去铁硫素类似物的用途
EP2968346B1 (en) * 2013-03-15 2024-02-07 Cancer Research Technology, LLC Methods and compositions for gamma-glutamyl cycle modulation
EP3071201A4 (en) 2013-11-22 2017-04-26 University of Florida Research Foundation, Inc. Desferrithiocin analogs and uses thereof
WO2016176343A1 (en) 2015-04-27 2016-11-03 University Of Florida Research Foundation, Incorporated Metabolically programmed metal chelators and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR923562A (fr) * 1946-02-01 1947-07-10 Tube électronique
CH540234A (de) * 1968-09-06 1973-08-15 Degussa Verfahren zur Herstellung von Penicillamin
ES381037A1 (es) * 1969-06-05 1973-07-01 Ferlux Acido tiazolidin dicarboxilico-2,4 y sus derivados y proce-dimiento para su obtencion.
DE2116629A1 (en) * 1971-04-05 1972-10-19 Institutul de Biochimie, Bukarest 4-thiazolidinecarboxylic acid derivs - with in vivo thiol liberating activity
CA962269A (en) * 1971-05-05 1975-02-04 Robert E. Grahame (Jr.) Thiazoles, and their use as insecticides
US3947464A (en) * 1972-07-28 1976-03-30 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler Salts of phenylpropanolamine with thiazolidine carboxylic acids
DE2446100C3 (de) * 1974-09-26 1982-01-14 Ludwig Merckle Kg Chem. Pharm. Fabrik, 7902 Blaubeuren Phenoxyalkancarbonsäureamide von Thiazolidincarbonsäuren, Verfahren zu ihrer Herstellung und Arzneimittel
GB1473752A (en) * 1975-04-09 1977-05-18 Rexolin Chem Ab Composition of nitrofurans and its use in controlling formation of slime
FR2356423A1 (fr) * 1976-07-01 1978-01-27 Oeriu Simion Derives de l'acide thiazolidinecarboxylique, leur preparation et leur application comme medicaments
DE3170401D1 (en) * 1980-07-28 1985-06-13 Ciba Geigy Ag Triazoline derivatives and processes for their preparation

Also Published As

Publication number Publication date
FI862608A (fi) 1986-12-19
BG46457A3 (en) 1989-12-15
HUT41774A (en) 1987-05-28
NO862408L (no) 1986-12-19
PL148541B1 (en) 1989-10-31
GB2177089B (en) 1989-07-19
KR870000312A (ko) 1987-02-17
DD259866A5 (de) 1988-09-07
SU1443800A3 (ru) 1988-12-07
ES8800919A1 (es) 1987-12-01
DK259386A (da) 1986-12-19
PT82769A (en) 1986-07-01
PH22790A (en) 1988-12-12
GR861517B (en) 1986-10-10
FI862608A0 (fi) 1986-06-18
JPS6248672A (ja) 1987-03-03
ES556135A0 (es) 1987-12-01
US4775675A (en) 1988-10-04
GB8614616D0 (en) 1986-07-23
IN165646B (hu) 1989-12-02
SU1475905A1 (ru) 1989-04-30
PT82769B (pt) 1988-04-21
IL78942A0 (en) 1986-09-30
AR241532A1 (es) 1992-08-31
PL149453B1 (en) 1990-02-28
DK259386D0 (da) 1986-06-02
EP0206197A1 (de) 1986-12-30
GB2177089A (en) 1987-01-14
CN86104085A (zh) 1987-04-22
NO862408D0 (no) 1986-06-17

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee